Future detection and monitoring of diabetes may entail analysis of both β-cell function and volume: How markers of β-cell loss may assist

The pancreatic beta cell surface proteome

(2012) I. Stützer et al.   DIABETOLOGIA

Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans

(2012) J. J. Meier et al.   DIABETOLOGIA

Transcellular Neuroligin-2 Interactions Enhance Insulin Secretion and Are Integral to Pancreatic β Cell Function

(2012) Arthur T. Suckow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurexin-1α Contributes to Insulin-containing Secretory Granule Docking

(2012) Merrie Mosedale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix metalloproteinase inhibition therapy for vascular diseases

(2012) Andrew C. Newby   VASCULAR PHARMACOLOGY

Post-translational modifications of the extracellular matrix are key events in cancer progression: Opportunities for biochemical marker development

(2011) D. J. Leeming et al.   BIOMARKERS

Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis

(2011) Efstathios Vassiliadis et al.   BIOMARKERS

Management of diabetes and associated cardiovascular risk factors in seven countries: a comparison of data from national health examination surveys

(2011) Emmanuela Gakidou et al.   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Development and validation of an enzyme-linked immunosorbent assay for the quantification of a specific MMP-9 mediated degradation fragment of type III collagen—A novel biomarker of atherosclerotic plaque remodeling

(2011) Natasha Barascuk et al.   CLINICAL BIOCHEMISTRY

Protein fingerprints — Relying on and understanding the information of serological protein measurements

(2011) M.A. Karsdal et al.   CLINICAL BIOCHEMISTRY

Efficacy and safety of the PPARγ partial agonist balaglitazone compared with pioglitazone and placebo: a phase III, randomized, parallel-group study in patients with type 2 diabetes on stable insulin therapy

(2011) Kim Henriksen et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Serum omentin-1 and chemerin levels are interrelated in patients with Type 2 diabetes mellitus with or without ischaemic heart disease

(2011) H. O. El-Mesallamy et al.   DIABETIC MEDICINE

Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio in the prediction of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS)

(2011) R. C. Loopstra-Masters et al.   DIABETOLOGIA

A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes

(2011) Fariba Vaziri-Sani et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Type 2 diabetes across generations: from pathophysiology to prevention and management

(2011) Christopher J Nolan et al.   LANCET

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker Assay

(2011) Sanne Skovgård Veidal et al.   PLoS One

Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption - implications for osteoclast quality

(2010) Anita V Neutzsky-Wulff et al.   BMC MUSCULOSKELETAL DISORDERS

A novel assay for extracellular matrix remodeling associated with liver fibrosis: An enzyme-linked immunosorbent assay (ELISA) for a MMP-9 proteolytically revealed neo-epitope of type III collagen

(2010) N. Barascuk et al.   CLINICAL BIOCHEMISTRY

Novel combinations of Post-Translational Modification (PTM) neo-epitopes provide tissue-specific biochemical markers—are they the cause or the consequence of the disease?

(2010) Morten Asser Karsdal et al.   CLINICAL BIOCHEMISTRY

Biomarkers in Fasting Serum to Estimate Glucose Tolerance, Insulin Sensitivity, and Insulin Secretion

(2010) A. B. Goldfine et al.   CLINICAL CHEMISTRY

The FDA's critical path initiative: A brief introduction

(2010) Stephen Joel Coons   CLINICAL THERAPEUTICS

A multicenter, randomized, placebo-controlled, double-blind phase II trial evaluating the optimal dose, efficacy and safety of LC 15-0444 in patients with type 2 diabetes

(2010) E. J. Rhee et al.   DIABETES OBESITY & METABOLISM

Glucose-Dependent Insulinotropic Polypeptide Is Expressed in Pancreatic Islet α-Cells and Promotes Insulin Secretion

(2010) Yukihiro Fujita et al.   GASTROENTEROLOGY

Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial

(2010) Richard E Pratley et al.   LANCET

Genetics, pathogenesis and clinical interventions in type 1 diabetes

(2010) Jeffrey A. Bluestone et al.   NATURE

Immunocytochemical localisation of caspase-3 in pancreatic islets from type 2 diabetic subjects

(2010) Tatsuo Tomita   PATHOLOGY

Thirty-One Novel Biomarkers as Predictors for Clinically Incident Diabetes

(2010) Veikko Salomaa et al.   PLoS One

Biochemical markers and the FDA Critical Path: How biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug development

(2009) M.A. Karsdal et al.   BIOMARKERS

Development of a Type 2 Diabetes Risk Model From a Panel of Serum Biomarkers From the Inter99 Cohort

(2009) J. A. Kolberg et al.   DIABETES CARE

Effect of Rosiglitazone, Metformin, and Glyburide on Bone Biomarkers in Patients with Type 2 Diabetes

(2009) Bernard Zinman et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Is bone quality associated with collagen age?

(2009) D. J. Leeming et al.   OSTEOPOROSIS INTERNATIONAL

Peroxisome Proliferator-Activated Receptor γ Agonists as Insulin Sensitizers: From the Discovery to Recent Progress

(2008) Nobuo Cho et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

New Drugs for Type 2 Diabetes Mellitus

(2008) Andrew J Krentz et al.   DRUGS

Expression of Neurexin, Neuroligin, and Their Cytoplasmic Binding Partners in the Pancreatic β-Cells and the Involvement of Neuroligin in Insulin Secretion

(2008) Arthur T. Suckow et al.   ENDOCRINOLOGY

Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes

(2008) Benbo Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Glucagon-like peptide-1, glucose homeostasis and diabetes

(2008) Jens J. Holst et al.   TRENDS IN MOLECULAR MEDICINE