Article
Oncology
Christopher Morrison, Eric Weterings, Daruka Mahadevan, Abhay Sanan, Martin Weinand, Baldassarre Stea
Summary: Identifying high RAD51 expression as a poor prognostic marker in GBM patients, this study suggests RAD51 may serve as a therapeutic target in GBM.
Article
Cell Biology
Hao Wang, Wei Wei, Zhong-Yuan Zhang, Yao Liu, Bin Shi, Wen Zhong, Hou-Shun Zhang, Xin Fang, Chun-Lei Sun, Jia-Bei Wang, Lian-Xin Liu
Summary: Metastasis in colorectal cancer (CRC) remains a major challenge, and dysregulation of N6-methyladenosine (m6A) is associated with this process. This study reveals that METTL14, a key component of m6A methylation, plays a role in inhibiting CRC metastasis by regulating the ARRDC4/ZEB1 signaling pathway. METTL14 regulates ARRDC4 mRNA stability through YHTDF2, and its protein expression is controlled by TCF4 and HuR. Clinical studies show that decreased METTL14 is associated with poor prognosis in CRC patients.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Peng Guo, Qiang Chen, Kesong Peng, Jianyuan Xie, Junjia Liu, Wenjing Ren, Zhangwei Tong, Ming Li, Jianming Xu, Yongyou Zhang, Chundong Yu, Pingli Mo
Summary: This study reveals the association between SRC-1 and Hh signaling in colorectal cancer, and demonstrates that SRC-1 plays a crucial role in promoting CRC tumorigenesis through regulation of the Hh pathway.
Article
Oncology
Fangyuan Zhou, Haiyang Gao, Luorui Shang, Jinxiao Li, Mengqi Zhang, Shuhan Wang, Runze Li, Lin Ye, Shenglan Yang
Summary: Traditional Chinese medicine therapy has a unique effect in prolonging survival time and improving the prognosis of patients with colorectal cancer. Oridonin has anti-cancer effects, possibly through inducing ER stress, upregulating TP53, and inhibiting TCF4 transactivation in colorectal cancer cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Anastasia Kottorou, Foteinos-Ioannis Dimitrakopoulos, Georgia Diamantopoulou, Foteini Kalofonou, Michalis Stavropoulos, Konstantinos Thomopoulos, Thomas Makatsoris, Angelos Koutras, Haralabos Kalofonos
Summary: This study evaluated the expression levels of the most important genes implicated in sEVs biogenesis in colorectal cancer patients and their association with sEVs plasma levels and clinical outcomes. The results showed that high expression of RAB27A, RAB27B, RAB9A, RAB11B, and STX1A was favorable for 5-year survival. The conclusion is that sEVs biogenesis plays a significant role in colorectal cancer.
Article
Multidisciplinary Sciences
Philippe A. Cassier, Raul Navaridas, Melanie Bellina, Nicolas Rama, Benjamin Ducarouge, Hector Hernandez-Vargas, Jean-Pierre Delord, Justine Lengrand, Andrea Paradisi, Laurent Fattet, Gwenaele Garin, Hanane Gheit, Cecile Dalban, Ievgenia Pastushenko, David Neves, Remy Jelin, Nicolas Gadot, Nicolas Braissand, Sophie Leon, Cyril Degletagne, Xavier Matias-Guiu, Mojgan Devouassoux-Shisheboran, Eliane Mery-Lamarche, Justine Allard, Egor Zindy, Christine Decaestecker, Isabelle Salmon, David Perol, Xavi Dolcet, Isabelle Ray-Coquard, Cedric Blanpain, Agnes Bernet, Patrick Mehlen
Summary: Netrin-1 is found to be upregulated in most endometrial carcinomas (ECs). Blocking netrin-1 with an anti-netrin-1 antibody (NP137) effectively reduces tumor progression in an EC mouse model and shows promising results in a Phase I trial with advanced EC patients. NP137 induces cell death and inhibits epithelial-to-mesenchymal transition (EMT), resulting in reduced tumor EMT, changes in immune infiltrate, and enhanced interactions between cancer cells and the tumor microenvironment.
Article
Cell Biology
Sha Zhou, Jianhong Peng, Liuniu Xiao, Caixia Zhou, Yujing Fang, Qingjian Ou, Jiayi Qin, Mengzhong Liu, Zhizhong Pan, Zhenlin Hou
Summary: TRIM25 is identified as an epigenetic regulator of oxaliplatin resistance in colorectal cancer patients, affecting disease-free survival and recurrence rates. Its overexpression promotes stem cell properties in CRC cells and resistance to chemotherapy. Targeting TRIM25 may be a potential strategy for managing OXA resistance in clinical practice.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Viviane A. Lin, Robin Lohse, Michael T. Madsen, Tina Fransgaard, Feza H. Remzi, Ismail Goegenur
Summary: This study found no significant differences in long-term outcomes between patients with ulcerative colitis-associated colorectal cancer and those with sporadic colorectal cancer. However, the results are limited by potential residual confounding and heterogeneity in confounding adjustment during the meta-analysis.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lei Xu, Qi-Xin Wu, Xue Li, Yu-Jing Fang, Ruo-Lin Zhou, Meng-Meng Che, Ting Ma, Cai-Xia Zhang
Summary: This study found a significant inverse association between serum FMN and colorectal cancer risk, while serum riboflavin or vitamin B-2 sum was not associated with colorectal cancer risk. Individuals with a lower PLP level or an adequate folate level could be more sensitive to the protective role of vitamin B-2.
Article
Multidisciplinary Sciences
Justine Lengrand, Ievgenia Pastushenko, Sebastiaan Vanuytven, Yura Song, David Venet, Rahul M. Sarate, Melanie Bellina, Virginie Moers, Alice Boinet, Alejandro Sifrim, Nicolas Rama, Benjamin Ducarouge, Jens Van Herck, Christine Dubois, Samuel Scozzaro, Sophie Lemaire, Sarah Gieskes, Sophie Bonni, Amandine Collin, Nicolas Braissand, Justine Allard, Egor Zindy, Christine Decaestecker, Christos Sotiriou, Isabelle Salmon, Patrick Mehlen, Thierry Voet, Agnes Bernet, Cedric Blanpain
Summary: Epithelial-to-mesenchymal transition (EMT) plays a crucial role in cancer initiation, progression, metastasis, and resistance to therapy. In this study, the upregulation of netrin-1 in skin squamous cell carcinoma (SCC) was found to induce EMT, and pharmacological inhibition of netrin-1 decreased EMT and enhanced chemotherapy sensitivity. These findings suggest a potential therapeutic strategy for targeting EMT in cancer.
Article
Cell Biology
Wei Tu, Jin Gong, Zhenzhen Zhou, Dean Tian, Zhijun Wang
Summary: Colorectal cancer liver metastasis is a significant clinical problem, and tumor-associated macrophage (TAM) recruitment and M2 polarization are closely associated with elevated TCF4 expression in the metastatic site. TCF4 deficiency reduces TAM infiltration and M2 polarization, mediated by the regulated CCL2 and CCR2 expression. These findings suggest that the TCF4-CCL2-CCR2 axis plays a crucial role in CRC liver metastasis by enhancing TAMs recruitment and M2 polarization.
CELL DEATH & DISEASE
(2021)
Article
Gastroenterology & Hepatology
Shouhan Feng, Zeshi Li, Mei Liu, Qianwen Ye, Tianhui Xue, Bing Yan
Summary: The preoperative serum levels of inflammatory mediators, including CRP, PCT and IL-6, have been shown to be correlated with patient outcomes in colorectal cancer (CRC). However, their prognostic role in postoperative settings remains less well-studied. This study retrospectively enrolled 122 stage I-III CRC patients and evaluated the prognostic value of postoperative serum levels of CRP, PCT and IL-6. The results showed that compared to CRP and PCT, IL-6 level was the only significant factor in predicting the prognosis of stage I-III CRC patients after surgery, and a low level of IL-6 was associated with good disease-free survival.
BMC GASTROENTEROLOGY
(2023)
Article
Cell Biology
Jiayu Wang, Hongya Wu, Yanjun Chen, Jinghan Zhu, Linqing Sun, Juntao Li, Zhendong Yao, Yuqi Chen, Xueguang Zhang, Suhua Xia, Weichang Chen, Tongguo Shi
Summary: The study revealed that high expression of B7-H5 in colorectal cancer tissues is significantly correlated with lymph node involvement, AJCC stage, and patient survival, and exhibits a significant negative correlation with CD8(+) T cell infiltration. High B7-H5 expression and low CD8(+) T cell infiltration are associated with the worst prognosis in CRC patients.
CELL DEATH DISCOVERY
(2021)
Review
Medicine, Research & Experimental
Phimmada Hatthakarnkul, Jean A. Quinn, Aula Ammar, Gerard Lynch, Hester Van Wyk, Donald C. McMillan, Chanitra Thuwajit, Joanne Edwards
Summary: Colorectal cancer is the third most common cancer worldwide. Poor survival and disease metastasis are associated with the development of tumor metastasis in CRC patients, making it important to study potential biomarkers for predicting outcomes. Tumor budding is an independent prognostic marker for poor survival and disease metastasis, and it has been suggested to be included in routine clinicopathological factors for risk assessment. However, there is currently no clear evidence regarding the underlying molecular mechanism driving this phenotype, or the relationship between tumor budding and the tumor microenvironment.
Article
Biochemistry & Molecular Biology
Kaisa Cui, Surui Yao, Han Zhang, Mingyue Zhou, Bingxin Liu, Yulin Cao, Bojian Fei, Shenglin Huang, Zhaohui Huang
Summary: The study comprehensively analyzed the prognostic value of FOXP3 and CTLA4 in colorectal cancer, revealing two distinct survival patterns and a novel high-risk subpopulation. The established FOXP3/CTLA4 molecular subtyping system could guide treatment and management strategies for colorectal cancer and other cancers.