Anticoagulant therapy for sepsis-associated disseminated intravascular coagulation: the view from Japan

Bleeding and Coagulopathies in Critical Care

(2014) Beverley J. Hunt   NEW ENGLAND JOURNAL OF MEDICINE

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis

(2013) K. C. A. A. Wildhagen et al.   BLOOD

Surviving Sepsis Campaign

(2013) R. Phillip Dellinger et al.   CRITICAL CARE MEDICINE

A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*

(2013) Jean-Louis Vincent et al.   CRITICAL CARE MEDICINE

Combination of antithrombin and recombinant thrombomodulin attenuates leukocyte–endothelial interaction and suppresses the increase of intrinsic damage–associated molecular patterns in endotoxemic rats

(2013) Toshiaki Iba et al.   JOURNAL OF SURGICAL RESEARCH

Guidance for diagnosis and treatment of disseminated intravascular coagulation from harmonization of the recommendations from three guidelines

(2013) H. Wada et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway

(2013) E. A. M. Bouwens et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism

(2013) Mayumi Nakahara et al.   PLoS One

Sepsis and Thrombosis

(2013) Marcus Schultz et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation

(2012) R. Darbousset et al.   BLOOD

Activated protein C and septic shock

(2012) Emily Rimmer et al.   CRITICAL CARE MEDICINE

Damage- and Pathogen-Associated Molecular Patterns and Alarmins: Keys to Sepsis?

(2012) S. Denk et al.   EUROPEAN SURGICAL RESEARCH

Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo

(2012) Marie-Luise von Brühl et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effectiveness and safety of drotrecogin alfa (activated) for severe sepsis: a meta-analysis and metaregression

(2012) Andre C Kalil et al.   LANCET INFECTIOUS DISEASES

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Autophagy Mediates the Delivery of Thrombogenic Tissue Factor to Neutrophil Extracellular Traps in Human Sepsis

(2012) Konstantinos Kambas et al.   PLoS One

Efficacy and bleeding risk of antithrombin supplementation in septic disseminated intravascular coagulation: A prospective multicenter survey

(2012) Toshiaki Iba et al.   THROMBOSIS RESEARCH

Histones induce rapid and profound thrombocytopenia in mice

(2011) T. A. Fuchs et al.   BLOOD

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Thrombomodulin: protectorate God of the vasculature in thrombosis and inflammation

(2011) T. ITO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study

(2011) Naoki Aikawa et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Diagnosis and treatment of disseminated intravascular coagulation: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET)

(2011) Marcello Di Nisio et al.   THROMBOSIS RESEARCH

Endotoxin removal devices for the treatment of sepsis and septic shock

(2010) B Davies et al.   LANCET INFECTIOUS DISEASES

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Guidelines for the diagnosis and management of disseminated intravascular coagulation

(2009) M Levi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008

(2009) R Phillip Dellinger et al.   CRITICAL CARE MEDICINE

Unfractioned heparin for treatment of sepsis: A randomized clinical trial (The HETRASE Study)*

(2009) Fabián Jaimes et al.   CRITICAL CARE MEDICINE

Promoting Global Research Excellence in Severe Sepsis (PROGRESS): Lessons from an International Sepsis Registry

(2009) R. Beale et al.   INFECTION

International Differences in the Treatment of Sepsis

(2009) John A. Kellum et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Expert consensus for the treatment of disseminated intravascular coagulation in Japan

(2009) Hideo Wada et al.   THROMBOSIS RESEARCH

Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin-Thrombomodulin Complexes

(2008) Takashi Ito et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Molecular biology of inflammation and sepsis: A primer*

(2008) Ismail Cinel et al.   CRITICAL CARE MEDICINE