Article
Engineering, Multidisciplinary
Maha M. Abou El-Alamin, Dina A. Mohamed, Safaa S. Toubar
Summary: Selective, sensitive, and reproducible ion-selective electrodes containing dabigatran etexilate-phosphotungstate ion pair as a modifier have been fabricated to determine dabigatran etexilate in pure and pharmaceutical dosage form with high accuracy and precision.
Article
Hematology
Kiyotaka Oi, Mie Shimizu, Tatsunori Natori, Keisuke Tsuda, Makiko Yoshida, Asami Kamada, Yoko Ishigaku, Shinsuke Narumi, Kazumasa Oura, Tetsuya Maeda, Yasuo Terayama
Summary: The study evaluated the expression and activation of PAR-1 and CD62P on platelets from NVAF patients before and after dabigatran treatment. The results showed lower PAR-1 expression in NVAF patients and inhibition of CD62P expression by dabigatran treatment, indicating potential antithrombotic activity with antiplatelet and anticoagulant effects.
THROMBOSIS RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Ya-ou Liu, Qiu-fen Xie, Zhi-yan Liu, Zhe Wang, Guang-yan Mu, Ya-tong Zhang, Zi-nan Zhao, Dong-dong Yuan, Li-ping Guo, Na Wang, Jing Xiang, Hong-tao Song, Jie Jiang, Qian Xiang, Yi-min Cui
Summary: The study developed PK/PD models from healthy Chinese subjects and real-world NVAF patients, and investigated factors and biomarkers for bleeding events. Fixed dabigatran doses could be prescribed for NVAF patients without adjusting for age and HDL-C. Elevated APTT, PT, and anti-FIIa values were associated with increased bleeding tendency.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
J. Robert Powell, Farah Al Qaraghuli, Jill Fiedler-Kelly, Daniel Gonzalez, Daniel Weiner
Summary: Dabigatran, a direct-acting oral anticoagulant, is more effective than warfarin in stroke reduction and has similar bleeding risk in adult patients with atrial fibrillation. Its efficacy and safety correlate with steady-state plasma concentrations. A population pharmacokinetic model based on clinical trial patients was used to compare different dosing regimens, and an improved regimen requiring five different dosing schedules was identified. This information can better inform patient outcomes and guide future dabigatran development.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Zhu Zhu, Zhu Shen, Aiming Shi, Cunjin Su, Jiaojiao Mao, Hong Tao, Feng Xu, Zhanhong Hu, Jie Pan
Summary: The study found significant variability in dabigatran plasma concentration among Chinese patients with non-valvular atrial fibrillation treated with dabigatran etexilate, influenced by age, BMI, and history of heart failure. Dabigatran trough concentration was identified as a key factor in predicting the risk of bleeding events, along with history of hypertension.
Article
Endocrinology & Metabolism
Yu-Huan Gu, Brian T. Hawkins, Yoshikane Izawa, Yoji Yoshikawa, James A. Koziol, Gregory J. del Zoppo
Summary: A study found that anti-thrombin activity decreases the risk of intracerebral hemorrhage by inhibiting thrombin-mediated degradation of cerebral microvessel basal lamina matrix. This has implications for understanding focal ischemia and other related conditions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Shin-Yi Lin, Sung-Chun Tang, Ching-Hua Kuo, Li-Ting Ho, Yen-Bin Liu, Yu-Fong Peng, Li-Kai Tsai, Chih-Fen Huang, Jiann-Shing Jeng
Summary: This study reports on the association between direct oral anticoagulant (DOAC) concentration and clinical outcomes in Asian patients with atrial fibrillation (AF). The proportion of DOAC concentrations falling outside the expected range was higher than reported in clinical trials. Low trough concentration was associated with increased risk of systemic thromboembolism (SSE), while high trough concentration was associated with major bleeding. Measurement of trough DOAC concentration should be considered for patients at risk of concentration deviations.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Genetics & Heredity
Bo Hu, Wen Ge, Yuliang Wang, Xiaobin Zhang, Tao Li, Hui Cui, Yongjun Qian, Yangyang Zhang, Zhi Li
Summary: Atrial fibrillation (AF) is associated with an increased risk of heart failure, dementia, and stroke. Proteomics and metabolomics analyses revealed distinct metabolite and protein profiles between valvular and non-valvular AF patients, indicating potential different mechanisms underlying the two types of AF. The study identified specific biomarkers and metabolic pathways associated with each type of AF, providing insights for prognosis and potential treatment strategies.
FRONTIERS IN GENETICS
(2021)
Article
Hematology
Jamie Coates, Emily Bitton, Ashley Hendje, Thomas Delate, Kari L. Olson, Carla Knowles, Sara Ly, Kristen M. Fink, Nathan P. Clark
Summary: This study compared the clinical outcomes of patients with NVAF and different weight categories receiving dabigatran, finding that patients over 120 kg tended to be younger with a higher burden of chronic disease. While there was no difference in the overall composite outcome between the weight groups, the >120 kg group had a higher risk of gastrointestinal bleeding according to a subanalysis.
THROMBOSIS RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Jingya Liu, Mingchen Jin
Summary: This study investigated the antithrombotic effect of Ningxinbao capsules combined with dabigatran etexilate on NVAF patients after PCI. The combination therapy effectively improved the patients' coagulation status and reduced the risk of hemorrhage.
LATIN AMERICAN JOURNAL OF PHARMACY
(2022)
Article
Medicine, General & Internal
Wayne A. Ray, Cecilia P. Chung, C. Michael Stein, Walter Smalley, Eli Zimmerman, William D. Dupont, Adriana M. Hung, James R. Daugherty, Alyson Dickson, Katherine T. Murray
Summary: This cohort study found that in Medicare beneficiaries aged 65 or older with atrial fibrillation, treatment with rivaroxaban compared with apixaban was associated with a significantly increased risk of major ischemic or hemorrhagic events.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Medical Laboratory Technology
Oksana Volod, Marian Rollins-Raval, Andrew J. Goodwin, Russell A. Higgins, Thomas Long, Wayne L. Chandler, Neil S. Harris, Huy P. Pham, James Alexander Isom, Karen Moser, John D. Olson, Kristi J. Smock, Amanda VanSandt, Geoffrey Wool, Dong Chen
Summary: This study evaluated the performance of DOAC-specific assays for dabigatran and rivaroxaban, as well as the interlaboratory variability in measuring these drugs. Results showed reasonable performance of the assays, with specific variations in responsiveness of routine clotting assays to different DOACs. The undiluted thrombin time was found to be too sensitive for drug-level monitoring but suitable as a qualitative screening assay.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Daisuke Yanagisawa, Koichiro Abe, Hirohito Amano, Shogo Komatsuda, Taku Honda, Daisuke Manabe, Hirosada Yamamoto, Ken Kozuma, Shinya Kodashima, Yoshinari Asaoka, Takatsugu Yamamoto, Atsushi Tanaka
Summary: Direct oral anticoagulants can lead to bleeding which may result in rebleeding, especially in patients who initially experienced gastrointestinal bleeding. Therefore, caution should be taken when resuming anticoagulation therapy after bleeding.
Article
Cardiac & Cardiovascular Systems
Dominic Millenaar, Helmut Schumacher, Martina Brueckmann, John W. Eikelboom, Michael Ezekowitz, Jonathan Slawik, Sebastian Ewen, Christian Ukena, Lars Wallentin, Stuart Connolly, Salim Yusuf, Michael Bohm
Summary: Polypharmacy and non-adherence are risk indicators for increased adverse cardiovascular and bleeding events, especially for patients with comorbidities and multiple medications.
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Clinical Neurology
Daniel Caldeira, Pedro Alves da Silva, Fausto J. Pinto
Summary: This study analyzed the RE-LY clinical trial and found that patients with atrial fibrillation who experienced falls or head injuries had a higher risk of major bleeding, intracranial hemorrhage, and mortality. Among these patients, those treated with dabigatran had a lower risk of intracranial hemorrhage compared to those treated with warfarin.
Article
Dermatology
Rasnah Appil, Elly Lilianty Sjattar, Saldy Yusuf, Kasmawati Kadir
Summary: Family empowerment through educational interventions can help control HbA1c levels in diabetic patients and accelerate the healing progress of diabetic foot ulcers.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander P. Benz, Jeff S. Healey, Ashley Chin, Patrick Commerford, Tamara Marsden, Ganesan Karthikeyan, William F. McIntyre, Jorge A. Wong, Albertino Damasceno, Stefan H. Hohnloser, Jonas Oldgren, Lars Wallentin, Michael D. Ezekowitz, John W. Eikelboom, Salim Yusuf, Stuart J. Connolly
Summary: This study found that AF patients with RHD had lower CHA(2)DS(2)-VASc scores but higher actual stroke rates. Predictors for stroke in this cohort included advanced age, female sex, prior stroke, tobacco use, and anticoagulation non-use. Mitral stenosis was not independently associated with stroke risk.
CARDIOVASCULAR RESEARCH
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Philip Joseph, Salim Yusuf
Summary: This editorial discusses the PolyIran-Liver trial, which focuses on the use of a polypill for the prevention of cardiovascular diseases, with a specific focus on non-alcoholic steatohepatitis.
EUROPEAN HEART JOURNAL
(2022)
Article
Peripheral Vascular Disease
Nonhlanhla Mthembu, Gavin R. Norton, Vernice R. Peterson, Ravi Naran, Suraj M. Yusuf, Grace Tade, Hamza Bello, Adamu Bamaiyi, Carlos D. Libhaber, Patrick Dessein, Ferande Peters, Pinhas Sareli, Angela J. Woodiwiss
Summary: The study explores the mechanisms of the relationship between heart rate and central pulse pressure and its dependence on age. It finds that the increased central pulse pressure associated with a lower heart rate is mainly attributed to the enhanced backward wave rather than the prolonged ejection or filling duration. These findings have clinical implications, especially in older adults.
Article
Public, Environmental & Occupational Health
Aditya K. Khetan, Darryl P. Leong, Rajeev Gupta, Yibing Zhu, Sidong Li, Weida Liu, Iolanthe M. Kruger, Koon K. Teo, Andreas Wielgosz, Rita Yusuf, Nor-Ashikin Mohamed Noor Khan, Rasha Khatib, Khalid F. Alhabib, Kubilay Karsidag, Jephat Chifamba, Noushin Mohammadifard, Pamela Seron, Patricio Lopez-Jaramillo, Andres Orlandini, Andrzej Szuba, Afzalhussein Yusufali, Sanjeev Nair, Annika Rosengren, Karen Yeates, Antonio Miguel Dans, Romaina Iqbal, Alvaro Avezum, Sumathy Rangarajan, Salim Yusuf
Summary: Final adult height is associated with risks of all-cause mortality, major cardiovascular events, and cancer. The association varies by country-income level, with taller individuals having lower risks of mortality and cardiovascular events, but higher risk of cancer in low-income countries. In high- and middle-income countries, there is no significant association between height and these outcomes.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jaffar Al-Sheikhli, Ian Patchett, Ven Gee Lim, Leeann Marshall, Will Foster, Michael Kuehl, Shamil Yusuf, Sandeep Panikker, Kiran Patel, Faizel Osman, Prithwish Banerjee, Nicolas Lellouche, Tarvinder Dhanjal
Summary: The feasibility study of using the DiamondTemp ablation (DTA) catheter system for ventricular tachycardia (VT) ablation in ischaemic cardiomyopathy (ICM) patients showed significant improvements in patient condition and clinical outcomes.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Loubna Akhabir, Randa Stringer, Dipika Desai, Piush J. Mandhane, Meghan B. Azad, Theo J. Moraes, Padmaja Subbarao, Stuart E. Turvey, Guillaume Pare, Sonia S. Anand
Summary: Background environmental exposures during pregnancy can have long-lasting effects on DNA methylation and offspring health. This study aimed to identify and replicate previously reported genomic loci associated with in utero exposures in the NutriGen birth cohort studies. The findings reveal strong associations between maternal smoking and gestational age with DNA methylation changes in cord blood of newborns.
Article
Cardiac & Cardiovascular Systems
Patricio Lopez-Jaramillo, Philip Joseph, Jose P. Lopez-Lopez, Fernando Lanas, Alvaro Avezum, Rafael Diaz, Paul A. Camacho, Pamela Seron, Gustavo Oliveira, Andres Orlandini, Sumathy Rangarajan, Shofiqul Islam, Salim Yusuf
Summary: In a multinational South American cohort, variations in CVD incidence and mortality rates were examined between sub-populations stratified by country, sex, and urban or rural location. The study found that men had higher rates of CVD and death compared to women, and death rates were higher in rural areas. Hypertension, obesity, diabetes, and tobacco use were identified as leading risk factors for both CVD and death.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Isabelle Johansson, Kumar Balasubramanian, Shrikant Bangdiwala, Lisa Mielniczuk, Camilla Hage, Sanjib Kumar Sharma, Kelley Branch, Jun Zhu, Kristian Kragholm, Karen Sliwa, Francois Alla, Gerald Yonga, Ambuj Roy, Andres Orlandini, Alex Grinvalds, Tara McCready, Nana Pogosova, Stefan Stoerk, John J. V. McMurray, David Conen, Salim Yusuf
Summary: The health-related quality of life (HRQL) in patients with heart failure (HF) is influenced by factors such as income level and severity of symptoms. Symptoms are the most important factor affecting HRQL.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Philip Joseph, Vellappillil Raman Kutty, Viswanathan Mohan, Rajesh Kumar, Prem Mony, Krishnapillai Vijayakumar, Shofiqul Islam, Romaina Iqbal, Khawar Kazmi, Omar Rahman, Rita Yusuf, Ranjit Mohan Anjana, Indu Mohan, Sumathy Rangarajan, Rajeev Gupta, Salim Yusuf
Summary: Rates of cardiovascular disease and mortality are highest in rural areas and among men in South Asia, with modifiable risk factors contributing significantly to the incidence of both outcomes.
EUROPEAN HEART JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Maria M. Costello, Conor Judge, Catriona Reddin, Sumathy Rangarajan, Peter Langhorne, Hongye Zhang, Helle K. Iversen, Denis Xavier, Andrew Smyth, Michelle D. Canavan, Salim Yusuf, Martin J. O'Donnell
Summary: Using proxy respondents enhances the generalizability of international stroke research, particularly among underrepresented women, patients with severe stroke, older age groups, and those with lower education levels.
Article
Nutrition & Dietetics
Stellena Mathiaparanam, Adriana Nori de Macedo, Andrew Mente, Paul Poirier, Scott A. Lear, Andreas Wielgosz, Koon K. Teo, Salim Yusuf, Philip Britz-Mckibbin
Summary: This study investigated the prevalence of iodine deficiency and associated factors in Canadian adults. Overall, the study found that Canadian adults have adequate iodine status, but there is a population with moderate to severe iodine deficiency. Factors such as iodine supplements, urinary volume, daily sodium excretion, and thyroxine use were found to be protective against iodine deficiency. Self-reported intake of dairy products was strongly associated with iodine status. Residents in Quebec City and Vancouver were more susceptible to iodine deficiency.
Article
Pharmacology & Pharmacy
Laura Maria Fuhr, Fatima Zahra Marok, Maximilian Mees, Felix Mahfoud, Dominik Selzer, Thorsten Lehr
Summary: This study developed a PBPK/PD model of felodipine and its metabolite dehydrofelodipine for DDI predictions, successfully capturing their metabolic pathways and interactions with CYP3A4 perpetrators such as itraconazole, erythromycin, carbamazepine, and phenytoin.
Article
Health Policy & Services
Markus Alexander Mueller, Melanie Astrid Scholtes, Chiara Louis, Frank Doerje, Thorsten Lehr
Summary: This pilot survey conducted in Germany examines the continuing education (CE) situation of pharmacists, revealing a lack of awareness among participants regarding their CE obligations. Pharmacists holding the voluntary advanced training certificate from the Chambers of Pharmacists gathered significantly more CE points. The findings suggest the introduction of nationwide standard regulations to promote greater participation in CE.
ZEITSCHRIFT FUR EVIDENZ FORTBILDUNG UND QUALITAET IM GESUNDHEITSWESEN
(2022)
Article
Pharmacology & Pharmacy
Fatima Zahra Marok, Jan-Georg Wojtyniak, Laura Maria Fuhr, Dominik Selzer, Matthias Schwab, Johanna Weiss, Walter Emil Haefeli, Thorsten Lehr
Summary: This study developed a physiologically based pharmacokinetic (PBPK) model to investigate the drug-food interactions (DFIs) and drug-drug interactions (DDIs) potential of ketoconazole and its metabolites. The results showed that the metabolites of ketoconazole have an impact on its DDI potential. Various scenarios were simulated and evaluated, and the best predictive performance was achieved by including all metabolites as reversible inhibitors.