Article
Cell Biology
Dianbo Long, Yiyang Xu, Guping Mao, Ruobing Xin, Zengfa Deng, Hongyi Liao, Zhiwen Li, Zhi Yang, Baoxi Yu, Zhijian Yang, Aishan He, Ziji Zhang, Yan Kang
Summary: tRNA-derived fragments (tRFs) have been shown to play important roles in cell metabolism by regulating gene expression. This study investigates the role of tRFs in the cellular metabolism of the anterior cruciate ligament (ACL). The findings reveal that TRF365 regulates ACL cell metabolism by targeting IKBKB.
CELL DEATH DISCOVERY
(2022)
Article
Toxicology
Abeer A. A. Salama, Rania Elgohary, Mohamed Ibrahim Fahmy
Summary: The study aimed to investigate the nephroprotective effects of protocatechuic acid in LPS-induced acute kidney injury in mice. It was found that protocatechuic acid can inhibit inflammatory response and oxidative stress induced by LPS, and restore the normal morphology of kidney tissues.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Eijiro Jimi, Takenobu Katagiri
Summary: The NF-kappa B transcription factor family plays important roles in inflammation, immune response, and bone metabolism. Its activation occurs through different pathways and is crucial for osteoclast differentiation. Recent studies have identified genetic mutations in NF-kappa B signaling molecules associated with diseases like osteopetrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Song Yang, Fangyu Li, Shuyan Lu, Limei Ren, Shuai Bian, Meichen Liu, Daqing Zhao, Siming Wang, Jiawen Wang
Summary: This study investigated the anti-inflammatory, anti-oxidative, and autophagy regulatory mechanisms of ginseng root extract (GRE) in LPS-treated RAW264.7 cells. The results showed that GRE significantly reduced levels of nitric oxide, TNF-alpha, and IL-6 while also decreasing NF-kappa B activity and MAPK phosphorylation. Furthermore, GRE induced autophagy via the Akt-mTOR signaling pathway, relieving excessive oxidation, mitochondrial dysfunction, and inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Seungjin Ryu, Jeehae Han, Trina M. Norden-Krichmar, Quanwei Zhang, Seunggeun Lee, Zhengdong Zhang, Gil Atzmon, Laura J. Niedernhofer, Paul D. Robbins, Nir Barzilai, Nicholas J. Schork, Yousin Suh
Summary: Gene variants associated with longevity were found to be enriched in the nPKC and NF-kappa B signaling pathways, with non-coding variants modulating the expression of cognate genes to reduce signaling. This matches genetic studies in other model organisms and suggests evolutionary conservation of reduced PKC and NF-kappa B signaling in exceptional longevity, possibly including humans.
Article
Biochemistry & Molecular Biology
Xiaogao Diao, Chunhui Duan, Lingyun Yao, Jiaxin Qin, Liwen He, Wei Zhang
Summary: Exogenous melatonin (MT) improves the development of secondary hair follicles and cashmere fiber quality by enhancing antioxidant capacity, reducing reactive oxygen and nitrogen species levels, and inhibiting the expression of senescence-associated cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Cailan Li, Meigui Liu, Li Deng, Dandan Luo, Runfang Ma, Qiang Lu
Summary: This study firstly indicated that OBB had a superior therapeutic effect than BBR against TNBS-elicited colitis in rats. The protective effect of OBB might be closely related to the modulation of Keap1/Nrf2/NF-kappa B mediated inflammatory response and oxidant stress. The evidences highlight the potentiality of OBB as a prospective candidate for the amelioration of colitis.
Article
Medicine, Research & Experimental
Weiming Zhao, Shaoyong Song, Wei Chu, Yixuan Li, Shiwen Chen, Yumeng Ji, Qingcai Chen, Xin Jin, Fuhai Ji
Summary: This study evaluated the long-term effects of neonatal surgery plus anesthesia on cognitive function using a mouse model. The findings suggest that this procedure may impair learning and memory, potentially through alterations in P2RX2 and CaMKII/NF-kappa B signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Di Wu, Haomin Li, Mingwei Liu, Jun Qin, Yi Sun
Summary: This study reveals that the absence of Rbx1, a component of Cullin-RING ligases, in regulatory T cells leads to a severe inflammatory disease. The Ube2m-Rbx1 axis is specifically required for intrinsic regulatory processes in Treg cells.
NATURE COMMUNICATIONS
(2022)
Article
Food Science & Technology
Yongsong Bai, Kaidi Ma, Jibo Li, Jianping Li, Chongpeng Bi, Anshan Shan
Summary: The study showed that Deoxynivalenol (DON) has detrimental effects on the liver, while Lactobacillus rhamnosus GG (LGG) can protect the liver from DON-induced injury.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Immunology
Gongbiao Lu, Cunxin Zhang, Kang Li, Kai Gao, Maoqing Fu, Chaoliang Lyu, Zhengxue Quan
Summary: This study found that sinomenine (SN) can prevent IL-1 beta-induced apoptosis in nucleus pulposus cells (NPCs) and improve intervertebral disk degeneration (IDD) by activating the Keap1/Nrf2 pathway and inhibiting the NF-kappa B signaling pathway.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Immunology
Keith Sacco, Hye Sun Kuehn, Tomoki Kawai, Nouf Alsaati, Lauren Smith, Blachy Davila, Vanessa Bundy, Douglas B. Kuhns, Kerry Dobbs, Ottavia Delmonte, Luigi D. Notarangelo, Sergio D. Rosenzweig, Michael D. Keller
Summary: This study describes a rare case of autoimmunity and autoinflammation caused by a heterozygous gain-of-function variant in the IKBKB gene. The variant is associated with impaired cell degradation and increased macrophage activation, providing important insights into a novel clinical phenotype.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han
Summary: Glycine, acting as an inhibitory neurotransmitter, not only affects the functions of macrophages but also shapes their polarization through cellular signaling pathways and microRNAs. Additionally, glycine has beneficial effects in preventing and treating macrophage-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Paulina Hennig, Gabriele Fenini, Michela Di Filippo, Tugay Karakaya, Hans-Dietmar Beer
Summary: P62 is a highly conserved adaptor protein involved in important cellular processes, regulating tissue homeostasis, inflammation, and diseases like cancer. Through interactions with multiple partners, P62 influences key pathways and acts as a central signaling hub for pro- and anti-inflammatory pathways. Its roles in autophagy, inflammation, and cancer highlight its potential as a target for therapeutic strategies in disease progression.
Article
Immunology
Bo Wu, Lihua Qiang, Yong Zhang, Yesheng Fu, Mengyuan Zhao, Zehui Lei, Zhe Lu, Yan-Ge Wei, Hongmiao Dai, Yingwei Ge, Mingqiu Liu, Xuemei Zhou, Zhiqiang Peng, Hongchang Li, Chun-Ping Cui, Jing Wang, Hui Zheng, Cui Hua Liu, Lingqiang Zhang
Summary: The E3 ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquitination play crucial roles in colonic inflammation. Ovarian tumor deubiquitinase 1 (OTUD1) inhibits RIPK1-mediated NF-kappa B activation to alleviate inflammation, with lower expression in UC patients. OTUD1 is a potential target for treating IBD due to its regulatory role in intestinal inflammation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Oncology
Mari Mino-Kenudson, Nolwenn Le Stang, Jillian B. Daigneault, Andrew G. Nicholson, Wendy A. Cooper, Anja C. Roden, Andre L. Moreira, Erik Thunnissen, Mauro Papotti, Giuseppe Pelosi, Noriko Motoi, Claudia Poleri, Elisabeth Brambilla, Mary Redman, Deepali Jain, Sanja Dacic, Yasushi Yatabe, Ming Sound Tsao, Fernando Lopez-Rios, Johan Botling, Gang Chen, Teh-Ying Chou, Fred R. Hirsch, Mary Beth Beasley, Alain Borczuk, Lukas Bubendorf, Jin-Haeng Chung, David Hwang, Dongmei Lin, John Longshore, Masayuki Noguchi, Natasha Rekhtman, Lynette Sholl, William Travis, Akihiko Yoshida, Murry W. Wynes, Ignacio I. Wistuba, Keith M. Kerr, Sylvie Lantuejoul
Summary: The survey reveals heterogeneity in PD-L1 immunohistochemistry testing across regions and laboratories, highlighting the need for additional quality assurance measures, formal training, and standardized reporting.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Review
Oncology
Deborah Blythe Doroshow, Sheena Bhalla, Mary Beth Beasley, Lynette M. Sholl, Keith M. Kerr, Sacha Gnjatic, Ignacio I. Wistuba, David L. Rimm, Ming Sound Tsao, Fred R. Hirsch
Summary: PD-L1 expression is currently the best predictor of responsiveness to immune-checkpoint inhibitors, despite challenges in clinical use such as variability in different assays and cut-off points, as well as the lack of prospective comparisons with clinical outcomes. Nevertheless, several immunohistochemical assays have been approved for clinical use, with implications for pathology services and potential impacts on clinical outcomes. Comparison of FDA-approved PD-L1 assays, understanding of the varying implications of PD-L1 expression across different tumour types, and exploration of novel approaches to optimize its clinical utility are important topics for further research and practice.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Editorial Material
Oncology
Ming-Sound Tsao, Andrew G. Nicholson, Joseph J. Maleszewski, Alexander Marx, William D. Travis
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
Ku-Geng Huo, Hirotsugu Notsuda, Zhenhao Fang, Ningdi Feng Liu, Teklab Gebregiworgis, Quan Li, Nhu-An Pham, Ming Li, Ni Liu, Frances A. Shepherd, Christopher B. Marshall, Mitsuhiko Ikura, Nadeem Moghal, Ming-Sound Tsao
Summary: This study found that clinically approved EGFR TKIs can be used to treat patients with non-small cell lung cancer harboring the BRAF(G469V) mutation. Through experiments with a xenograft model and a cell line, it was confirmed that BRAF G469v is the oncogenic driver in this mutation. Structural modeling and experiments further demonstrated that BRAF(G469V) is a direct target of EGFR TKIs.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
Dalam Ly, Quan Li, Roya Navab, Cedric Zeltz, Linan Fang, Michael Cabanero, Chang-Qi Zhu, Ming-Sound Tsao, Li Zhang
Summary: Understanding how the immune system regulates the tumor microenvironment is crucial for the development of effective cancer treatments. This study reveals the adverse prognostic role of LAIR2 expression in regulatory T cells and identifies it as a potential target for future immunotherapies.
Article
Gastroenterology & Hepatology
Cerise Yuen-Ki Chan, Vincent Wai-Hin Yuen, David Kung-Chun Chiu, Chi-Ching Goh, Kelsie L. Thu, David W. Cescon, Isabel Soria-Bretones, Cheuk-Ting Law, Jacinth Wing-Sum Cheu, Derek Lee, Aki Pui-Wah Tse, Kel Vin Tan, Misty Shuo Zhang, Bowie Po-Yee Wong, Chun-Ming Wong, Pek-Lan Khong, Irene Oi-Lin Ng, Mark R. Bray, Tak Wah Mak, Thomas Chung-Cheung Yau, Carmen Chak-Lui Wong
Summary: This study found that targeting the centrosome regulator PLK4 to activate the cytosolic DNA sensing-mediated immune response effectively suppressed tumor progression in late-stage mouse HCC through cell cycle inhibition and induction of antitumor immunity, presenting a durable suppressive effect.
Article
Biochemistry & Molecular Biology
Cedric Zeltz, Maryam Khalil, Roya Navab, Ming-Sound Tsao
Summary: Collagen type XI restrains collagen remodeling and cell migration mediated by cancer-associated fibroblasts (CAF), thereby limiting the invasion of lung cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Isabel Soria-Bretones, Kelsie L. Thu, Jennifer Silvester, Jennifer Cruickshank, Samah El Ghamrasni, Wail Ba-alawi, Graham C. Fletcher, Reza Kiarash, Mitchell J. Elliott, Jordan J. Chalmers, Andrea C. Elia, Albert Cheng, April A. N. Rose, Mark R. Bray, Benjamin Haibe-Kains, Tak W. Mak, David W. Cescon
Summary: In this study, a panel of CDK4/6i-resistant breast cancer cell lines and patient-derived organoids were developed. It was found that RB1 loss caused mitotic defects and enhanced sensitivity to TTK inhibition, suggesting TTK inhibitor CFI-402257 as a potential therapeutic strategy for CDK4/6i-resistant breast cancer patients.
Article
Pharmacology & Pharmacy
Kushal Joshi, Rajiv Sanwal, Kelsie L. Thu, Scott S. H. Tsai, Warren L. Lee
Summary: This paper presents an in vitro experimental setup using a clinical ultrasound system to study drug delivery mediated by ultrasound and microbubbles (USMB). The results show that optimal drug delivery efficiency can be achieved by adjusting the mechanical index, ultrasound treatment time, and microbubble concentration.
Review
Oncology
Asa P. Y. Lau, Sharon S. Khavkine Binstock, Kelsie L. Thu
Summary: CD47 is a promising immunotherapeutic target in lung cancer, and this review summarizes its roles in tumor biology, its therapeutic potential in non-small cell lung cancer, and the challenges that need to be overcome.
Review
Oncology
Joshua C. Rosen, Adrian Sacher, Ming-Sound Tsao
Summary: KRAS(G12C) inhibitors have shown promising results in clinical trials with overall response rates ranging between 32% and 46%, and have been granted FDA approvals as second-line or later monotherapies. However, rapid tumor resistance complicates their use as a monotherapy.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
Article
Oncology
Shelley Kuang, Andrea S. Fung, Kirstin A. Perdrizet, Kaitlin Chen, Janice J. N. Li, Lisa W. Le, Michael Cabanero, Ola Abu Al Karsaneh, Ming S. Tsao, Josh Morganstein, Laura Ranich, Adam C. Smith, Cuihong Wei, Carol Cheung, Frances A. Shepherd, Geoffrey Liu, Penelope Bradbury, Prodipto Pal, Joerg Schwock, Adrian G. Sacher, Jennifer H. Law, Tracy L. Stockley, Natasha B. Leighl
Summary: In NSCLC patients, reflex testing using NGS panels can identify actionable genetic variants in the majority of cases with minimal increase in testing cost. Implementation of NGS panels is essential for the treatment of NSCLC patients as treatment paradigms continue to evolve.
Meeting Abstract
Medicine, Research & Experimental
Ellen Yang, Najd Alshamlan, Jessica Weiss, Michael Cabanero, Ming Tsao
LABORATORY INVESTIGATION
(2022)
Meeting Abstract
Oncology
R. Osarogiagbon, K. Nishimura, R. Rami Porta, L. Montuenga, D. Giroux, K. Suda, L. Araujo, F. Detterbeck, O. Gautschi, K. Kerr, P. Kneuertz, P. Mack, J. Matilla, A. Nicholson, H. Pass, C. Presley, R. Terra, I. Wistuba, D. Yang, Y. Yatabe, W. Travis, M. Tsao, H. Asamura, V. Rusch, F. Hirsch, D. Carbone
JOURNAL OF THORACIC ONCOLOGY
(2021)
Meeting Abstract
Oncology
M. Tsao
JOURNAL OF THORACIC ONCOLOGY
(2021)