Article
Biology
Menna H. E. Morsy, Zohour I. Nabil, Samah T. Darwish, Rasha A. Al-Eisa, Amir E. Mehana
Summary: Obesity is a major global health issue and an independent risk factor for developing type 2 diabetes. This study investigated the anti-diabetic and anti-adipogenic effects of Harmine in albino mice. The results showed that Harmine improved the detrimental effects caused by a high-fat diet, including organ weight gain, lipid metabolism abnormalities, and pathological damage.
Article
Nutrition & Dietetics
Kunli Wang, Linghua Kong, Xin Wen, Mo Li, Shan Su, Yuanying Ni, Junlian Gu
Summary: The study aims to evaluate the positive influence of 6-gingerol (6G) on glucose regulation in mice with prediabetes and elucidate the mechanisms involved. Results show that 6G intervention significantly reduced fasting glucose levels, improved insulin resistance, glucose tolerance, and liver and pancreatic health. 6G also altered the gut microbiota and activated specific pathways to regulate glucose metabolism and oxidative stress. These findings demonstrate 6G's potential as a dietary supplement for individuals with prediabetes.
Article
Plant Sciences
Eun A. Kim, Ju-Hwan Yang, Eun-Hye Byeon, Woong Kim, Dawon Kang, Jaehee Han, Seong-Geun Hong, Deok-Ryong Kim, Sang-Je Park, Jae-Won Huh, Hyeonsook Cheong, Seung-Pil Yun, Dong-Kun Lee
Summary: The study demonstrates that pine needle extract inhibits obesity by increasing hypothalamic POMC neuronal activity and improving physiological conditions after high-fat diet-induced obesity. Additionally, PNE also suppresses lipogenesis in white adipose tissue.
Article
Nutrition & Dietetics
Kyung Hee Hong, Min Young Um, Jiyun Ahn, Tae Youl Ha
Summary: This study investigated the effects of 6-gingerol on adiposity and obesity-induced inflammation in white adipose tissue of diet-induced obese mice. The results showed that 6-gingerol supplementation significantly reduced body weight, WAT mass, triglyceride, leptin, and insulin levels in HFD-fed mice. It also reduced adipogenesis-related transcription factors and lipogenesis-related genes in WAT. In addition, 6-gingerol increased adiponectin expression and decreased inflammatory adipokines and macrophage marker expression in WAT. In conclusion, 6-gingerol effectively alleviated adiposity and inflammation by regulating adipokines in diet-induced obese mice.
Article
Biochemistry & Molecular Biology
You-Suk Lee, Eun-Jung Park, Sung-Min Kim, Jong-Yeon Kim, Hae-Jeung Lee
Summary: Honeysuckle berry extract showed beneficial effects on high-fat diet-induced mice with sarcopenic obesity, including reducing obesity, increasing muscle strength and mass, and decreasing markers of muscle atrophy.
Article
Food Science & Technology
Gowtham Subramanian, Deepankumar Shanmugamprema, Ramya Subramani, Karthi Muthuswamy, Vinithra Ponnusamy, Kalpana Tankay, Thirunavukkarasu Velusamy, Vasanth Krishnan, Selvakumar Subramaniam
Summary: The study evaluated the anti-obesity effects of ethanolic fruit extract of Terminalia chebula on high fat diet induced obese mice, showing its potential in reducing high fat blood and obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Daphne K. Weikart, Vijaya V. Indukuri, Kathryn C. Racine, Kiana M. Coleman, Jasna Kovac, Darrell W. Cockburn, Helene Hopfer, Andrew P. Neilson, Joshua D. Lambert
Summary: Fermentation and roasting protocols do not affect the anti-obesity and anti-inflammatory efficacy of cocoa in obese mice. Cocoa supplementation reduces body weight gain, increases colonic length, and decreases gut permeability in both male and female mice. There are significant sex differences in the effects of both high-fat diet and cocoa supplementation.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Food Science & Technology
Xu Yan, Yuanyuan Zhai, Wenling Zhou, Yuan Qiao, Lingling Guan, Hao Liu, Jizhi Jiang, Liang Peng
Summary: Rutin supplementation can alleviate obesity and metabolic disorders induced by high-fat diet through modulating the composition of intestinal flora. Rutin supplementation reduces body-weight gain, improves insulin resistance, and acts favorably on intestinal barrier, reducing endotoxemia and systemic inflammation. Antibiotic treatment and fecal microbiota transplantation demonstrate the importance of intestinal flora in the beneficial effects of rutin on obesity control.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Medicine, Research & Experimental
Zhe Cheng, Xinyu Xiong, Yi Zhou, Fan Wu, Qingqing Shao, Ruolan Dong, Qiong Liu, Lingli Li, Guang Chen
Summary: The study demonstrated that 6-gingerol can alleviate obesity by regulating adipocytokines and the TLR3/IL-6/JAK1/STAT3 axis, inhibiting excessive hyperplasia and hypertrophy of adipocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Junting Xie, Xiaoning Hou, Wanshi He, Jie Xiao, Yong Cao, Xiaojuan Liu
Summary: Although the specific action site and signal pathway of astaxanthin in weight loss remain unclear, this study used Caenorhabditis elegans to shed light on its efficacy and specific action sites. The supplementation of 60 μM astaxanthin significantly reduced fat deposition and triglyceride levels and prevented obesity caused by excessive energy accumulation. These effects were induced by sbp-1/mdt-15 and insulin/insulin-like growth factor pathways, and co-regulated the down-regulation of specific sites fat-6 and fat-7.
Article
Biochemistry & Molecular Biology
Muhammad Aleem Abbas, Naila Boby, Eon-Bee Lee, Joo-Heon Hong, Seung-Chun Park
Summary: The study investigates the anti-obesity properties of E. cava and finds that it can suppress pre-adipocyte differentiation, reduce body weight and organ weight in obese rats, and lower the risk of liver injury and fatty liver. This suggests that E. cava could be a potential candidate for preventing obesity induced by a high-fat diet.
Article
Biochemistry & Molecular Biology
Wenting Wei, Manjiang Hu, Jie Huang, Siyan Yu, Xudong Li, Yanhui Li, Limei Mao
Summary: The study found that DHA and EPA have different mechanisms in anti-obesity in insulin-resistant mice. Specifically, 1% DHA and EPA can inhibit adipogenesis by regulating GPR120, while 4% DHA can stimulate browning of adipose tissue by up-regulating PPAR-γ, improving insulin resistance and inflammatory infiltration.
Article
Food Science & Technology
Hsin-Lin Cheng, Wei-Tang Chang, Jiun-Ling Lin, Ming-Ching Cheng, Shih-Chien Huang, Shiuan-Chih Chen, Yue-Ching Wong, Chin-Lin Hsu
Summary: This study investigates the anti-obesity properties of the Mei-Gin formula (MGF) consisting of bainiku-ekisu, Prunus mume, black garlic, and Mesona procumbens Hemsl. It found that MGF-1-7 significantly reduces lipid accumulation and cell differentiation by down-regulating GPDH activity. MGF-3 and MGF-7 exhibit a greater inhibitory effect on adipogenesis. MGF-3 and MGF-7 also effectively improve body weight, liver weight, and total body fat in obese rats.
Article
Biochemistry & Molecular Biology
Prince K. K. Akowuah, Carolina Lema, Rolando E. E. Rumbaut, Alan R. R. Burns
Summary: Feeding mice with a high-fat/sucrose diet causes loss of corneal nerve function and impairs corneal wound healing. Changing to a low fat/sugar diet with enrichments in complex carbohydrates mitigates the reduction in nerve function, but its effect on corneal wound healing needs further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Yan Zhu, Xianghui Zhou, Nan Ling, Qiming Yu, Huijuan Wang, Qizhen Du
Summary: This study aimed to investigate the effect of Guisangyou tea (GSY tea) on abnormal lipid metabolism in mice with obesity induced by a high-fat diet (HFD). The results showed that GSY tea decreased serum lipid levels, regulated antioxidant enzyme activities and inflammatory factors, and modulated mRNA and protein expression levels related to lipid synthesis and bile acid production in the liver. These findings indicate that GSY tea can improve abnormal lipid metabolism by enhancing antioxidant capacity, regulating inflammation, and modulating lipid synthesis and bile acid production.
Article
Endocrinology & Metabolism
Parim Brahma Naidu, V. V. Sathibabu Uddandrao, Ramavat Ravindar Naik, Suresh Pothani, Praveen Kurnar Munipally, Balaji Meriga, Mustapha Sabana Begum, Chandrasekar Varatharaju, Rajesh Pandiyan, Ganapathy Saravanan
CANADIAN JOURNAL OF DIABETES
(2016)
Article
Cell Biology
P. Rameshreddy, V. V. Sathibabu Uddandrao, Parim Brahmanaidu, S. Vadivukkarasi, Ramavat Ravindarnaik, Pothani Suresh, K. Swapna, A. Kalaivani, Parimi Parvathi, P. Tamilmani, Ganapathy Saravanan
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2018)
Article
Cell Biology
Parim Brahmanaidu, V. V. Sathibabu Uddandrao, Vadivukkarasi Sasikumar, Ramavat Ravindar Naik, Suresh Pothani, Mustapha Sabana Begum, M. Prasanna Rajeshkumar, Chandrasekar Varatharaju, Balaji Meriga, P. Rameshreddy, A. Kalaivani, Ganapathy Saravanan
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2017)
Article
Chemistry, Applied
A. Kalaivani, V. V. Sathibabu Uddandrao, P. Brahmanaidu, Ganapathy Saravanan, P. R. Nivedha, P. Tamilmani, K. Swapna, Sasikumar Vadivukkarasi
NATURAL PRODUCT RESEARCH
(2018)
Article
Nutrition & Dietetics
Balaji Meriga, Brahmanaidu Parim, Venkata Rao Chunduri, Ramavat Ravindar Naik, Harishankar Nemani, Pothani Suresh, Saravanan Ganapathy, Satthi W. U. Babu
NUTRITION & METABOLISM
(2017)
Article
Nutrition & Dietetics
V. V. Sathibabu Uddandrao, Parim Brahmanaidu, Ramavat Ravindarnaik, Pothani Suresh, S. Vadivukkarasi, Ganapathy Saravanan
EUROPEAN JOURNAL OF NUTRITION
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Brahmanaidu Parim, Sathibabu V. V. Uddandrao, Saravanan Ganapathy, Balaji Meriga
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Review
Cardiac & Cardiovascular Systems
Brahmanaidu Parim, V. V. Sathibabu Uddandrao, Ganapathy Saravanan
HEART FAILURE REVIEWS
(2019)
Article
Biochemistry & Molecular Biology
V. V. Sathibabu Uddandrao, P. Rameshreddy, P. Brahmanaidu, Ponmurugan Ponnusamy, Santhanaraj Balakrishnan, Ravindar Naik Ramavat, K. Swapna, Suresh Pothani, Harishankar Nemani, Balaji Meriga, S. Vadivukkarasi, P. R. Nivedha, Saravanan Ganapathy
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
K. Pavithra, V. V. Sathibabu Uddandrao, P. Chandrasekaran, P. Brahmanaidu, S. Sengottuvelu, S. Vadivukkarasi, G. Saravanan
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Article
Chemistry, Medicinal
Sethumathi Ponnusamy Pudhupalayam, V. V. Sathibabu Uddandrao, Chandrasekaran Ponnusamy, Sengottuvelu Singaravel, Tamilmani Periyasamy, Ponmurugan Ponnusamy, Vadivukkarasi Sasikumar, Mustapha Shabana Begum, Saravanan Ganapathy
Summary: This study evaluated the antihyperglycemic effects of biochanin A in a high-fat diet-streptozotocin-induced type 2 diabetes rat model. The results showed that biochanin A significantly reduced glucose levels, insulin resistance, hemoglobin levels, and the activity of certain enzymes, while increasing the activity of hexokinase and glycogen synthase and hepatic levels of glycogen in hyperglycemic rats.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2022)
Article
Pharmacology & Pharmacy
Santhanaraj Balakrishnan, Ponmurugan Ponnusamy, V. V. Sathibabu Uddandrao, Ganapathy Saravanan
ADVANCES IN TRADITIONAL MEDICINE
(2020)
Article
Pharmacology & Pharmacy
V. V. Sathibabu Uddandrao, Brahmanaidu Parim, P. R. Nivedha, K. Swapna, P. Rameshreddy, S. Vadivukkarasi, Mustapha Shabana Begum, Saravanan Ganapathy
ORIENTAL PHARMACY AND EXPERIMENTAL MEDICINE
(2019)
Article
Toxicology
Li Zaoni, Liu Zhongxi, V. V. Sathibabu Uddandrao, Ponmurugan Ponnusamy, Santhanaraj Balakrishnan, P. Brahmanaidu, S. Vadivukkarasi, Ganapathy Saravanan
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY
(2019)
Review
Cardiac & Cardiovascular Systems
V. V. Sathibabu Uddandrao, Parim Brahmanaidu, P. R. Nivedha, S. Vadivukkarasi, Ganapathy Saravanan
CARDIOVASCULAR TOXICOLOGY
(2018)