Review
Chemistry, Multidisciplinary
Amandine L. Flourat, Jeanne Combes, Claire Bailly-Maitre-Grand, Kevin Magnien, Arnaud Haudrechy, Jean-Hugues Renault, Florent Allais
Summary: p-Hydroxycinnamic acids are phenolic compounds involved in lignin biosynthesis pathway, with attractive properties such as antioxidant, anti-UV, and anticancer activities, and are used as building blocks for various industries, but their production cost remains high.
Article
Food Science & Technology
Zi-Ying Wang, Ying Yin, Dong-Ni Li, Dan-Yue Zhao, Jun-Qing Huang
Summary: The review summarizes the protective effects of p-Hydroxycinnamic acids (HCAs) on the intestinal barrier. These effects are achieved through four mechanisms: preserving tight junction proteins, modulating pro-inflammatory cytokines, exerting antioxidant activity, and regulating the intestinal microbiota.
Article
Chemistry, Applied
Shaoxiang Lee, Meng Zhang, Guohui Wang, Wenqiao Meng, Xin Zhang, Dong Wang, Yue Zhou, Zhonghua Wang
Summary: Polyvinyl alcohol/starch composite films with p-coumaric acid modified chitosan (P-CS) and chitosan nanoparticles (P-CSNPs) at different concentrations were prepared, showing that P-CS significantly increased the tensile strength of the film, while P-CSNPs films exhibited better thermal stability and antibacterial activity.
CARBOHYDRATE POLYMERS
(2021)
Article
Biotechnology & Applied Microbiology
Miao Cai, Jiayu Liu, Xiaofei Song, Hang Qi, Yuanzi Li, Zhenzhou Wu, Haijin Xu, Mingqiang Qiao
Summary: This study achieved the de novo biosynthesis of p-coumaric acid and caffeic acid from lignocellulose through a co-cultivation strategy. The improved inoculation ratio and carbon source content significantly increased the production yield of these aromatic compounds.
MICROBIAL CELL FACTORIES
(2022)
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Majed S. Alokail, Amal Majed H. Alenad, Nojood Altwaijry, Nouf Omar Alafaleq, Abdulaziz Mohammed Alamri, Mubarak Ali Zawba
Summary: Alpha-amylase plays an important role in the management of diabetes and its complications. This study explored the binding of caffeic acid and coumaric acid with alpha-amylase and their effects on the formation of advanced glycation end-products (AGEs). The results showed that both compounds could bind to alpha-amylase and inhibit the formation of AGEs. Caffeic acid exhibited stronger antiglycative activity compared to p-coumaric acid, which could be attributed to its additional -OH group and high antioxidant activity. The study also highlighted the role of hydrogen bonding in the complex formation. Molecular docking studies suggested that these compounds could be utilized in the design of antidiabetic drugs.
Article
Chemistry, Physical
Gabriela Petrisor, Ludmila Motelica, Denisa Ficai, Roxana Doina Trusca, Vasile-Adrian Surdu, Georgeta Voicu, Ovidiu Cristian Oprea, Anton Ficai, Ecaterina Andronescu
Summary: In this study, two types of mesoporous silica materials with different pore structures and volumes were synthesized and loaded with three types of polyphenols. The obtained materials were characterized from a morphological and structural point of view, and the differences between the two types of materials and the changes after loading with polyphenols were observed. In vitro studies demonstrated the potential biomedical applications of these materials.
Article
Biochemistry & Molecular Biology
Amalan Venkatesan, Jose Vinoth Raja Antony Samy, Karthikeyan Balakrishnan, Vijayakumar Natesan, Sung-Jin Kim
Summary: This study successfully synthesized p-coumaric acid nanoparticles (PCNPs) and evaluated their in vitro activities. The PCNPs showed significant antioxidant, antimicrobial, anti-inflammatory, antithrombotic, and antidiabetic effects, indicating their potential as a medication delivery approach for the treatment of diabetic nephropathy.
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Hemanjali Mude, Aniket Balapure, Anindita Thakur, Ramakrishnan Ganesan, Jayati Ray Dutta
Summary: Water-soluble complexes of caffeic acid with spermine and spermidine have been synthesized using acid-base interaction. The complexes showed enhanced antibacterial, antioxidant, and anticancer activities compared to pristine caffeic acid at their native pH values.
NATURAL PRODUCT RESEARCH
(2022)
Review
Chemistry, Medicinal
Ramin Negahdari, Sepideh Bohlouli, Simin Sharifi, Solmaz Maleki Dizaj, Yalda Rahbar Saadat, Khadijeh Khezri, Samira Jafari, Elham Ahmadian, Negar G. Jahandizi, Safa Raeesi
Summary: Rutin, a natural flavonoid compound, has shown a wide range of therapeutic potentials in nanoformulations, including antimicrobial, antifungal, and anti-allergic effects. Improving the bioavailability of rutin through novel drug-delivery methods can enhance its efficacy in treating chronic diseases. Further investigations are needed to confirm the enhanced bioavailability of rutin nanoformulations.
PHYTOTHERAPY RESEARCH
(2021)
Review
Chemistry, Medicinal
Neelam Malik, Priyanka Dhiman
Summary: P-coumaric acid is a common dietary polyphenol with low toxicity and various pharmacological actions. It can be used for multiple purposes such as antioxidant and preservative.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Sureyya Oguz Tumay, Vildan Sanko, Ahmet Senocak, Yasin Orooji, Erhan Demirbas, Yeojoon Yoon, Alireza Khataee
Summary: In this study, a novel MAX-phase material, Nb4AlC3, was successfully synthesized and characterized. The Nb4AlC3 modified glassy carbon electrode (Nb4AlC3@GCE) showed good sensor performance for the determination of para-coumaric acid (p-CA). The accuracy of the sensing system was confirmed through spike/recovery and high-performance liquid chromatography analysis.
Article
Biochemistry & Molecular Biology
Thiago Dantas Teixeira, Bruna Aparecida Souza Machado, Gabriele de Abreu Barreto, Jeancarlo Pereira dos Anjos, Ingrid Lessa Leal, Renata Quartieri Nascimento, Katharine Valeria Saraiva Hodel, Marcelo Andres Umsza-Guez
Summary: This study aimed to investigate the impact of low and high-pressure extractions on green propolis and determine the antioxidant profile in the extracts using sonication as a pretreatment. The total flavonoid content, total phenolic compounds, and antioxidant capacity of the twelve green propolis extracts were measured. Results showed higher levels of formononetin and p-coumaric acid in green propolis.
Article
Microbiology
Ronnie J. M. Lubbers, Ronald P. de Vries
Summary: Protocatechuic acid is an important chemical building block with pharmaceutical properties that can also be used to produce polymers and plastics. By identifying protocatechuate hydroxylase, it was found that a fungal cell factory can accumulate protocatechuic acid from plant-derived aromatic compounds. This research contributes to creating alternative methods for producing valuable aromatic compounds and platform chemicals.
Article
Agriculture, Multidisciplinary
Xihui Wang, Cui Zhao, Xinyao Lu, Hong Zong, Bin Zhuge
Summary: A growth-coupled dual-layered dynamic regulation system was developed to boost the yield of caffeic acid. This system autonomously controls intracellular pyruvate supply and coordinates gene expression to redirect carbon metabolism for caffeic acid synthesis. The engineered strain achieved a caffeic acid titer of 559.7 mg/L in a 5 L bioreactor, demonstrating the efficiency and potential of this system in enhancing the production of aromatic compounds.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Green & Sustainable Science & Technology
Marika Grodzicka, Cornelia E. Pena-Gonzalez, Paula Ortega, Sylwia Michlewska, Rebeca Lozano, Maria Bryszewska, Francisco Javier de la Mata, Maksim Ionov
Summary: Dendrimers, a type of branched polymer structure, are being extensively studied as effective drug carriers. Scientists are searching for new dendrimer-based formulations that possess the desired properties for biomedical applications, such as improved bioavailability, low toxicity, and high transfection profiles. The unique drug delivery properties of carbosilane dendrimers have already been demonstrated, and their efficacy has been further enhanced through conjugation with polyphenols. This study focuses on the synthesis and characterization of two new types of carbosilane dendritic systems, one with water solubility facilitated by the presence of caffeic acid units and ammonium groups on the surface, and the other with improved biocompatibility by incorporating polyethylene glycol chains into the structure.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2022)
Article
Chemistry, Applied
Ljubos Usjak, Milica Drobac, Marija Ivanov, Marina Sokovic, Marina T. Milenkovic, Marjan Niketic, Silvana Petrovic
Summary: The composition and antimicrobial activity of essential oils from different parts of cultivated Pastinaca sativa subsp. sativa, as well as its two wild-growing relatives, P. sativa subsp. urens and P. hirsuta, were investigated. The oils showed variations in composition and activity against various microorganisms.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maia Merlani, Nanuli Nadaraia, Lela Amiranashvili, Anthi Petrou, Athina Geronikaki, Ana Ciric, Jasmina Glamoclija, Tamara Carevic, Marina Sokovic
Summary: Twelve steroid-based hydrazones were evaluated in silico as antimicrobial agents using the computer program PASS. Experimental evaluation revealed low to moderate antibacterial activity against all tested bacteria, except for B. cereus. The most potent compound was number 11. It exhibited superior activity against MRSA compared to ampicillin and showed good antifungal activity.
Article
Biochemistry & Molecular Biology
Tamires Barlati Vieira da Silva, Maria Ines Dias, Carla Pereira, Filipa Mandim, Marija Ivanov, Marina Sokovic, Isabel C. F. R. Ferreira, Lillian Barros, Flavio Augusto Vicente Seixas, Adelar Bracht, Rosane Marina Peralta
Summary: Kenyan purple tea is a variety of green tea plant exclusive to Kenya, known for its purple color and high content of anthocyanin polyphenols. This study aimed to identify and quantify the major anthocyanin polyphenols in the purple tea leaves and test its ability to inhibit triglyceride absorption. The results showed that the purple tea extract had strong inhibitory effects on pancreatic lipase and triglyceride digestion, suggesting that regular consumption of Kenyan purple tea may be beneficial for obesity control.
Article
Integrative & Complementary Medicine
Juliana Scanavacca, Wanessa de Campos Bortolucci, Ezilda Jacomassi, Irineia Paulina Baretta, Maria Graciela Iecher Faria, Carla Maria Mariano Fernandez, Vele Tesevic, Jasmina Glamoclija, Marina Sokovic, Nelson Barros Colauto, Giani Andrea Linde, Zilda Cristiani Gazim
Summary: This study evaluated the chemical composition and antimicrobial activity of Tetradenia riparia leaf essential oil. The essential oil showed broad antibacterial and antifungal activity, making it a potential alternative for microbial control.
BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
(2023)
Review
Pharmacology & Pharmacy
Tamara Carevic, Dejan Stojkovic, Marija Ivanov
Summary: Flavonoids, secondary metabolites found abundantly in plants, have been extensively studied for their potential health-beneficial effects. While there is data on their antimicrobial potential, less is known about their antivirulence traits. This review aims to present the newest research on the antivirulence effects of flavonoids, highlighting their diverse attributes and potential for development in novel antimicrobial strategies.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Chemistry, Multidisciplinary
A. Petrou, V. Kartsev, A. Geronikaki, J. Glamoclija, A. Ciric, M. Sokovic
Summary: Nine new derivatives of 2-aminothiazole were tested for their antimicrobial activity against bacteria and fungi. The compounds showed potent antibacterial and antifungal effects, with some exceptions. Compound 8 was found to be the most effective antibacterial agent, while compound 1 exhibited the best antifungal activity. Different bacteria and fungi exhibited varying levels of sensitivity towards the tested compounds. Molecular docking studies revealed the potential mechanisms of action for antibacterial and antifungal activities. Furthermore, all compounds displayed excellent druglikeness scores.
SAR AND QSAR IN ENVIRONMENTAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Mihai Babota, Oleg Frumuzachi, Alexandru Nicolescu, Dejan Stojkovic, Marina Sokovic, Gabriele Rocchetti, Leilei Zhang, Luigi Lucini, Gianina Crisan, Andrei Mocan, Oliviu Vostinaru
Summary: This study evaluated the diuretic effect and antimicrobial properties of herbal preparations obtained from Thymus comosus. The results showed that all the extracts exhibited a mild diuretic action, with TCT and OpTC inducing the most intense diuretic effect. In terms of antimicrobial activity, certain bacterial and fungal strains showed sensitivity to the extracts. The composition analysis revealed that the extracts contained significant amounts of phenolic acids, flavonoids, and other phenolics.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Beatriz Nunes Silva, Vasco Cadavez, Cristina Caleja, Eliana Pereira, Ricardo C. Calhelha, Mikel Anibarro-Ortega, Tiane Finimundy, Marina Kostic, Marina Sokovic, Jose Antonio Teixeira, Lillian Barros, Ursula Gonzales-Barron
Summary: This study aimed to characterize the polyphenolic profile and bioactive properties of lemon balm, sage, and spearmint extracts. The results showed that some of these extracts may have the ability to prevent food spoilage and promote health benefits while not displaying toxicity against healthy cells. Although sage extracts did not exhibit anti-inflammatory capacity, they often showed the best outcomes in terms of other bioactivities. Overall, the research provides insight into the potential of plant extracts as a source of active phytochemicals and as natural food additives.
Review
Infectious Diseases
Dejan Stojkovic, Jovana Petrovic, Tamara Carevic, Marina Sokovic, Konstantinos Liaras
Summary: This narrative review provides an overview of the potential of novel synthetic and semisynthetic compounds as antibacterials that target virulence traits in antibiotic-resistant strains. The review focuses on recent research and discusses a range of compounds that show promise in combating antibiotic resistance by targeting bacterial virulence factors. The findings suggest that further research is needed to identify and optimize new compounds with the potential to combat antibiotic-resistant bacterial infections.
Article
Chemistry, Medicinal
Jelena Bozunovic, Marija Ivanov, Jovana Petrovic, Uros Gasic, Dura Nakarada, Milica Milutinovic, Neda Anicic, Zlatko Giba, Danijela Misic, Dejan Stojkovic
Summary: This study found that ethanol-water-based extraction was the most efficient in isolating polyphenols, while less polar butanol extract contained the highest amount of iridoids. Antioxidant potential analysis revealed stronger activity in extracts with higher polyphenol content. The extracts from Centaurium spicatum showed antimicrobial and wound healing effects without cytotoxicity to human cells.
Article
Biochemistry & Molecular Biology
Tatjana Markovic, Natalija Cutovic, Tamara Carevic, Uros Gasic, Dejan Stojkovic, Jingqi Xue, Aleksandra Jovanovic
Summary: This study aimed to determine the chemical composition of Paeonia peregrina Mill. petals and optimize the extraction parameters, medium, and method. The extracted petal extracts showed high content of total polyphenols and total flavonoids, as well as strong antioxidant activity. The extracts also exhibited potential antimicrobial, wound healing, and anti-inflammatory properties, with methanol being the preferred extraction medium. The most promising locality for P. peregrina petals collection was found to be Pancevo in Serbia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Horticulture
Angela Fernandes, Nikolaos Polyzos, Filipa Mandim, Carla Pereira, Jovana Petrovic, Marina Sokovic, Spyridon A. Petropoulos
Summary: The aim of this study was to evaluate the effects of different biostimulant formulations with various application regimes, combined with or without mineral fertilizers, on the yield parameters and fruit quality of watermelon plants. The results showed that the W5 treatment resulted in the highest yield due to increased fruit formation. Different treatments had varying effects on the content of fat, proteins, carbohydrates, sugars, and acids in the watermelon fruit.