Article
Plant Sciences
Hasan M. Rashid, Asma Ismail Mahmod, Fatma U. Afifi, Wamidh H. Talib
Summary: This study evaluated the antioxidant and anti-proliferative effects of Aloysia citrodora. The ethyl acetate extract showed significant antiproliferative efficacy, while the ethanol extract exhibited the strongest radical scavenging effect.
Article
Nutrition & Dietetics
Boonyarut Ladda, Chittapon Jantararussamee, Wisuit Pradidarcheep, Anongnard Kasorn, Udomlak Matsathit, Malai Taweechotipatr
Summary: This study examined the properties of three probiotic strains in colorectal adenocarcinoma cells. It was found that the probiotic L. paracasei strain MSMC39-1 significantly suppressed TNF-a secretion in the cells. Further experiments showed that this strain reduced liver enzyme levels, inhibited TNF-a secretion in colon and liver tissues, alleviated colon and liver histopathology, and increased beneficial bacteria in the gut.
Article
Pathology
Li-Yin Hung, Christopher F. Pastore, Bonnie Douglas, De'Broski R. Herbert
Summary: The study demonstrates that myeloid-derived IL-33 plays a key role in restraining colitic disease, while intestinal epithelial cell-derived IL-33 is dispensable for disease severity or tissue recovery.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Environmental Sciences
Fahad Alharthi
Summary: Chicoric acid (CA) has been found to have anti-inflammatory and antioxidant effects on DSS-induced colitis, significantly reducing inflammation and apoptosis cascades associated with the development of colitis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Immunology
Dadi Xie, Fengfeng Li, Deshui Pang, Shiyuan Zhao, Meihua Zhang, Zhongfa Ren, Chunmei Geng, Changshui Wang, Ning Wei, Pei Jiang
Summary: This study aimed to evaluate the utility metabolomic analysis of target tissues in exploring new biomarkers for early diagnosis and treatment of IBD. The results showed significant changes in amino acid, organic acid, glucide, and purine profiles, impacting pathways ranging from amino acid metabolism to purine metabolism. Using GC-MS-based profiling of metabolite changes may provide a more comprehensive view for understanding IBD pathogenesis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Tian-Yuan Yu, Yi-Ming Feng, Wei-Song Kong, Shan-Ni Li, Xue-Jiao Sun, Gui Zhou, Rui-Fang Xie, Xin Zhou
Summary: This study aimed to evaluate the effect of the natural polyphenol gallic acid (GA) on the NLRP3 inflammasome in DSS-induced colitis in mice. The results showed that GA could attenuate weight loss, relieve symptoms, and improve colonic morphological injury in mice with colitis. GA also reduced the levels of pro-inflammatory cytokines and downregulated the protein and mRNA expressions of the NLRP3 pathway. Furthermore, GA inhibited the expression of inflammatory markers and suppressed NO release in macrophage cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Bihui Liu, Lei Yang, Ya Wu, Xin Zhao
Summary: This study investigated the effects of Limosilactobacillus fermentum HFY06 (LF-HFY06) on murine colitis. The results showed that LF-HFY06 increased colon length and ameliorated pathological damage, enhanced antioxidant enzyme activities, reduced inflammatory cytokine levels, and inhibited inflammation through the NF-κB signaling pathway. LF-HFY06 has the potential to prevent and treat colitis.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yu-Shan Chen, Yu Zhi Lian, Wen-Chao Chen, Chun-Chao Chang, Alexey A. Tinkov, Anatoly V. Skalny, Jane C. -J. Chao
Summary: This study found that Lycium barbarum polysaccharides and capsaicin can alleviate symptoms in DSS-induced ulcerative colitis rats. They exert their effects by inhibiting oxidative stress, proinflammatory cytokines, and protein expression of TRPV1 and TRPA1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sung Hun Bae, Hyo Sung Kim, Hyeon Gyeom Choi, Sun-Young Chang, So Hee Kim
Summary: Ulcerative colitis inhibits CYP3A1/2 and CYP2C11 in the liver and intestines of DSS rats, slowing the metabolism of tofacitinib and increasing its plasma concentrations.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Food Science & Technology
Min Seo Kim, Yong Dae Kim, Seunghee Kang, Oran Kwon, Jae-Ho Shin, Ji Yeon Kim
Summary: In this study, the effect of cinnamon subcritical water extract (CSE) on gut health in a mouse colitis model induced by dextran sodium sulfate was evaluated. Results showed that CSE improved clinical symptoms, reduced inflammatory markers, increased expression of tight junction proteins, and altered the microbiome to reduce inflammation. These findings suggest that CSE could prevent colitis-induced intestinal disruption.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Johnson O. Oladele, Joy C. Anyim, Oyedotun M. Oyeleke, Boyede D. Olowookere, Mutiat O. Bamigboye, Oluwaseun T. Oladele, Adenike T. Oladiji
Summary: The aqueous leaf extract of Telfairia occidentalis exhibited significant therapeutic effects in treating dextran sodium sulfate-mediated colitis in rats, as it reduced mucosal inflammation, suppressed lipid peroxidation, attenuated oxidative stress, enhanced antioxidant enzymes activities, and reduced both infiltration of inflammatory cells and mucosal damage in colon. These effects could be attributed to the phytochemicals present in the extract, as indicated by gas chromatography-mass spectroscopy results.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Immunology
Jie Wang, Ke Shi, Shuaifei Li, Lu Chen, Wentao Liu, Xudong Wu, Yan Shen, Yang Sun, Jingcai Cheng, Xuefeng Wu, Qiang Xu
Summary: Meisoindigo effectively alleviates experimental colitis in mice by regulating the levels of various molecules and inflammatory cytokines, suppressing NF-κB pathway activation. In addition, meisoindigo targets TAK1 to inhibit inflammatory responses, providing a novel direction for clinical anti-inflammatory therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Mona H. Zohny, Mohammed Alrouji, Sharif Alhajlah, Othman AlOmeir, Mohamed Gamal El-Din Ewees, Dalia M. Abdel Ghaffar, Noura El Adle Khalaf, Osama A. Mohammed, Mahmoud Said Ibrahim Abdeldaiem, Waleed Barakat El-Bahouty, Amr Elrabat, Sahar Zakaria, Zeinab M. Abdel-Nasser, Amira A. Haleem, Doaa M. El-Gharbawy, Rasha Abdelhady, Mohamed M. Y. Kaddah, Ahmed Shata, Sameh Saber
Summary: Diacetylrhein has significant antioxidant and anti-inflammatory potential for the treatment of acute ulcerative colitis (UC) and may represent a promising agent in the management of the disease.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Mohammed Gamah, Murad Alahdal, Yu Zhang, Yiling Zhou, Qiaorong Ji, Zhouyang Yuan, Ying Han, Xiangqun Shen, Yanming Ren, Wei Zhang
Summary: This study found that high altitude hypoxia exacerbates the severity of ulcerative colitis in mice by activating the increase of inflammatory Th1 and Th17 lymphocytes.
Article
Food Science & Technology
Hye-Jung Moon, Suk-Heung Oh, Ki-Bum Park, Youn-Soo Cha
Summary: This study investigated the alleviating effects of kimchi and Leuconostoc mesenteroides DRC 1506 on ulcerative colitis (UC). Mice were orally given a dose of 1 x 10(9) CFU/day of freeze-dried kimchi suspension and DRC for 3 weeks, and UC was induced with dextran sulfate sodium (DSS). The results showed that the kimchi and DRC groups reduced colitis symptoms and improved the inflammatory response and mucosal barrier function in the colon.
