Article
Food Science & Technology
Hui Huang, Fei Peng, Junyi Li, Zhanggen Liu, Mingyong Xie, Tao Xiong
Summary: This study isolated five Lactiplantibacillus plantarum strains with superior antibacterial activity against Helicobacter pylori. The strains' supernatants effectively reduced the viable counts of H. pylori and inhibited urease activity, while also showing strong cell adhesion and beta-glucosidase activity. The strains were found to be safe and nonhemolytic, contributing to the development of antibiotics-free anti-H. pylori foods.
Article
Biochemistry & Molecular Biology
Anastasia Dmitrieva, Oksana Kozlova, Victor Atuchin, Irina Milentieva, Anna Vesnina, Svetlana Ivanova, Lyudmila Asyakina, Alexander Prosekov
Summary: The antimicrobial properties of baicalin against H. pylori and several probiotic cultures were evaluated. Baicalin exhibited high antimicrobial activity against H. pylori and a stimulating effect on the growth of certain probiotic strains.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Samantha A. Whiteside, Mahi M. Mohiuddin, Sargon Shlimon, Jaspreet Chahal, Chad W. MacPherson, Jana Jass, Thomas A. Tompkins, Carole Creuzenet
Summary: The study revealed that secretions from lactic acid bacteria can inhibit the growth of Helicobacter pylori, reduce its urease activity, and decrease its ability to induce inflammatory responses in gastric cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jimin Hwang, Sonya Mros, Allan B. Gamble, Joel D. A. Tyndall, Arlene McDowell
Summary: Nanoparticle drug delivery systems offer a promising approach to address limitations of antimicrobial drugs. Controlled engineering of nanoparticle size using microfluidic technology can significantly improve drug delivery optimization.
Article
Immunology
Ya Wang, Shuang Wu, Le Wang, Youhua Wang, Dongsheng Liu, Yingjun Fu, Yong Xie
Summary: LipoLLA exhibited strong antimicrobial effects against H. pylori by destroying the outer membrane barrier and causing leakage of bacterial contents, while having minimal impact on human fecal bacteria in vitro.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yalda Mahjoory, Reza Mohammadi, Mohammad Amin Hejazi, Yousef Nami
Summary: The potential of two identified probiotic strains, ABRIIFBI-6 and ABRIIFBI-7, to inhibit the growth of aspergilli and reduce aflatoxin availability was investigated. Both strains survived in simulated gastrointestinal conditions and significantly inhibited Aspergillus growth. They also exhibited high auto-aggregation, hydrophobicity, and coaggregation abilities with other bacteria. These findings contribute to the understanding of LAB probiotic potential in dairy products and their use as biocontrol agents against aflatoxin-producing species.
SCIENTIFIC REPORTS
(2023)
Review
Agronomy
Barbara Wrobel, Janusz Nowak, Agata Fabiszewska, Anna Paszkiewicz-Jasinska, Wojciech Przystupa
Summary: This review provides an overview of the dry matter (DM) and quality losses that occur during the ensiling process. It reviews the current knowledge on fermentation pathways and DM losses in various raw materials. The review discusses microorganisms involved in ensiling, fermentation patterns, and strategies to reduce losses. The paper concludes with future perspectives and recommended management practices to minimize losses in the ensiling process.
Article
Oncology
Katarzyna Garbacz
Summary: Lactic acid bacteria (LAB), naturally occurring in fermented food products and used as probiotics, have bioactive compounds with potential anticancer activity. Research has shown that these compounds can inhibit tumor growth through various mechanisms and have immunomodulatory effects. LAB has promising clinical applications in anticancer therapy.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyun Jun Woo, Ji Yeong Yang, Pyeongjae Lee, Jong-Bae Kim, Sa-Hyun Kim
Summary: The natural compound zerumbone extracted from Zingiber zerumbet Smith was found to inhibit the urease activity of H. pylori by forming dimers, trimers, or tetramers, suggesting its potential as a therapeutic agent for treating H. pylori infections in humans.
Article
Food Science & Technology
Jun Chen, Huili Pang, Lei Wang, Cunming Ma, Guofang Wu, Yuan Liu, Yifei Guan, Miao Zhang, Guangyong Qin, Zhongfang Tan
Summary: A total of 116 LAB strains were isolated from Bamei pig feces, among which L. plantarum subsp. plantarum QP28-1 was identified as a promising strain for LAB-related food fermentation due to its excellent antimicrobial properties and bacteriocin production capacity. This study provides a comprehensive profile for screening superior functional LAB strains in the food industry.
Article
Food Science & Technology
Yushi Fujimura, Mariko Shimura, Hiroshi Nagai, Naoko Hamada-Sato
Summary: This study demonstrated that abalone viscera fermented by lactic acid bacteria have the ability to inhibit angiotensin-converting enzyme (ACE) and suppress blood pressure increases, with homarine identified as the active compound. Therefore, fermented abalone viscera have the potential to be used as functional food materials to manage blood pressure.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Multidisciplinary Sciences
Hidenori Matsu, Emiko Rimbara, Masato Suzuki, Kengo Tokunaga, Hidekazu Suzuki, Masaya Sano, Takashi Ueda, Hitoshi Tsugawa, Sohachi Nanjo, Akira Takeda, Makot Sakshi, Shuich Terao, Tsuyosh Suda, Sae Aoki, Keigo Shibayama, Hiroyosh Ota, Katsuhiro Mabe
Summary: Helicobacter suis, the most common gastric non-Helicobacter pylori Helicobacter species found in humans, has been suggested to cause many cases of gastric disease, but the transmission route from hogs remains unclear. Diagnostic methods for H. suis infection often yield negative results, making it difficult to diagnose without gastric biopsy specimens. This study introduces the use of whole-bacterial cell ELISA to simultaneously assess H. suis and H. pylori infections, with high accuracy and sensitivity.
Article
Biotechnology & Applied Microbiology
Ashok Kumar Yadav, Sudarshan Reddy Varikuti, Ashwani Kumar, Manoj Kumar, Nabendu Debanth, Hemalatha Rajkumar
Summary: The aim of this study was to discover the anti-H. pylori activities and faster exclusion of H. pylori from host cells by the recombinant strain of Lactobacillus expressing the immunogenic Hsbp protein. The results showed a promising reduction in H. pylori adhesion after pre-incubation, co-incubation, and post-incubation with recombinant-LGG. Moreover, the expression of proinflammatory cytokines was downregulated in recombinant-LGG treated cells when challenged with H. pylori.
Article
Biotechnology & Applied Microbiology
Buket Kunduhoglu, Seda Hacioglu
Summary: This study explored the gluten hydrolysis ability and probiotic potential of Lact. brevis KT16-2, which showed promising results in terms of surviving in adverse conditions, producing antimicrobial peptides, and exhibiting high antioxidant activity.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Agriculture, Dairy & Animal Science
Fernando M. M. Sanca, Iago R. Blanco, Meriellen Dias, Andrea M. Moreno, Simone M. M. K. Martins, Marco A. Stephano, Maria A. Mendes, Carlos M. N. Mendonca, Wellison A. Pereira, Pamela O. S. Azevedo, Martin Gierus, Ricardo P. S. Oliveira
Summary: In this study, the inhibitory effects of antimicrobial peptides produced by Lactococcus lactis L2 on pig pathogens were tested. The peptides showed good bacteriostatic and bactericidal effects, especially against Gram-positive bacteria, and their low molecular weight may be responsible for their antimicrobial properties. The use of probiotics in controlling pig pathogens has potential benefits.
Article
Food Science & Technology
Shyang-Chwen Sheu, Jhong-Yong Huang, Yi-Yang Lien, Meng-Shiou Lee
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2020)
Article
Nutrition & Dietetics
Li-Chan Yang, Shih-Wei Lin, I-Chen Li, Yen-Po Chen, Shih-Yang Tzu, Wei Chou, Chin-Chu Chen, Wen-Chuan Lin, Yen-Lien Chen, Wen-Hsin Lin
Article
Plant Sciences
Chia-Chen Chen, Maw-Rong Lee, Chi-Rei Wu, Hsin-Ju Ke, Hui-Min Xie, Hsin-Sheng Tsay, Dinesh Chandra Agrawal, Hung-Chi Chang
Article
Chemistry, Medicinal
Hui-Chi Huang, Wen-Te Chang, Meng-Shiou Lee, Hsing-Yu Chen, Yu-Hua Chen, Chi-Chen Lin, Ming-Kuem Lin
Summary: The study demonstrated that bufadienolides isolated from Kalanchoe tubiflora did not induce apoptosis but rather activated an autophagy pathway in highly metastatic human lung cancer cells. These bufadienolides induced autophagy was linked to the down-regulation of p-mTOR and the up-regulation of various proteins, providing evidence of their potential therapeutic strategy for lung cancer.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Kuan-Chung Chen, Chi-Rei Wu, Jin-Cherng Lien
Summary: This research investigated the relationship between inhibitory activities and compound properties using molecular docking simulation, pharmacophore model, comparative force field analysis model, and comparative similarity indices analysis model. It was found that compounds with different substituents showed variations in docking poses. The results provide valuable insights for future anticancer drug development studies.
JOURNAL OF BIOCHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Shih-Wei Lin, You-Shan Tsai, Yen-Lien Chen, Ming-Fu Wang, Chin-Chu Chen, Wen-Hsin Lin, Tony J. Fang
Summary: Probiotics GKS6 and GKK2 demonstrated antioxidative effects in delaying aging and preventing age-related muscle loss in SAMP8 mice.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Zi-Wei Zhao, Hung-Chi Chang, Hui Ching, Jin-Cherng Lien, Hui-Chi Huang, Chi-Rei Wu
Summary: The study found that the flower part of Cirsium japonicum var. australe exhibited the best antioxidant activities and highest content of phenolic compounds and phenylpropanoids. There was a positive correlation between total phenylpropanoid content and ABTS radical-scavenging activities, while the radical-scavenging activities of phenylpropanoids were closely related to their reducing power. Additionally, the flavonolignans and diosmetin in CJF synergistically scavenged radicals.
Article
Nutrition & Dietetics
Shih-Wei Lin, You-Shan Tsai, Yen-Lien Chen, Ming-Fu Wang, Chin-Chu Chen, Wen-Hsin Lin, Tony J. Fang
Summary: The study revealed that the probiotic Lactobacillus plantarum GKM3 has significant effects in delaying aging, alleviating age-related cognitive impairment, and reducing oxidative stress.
Article
Pharmacology & Pharmacy
Chun-Yi Lai, Chia-Yuan Lin, Chi-Rei Wu, Chon-Haw Tsai, Chia-Wen Tsai
Summary: The study found that CA can improve LID by regulating D1R signaling and preventing apoptotic cell death induced by L-dopa through modulating ERK1/2-c-Jun and inducing parkin. Therefore, CA may be used to alleviate the adverse effects of LID for PD patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agricultural Engineering
Hui-Chi Huang, Wen-Te Chang, Yi-Hsuan Wu, Bo-Cheng Yang, Mo-Rong Xu, Ming-Kuem Lin, Hsi-Jien Chen, Jai-Hong Cheng, Meng-Shiou Lee
Summary: In this study, microbial fermentation of Hibiscus sabdariffa L. calyx extract was used to enhance its phytochemical constituents and biological activity, resulting in increased antioxidant activity and phenolic content, especially with Galactomyces geotrichum inoculation. The optimized fermentation conditions included 1% eHS addition and static culture method. High performance liquid chromatography (HPLC) and enzymatic activity analysis showed that the improved biological activities of fermented eHS were mainly due to increased levels of phenolic compounds, flavonoids, anthocyanin and its aglycone derivatives. This is the first report to demonstrate the use of microbial fermentation to improve the biological functionalities of fermented eHS.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Medicine, General & Internal
Jai-Hong Cheng, Wen-Yi Chou, Ching-Jen Wang, Ka-Kit Siu, Jei-Ming Peng, Yi-No Wu, Meng-Shiou Lee, Chien-Yiu Huang, Jih-Yang Ko, Shun-Wun Jhan
Summary: This study demonstrated the effects of extracorporeal shockwave therapy (ESWT) on rat knee osteoarthritis (OA) and its associated pathological changes. The results revealed that ESWT had better outcomes in the medial group compared to the lateral group. The study also identified correlations between the modified Mankin score, tidemark roughness, and calcified cartilage thickness.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biology
Shyang-Chwen Sheu, Yi-Cheng Wu, Yi-Yang Lien, Meng-Shiou Lee
Summary: A loop-mediated isothermal amplification (LAMP) method was developed for detecting C. longa DNA, allowing rapid and accurate identification of turmeric and prevention of adulteration, with a sensitivity 10 times higher than PCR.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Food Science & Technology
Priya Rana, Shu-Yi Liaw, Meng-Shiou Lee, Shyang-Chwen Sheu
Summary: A new method was developed to discriminate four Cinnamomum species using physico-functional properties and chemometric techniques. The principal component analysis and multiclass discriminant analysis showed significant separation of the different species. The model proved to be valid and reliable with a 100% prediction rate upon testing.
Review
Biochemistry & Molecular Biology
Shu-Er Yang, Jin-Cherng Lien, Chia-Wen Tsai, Chi-Rei Wu
Summary: Isoflavones, including simple O-substituted derivatives, have been extensively studied and shown to possess various pharmacological activities such as antioxidant, anti-inflammatory, anticancer, and neuroprotective effects. Simple O-substituted isoflavones, in particular, have potential therapeutic effects against cerebral ischemia reperfusion through estrogenic receptor modulation and multiple signaling pathways. However, clinical trials are needed to confirm their efficacy in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Chia-Cheng Yu, Lih-Chyang Chen, Wen-Hsin Lin, Victor C. Lin, Chao-Yuan Huang, Te-Ling Lu, Cheng-Hsueh Lee, Shu-Pin Huang, Bo-Ying Bao
CANCER GENOMICS & PROTEOMICS
(2020)
