Article
Health Care Sciences & Services
Oriana Ciani, Maximilian Salcher-Konrad, Michela Meregaglia, Kathrine Smith, Sarah L. Gorst, Susanna Dodd, Paula R. Williamson, Giovanni Fattore
Summary: This study reviewed core outcome sets (COS) with patient-reported outcomes measures (PROMs) and found that while most instruments cover broad health-related constructs, there are issues of resource overlap within and across different disease areas.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Article
Oncology
Vanessa L. Beesley, Tanya L. Ross, Madeleine T. King, Rachel Campbell, Christina M. Nagle, Andreas Obermair, Peter Grant, Anna DeFazio, Penelope M. Webb, Michael L. Friedlander
Summary: This study documented the prevalence and trajectories of symptoms experienced by ovarian cancer patients after first-line chemotherapy. The findings showed that abdominal symptoms were worst at chemotherapy end but improved over time. Neurotoxicity symptoms peaked at 1 month after treatment before improving. Long-term fatigue, trouble sleeping, sore hands and feet, pins and needles, and anxiety were common symptoms.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Juliette Maurel, Rosine Guimbaud, Thierry Lecomte, Astrid Lievre, Vincent Hautefeuille, Philip Robinson, Laurent Francois, Catherine Lombard-Bohas, Julien Forestier, Laurent Milot, Fabien Subtil, Thomas Walter
Summary: The study found that patient-reported outcomes of carcinoid syndrome patients showed that the main domains affecting daily life were traveling and food restriction. The most common symptoms were diarrhea, imperiousness, fatigue, abdominal pain, and flushing episodes. The PRO-CSS score was not correlated with clinical assessments, and patients with a low PRO-CSS score generally had a higher tumor burden.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Oncology
Mallorie H. Fiero, Jessica K. Roydhouse, Vishal Bhatnagar, Ting-Yu Chen, Bellinda L. King-Kallimanis, Shenghui Tang, Paul G. Kluetz
Summary: Time-to-event endpoints for patient-reported outcomes, such as time to deterioration of symptoms or function, have unique considerations and challenges in cancer clinical trials. Analytical decisions using the estimand framework can help answer specific clinical questions, while the complexity and burdens associated with measuring time to deterioration make it problematic for widespread use. Instead, analyzing at pre-specified relevant time-points might be a better approach for trials focusing on comparative symptom or functional benefits.
Article
Clinical Neurology
Pamela L. Wolters, Ana-Maria Vranceanu, Heather L. Thompson, Staci Martin, Vanessa L. Merker, Andrea Baldwin, Carolina Barnett, Kimberley S. Koetsier, Cynthia M. Hingtgen, Christopher J. Funes, James H. Tonsgard, Elizabeth K. Schorry, Taryn Allen, Taylor Smith, Barbara Franklin, Stephanie Reeve, REiNS Int Collaboration
Summary: The study reviewed and recommended patient-reported outcome measures for assessing multidimensional domains of quality of life for patients with neurofibromatosis types 1, 2, and schwannomatosis, with a focus on generic and disease-specific tools for use in clinical trials.
Article
Clinical Neurology
Pamela L. Wolters, Ana-Maria Vranceanu, Heather L. Thompson, Staci Martin, Vanessa L. Merker, Andrea Baldwin, Carolina Barnett, Kimberley S. Koetsier, Cynthia M. Hingtgen, Christopher J. Funes, James H. Tonsgard, Elizabeth K. Schorry, Taryn Allen, Taylor Smith, Barbara Franklin, Stephanie Reeve
Summary: The REiNS Collaboration recommends the use of generic and disease-specific PRO measures to assess multidimensional domains of QoL for NF clinical trials in children and adults. Further research is needed to evaluate the effectiveness of these measures in both medical and psychosocial trials.
Review
Cardiac & Cardiovascular Systems
Ruth Masterson Creber, Cristiano Spadaccio, Arnaldo Dimagli, Annie Myers, Brittany Taylor, Stephen Fremes
Summary: Patient-reported outcomes (PROs) offer a global perspective of a person's health status and are categorized into global, mental, physical, and social health domains. Challenges in using PROs in cardiac clinical trials include long-term measurement, inconsistency in outcome measures, and lack of measurement across multiple domains. Opportunities for advancement include utilizing consumer health informatics tools to measure PROs and quantifying minimal clinically important differences.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Maurizio S. Tonetti, Mariano Sanz, Gustavo Avila-Ortiz, Tord Berglundh, Francesco Cairo, Jan Derks, Elena Figuero, Filippo Graziani, Fernando Guerra, Lisa Heitz-Mayfield, Ronald E. E. Jung, Hongchang Lai, Ian Needleman, Panos N. Papapanou, Irena Sailer, Ignacio Sanz-Sanchez, Frank Schwarz, Junyu Shi, Daniel Thoma
Summary: This study aimed to develop a core outcome set and measurements for implant dentistry clinical trials in order to improve evidence-based implant dentistry and quality of care. The study involved steps such as systematic reviews, patient focus groups, a Delphi project, and expert group discussions. The results identified 22 core outcomes in four domains, including pathophysiology, implant/prosthesis lifespan, life impact, and access to care. This study is of significant importance in improving implant dentistry and quality of care.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Oncology
Teyl Engstrom, Sarah Tanner, Wen Ray Lee, Cheryl Forbes, Rick Walker, Natalie Bradford, Jason D. Pole
Summary: Adolescent and young adult (AYA) cancer patients and survivors face unique issues and it is important to use appropriate Patient Reported Outcome Measures (PROMs) to measure these issues.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Fiona Kennedy, Leanne Shearsmith, Marie Holmes, Zoe Rogers, Rob Carter, Uschi Hofmann, Galina Velikova
Summary: This study explored the feasibility and acceptability of an electronic patient-reported outcome (ePRO) follow-up pathway for ovarian cancer patients. The results showed that remote ePRO follow-up is feasible and acceptable to patients who are able and willing to participate. However, the low recruitment rate indicates that it may not be suitable for all patients.
Article
Gastroenterology & Hepatology
Anika Varma, Jennifer Weinstein, Jamison Seabury, Spencer Rosero, Ellen Wagner, Christine Zizzi, Elizabeth Luebbe, Nuran Dilek, Michael McDermott, John Heatwole, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole
Summary: This study aimed to identify the most prevalent and impactful symptoms in patients with Crohn's disease (CD) and to determine the modifying factors associated with a higher disease burden in CD.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Maurizio S. Tonetti, Mariano Sanz, Gustavo Avila-Ortiz, Tord Berglundh, Francesco Cairo, Jan Derks, Elena Figuero, Filippo Graziani, Fernando Guerra, Lisa Heitz-Mayfield, Ronald E. Jung, Hongchang Lai, Ian Needleman, Panos N. Papapanou, Irena Sailer, Ignacio Sanz-Sanchez, Frank Schwarz, Junyu Shi, Daniel Thoma
Summary: To improve evidence-based implant dentistry and quality of care, this study aimed to develop a core outcome set and measurements for implant dentistry clinical trials. Through systematic reviews, patient focus groups, and expert discussions, 13 mandatory outcome domains were identified, including pathophysiology, implant/prosthesis lifespan, life impact, and access to care. These domains captured both the benefits and harms of therapy and will contribute to improving evidence-informed implant dentistry and quality of care.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
V. Vien Lee, Ni Yin Lau, Agata Blasiak, Kewin Tien Ho Siah, Dean Ho
Summary: This study aimed to develop a constipation PROM with multiple phases of patient and clinician involvement, which can measure both symptom severity and constipation-related quality of life.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Rheumatology
Y. El Miedany, M. El Gaafary, M. Toth, D. Palmer, Ayman Ali, S. Bahlas, S. Mahran, W. Hassan, Mh Abu-zaid, S. Saber, W. Elwakil
Summary: A reliable and valid instrument for assessing Giant Cell Arteritis (GCA) patients has been developed. Stratified treatment regimens based on disease activity status and individual patient's risk factors, preferences, and associated comorbidities are the best approach to tailored patient management.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Ophthalmology
Ron D. Hays, Scott Macrae, Jack Holladay, Michelle E. Tarver, Flora Lum, Walter Stark, Beverly Weidmer, Nisha Kumar, George Lau, Tieuvi Nguyen, Steven Schallhorn, Malvina Eydelman, Samuel Masket
Summary: This study aimed to develop a standardized patient-reported outcome measure for assessing visual perceptions and symptoms in patients with implanted premium and monofocal intraocular lenses. The results showed that most symptoms improved after surgery, with monofocal IOL patients experiencing lower levels of improvement.
Article
Oncology
Connie M. Ulrich, Snehal Deshmukh, Stephanie L. Pugh, Alexandra Hanlon, Christine Grady, Deborah Watkins Bruner, Walter Curran
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Health Care Sciences & Services
Katherine A. Yeager, Bryan Williams, Jinbing Bai, Hannah L. F. Cooper, Tammie Quest, Salimah H. Meghani, Deborah W. Bruner
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2019)
Article
Oncology
Deborah W. Bruner, Stephanie L. Pugh, W. Robert Lee, William A. Hall, James J. Dignam, Daniel Low, Gregory P. Swanson, Amit B. Shah, Shawn Malone, Jeff M. Michalski, Ian S. Dayes, Samantha A. Seaward, Paul L. Nguyen, Thomas M. Pisansky, Yuhchyau Chen, Howard M. Sandler, Benjamin Movsas
Article
Oncology
Karen M. Gil, Stephanie L. Pugh, Ann H. Klopp, Anamaria R. Yeung, Lari Wenzel, Shannon N. Westin, David K. Gaffney, William Small, Spencer Thompson, Desiree E. Doncals, Guilherme H. C. Cantuaria, Brian P. Yaremko, Amy Chang, Vijayananda Kundapur, Dasarahally S. Mohan, Michael L. Haas, Yong Bae Kim, Catherine L. Ferguson, Snehal Deshmukh, Lisa A. Kachnic, Deborah W. Bruner
GYNECOLOGIC ONCOLOGY
(2019)
Article
Oncology
Maria Thor, Joseph O. Deasy, Rebecca Paulus, W. Robert Lee, Mahul B. Amin, Deborah W. Bruner, Daniel A. Low, Amit B. Shah, Shawn C. Malone, Jeff M. Michalski, Ian S. Dayes, Samantha A. Seaward, Elizabeth M. Gore, Michele Albert, Thomas M. Pisansky, Sergio L. Faria, Yuhchyau Chen, Bridget F. Koontz, Gregory P. Swanson, Stephanie L. Pugh, Howard M. Sandler
RADIOTHERAPY AND ONCOLOGY
(2019)
Article
Otorhinolaryngology
Ronald C. Eldridge, Stephanie L. Pugh, Andy Trotti, Kenneth Hu, Sharon Spencer, Sue Yom, David Rosenthal, Nancy Read, Anand Desai, Elizabeth Gore, George Shenouda, Mark V. Mishra, Deborah Bruner, Canhua Xiao
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2019)
Article
Nursing
Gaea A. Daniel, Yingtian Hu, Despina Tsementzi, C. Ileen Jhaney, Yi-Juan Hu, Katherine A. Yeager, Jinbing Bai, Mary Dolan, Deborah W. Bruner
Summary: This pilot study characterized the vaginal microbiome of postmenopausal women and identified types and frequency of intravaginal practices (IVPs). The study found that there were no associations between IVPs and the vaginal microbiome in postmenopausal women. Further research is needed to understand the reasoning behind women's use of IVPs and their perceived effects.
Article
Oncology
Rahul Khairnar, Lyudmila DeMora, Howard M. Sandler, W. Robert Lee, Ester Villalonga-Olives, C. Daniel Mullins, Francis B. Palumbo, Deborah W. Bruner, Fadia T. Shaya, Soren M. Bentzen, Amit B. Shah, Shawn Malone, Jeff M. Michalski, Ian S. Dayes, Samantha A. Seaward, Michele Albert, Adam D. Currey, Thomas M. Pisansky, Yuhchyau Chen, Eric M. Horwitz, Albert S. DeNittis, Felix Feng, Mark V. Mishra
Summary: The study aimed to compare the predictive ability of mapping algorithms derived from cross-sectional and longitudinal data. By using data from a trial of patients with low-risk prostate cancer, researchers found that models obtained from baseline cross-sectional data showed the best predictive performance. Models using only EPIC domain/subdomain data had better predictive ability when combined data was used, while models using baseline data outperformed others when patient covariates were considered.
JCO CLINICAL CANCER INFORMATICS
(2022)
Article
Oncology
Daniel J. Krauss, Theodore Karrison, Alvaro A. Martinez, Gerard Morton, Di Yan, Deborah Watkins Bruner, Benjamin Movsas, Mohamed Elshaikh, Deborah Citrin, Bruce Hershatter, Jeff M. Michalski, Jason Alexander Efstathiou, Adam Currey, Vivek S. Kavadi, Fabio L. Cury, Michael Lock, Adam Raben, Samantha Andrews Seaward, Ali El-Gayed, Joseph P. Rodgers, Howard M. Sandler
Summary: This study found that short-term androgen deprivation therapy did not improve the overall survival rates in men with intermediate-risk prostate cancer treated with dose-escalated radiotherapy. However, it did lower prostate cancer-specific mortality, distant metastases, and PSA failure rates.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Diane Von Ah, Carlton G. Brown, Susan J. Brown, Ashley Leak Bryant, Marianne Davies, Marylin Dodd, Betty Ferrell, Marilyn Hammer, M. Tish Knobf, Teresa J. Knoop, Geri LoBiondo-Wood, Deborah K. Mayer, Christine Miaskowski, Sandra A. Mitchell, Lixin Song, Deborah Watkins Bruner, Susan Wesmiller, Mary E. Cooley
ONCOLOGY NURSING FORUM
(2019)
Article
Nursing
Canhua Xiao, Deborah W. Bruner, Tian Dai, Ying Guo, Alexandra Hanlon
JOURNAL OF NURSING MEASUREMENT
(2019)
Article
Oncology
Mustafa Abugideiri, Eduard Schreibmann, Jeffrey Switchenko, Mark W. McDonald, Jonathan J. Beitler, Walter J. Curran, Deborah Bruner, Pretesh Patel, Wondemagegnhu Tigeneh, Miressa Mijena, Sibo Tian, Anees Dhabaan, Natia Esiashvili, Tian Liu, Arif N. Ali
JOURNAL OF GLOBAL ONCOLOGY
(2019)
Article
Pediatrics
J. Bai, Y. Hu, D. W. Bruner
Article
Computer Science, Information Systems
Arlene E. Chung, Kimberly Shoenbill, Sandra A. Mitchell, Amylou C. Dueck, Deborah Schrag, Deborah W. Bruner, Lori M. Minasian, Diane St Germain, Ann M. O'Mara, Paul Baumgartner, Lauren J. Rogak, Amy P. Abernethy, Ashley C. Griffin, Ethan M. Basch
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
(2019)
Article
Oncology
Jinbing Bai, Ileen Jhaney, Gaea Daniel, Deborah Watkins Bruner
ONCOLOGY NURSING FORUM
(2019)
