Article
Biochemistry & Molecular Biology
Wenjing Wang, Xupeng Zang, Yaokun Li, Dewu Liu, Linjun Hong, Guangbin Liu
Summary: This study aims to identify potential circRNAs and regulatory mechanisms related to goat endometrial receptivity. The results show that 4666 circRNAs were identified, including 7 downregulated and 11 upregulated differentially expressed circRNAs (DE-circRNAs). Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses suggest that DE-circRNAs were significantly involved in establishing endometrial receptivity. Furthermore, circ_MYRF derived from the host gene MYRF was found to regulate the expression of ISG15, thereby promoting the formation of endometrial receptivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Ronan Adler Tavella, Caroline Lopes Feijo Fernandes, Lucia Emanueli Schimith, Lisiane Martins Volcao, Marina dos Santos, Flavio Manoel Rodrigues da Silva Junior
Summary: Socioeconomic and demographic factors, lifestyle, and cultural characteristics may have an important impact on genetic damage. This study analyzed the association between a set of factors and genetic damage by studying populations in southern Brazil. The results showed that age had a weak association with genetic damage, while factors such as skin color, occupational exposure, drug use, exposure to radiation, and the cultural habit of consuming chimarrao were found to be associated with genetic damage. Yerba mate consumption was identified as a confounding factor in cytogenetic studies in the southern region of South America.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Yuliannis Lugones, Pia Loren, Luis A. Salazar
Summary: Cisplatin is a widely used anti-cancer drug, but tumor cells can develop resistance to its damaging effects through genetic and epigenetic changes, as well as other resistance mechanisms.
Article
Agronomy
Jin Shi, Jianxin Shi, Wanqi Liang, Dabing Zhang
Summary: Several key QTLs and genes related to seed dormancy were identified, with SNP candidates influencing seed germination. The study provides valuable insights for understanding seed dormancy mechanisms and crop improvement in the future.
THEORETICAL AND APPLIED GENETICS
(2021)
Article
Environmental Sciences
Jianing Wang, Dankang Li, Yu Sun, Yaohua Tian
Summary: This study investigates the effect of air pollutants on chronic kidney disease in the European population and explores the modification effect of genetic risk. The results show that exposure to PM2.5, PM10, NO2, and NOx increases the risk of CKD, especially in individuals with low to intermediate genetic risk.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Pharmacology & Pharmacy
Frederikke E. Sembach, Mette Ostergaard, Niels Vrang, Bo Feldt-Rasmussen, Keld Fosgerau, Jacob Jelsing, Lisbeth N. Fink
Summary: The lack of animal models replicating the clinical features of human DKD has hindered progress in its treatment for the past 25 years. Better predictive models are needed for future research to improve clinical outcomes.
DRUG DISCOVERY TODAY
(2021)
Article
Genetics & Heredity
Jian Zhou, Dazhi Zou, Rongjun Wan, Jie Liu, Qiong Zhou, Zhen Zhou, Wanchun Wang, Cheng Tao, Tang Liu
Summary: This study investigates the molecular mechanisms and hub genes associated with osteoarthritis (OA) using bioinformatics analysis. Differential gene expression analysis and GO/KEGG pathway analysis were performed on OA synovial tissue samples. Various upregulated and downregulated genes were identified, with upregulated genes involved in immune response and cell adhesion, and downregulated genes enriched in response to mechanical stimuli and the MAPK signaling pathway. Several intersection genes and hub genes were also identified. These findings provide insights into the molecular mechanisms of OA and may contribute to the development of biomarkers and drug targets.
FRONTIERS IN GENETICS
(2022)
Article
Biochemical Research Methods
Isaac H. Goldstein, Damon Bayer, Ivan Barilar, Balladiah Kizito, Ogopotse Matsiri, Chawangwa Modongo, Nicola M. Zetola, Stefan Niemann, Volodymyr M. Minin, Sanghyuk S. Shin
Summary: Identifying host factors that influence infectious disease transmission is crucial for developing interventions to reduce disease incidence. The study uses simulations to investigate the impact of host factors on the probability of being an infection source and highlights the challenges of imprecise transmission event inference when using TransPhylo and logistic regression.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yadong Wu, Jukun Song, Manyi Liu, Hong Ma, Junmei Zhang
Summary: This study identified 35 genes associated with the pathogenesis of mouth ulcers through genome-wide association analysis and identified 6 key genes. These findings are important for further research and treatment of mouth ulcers.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Jyotsna Chawla, Ilana Goldowitz, Jenna Oberstaller, Min Zhang, Camilla Valente Pires, Francesca Navarro, Lauriane Sollelis, Chengqi C. Q. Wang, Andreas Seyfang, Jeffrey Dvorin, Thomas D. D. Otto, Julian C. C. Rayner, Matthias Marti, John H. H. Adams
Summary: This article reports a study to identify genes associated with gametocyte development in the deadly malaria parasite Plasmodium falciparum. The study found a new set of genes that have not been implicated in gametocytogenesis before and demonstrated the potential of forward genetic screens in isolating genes impacting parasite sexual biology, which could lead to the discovery of new antimalarials.
MICROBIOLOGY SPECTRUM
(2023)
Article
Genetics & Heredity
Wenqiang Zhang, Li Zhang, Luo M. Yang, Chenghan Xiao, Xueyao Wu, Peijing Yan, Huijie Cui, Chao Yang, Jingwei Zhu, Xuan Wu, Mingshuang R. Tang, Yutong Wang, Lin Chen, Yunjie A. Liu, Yanqiu M. Zou, Ling E. Zhang, Chunxia Yang, Yuqin Yao, Jiayuan Li, Zhenmi S. Liu, Ben Zhang, Xia Jiang
Summary: Epidemiological studies suggest an association between migraine and chronic kidney disease (CKD), but the genetic basis has not been investigated. We aimed to understand the phenotypic and genetic relationships between migraine, CKD, and kidney function to guide interventions for migraine patients.
Article
Biochemistry & Molecular Biology
Sara Denicolo, Viji Nair, Johannes Leierer, Michael Rudnicki, Matthias Kretzler, Gert Mayer, Wenjun Ju, Paul Perco
Summary: The study found that Fibrinogen-like 2 (FGL2) is associated with fibrosis in kidney damage and may be a potential therapeutic target for chronic kidney disease (CKD). Analysis of CKD cohorts showed that higher renal FGL2 mRNA expression is associated with kidney fibrosis and worse outcomes. FGL2 protein expression was detected in specific renal tissue sections. The study also identified regulators of FGL2 expression in renal tissue, as well as factors potentially inducing or counterbalancing FGL2-co-expressed genes. In conclusion, elevated FGL2 levels in human CKD are associated with fibrosis and worse outcomes.
Article
Biochemical Research Methods
Gonzalo Vidal, Carlos Vidal-Cespedes, Timothy J. Rudge
Summary: Genetic design automation tools enhance the scale and complexity of synthetic genetic networks by abstracting standardized components and devices. LOICA, a Python package, introduces a simple object-oriented design abstraction for designing, modeling, and characterizing genetic networks. It uses classes to represent biological and experimental components, generating models that can be parametrized with data from Flapjack.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Health Care Sciences & Services
Ning Shang, Atlas Khan, Fernanda Polubriaginof, Francesca Zanoni, Karla Mehl, David Fasel, Paul E. Drawz, Robert J. Carrol, Joshua C. Denny, Matthew A. Hathcock, Adelaide M. Arruda-Olson, Peggy L. Peissig, Richard A. Dart, Murray H. Brilliant, Eric B. Larson, David S. Carrell, Sarah Pendergrass, Shefali Setia Verma, Marylyn D. Ritchie, Barbara Benoit, Vivian S. Gainer, Elizabeth W. Karlson, Adam S. Gordon, Gail P. Jarvik, Ian B. Stanaway, David R. Crosslin, Sumit Mohan, Iuliana Ionita-Laza, Nicholas P. Tatonetti, Ali G. Gharavi, George Hripcsak, Chunhua Weng, Krzysztof Kiryluk
Summary: The study implemented a portable and scalable electronic CKD phenotype to aid in early disease recognition and large-scale observational and genetic studies. Through manual validation and case-control validation, the algorithm showed high accuracy and detected a significant number of undetected CKD cases.
NPJ DIGITAL MEDICINE
(2021)
Article
Ecology
Sean Carim, Ashley L. Azadeh, Alexey E. Kazakov, Morgan N. Price, Peter J. Walian, Lauren M. Lui, Torben N. Nielsen, Romy Chakraborty, Adam M. Deutschbauer, Vivek K. Mutalik, Adam P. Arkin
Summary: Tailocins are bactericidal protein complexes produced by various bacteria with high specificity, making them potential precision antibacterial agents. Research indicates that O-antigen composition and display are crucial factors defining sensitivity to Tailocins, while LPS thinning can increase sensitivity of resistant strains to Tailocins.
