Article
Immunology
Erye Zhou, Jian Wu, Xin Zhou, Yufeng Yin
Summary: This study investigated the association between neutrophil-to-lymphocyte ratio (NLR) and all-cause and cardiovascular mortality risk in individuals with rheumatoid arthritis (RA). The study found that individuals with higher NLR had a 2-fold increased risk of long-term mortality. NLR may serve as an inexpensive and widely available prognostic marker in RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nicholas H. Adamstein, Jean G. MacFadyen, Lynda M. Rose, Robert J. Glynn, Amit K. Dey, Peter Libby, Ira A. Tabas, Nehal N. Mehta, Paul M. Ridker
Summary: The study demonstrates that the neutrophil-lymphocyte ratio (NLR) can predict cardiovascular events and mortality risk, and can be reduced by anti-inflammatory therapy with canakinumab.
EUROPEAN HEART JOURNAL
(2021)
Review
Cell Biology
Samaneh Hosseini, Amir Mohammad Eghbalnejad Mofrad, Peyman Mokarian, Shima Nourigheimasi, Amir Azarhomayoun, Shokoufeh Khanzadeh, Saba Habibzadeh, Arshin Ghaedi
Summary: This study summarizes the role of neutrophil to lymphocyte ratio (NLR) in epilepsy. The findings indicate that NLR levels are higher in patients with epilepsy during the acute and subacute phases compared to healthy controls. There is also a significant difference in NLR between the acute and subacute phases. Inflammation plays a role in epilepsy, and elevated NLR can serve as a biomarker for inflammation and epilepsy.
MEDIATORS OF INFLAMMATION
(2022)
Article
Immunology
Fang Liu, Hong Liu, Wen-Yan Yu, Zhan Liu, Xia Zhang, Yi Wang, Liang-Bin Miao, Zhao-Yi Li, Jin-Song Huang, Jian-Feng Bao
Summary: Limited data is available on the impact of lymphocytes and neutrophils on liver dysfunction in COVID-19 patients. This study found a U-shaped relationship between lymphocyte ratio, neutrophil ratio, and AST with the incidence of AST-linked liver dysfunction, suggesting a potential predictive value for these markers.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Yang Chen, Wei Wang, Lizhong Zeng, Ke Mi, Na Li, Jie Shi, Shuanying Yang
Summary: High NLR levels are significantly associated with increased risk of all-cause mortality, with some correlation observed with cardiovascular disease and cancer mortality.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Shirin Sarejloo, Moein Dehesh, Mobina Fathi, Monireh Khanzadeh, Brandon Lucke-Wold, Arshin Ghaedi, Shokoufeh Khanzadeh
Summary: This study systematically reviewed the evidence on the differences in neutrophil to lymphocyte ratio (NLR) levels between individuals with hypertension and those with normal blood pressure, as well as between patients with dipper and non-dipper hypertension (HTN). A total of 21 studies were included, and it was found that hypertensive patients had significantly higher NLR levels compared to individuals with normal blood pressure (WMD = 0.40, 95%CI = 0.22-0.57, P < 0.0001). Furthermore, non-dipper patients had higher NLR levels compared to dipper patients (WMD = 0.58, 95%CI = 0.19-0.97, P = 0.003).
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Medicine, General & Internal
Lisanne Tap, Andrea Corsonello, Mirko Di Rosa, Paolo Fabbietti, Francesc Formiga, Rafael Moreno-Gonzalez, Johan Arnlov, Axel C. Carlsson, Harmke A. Polinder-Bos, Regina E. Roller-Wirnsberger, Gerhard H. Wirnsberger, Tomasz Kostka, Agnieszka Guligowska, Rada Artzi-Medvedik, Ilan Yehoshua, Christian Weingart, Cornel C. Sieber, Pedro Gil, Sara Lainez Martinez, Fabrizia Lattanzio, Francesco U. S. Mattace-Raso
Summary: The neutrophil-to-lymphocyte ratio (NLR) was found to be unrelated to blood pressure profiles in older individuals, regardless of whether they had hypertension or not.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Murat Sahin, Ayten Oguz, Dilek Tuzun, Okay Isiktas, Songul Isiktas, Cansu ulgen, Hatice Sahin, Kamile Gul
Summary: This study aimed to investigate whether the neutrophil-lymphocyte ratio (NLR), an indicator of systemic inflammation, could predict gestational diabetes mellitus (GDM). The results showed a significant increase in NLR in the 1st and 3rd trimesters in the GDM group, supporting the presence of systemic inflammation in early pregnancy and throughout pregnancy. The study also found a positive correlation between NLR and fasting plasma glucose and body mass index in both trimesters. The first trimester NLR was found to independently predict the development of GDM.
Review
Immunology
Tracy Bhikram, Paul Sandor
Summary: The review found that NLR is elevated in certain adult psychiatric disorders like schizophrenia, major depressive disorder, and bipolar disorder, but the associations with symptom severity and clinical parameters are not entirely clear. Results in youth populations are similar to those in adults, indicating a need for further research to better understand the relationship between NLR and specific psychiatric disorders. Future work is required to determine the neuroinflammatory mechanisms underlying these disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Pharmacology & Pharmacy
Faysal Saylik, Remzi Sarikaya
Summary: The study found that patients with high-value MS had higher levels of neutrophil, platelet, SII, NLR, and PLR, whereas lymphocyte counts were lower. These indices were all independently associated with exaggerated MS, with SII being superior to other indices for detecting the presence of exaggerated MS.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2021)
Article
Multidisciplinary Sciences
Aysun Firat, Aysegul Ercan, Cengiz Mordeniz, Fatma Ferda Verit Atmaca
Summary: This study aimed to investigate whether the pretreatment hemogram parameters and their ratios can predict the endometrial transformation in patients with abnormal uterine bleeding. The study found that age, postmenopausal state, obesity, diabetes, and increased estrogen exposure were risk factors for endometrial atypia and carcinoma. Hemoglobin and hematocrit levels were significantly higher in early and advanced endometrial cancer groups, while platelet value was significantly higher in atypia and carcinoma groups.
Article
Clinical Neurology
Minwoo Lee, Jae-Sung Lim, Chul-Ho Kim, Sang-Hwa Lee, Yerim Kim, Ju Hun Lee, Min Uk Jang, Mi Sun Oh, Byung-Chul Lee, Kyung-Ho Yu
Summary: This study found that systemic inflammation represented by NLR in the acute stage of ischemic stroke is associated with post-stroke cognitive impairment (PSCI) at 3 months after stroke, with high NLR specifically linked to cognitive dysfunction in the memory and visuospatial domains.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Bin Shu, Fang Xu, Xuemei Zheng, Yamei Zhang, Qi Liu, Shiqi Li, Jie Chen, Yuanjing Chen, He Huang, Guangyou Duan
Summary: This study aimed to investigate the incidence and risk factors of chronic postsurgical pain (CPSP) after abdominal surgery, with a focus on plasma immunological markers. The results showed that patients with older age, open surgery, higher American Association of Anesthesiologists classification, patient-controlled intravenous analgesia application, longer surgery duration, higher postoperative absolute neutrophil count, and neutrophil-lymphocyte ratio (NLR), lower postoperative absolute lymphocyte count, and higher white blood cell count were more likely to suffer from CPSP.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Sang-Hwa Lee, Jong-Ho Kim, Young-Suk Kwon, Jong-Hee Sohn
Summary: The study found that peripheral inflammatory markers (PIMs) significantly increased during migraine attacks, indicating that inflammation may play a role in migraines. Among different markers, NLR and NMR had poor ability to differentiate between migraine and non-migraine headaches, but performed well in distinguishing migraines from other types of headaches.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Veterinary Sciences
Ryan C. Fries, Saki Kadotani, Jonathan P. Stack, Leah Kruckman, Gabrielle Wallace
Summary: This study assessed the predictive value of NLR for cardiac death in cats with hypertrophic cardiomyopathy. The results showed that cats with higher NLR had a higher risk of cardiac death, and NLR was significantly associated with echocardiographic measurements.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Review
Pharmacology & Pharmacy
Hassan Yousefi, Ladan Mashouri, Samuel C. Okpechi, Nikhilesh Alahari, Suresh K. Alahari
Summary: The outbreak of the novel coronavirus has caused a major global public health concern, with over 31 million cases confirmed and efforts being made to repurpose existing cancer drugs to treat COVID-19. These drugs target the viral replication cycle and immune response, offering a potential novel approach to combat the virus.
BIOCHEMICAL PHARMACOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Georgios Zakynthinos, Gerasimos Siasos, Evangelos Oikonomou, Maria Gazouli, Konstantinos Mourouzis, Marina Zaromitidou, Vasiliki Tsigkou, Evanthia Bletsa, Panagiota Stampouloglou, Stamatis Tsouroulas, Georgios Marinos, Konstantinos Vlasis, Manolis Vavuranakis, Christodoulos Stefanadis, Dimitris Tousoulis
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Eirini Pagkalidou, Athanasios Kordalis, Spyridon Deftereos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: Our network meta-analysis identified the most effective antiarrhythmics for pharmacologic cardioversion over different time settings, with intravenous vernakalant and flecainide showing the highest conversion rate within 4 hours. Flecainide, especially when compared to propafenone, demonstrated superiority for conversion rates within 12 hours, while amiodarone exhibited efficacy within 24 hours, particularly if ranolazine was added.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Gastroenterology & Hepatology
Corey J. Ketchem, Craig C. Reed, Zoe Stefanadis, Evan S. Dellon
Summary: The study evaluated the efficacy of a compounded fluticasone suspension for treating eosinophilic esophagitis, showing significant improvements in symptoms and endoscopic findings, with over a third of patients achieving histologic response.
DISEASES OF THE ESOPHAGUS
(2021)
Letter
Cardiac & Cardiovascular Systems
Dimitrios A. Vrachatis, George V. Giannopoulos, Sotiria G. Giotaki, Konstantinos Raisakis, Charalampos Kossyvakis, Konstantinos E. Iliodromitis, Bernhard Reimers, Dimitrios Tousoulis, Michael Cleman, Christodoulos Stefanadis, Alexandra Lansky, Spyridon G. Deftereos
HELLENIC JOURNAL OF CARDIOLOGY
(2021)
Review
Immunology
Joshua Adedeji Bolarin, Mercy Adaramodu Oluwatoyosi, Joshua Iseoluwa Orege, Emmanuel Ayodeji Ayeni, Yusuf Ajibola Ibrahim, Sherif Babatunde Adeyemi, Bashir Bolaji Tiamiyu, Lanre Anthony Gbadegesin, Toluwanimi Oluwadara Akinyemi, Chuks Kenneth Odoh, Happiness Ijeoma Umeobi, Adenike Bernice-Eloise Adeoye
Summary: This review outlines the usage of antiviral drugs, antibiotics, and immune-stimulants in managing SARS-CoV-2, as well as discussing potential drug interactions and monitoring methods.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitris Tsiachris, Ioannis Doundoulakis, Christos-Konstantinos Antoniou, Eirini Pagkalidou, Stefanos Zafeiropoulos, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study conducted a systematic review and meta-analysis to evaluate the effectiveness and safety of a time to isolation (TTI)-based strategy of cryoballoon ablation (CBA) in the treatment of atrial fibrillation. The results suggest that an individualized CBA dosing strategy based on TTI and extended duration of CBA can reduce recurrence post-AF ablation and decrease procedure time and incidence of phrenic nerve palsy.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Athanasios Kordalis, Dimitrios Konstantinou, Konstantinos Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This study compared the clinical outcomes of a three-dimensional electroanatomical mapping (3D-EAM)-based strategy targeting slow pathway (SP) elimination with the conventional fluoroscopic approach in atrioventricular node reentrant tachycardia (AVNRT) ablation. The results showed that 3D-EAM improved procedural parameters, reduced fluoroscopy time and dose, and increased SP elimination frequency. Follow-up results demonstrated lower recurrence rates and redo procedure rates in the 3D-EAM-based group.
JOURNAL OF ARRHYTHMIA
(2022)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)