High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts

Engineered microenvironments provide new insights into ovarian and prostate cancer progression and drug responses

(2014) Daniela Loessner et al.   ADVANCED DRUG DELIVERY REVIEWS

A Positive Feedback Loop between Mesenchymal-like Cancer Cells and Macrophages Is Essential to Breast Cancer Metastasis

(2014) Shicheng Su et al.   CANCER CELL

The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

(2014) Gvantsa Kharaishvili et al.   Cancer Cell International

A Signature Predicting Poor Prognosis in Gastric and Ovarian Cancer Represents a Coordinated Macrophage and Stromal Response

(2014) R. A. Busuttil et al.   CLINICAL CANCER RESEARCH

Carcinoma-associated fibroblasts provide operational flexibility in metastasis

(2014) Olivier De Wever et al.   SEMINARS IN CANCER BIOLOGY

Chronic Inflammation and Cytokines in the Tumor Microenvironment

(2014) Glauben Landskron et al.   Journal of Immunology Research

Cancer Associated Fibroblasts express pro-inflammatory factors in human breast and ovarian tumors

(2013) Neta Erez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth

(2013) M.-H. Lee et al.   Cancer Prevention Research

MET and AXL Inhibitor NPS-1034 Exerts Efficacy against Lung Cancer Cells Resistant to EGFR Kinase Inhibitors Because of MET or AXL Activation

(2013) J. K. Rho et al.   CANCER RESEARCH

Thrombin-induced NF-κB activation and IL-8/CXCL8 release is mediated by c-Src-dependent Shc, Raf-1, and ERK pathways in lung epithelial cells

(2013) Chien-Huang Lin et al.   CELLULAR SIGNALLING

A review of the profile of endothelin axis in cancer and its management

(2013) Soussan Irani et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Investigating the Link between Molecular Subtypes of Glioblastoma, Epithelial-Mesenchymal Transition, and CD133 Cell Surface Protein

(2013) Hadi Zarkoob et al.   PLoS One

Chemotherapeutic Potential of 2-[Piperidinoethoxyphenyl]-3-Phenyl-2H-Benzo(b)pyran in Estrogen Receptor- Negative Breast Cancer Cells: Action via Prevention of EGFR Activation and Combined Inhibition of PI-3-K/Akt/FOXO and MEK/Erk/AP-1 Pathways

(2013) Ruchi Saxena et al.   PLoS One

Gefitinib Inhibits Invasive Phenotype and Epithelial-Mesenchymal Transition in Drug-Resistant NSCLC Cells with MET Amplification

(2013) Silvia La Monica et al.   PLoS One

Tyrosine kinase signaling in fibrotic disorders

(2012) Christian Beyer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abstract 3665: An EMT gene expression diagnostic predicts resistance to EGFR and MEK-targeted therapies in cell lines and patients

(2012) Sean F. Eddy et al.   CANCER RESEARCH

Hereditary ovarian cancer and two-compartment tumor metabolism

(2012) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth

(2012) Claudia Capparelli et al.   CELL CYCLE

An Epithelial-Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

(2012) L. A. Byers et al.   CLINICAL CANCER RESEARCH

Tumor–stromal interactions in lung cancer: novel candidate targets for therapeutic intervention

(2012) Nefertiti El-Nikhely et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dasatinib reverses Cancer-associated Fibroblasts (CAFs) from primary Lung Carcinomas to a Phenotype comparable to that of normal Fibroblasts

(2012) Silke Haubeiss et al.   Molecular Cancer

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

The Heterotrimeric Laminin Coiled-Coil Domain Exerts Anti-Adhesive Effects and Induces a Pro-Invasive Phenotype

(2012) Patricia Santos-Valle et al.   PLoS One

The First Type III Domain of Fibronectin is Associated with the Expression of Cytokines within the Lung Tumor Microenvironment

(2012) Mingzhe Zheng et al.   Journal of Cancer

Modeling Colon Adenocarcinomas in Vitro

(2011) Helmut Dolznig et al.   AMERICAN JOURNAL OF PATHOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

GSK1120212 (JTP-74057) Is an Inhibitor of MEK Activity and Activation with Favorable Pharmacokinetic Properties for Sustained In Vivo Pathway Inhibition

(2011) A. G. Gilmartin et al.   CLINICAL CANCER RESEARCH

Potential of CXCR4 antagonists for the treatment of metastatic lung cancer

(2011) Jan A Burger et al.   Expert Review of Anticancer Therapy

Tumor-associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression

(2011) Rui Wang et al.   LUNG CANCER

Glucocorticoids inhibit IL-1β-induced GM-CSF expression at multiple levels: roles for the ERK pathway and repression by MKP-1

(2010) Robert Newton et al.   BIOCHEMICAL JOURNAL

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

HIF1-alpha functions as a tumor promoter in cancer-associated fibroblasts, and as a tumor suppressor in breast cancer cells

(2010) Barbara Chiavarina et al.   CELL CYCLE

Novel Changes in NF-κB Activity during Progression and Regression Phases of Hyperplasia

(2010) Parthasarathy Chandrakesan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokines at the crossroads of tumor-fibroblast interactions that promote malignancy

(2010) Pravin Mishra et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

(2010) J. H. Taube et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammary Gland ECM Remodeling, Stiffness, and Mechanosignaling in Normal Development and Tumor Progression

(2010) P. Schedin et al.   Cold Spring Harbor Perspectives in Biology

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

Clustering of fibroblasts induces proinflammatory chemokine secretion promoting leukocyte migration

(2009) Anna Enzerink et al.   MOLECULAR IMMUNOLOGY

Roles of Krüppel-like factor 4 in normal homeostasis, cancer and stem cells

(2008) Paul M Evans et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Interleukin-6 predicts recurrence and survival among head and neck cancer patients

(2008) Sonia A. Duffy et al.   CANCER

Identification of Secreted Proteins that Mediate Cell-Cell Interactions in an In vitro Model of the Lung Cancer Microenvironment

(2008) L. Zhong et al.   CANCER RESEARCH

TGF-β coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival

(2008) Anne Gingery et al.   EXPERIMENTAL CELL RESEARCH

Cytokine regulation networks in the cancer microenvironment

(2008) Bor-Ching Sheu   Frontiers in Bioscience-Landmark