Article
Clinical Neurology
Jingjing Liang, Ronghui Cui, Jinglei Wang, Jiabing Shen, Ying Chen, Maosheng Cao, Kaifu Ke
Summary: Transplantation of SKP-SCs through the intracarotid route led to improved neurological outcomes in rat models of acute ischemic stroke, demonstrating potential as a novel therapy for ischemic stroke treatment in humans.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huachen Huang, Mengxuan Shi, Caiyun Qi, Qi Tian, Handong Li, Mingming Liu, Minshu Li, Qiang Liu
Summary: S1PR modulation improves neurogenesis and functional recovery following brain ischemia by increasing the number of type A cells and promoting the proliferation of DCX+ cells.
Article
Multidisciplinary Sciences
Yueyang Liu, Jingyu Yang, Xiaohang Che, Jianhua Huang, Xianyang Zhang, Xiaoxiao Fu, Jialing Cai, Yang Yao, Haotian Zhang, Ruiping Cai, Xiaomin Su, Qian Xu, Fu Ren, Renzhi Cai, Andrew Schally, Ming-Sheng Zhou
Summary: The GHRH agonist MR-409 has remarkable neuroprotective effects in ischemic stroke mice by enhancing endogenous neurogenesis. It reduces mortality, ischemic insult, and hippocampal atrophy while improving neurological functional recovery.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Plant Sciences
Yuan Zhang, Ling Shen, Jian Xie, Lu Li, Wen Xi, Bin Li, Ying Bai, Honghong Yao, Shenyang Zhang, Bing Han
Summary: This study assessed the efficiency of Pushen capsule in treating ischemic stroke and identified its potential therapeutic targets and active ingredients. The results showed that Pushen reduced infarct volume, improved the blood-brain barrier, and promoted functional restoration in stroke model mice. Key active ingredients in Pushen, including tricin, quercetin, luteolin, kaempferol, and physcion, were found to regulate the expression of genes in the cAMP signaling pathway through binding with the transcription factor c-Myc. Pushen also improved gut microbiota dysbiosis and reduced inosine levels, leading to reduced Adora2a expression in the brain.
Article
Chemistry, Multidisciplinary
Yang Liu, Linyu Long, Fanjun Zhang, Xuefeng Hu, Jieyu Zhang, Cheng Hu, Yunbing Wang, Jianguo Xu
Summary: The study introduced a GelMA microneedle platform for sustained and controlled local delivery of AAV-VEGF, which achieved homogeneous distribution and high transfection efficiency in ischemic brains. Results showed that MNs loaded with AAV-VEGF increased VEGF expression in the brain cortex and enhanced functional angiogenesis and neurogenesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Neurosciences
Anna K. Bonkhoff, Markus D. Schirmer, Martin Bretzner, Mark Etherton, Kathleen Donahue, Carissa Tuozzo, Marco Nardin, Anne-Katrin Giese, Ona Wu, Vince D. Calhoun, Christian Grefkes, Natalia S. Rost
Summary: This study aimed to explore the whole-brain dynamic functional connectivity patterns in acute ischemic stroke (AIS) patients and their relation to stroke severity. The research identified differences in dynamic connectivity configurations between patients with different levels of stroke severity and highlighted the importance of dynamic connectivity involving default mode network components for recovery in the first 3 months poststroke.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Florent Lebrun, Nicolas Violle, Annelise Letourneur, Christophe Muller, Nicolas Fischer, Anthony Levilly, Cyrille Orset, Aurore Sors, Denis Vivien
Summary: The study demonstrates that using the alpha 5-GABAA receptor antagonist S 44819 can effectively improve neurological deficits and promote sensorimotor recovery after stroke in juvenile rats.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Yunnan Lu, Mingming Zhou, Yun Li, Yan Li, Ye Hua, Yi Fan
Summary: The study found that minocycline can promote microglial phenotype shift, reduce brain infarct volume, protect neurons from injury, and improve neurological functional recovery after AIS.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Clinical Neurology
Isabella Stuckart, Timo Siepmann, Christian Hartmann, Lars-Peder Pallesen, Annahita Sedghi, Jessica Barlinn, Heinz Reichmann, Volker Puetz, Kristian Barlinn
Summary: In acute ischemic stroke patients, early treatment with sertraline may contribute to improved functional recovery. Patients in the sertraline group showed worse neurological scores at baseline, but had a higher rate of favorable functional outcomes at 3 months and lower incidence of incident depression compared to the control group.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Zhandong Qiu, Jia Yang, Gang Deng, Dayong Li, Suming Zhang
Summary: In this study, we investigated the effects of ANGPTL4 on promoting angiogenesis and neurogenesis post-stroke in mice. The results showed that ANGPTL4 significantly reduced infarct volume, increased the number of BrdU(+), BrdU(+)/vWF(+) and BrdU(+)/DCX+ cells, and inhibited BrdU(+)/Iba1(+) cells. ANGPTL4 enhanced angiogenesis and neurogenesis post-stroke by upregulating AKT phosphorylation, reducing neuronal death, and inhibiting inflammatory response.
BRAIN RESEARCH BULLETIN
(2021)
Article
Plant Sciences
Qiaohui Du, Ruixia Deng, Wenting Li, Dong Zhang, Bun Tsoi, Jiangang Shen
Summary: The study revealed that Bao Yuan Capsule could promote neurogenesis by regulating mitochondrial function and Akt signaling pathway, leading to improvement in neurological functions in post ischemic brains.
Article
Neurosciences
Elga Esposito, Ester Licastro, Ornella Cuomo, Eng H. Lo, Kazuhide Hayakawa, Giuseppe Pignataro
Summary: Experimental studies show that ischemic postconditioning can interfere with cell death mechanisms and reduce infarction during the acute phase after focal cerebral ischemia. However, there are many limitations to its clinical translation. This study aims to explore the mechanisms of improved long-term recovery after ischemic postconditioning, and the results suggest that it may involve the promotion of neurogenesis and angiogenic remodeling via BDNF released by astrocytes.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yu-Show Fu, Chang-Ching Yeh, Pei-Ming Chu, Wen-Hsing Chang, Maan-Yuh Anya Lin, Yung-Yang Lin
Summary: Transplantation of human umbilical mesenchymal stem cells (HUMSCs) in rats with chronic stroke showed therapeutic benefits, improving motor function and reducing cerebral atrophy. HUMSCs did not differentiate into neurons or astrocytes but may release cytokines to improve neuroprotection and increase angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Lan Li, Jie-hong Yang, Chang Li, Hui-fen Zhou, Li Yu, Xiao-long Wu, Yi-hang Lu, Yu He, Hai-tong Wan
Summary: This study aimed to investigate the effect of Danhong injection (DHI) on long-term neurological function recovery after cerebral ischemia and explore the underlying mechanisms. The results showed that DHI treatment significantly reduced the infarct volume, promoted neurological recovery, and reversed brain pathological changes. DHI also promoted neurogenesis by increasing the migration and proliferation of neural stem cells and enhancing synaptic plasticity. Furthermore, the pro-neurogenic effects of DHI were related to increased brain-derived neurotrophic factor (BDNF) expression and the activation of the BDNF/AKT/CREB signaling pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Neurosciences
Yunwei Shi, Xinyi Chen, Jiaxing Liu, Xingjuan Fan, Ying Jin, Jingxiao Gu, Jiale Liang, Xinmiao Liang, Caiping Wang
Summary: Isoquercetin has been identified as a neuroprotective agent against ischemic stroke, showing the potential to suppress inflammatory response and improve cell recovery in rats with cerebral ischemia/reperfusion injury. The study suggests that targeting the TLR4 and C5aR1-mediated cAMP/PKA/I-kappa B/NF-kappa B signaling pathway may provide a promising therapeutic strategy for ischemic stroke.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Clinical Neurology
Joanna M. Wardlaw, Helene Benveniste, Maiken Nedergaard, Berislav V. Zlokovic, Humberto Mestre, Hedok Lee, Fergus N. Doubal, Rosalind Brown, Joel Ramirez, Bradley J. MacIntosh, Allen Tannenbaum, Lucia Ballerini, Ravi L. Rungta, Davide Boido, Melanie Sweeney, Axel Montagne, Serge Charpak, Anne Joutel, Kenneth J. Smith, Sandra E. Black
NATURE REVIEWS NEUROLOGY
(2020)
Article
Multidisciplinary Sciences
Humberto Mestre, Ting Du, Amanda M. Sweeney, Guojun Liu, Andrew J. Samson, Weiguo Peng, Kristian Nygaard Mortensen, Frederik Filip Staeger, Peter A. R. Bork, Logan Bashford, Edna R. Toro, Jeffrey Tithof, Douglas H. Kelley, John H. Thomas, Poul G. Hjorth, Erik A. Martens, Rupal I. Mehta, Orestes Solis, Pablo Blinder, David Kleinfeld, Hajime Hirase, Yuki Mori, Maiken Nedergaard
Review
Biochemistry & Molecular Biology
Benjamin C. Reeves, Jason K. Karimy, Adam J. Kundishora, Humberto Mestre, H. Mert Cerci, Charles Matouk, Seth L. Alper, Iben Lundgaard, Maiken Nedergaard, Kristopher T. Kahle
TRENDS IN MOLECULAR MEDICINE
(2020)
Review
Neurosciences
Humberto Mestre, Yuki Mori, Maiken Nedergaard
TRENDS IN NEUROSCIENCES
(2020)
Article
Critical Care Medicine
Alexis N. Simpkins, Katharina M. Busl, Edilberto Amorim, Carolina Barnett-Tapia, Mackenzie C. Cervenka, Monica B. Dhakar, Mark R. Etherton, Celia Fung, Robert Griggs, Robert G. Holloway, Adam G. Kelly, Imad R. Khan, Karlo J. Lizarraga, Hannah G. Madagan, Chidinma L. Onweni, Humberto Mestre, Alejandro A. Rabinstein, Clio Rubinos, Dawling A. Dionisio-Santos, Teddy S. Youn, Lisa H. Merck, Carolina B. Maciel
NEUROCRITICAL CARE
(2020)
Article
Cell Biology
Guojun Liu, Humberto Mestre, Amanda M. Sweeney, Qian Sun, Pia Weikop, Ting Du, Maiken Nedergaard
Article
Biology
Aditya Raghunandan, Antonio Ladron-de-Guevara, Jeffrey Tithof, Humberto Mestre, Ting Du, Maiken Nedergaard, John H. Thomas, Douglas H. Kelley
Summary: New in vivo experiments have addressed the hypothesis that bulk flow of cerebrospinal fluid might be driven by the injection method, showing consistent particle-tracking flows with earlier experiments despite using a dual-syringe system that does not increase CSF volume or intracranial pressure.
Article
Clinical Neurology
Ting Du, Humberto Mestre, Benjamin T. Kress, Guojun Liu, Amanda M. Sweeney, Andrew J. Samson, Martin Kaag Rasmussen, Kristian Nygaard Mortensen, Peter A. R. Bork, Weiguo Peng, Genaro E. Olveda, Logan Bashford, Edna R. Toro, Jeffrey Tithof, Douglas H. Kelley, John H. Thomas, Poul G. Hjorth, Erik A. Martens, Rupal Mehta, Hajime Hirase, Yuki Mori, Maiken Nedergaard
Summary: Cerebral edema develops after anoxic brain injury and is associated with the availability of cerebrospinal fluid (CSF). An increase in CSF volume worsens the severity of edema. Edema primarily occurs in brain regions bordering CSF compartments. Anoxic brain tissue possesses a high intrinsic osmotic potential, which may contribute to the beneficial effect of therapeutic hypothermia.
Article
Multidisciplinary Sciences
Humberto Mestre, Natasha Verma, Thom D. Greene, LiJing A. Lin, Antonio Ladron-de-Guevara, Amanda M. Sweeney, Guojun Liu, V. Kaye Thomas, Chad A. Galloway, Karen L. de Mesy Bentley, Maiken Nedergaard, Rupal I. Mehta
Summary: The study reveals that the pia mater, previously thought to confine fluid flow around blood vessels in the brain, is actually perforated and permissive to cerebrospinal fluid (CSF) flow. The pial structure and function are found to be associated with CSF transport and amyloid clearance, suggesting a previously unrecognized role of pia in regulating aging and disease in the brain.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Gabriela Andrea Servin-Casas, Alejandra Romo-Araiza, Gabriela Gutierrez-Salmean, Enrique Martinez-Solis, Andrea Paola Ibarra-Garcia, Yolanda Cruz-Martinez, Roxana Rodriguez-Barrera, Elisa Garcia, Diego Incontri-Abraham, Antonio Ibarra
Summary: Prebiotic and probiotic supplementation can improve spatial memory in senile animals, but this improvement is not correlated with GLP-1 levels.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biology
Ryszard Stefan Gomolka, Lauren M. Hablitz, Humberto Mestre, Michael Giannetto, Ting Du, Natalie Linea Hauglund, Lulu Xie, Weiguo Peng, Paula Melero Martinez, Maiken Nedergaard, Yuki Mori, Saad Jbabdi
Summary: The glymphatic system is a fluid transport network that plays a crucial role in clearing interstitial solutes from the brain. The expression of AQP4 water channels facilitates cerebrospinal fluid transport and its genetic deletion results in abnormalities in brain structure and water transport. This study used advanced imaging techniques to explore the disruption of glymphatic function in AQP4 KO mice.
Article
Cell & Tissue Engineering
Alejandra Romo-Araiza, Rocio I. Picazo-Aguilar, Ernesto Griego, Luis A. Marquez, Emilio J. Galvan, Yolanda Cruz, Ana Maria Fernandez-Presas, Almudena Chavez-Guerra, Roxana Rodriguez-Barrera, Ana P. Azpiri-Cardos, Claudia Rosas-Quintero, Ricardo Jasso-Chavez, Cesar V. Borlongan, Antonio Ibarra
Summary: This study aimed to evaluate the effect of symbiotics supplementation on cognitive impairment induced by high fat and sugar diets. The results showed that symbiotic-supplemented rats had better memory, butyrate concentrations, neurogenesis, and synaptic plasticity enhancement.
CELL TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Fatima Min Rivas, Jia Liu, Benjamin C. Martell, Ting Du, Humberto Mestre, Maiken Nedergaard, Jeffrey Tithof, John H. Thomas, Douglas H. Kelley
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2020)
Meeting Abstract
Clinical Neurology
Humberto Mestre, Ting Du, Andrew Samson, Benjamin Kress, Amanda Sweeney, Martin Kaag Rasmussen, Kristian Nygaard Mortensen, Yuki Mori, Maiken Nedergaard
Proceedings Paper
Engineering, Biomedical
Gary R. Ge, Fernando Zvietcovich, Jannick P. Rolland, Humberto Mestre, Michael Giannetto, Maiken Nedergaard, Kevin J. Parker
OPTICAL ELASTOGRAPHY AND TISSUE BIOMECHANICS VI
(2019)