Article
Biochemistry & Molecular Biology
Ram Hari Pokhrel, Suman Acharya, Jae-Hee Ahn, Ye Gu, Mahesh Pandit, Jong-Oh Kim, Yun-Yong Park, Ben Kang, Hyun-Jeong Ko, Jae-Hoon Chang
Summary: In this study, it was found that AMP-activated protein kinase (AMPK) plays a regulatory role in the expression of PD-1 through the HMGCR/p38 MAPK/GSK3 beta signaling pathway in regulatory T cells (Tregs). This suggests that AMPK activators may have synergistic antitumor effects in murine tumor models when combined with other treatments.
Article
Medicine, Research & Experimental
Che Bian, Haibo Zhang, Jing Gao, Yuxia Wang, Jia Li, Dan Guo, Wei Wang, Yuling Song, Yang Weng, Huiwen Ren
Summary: This study demonstrates that SIRT6 regulates glycolipid metabolism through AMPK alpha-mTORC1 pathway, modulating SREBP1c expression in the liver and pancreas induced by overnutrition and starvation, independently of LXR.
LABORATORY INVESTIGATION
(2022)
Article
Pharmacology & Pharmacy
Si-wei Wang, Tian Lan, Hang-fei Chen, Hao Sheng, Chun-yi Xu, Li-feng Xu, Fang Zheng, Feng Zhang
Summary: This study reported the inhibitory effect of limonin on hepatic lipid accumulation and fatty acid synthesis in HFD fed mice, and found that this effect was dependent on the activation of AMPK. The activation of AMPK by limonin was achieved by inhibiting cellular energy metabolism and increasing the ADP:ATP ratio, leading to the suppression of the transcriptional activity of SREBP1/2. These findings suggest that limonin may be a promising therapeutic agent for the treatment of NAFLD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Anatomy & Morphology
U. Ajay Krishnan, Periyasamy Viswanathan, Anuradha Carani Venkataraman
Summary: The activation of AMPK by AICAR has been found to alleviate symptoms of NAFLD. In a mouse model, AICAR reduced lipid levels in the liver, improved oxidative stress, and upregulated FOXO3 and p-AMPK expression while downregulating p-mTOR expression. These findings reveal the crosstalk between AMPK, mTOR, and FOXO3, providing new insights into the treatment of NAFLD.
Article
Plant Sciences
Hang Chen, Ji Zhu, Yifei Le, Jieli Pan, Ying Liu, Zhijun Liu, Cui Wang, Xiaobing Dou, Dezhao Lu
Summary: Salidroside has been shown to have cardioprotective effects against doxorubicin-induced cardiomyopathy by activating AMPK-dependent signaling pathways. It reduces ferroptotic cell death and shows potential as a novel treatment for DIC.
Article
Pharmacology & Pharmacy
Mahdis Rahimi Naiini, Beydolah Shahouzehi, Shahrzad Azizi, Bentolhoda Shafiei, Mahdieh Nazari-Robati
Summary: Aging leads to impaired liver metabolic function, increasing the risk of liver and systemic diseases. Trehalose, a natural disaccharide, has shown potential in reducing dyslipidemia, hepatic steatosis, and glucose intolerance. This study aimed to investigate the effects of trehalose on lipid metabolism in aged liver.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Yi Cai, Shisheng Jiang, Chaoming Huang, Ao Shen, Xuan Zhang, Wanling Yang, Yichuan Xiao, Shuhan Gao, Rong Du, Guodong Zheng, Tingdong Yan, Chunpeng (Craig) Wan
Summary: In this study, baicalin was found to suppress cardiac hypertrophy through regulating the SIRT3/LKB1/AMPK signaling pathway. Additionally, baicalin upregulated SIRT3 protein expression by inhibiting proteasome and activating PSMB5. These results provide the first evidence that baicalin inhibits cardiac hypertrophy by targeting the SIRT3-dependent signaling pathway, suggesting its potential for the treatment of cardiac hypertrophy and heart failure.
Article
Pharmacology & Pharmacy
Thi Hoa Pham, Gi Ho Lee, Sun Woo Jin, Seung Yeon Lee, Eun Hee Han, Nam Doo Kim, Chul Yung Choi, Gil-Saeng Jeong, Sang Ki Lee, Hyung Sik Kim, Hye Gwang Jeong
Summary: This study found that sesamin can effectively reduce lipid accumulation, alleviate lipotoxicity, and improve lipid metabolism imbalance. Additionally, sesamin can regulate key factors involved in lipogenesis and lipolysis by activating specific signaling pathways. These findings suggest that sesamin may be a promising candidate for treating hepatic steatosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Meng Liang, Mohan Huo, Yi Guo, Yuyi Zhang, Xiao Xiao, Jianwen Xv, Lixue Fang, Tianqi Li, Huan Wang, Siyu Dong, Xiaowen Jiang, Wenhui Yu
Summary: Artemisia capillaris extract can improve NAFLD and obesity by activating the PI3K/AKT pathway, reducing SREBP-1c protein expression, decreasing fatty acid synthesis, and reducing lipid accumulation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haohong Zhan, Qiang Zhang, Chenyu Zhang, Jingge Cheng, Yilin Yang, Cong Liu, Shuhao Li, Chuyue Wang, Junqin Yang, Hanmei Ge, Dawang Zhou, Bo Li, Hongyan Wei, Chunlin Hu
Summary: This study investigated the protective mechanism of AMPK activation on brain injury secondary to cardiac arrest. The results showed that AMPK improved memory function, reduced neuronal cell injury and apoptosis after resuscitation. Further research found that AMPK activated HNF4a to target Bcl-2 and inhibit apoptosis.
NEUROCHEMICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Juan Li, Hanxiang Zhan, Yidan Ren, Maoxiao Feng, Qin Wang, Qinlian Jiao, Yuli Wang, Xiaoyan Liu, Shujun Zhang, Lutao Du, Yunshan Wang, Chuanxin Wang
Summary: This study found that SIRT4 activates the phosphorylation of p53 protein and promotes autophagy in PDAC by suppressing glutamine metabolism, thereby inhibiting tumor growth and progression.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.
Article
Immunology
Dan Li, Jiangping Xu, Yunyun Qin, Ningbo Cai, Yufang Cheng, Haitao Wang
Summary: ROF attenuates LPS-induced neuroinflammatory responses in microglia by activating the AMPK/Sirt1 pathway, leading to reduced production of pro-inflammatory factors and improved cognitive function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Juan-Juan Li, He-Chun Jiang, Ao Wang, Fang-Tian Bu, Peng-Cheng Jia, Sai Zhu, Lin Zhu, Cheng Huang, Jun Li
Summary: This study demonstrates that HD-16 exerts anti-fibrotic effects in liver fibrosis by activating the AMPK/SIRT3 pathway, alleviating liver inflammation and fibrosis induced by CCl4.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zekai Fan, Chong Wang, Ting Yang, Tianlin Gao, Dan Wang, Xiaoyan Zhao, Xiaofei Guo, Duo Li
Summary: Coffee peel extracts containing caffeine and seven monomers of flavonoids can protect against NAFLD by regulating the FGF21-adiponectin signaling pathway.
Article
Cardiac & Cardiovascular Systems
Yang Yang, Nianchun Peng, Gang Chen, Qin Wan, Li Yan, Guixia Wang, Yingfen Qin, Zuojie Luo, Xulei Tang, Yanan Huo, Ruying Hu, Zhen Ye, Guijun Qin, Zhengnan Gao, Qing Su, Yiming Mu, Jiajun Zhao, Lulu Chen, Tianshu Zeng, Xuefeng Yu, Qiang Li, Feixia Shen, Li Chen, Yinfei Zhang, Youmin Wang, Huacong Deng, Chao Liu, Shengli Wu, Tao Yang, Mian Li, Yu Xu, Min Xu, Zhiyun Zhao, Tiange Wang, Jieli Lu, Yufang Bi, Weiqing Wang, Guang Ning, Qiao Zhang, Lixin Shi
Summary: Smoking and diabetes interact with each other in relation to increased risk of cardiovascular disease events, and the beneficial effect of risk factor management on cardiovascular disease risk among participants with diabetes is attenuated by smoking.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Engineering, Multidisciplinary
Yafei Wu, Guijun Qin, Guixia Wang, Libin Liu, Bing Chen, Qingbo Guan, Zhongshang Yuan, Xu Hou, Ling Gao, Chao Xu, Haiqing Zhang, Xu Zhang, Qiu Li, Yongfeng Song, Fei Jing, Shizhan Ma, Shanshan Shao, Meng Zhao, Qingling Guo, Nanwei Tong, Hongyan Zhao, Xiaomin Xie, Chao Liu, Zhongyan Shan, Zhifeng Cheng, Xuefeng Yu, Shulin Chen, Tao Yang, Yangang Wang, Dongmei Li, Zhaoli Yan, Lixin Guo, Qiuhe Ji, Wenjuan Wang, Jiajun Zhao
Summary: The aim of this study was to explore the associations of moderate-to-vigorous-intensity physical activity (MVPA) time and sedentary (SED) time with a history of cardiovascular disease (CVD) and multifactorial control status among type 2 diabetes mellitus (T2DM) patients in China. The study found that higher MVPA time was associated with lower odds of CVD risk, regardless of SED time, among patients with T2DM. Rating: 8/10.
Article
Medicine, General & Internal
Xiaoshan Feng, Ruirui Xuan, Yingchun Dong, Xiaoqin Wu, Yiping Cheng, Zinuo Yuan, Hang Dong, Junming Han, Fang Zhong, Jiajun Zhao, Xiude Fan
Summary: As the diagnostic criteria for metabolic dysfunction-associated fatty liver disease (MAFLD) do not exclude alcohol consumption, some patients initially diagnosed with alcoholic fatty liver disease (AFLD) may be diagnosed with dual-etiology fatty liver disease (AFLD&MAFLD). It is important to explore the impact of this classification change on clinical manifestations.
Article
Health Care Sciences & Services
Jing Du, Shizhan Ma, Li Fang, Meng Zhao, Zhongshang Yuan, Yiping Cheng, Jiajun Zhao, Xiude Fan, Qingling Guo, Zhongming Wu
Summary: This study found a correlation between muscle distribution and nonalcoholic fatty liver disease (NAFLD). Higher muscle mass in the lower limbs, extremities, and trunk was associated with a lower risk of NAFLD. Furthermore, a decrease in muscle mass in the lower limbs and trunk was linked to increased severity of NAFLD.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Cell Biology
Yashuang Yang, Quanshu Wang, Ling Gao, Sijin Liu, Jiajun Zhao, Guoliang Liu, Shuping Zhang
Summary: Many indicators, including RDW and iron metabolism, are sensitive to various risk factors and are associated with pathological alterations and disease onset. Increased RDW indicates various conditions such as iron deficiency anemia and chronic inflammation. Understanding the factors affecting RDW, such as disordered iron metabolism and oxidative stress, can be valuable in diagnosing and monitoring pathological conditions.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Cell Biology
Xiude Fan, Junming Han, Enfa Zhao, Jiansong Fang, Dawei Wang, Yiping Cheng, Yingzhou Shi, Zhen Wang, Zhenyu Yao, Peng Lu, Tianbao Liu, Qihang Li, Kyle L. Poulsen, Zhongshang Yuan, Yongfeng Song, Jiajun Zhao
Summary: Breakthrough SARS-CoV-2 infections of vaccinated individuals are increasing the risk of hospitalization and death. It is crucial to identify modifiable risk factors and initiate early interventions.
Article
Immunology
Yunyun Xu, Xu Hou, Honglin Guo, Zhenyu Yao, Xiude Fan, Chao Xu, Guimei Li, Yanzhou Wang, Yan Sun, Ling Gao, Yongfeng Song, Jiajun Zhao
Summary: Patients with Prader-Willi syndrome (PWS) show hyper-inflammatory state in their peripheral immune cells, characterized by increased CD16(+) monocytes. These monocytes transmit chemokine and cytokine signaling to drive inflammatory process in other cell types. This study provides insights into the characteristics of peripheral immune cells in PWS at the single cell level and suggests potential targets for immunotherapy in the future.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Chao Xu, Zhao He, Yongfeng Song, Shanshan Shao, Guang Yang, Jiajun Zhao
Summary: It has been traditionally believed that pituitary hormones act on their cognate receptors in classical target glands to carry out their various functions. However, recent studies have revealed that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs. This article summarizes the additional biological functions of pituitary hormones (thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin) when they act on non-classical organs, defining them as part of an atypical pituitary hormone-target tissue axis. This novel concept provides insight into the mechanisms behind metabolic diseases and offers potential novel therapeutic targets.
FRONTIERS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Jie Jiang, Chao Xu, Zinuo Yuan, Junming Han, Zhixiang Wang, Yang Tian, Yingchun Dong, Weibo Xia, Xiude Fan, Jiajun Zhao
Summary: This study aimed to evaluate the impact of different metabolic obesity phenotypes on the burden of postmenopausal hospitalized patients with osteoporosis. It found that metabolic abnormalities were associated with elevated rates and risks of 30- or 90-day readmission among these patients, while obesity did not seem to be innocent. The combination of these factors led to an additional burden on healthcare systems and individuals.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Mengzhu Li, Yizhan Zhang, Jiajun Zhao, Dawei Wang
Summary: This study conducted a bibliometric analysis to reveal the research trends and new frontiers in phase separation-related cancer research. The results showed an increasing trend in this field, and future research hotspots were related to tumor microenvironments, immunotherapy, prognosis, p53, and cell death.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Ruizhi Zheng, Yu Xu, Mian Li., Zhengnan Gao, Guixia. Wang, Xinguo Hou, Li Chen, Yanan Huo, Guijun Qin, Li Yan, Qin Wan, Tianshu Zeng, Lulu Chen, Lixin Shi, Ruying Hu, Xulei Tang, Qing Su, Xuefeng Yu, Yingfen Qin, Gang Chen, Xuejiang Gu, Feixia Shen, Zuojie Luo, Yuhong Chen, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Qiang Li, Yiming Mu, Jiajun Zhao, Chunyan Hu, Xiaojing Jia, Min Xu, Tiange Wang, Zhiyun Zhao, Shuangyuan Wang, Hong Lin, Guang Ning, Weiqing Wang, Jieli Lu, Yufang Bi
Summary: By analyzing 12 variables related to body fat, glycemic measures, pancreatic b cell function, insulin resistance, blood lipids, and liver enzymes, the study examined the cluster characteristics of prediabetes and their associations with the development of diabetes and its complications. Significant differences in the risks of diabetes and its complications were observed among different clusters. Prediabetes in cluster 4, characterized by obesity and insulin resistance, had a higher risk of cardiovascular diseases compared to other clusters. This subcategorization has the potential to develop more precise strategies for targeted prediabetes prevention and treatment.
CELL REPORTS MEDICINE
(2023)
Article
Medicine, Research & Experimental
Wei Zhang, Jing Du, Hang Dong, Yiping Cheng, Fang Zhong, Zinuo Yuan, Yingchun Dong, Rong Wang, Shumin Mu, Jiajun Zhao, Wenxia Han, Xiude Fan
Summary: This study investigated the relationship between obesity, metabolic abnormalities, and hospitalizations related to diabetic kidney disease (DKD). The findings showed that both metabolic abnormalities and obesity were independently associated with increased readmission risk and hospitalization costs for DKD.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Moke Liu, Luna Liu, Honglin Guo, Xiude Fan, Tianbao Liu, Chao Xu, Zhao He, Yongfeng Song, Ling Gao, Shanshan Shao, Jiajun Zhao, Peng Lu
Summary: In this study, a mouse model carrying the HNF1a P291fsinsC mutation was established, and it was found that this mutation led to liver steatosis. Further analysis revealed changes in innate immune response and lipid metabolism pathways. The study also showed that HNF1a inhibited the expression of CFD in hepatocytes, and that CFD regulated hepatocyte lipid deposition.
Article
Endocrinology & Metabolism
Zhenyu Yao, Ying Gong, Wenbin Chen, Shanshan Shao, Yongfeng Song, Honglin Guo, Qihang Li, Sijin Liu, Ximing Wang, Zhenhai Zhang, Qian Wang, Yunyun Xu, Yingjie Wu, Qiang Wan, Xinya Zhao, Qiuhui Xuan, Dawei Wang, Xiaoyan Lin, Jiawen Xu, Jun Liu, Christopher G. Proud, Xuemin Wang, Rui Yang, Lili Fu, Shaona Niu, Junjie Kong, Ling Gao, Tao Bo, Jiajun Zhao
Summary: In this study, it is shown that WDR6 promotes hepatic de novo lipogenesis during insulin resistance by interacting with PPP1CB. A small natural compound, XLIX, is also identified as an inhibitor of the WDR6-PPP1CB interaction, reducing hepatic steatosis in insulin resistance.
Article
Gastroenterology & Hepatology
Mengzhu Li, Xiude Fan, Jiajun Zhao, Dawei Wang
Summary: In this study, a predictive signature based on stress granule-related genes was established as an independent prognostic tool for hepatocellular carcinoma (HCC). The signature demonstrated strong predictive power, with the identified genes affecting HCC cell proliferation and metastasis by regulating stress granule formation.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
