Article
Chemistry, Organic
Robert Micikas, Arusha Acharyya, Feng Gai, Amos B. Smith
Summary: A scalable synthesis of a Fmoc-protected blue fluorescent amino acid, L-4-cyanotryptophan (W-4CN), was reported in this study. The study leveraged the red-shifted emission of water-exposed W-4CN residues to investigate the solvation state of tryptophan residues within the influenza M2 proton channel. The correlation between the conformation of the channel and the fluorescence spectrum of a mutated W-4CN residue suggested that the channel's conformational state does not affect the hydration status of the Trp residues.
Article
Chemistry, Organic
Daniel Lasanyi, Daniel Math, Gergely L. Tolnai
Summary: This paper presents a one-pot procedure for the synthesis of various BCP molecules, showcasing the versatility of these stable intermediates.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Takuma Kato, Yuki Kita, Kazuki Iwanari, Akiko Asano, Makoto Oba, Masakazu Tanaka, Mitsunobu Doi
Summary: The introduction of dAAs containing both natural and unnatural amino acids can enhance the cellular uptake and membrane permeability of novel CPPs. The size of the dAA ring has a significant impact on cellular uptake, while the number of carbon atoms in the side chain ring has minimal effect.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Anugam V. Krishna, Shyam D. Sanwal, Sibani Rath, P. R. Lakshmi, Dhevalapally B. Ramachary
Summary: In this study, an unprecedented organocatalytic asymmetric desymmetrization strategy was reported for the synthesis of chiral Swaminathan ketones and their analogues with excellent enantioselectivities. A neat protocol for the high-yielding synthesis of functionally diverse synthons and a powerful green organocatalytic reductive coupling protocol were also reported. The construction of a sustainable library of functionally rich chiral Swaminathan ketones with excellent enantioselectivities is the key attraction of this study.
Article
Chemistry, Inorganic & Nuclear
Jayendra Ahire, Bhalchandra M. Bhanage
Summary: In this study, shape selective zinc oxide nanoflowers were successfully synthesized using solar energy and aromatic amino acids as photo capping agents. The synthesized ZnO nanoflowers showed excellent catalytic activity for the synthesis of glycerol carbonate, and high resolution XPS studies were conducted to explore the valence states and effectiveness of surface engineering of the ZnO catalyst.
JOURNAL OF SOLID STATE CHEMISTRY
(2021)
Article
Chemistry, Applied
Qi Yang, Ying Wang, Meng Yang, Xuanting Liu, Siwen Lyu, Boqun Liu, Jingbo Liu, Ting Zhang
Summary: This study investigates the effects of glycation on protein structure and digestive characteristics. The results show that glycation decreases the turbidity and hydrophobicity of protein and changes its structure. It also reduces the contents of essential amino acids and total amino acids after digestion.
Article
Biochemistry & Molecular Biology
Ayse Demirbas, Baris Karsli, Ismail Ocsoy
Summary: In this study, two amino acids, Glycine and Phenylalanine, interacted with copper ions to form flower-shaped amino acid-copper hybrid nanostructures. The catalytic activity of these structures was tested using peroxidase-like assays. The morphology and composition of the nanostructures were carefully characterized and optimized. The results of this investigation are expected to have significant implications in various technical and scientific sectors.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Chemistry, Multidisciplinary
Na Liu, Lian Wu, Jinhui Feng, Xiang Sheng, Jian Li, Xi Chen, Jianjiong Li, Weidong Liu, Jiahai Zhou, Qiaqing Wu, Dunming Zhu
Summary: This study reported the crystal structures of a l-erythro-3,5-diaminohexanoate dehydrogenase and its variants, the only known member of beta-AADH family, revealing differences in substrate binding and catalytic mechanism compared to alpha-AADHs. Engineered variants with improved activity towards various aliphatic beta-amino acids were obtained, allowing for the preparation of beta-amino acids with excellent enantioselectivity and high yields. These results provide insights into the molecular mechanism of 3,5-DAHDH and lay a solid foundation for further design of beta-AADHs for asymmetric synthesis of beta-amino acids.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Benjamin Grain, Remi Desmet, Benoit Snella, Oleg Melnyk, Vangelis Agouridas
Summary: In this study, a latent and highly reactive oxalyl thioester precursor was efficiently introduced into a fully synthetic protein domain, serving as an on-demand reactive handle. This approach has potential applications in life or materials sciences.
Article
Chemistry, Multidisciplinary
Takashi Tamura, Masaaki Inoue, Yuji Yoshimitsu, Ichihiko Hashimoto, Noriyuki Ohashi, Kyosuke Tsumura, Koo Suzuki, Takayoshi Watanabe, Takahiro Hohsaka
Summary: This study investigated the reaction characteristics and versatility of a novel type of cyclic peptide with a thiazoline ring structure. These peptides exhibited higher biomembrane permeability compared to amide- and thioether-bridged cyclic peptides. The factors contributing to the increased permeability were examined by comparing their solution structures. Additionally, the peptide cyclization method was successfully applied to a cell-free translation system.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Article
Chemistry, Multidisciplinary
Rui Geng, Rui Chang, Qianli Zou, Guizhi Shen, Tifeng Jiao, Xuehai Yan
Summary: This study reports the construction of nanoassemblies through coassembly of an amphiphilic amino acid and hemin, which allows tailored peroxidase-mimicking activities. The optimized nanoassemblies exhibit remarkable catalytic efficiency and robustness in multiple catalytic cycles, and can be effectively integrated into a sensing system for catalytic detection of glucose.
Article
Biochemistry & Molecular Biology
Huan Li, Shuang Fu, Yudan Wang, Xuan Yuan, Lijia Liu, Hongxing Dong, Qiang Wang, Zhijia Zhang
Summary: Thirteen cationic peptidomimetics derived from amino acids were designed and synthesized to mimic the structure of cationic antibacterial peptides. Most of them showed significant broad-spectrum antibacterial activity against various bacteria, with some exhibiting low cytotoxicity. These peptidomimetics may have potential for the treatment of bacterial infections.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Vincenzo Battaglia, Sara Meninno, Alessandra Lattanzi
Summary: In this study, a novel and concise method for the synthesis of the commonly used antiplatelet drug Plavix was developed. Through careful optimization of reaction conditions, a high synthesis yield and selectivity were achieved.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Aaron L. Featherston, Yongseok Kwon, Matthew M. Pompeo, Oliver D. Engl, David K. Leahy, Scott J. Miller
Summary: This study introduces a novel method for controlling the stereochemistry of dinucleotide synthesis using chiral phosphoric acid catalysts, achieving control over the stereogenic phosphorous centers and unprecedented levels of diastereodivergence. The method utilizes two different CPA scaffolds to achieve stereodivergence and does not require stoichiometric activators or chiral auxiliaries, making it a convenient and efficient asymmetric catalysis method for the synthesis of diastereomeric dinucleotides and cyclic dinucleotides of interest in immuno-oncology.
Article
Chemistry, Organic
Masayoshi Koshizuka, Kaito Shinoda, Kazuishi Makino, Naoyuki Shimada
Summary: Researchers have developed a simple method for the synthesis of hydroxymethyl functionalized 2,5-Diketopiperazines (DKPs) using diboronic acid anhydride-catalyzed hydroxy-directed peptide bond formations. This protocol involves three sequential reactions, including an intermolecular catalytic condensation reaction, a nitrogen-protecting group deprotection reaction, and an intramolecular cyclization reaction, resulting in high to excellent yields of functionalized DKPs without intermediate purification. The utility of this method has been demonstrated through the synthesis of natural products, phomamide and Cyclo(Deala-L-Leu).
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Nanoscience & Nanotechnology
Xi Yang, Bhanu Prasad Venkatesulu, Lakshmi Shree Mahadevan, Maureen L. Aliru, Yuri Mackeyev, Ajay Singh, Paras N. Prasad, Sunil Krishnan
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2018)
Article
Nanoscience & Nanotechnology
Ajay Singh, Byung Kyu Kim, Yuri Mackeyev, Parham Rohani, Supriya D. Mahajan, Mark T. Swihart, Sunil Krishnan, Paras N. Prasad
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2019)
Correction
Biotechnology & Applied Microbiology
Huanhuan Joyce Chen, Zhubo Wei, Jian Sun, Asmita Bhattacharya, David J. Savage, Rita Serda, Yuri Mackeyev, Steven A. Curley, Pengcheng Bu, Lihua Wang, Shuibing Chen, Leona Cohen-Gould, Emina Huang, Xiling Shen, Steven M. Lipkin, Neal G. Copeland, Nancy A. Jenkins, Michael L. Shuler
NATURE BIOTECHNOLOGY
(2019)
Article
Biology
Joseph Byung-Kyu Kim, Yuri Mackeyev, Subhiksha Raghuram, Sang Hyun Cho, Sunil Krishnan
Summary: The authors successfully developed a novel MRI contrast agent with higher relaxivity by coupling gadolinium ions to fullerene. However, this formulation did not result in the expected radiosensitization effect, suggesting the need for further exploration of alternative chemical modifications.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Oncology
Jihong Wang, Travis Salzillo, Yongying Jiang, Yuri Mackeyev, Clifton David Fuller, Caroline Chung, Seungtaek Choi, Neil Hughes, Yao Ding, Jinzhong Yang, Sastry Vedam, Sunil Krishnan
Summary: This study focused on analyzing the molecular stability of MRI contrast agents when exposed to high energy photons and secondary electrons in a 1.5T MR-Linac system. The results showed no significant changes in chemical composition or displacement of gadolinium ions from their chelates in samples irradiated with 7 MV photons at clinical doses. Additionally, there was no significant correlation observed between concentrations of irradiated MRI contrast agents and radiation dose.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Sanjeev Shukla, Steven Fletcher, Jay Chauhan, Victor Chalfant, Carlos Riveros, Yuri Mackeyev, Pankaj Kumar Singh, Sunil Krishnan, Teruko Osumi, K. C. Balaji
Summary: This study demonstrates that 3JC48-3 is a potent MYC/MAX heterodimerization inhibitor that decreases prostate cancer growth and viability associated with upregulation of PrKD1 expression and kinase activity.
CANCER GENE THERAPY
(2022)
Article
Oncology
Kshama Gupta, Jeremy C. Jones, Virginea De Araujo Farias, Yuri Mackeyev, Pankaj K. Singh, Alfredo Quinones-Hinojosa, Sunil Krishnan
Summary: Treatment resistance is common in advanced cancers, including colorectal adenocarcinoma (COAD). A study found that targeting the DDR1/BCR-ABL signaling axis with EGFR-ERBB2 could be a potential strategy for treating chemotherapy and radiotherapy-resistant COAD and glioblastoma (GBM) tumors driven by the KRAS mutation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Engineering, Biomedical
Subhiksha Raghuram, Yuri Mackeyev, Jessica Symons, Yasmin Zahra, Valeria Gonzalez, Krishnan K. Mahadevan, Katherinne I. Requejo, Anton Liopo, Paul Derry, Eugene Zubarev, Onur Sahin, Joseph Byung-Kyu Kim, Pankaj K. Singh, Sang Hyun Cho, Sunil Krishnan
Summary: This study describes a smart gold nanorod that can spontaneously transform into active nanoparticles within tumors, sensitizing tumors to radiation therapy. By cloaking the nanorod with a protective layer, it can be uncloaked by specific proteases in the tumor microenvironment, making it readily internalized by cancer cells. Selective uncloaking of the nanorod reduces off-target toxicity in normal tissues.
Article
Multidisciplinary Sciences
Pradipta Ranjan Rauta, Yuri Mackeyev, Keith Sanders, Joseph B. K. Kim, Valeria V. Gonzalez, Yasmin Zahra, Muhammad A. Shohayeb, Belal Abousaida, Geraldine V. Vijay, Okan Tezcan, Paul Derry, Anton V. Liopo, Eugene R. Zubarev, Rickey Carter, Pankaj Singh, Sunil Krishnan
Summary: This article investigates gold nanorods with a responsive epilayer that can transform into cell-penetrating particles in the acidic tumor microenvironment. The study finds that when administered intravenously in mice, these nanorods can accumulate in tumors without causing significant harm to animal health, and they can effectively enhance the efficacy of radiation therapy for tumors.
Review
Cell Biology
Danushka S. Seneviratne, Omran Saifi, Yuri Mackeyev, Timothy Malouff, Sunil Krishnan
Summary: BNCT is a high-linear-energy transfer therapy that selectively delivers radiation to tumor cells while sparing normal tissues. The focus is on developing boronated compounds with high selectivity, ease of delivery, and large boron payloads. There is also interest in exploring the immunogenic potential of BNCT and utilizing it to improve outcomes in difficult-to-treat malignancies. This review covers the radiobiological and physical aspects of BNCT, traditional and next-generation boron compounds, as well as translational studies and innovative approaches for leveraging BNCT's immunogenicity.
Review
Oncology
Muskan Goel, Yuri Mackeyev, Sunil Krishnan
Summary: Radiopharmaceuticals have shown their effectiveness in cancer diagnosis and therapy over the past three decades. The advancements in nanotechnology have led to the development of nanotechnology-aided radiopharmaceuticals, which utilize the unique properties of nanoparticles to enhance imaging and therapy of human diseases.
CANCER NANOTECHNOLOGY
(2023)
Article
Oncology
Nolan Jackson, Iona Hill, Abdulaziz Alhussan, Kyle Bromma, Jessica Morgan, Belal Abousaida, Yasmin Zahra, Yuri Mackeyev, Wayne Beckham, Steven Herchko, Sunil Krishnan, Devika Basnagge Chithrani
Summary: Incorporating docetaxel with gold nanoparticles and radiotherapy can enhance the efficacy of radiotherapy treatment, potentially improving tumor control through local dose enhancement.
CANCER NANOTECHNOLOGY
(2023)
Meeting Abstract
Oncology
O. Sahin, Y. Mackeyev, G. Vijay, S. Roy, V. Gonzalez, Y. Zahra, O. Tezcan, B. Abousaida, B. Venkatesulu, P. K. Singh, S. H. Cho, P. Ajayan, S. Krishnan
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Shanta Bhattarai, Yuri Mackeyev, Bhanu P. Venkatesulu, Sunil Krishnan, Pankaj K. Singh
Summary: CXCR4-targeted gold nanoparticles show enhanced radiosensitization of breast cancer cells with CXCR4 overexpression, leading to increased cellular internalization, unrepaired DNA double strand breaks, and production of oxygen free radicals. In a murine TNBC xenograft model, CXCR4 targeting significantly increases tumor regrowth delay following radiation compared to radiation with non-targeted GNPs or vehicle alone, suggesting that CXCR4-targeted GNPs can enhance the efficacy of TNBC radiotherapy through increasing oxidative stress and DNA damage.
Article
Engineering, Biomedical
Yuri Mackeyev, Colette Mark, Natasha Kumar, Rita E. Serda
ACTA BIOMATERIALIA
(2017)
