Article
Biochemistry & Molecular Biology
Kritika Kumari, Marina Warepam, Aniket Kumar Bansal, Tanveer Ali Dar, Vladimir N. Uversky, Laishram Rajendrakumar Singh
Summary: TMAO is a significant metabolite derived from various organic compounds, with diverse biological functions in humans. Studies have shown its crucial impact on protein folding and cell cycle, potentially leading to protein misfolding and the development of related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Physical
Abhigyan Sengupta, Lorenz E. Rognoni, Ulrich Merkel, Gabriel Zoldak, Matthias Rief
Summary: Prolyl isomerization catalyzed by the PPIase enzyme plays a crucial role in cellular signaling and molecular timing. This study demonstrates a 25-fold acceleration of trans-cis isomerization rate and a stabilization effect on the cis-isomer by SlyD in a single-molecule experiment with FlnA20 protein.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Plant Sciences
Zsolt Gulyas, Blanka Moncsek, Kamiran Aron Hamow, Pal Straner, Zoltan Tolnai, Eszter Badics, Norbert Incze, Eva Darko, Valeria Nagy, Andras Perczel, Laszlo Kovacs, Vilmos Soos
Summary: This study characterizes D27-LIKE1 in Arabidopsis and highlights its important physiological and enzymatic functions related to carotenoids. The results show that D27-LIKE1 has multi-substrate specificity and may regulate carotenoid cis pools and the biosynthesis pathways of strigolactones and ABA.
Article
Biochemistry & Molecular Biology
Fanni Sebak, Janos Szolomajer, Nandor Papp, Gabor K. Toth, Andrea Bodor
Summary: The type of neighboring amino acids, especially aromatic and positively charged sidechains, has been found to affect the cis-Pro content. These findings can assist in the design of protein regions with specific cis-Pro content and contribute to a better understanding of the roles and functions of IDPs.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Article
Biochemistry & Molecular Biology
Anais Terrien, Keyvan Rahgoshay, Emelyne Renaglia, Nathalie Lensen, Yves Jacquot, Rodrigue Marquant, Thierry Brigaud, Claire Loison, Emeric Miclet, Gregory Chaume
Summary: Numerous collagen mimetic peptides (CMPs) have been engineered with proline derivatives substituted at C(3) and/or C(4) position. However, there is no reported example with C(5) substitutions. In this study, we introduce a fluorinated CMP with trifluoromethyl groups at C(5) position of pseudoproline residues. CD, NMR, and MD studies confirm that the designed CMPs meet the structural requirements for triple-helix assembly and exhibit stable triple-helix structures with outwardly pointing trifluoromethyl groups.
Article
Chemistry, Multidisciplinary
Fanni Sebak, Peter Ecsedi, Wolfgang Bermel, Burkhard Luy, Laszlo Nyitray, Andrea Bodor
Summary: This study introduces two new NMR experiments to identify proline cis/trans isomers in proteins, detecting minor conformers present in 4-15%, and analyzes the impact of CK2 phosphorylation on the cis/trans-proline equilibrium. Statistical analysis indicates that the amino acid type also affects the distribution of cis/trans-proline.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Tomas Fiala, Emilia P. Barros, Marc-Olivier Ebert, Enrico Ruijsenaars, Sereina Riniker, Helma Wennemers
Summary: This study reveals the significant impact of terminal residues on the stability of collagen model peptides (CMPs). By combining various experimental and simulation techniques, the researchers demonstrate how peptide termini preorganize into a polyproline-II helical structure and affect the stability of triple helices. These findings have important implications for designing peptide mimics of structural proteins and provide a straightforward method to tune the stability of CMPs for various applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Kazunori K. Fujii, Yuki Taga, Yusuke K. Takagi, Ryo Masuda, Shunji Hattori, Takaki Koide
Summary: Procollagen forms a triple helix structure in the endoplasmic reticulum with post-translational modifications enhancing its thermal stability. Collagen properties remain constant at lower temperatures, but at higher temperatures, an increase in post-translational modifications leads to higher thermal stability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Jolanta Konieczkowska, Mariola Siwy
Summary: This work investigates the thermal cis-trans isomerization in solid-state for poly(ether imide)s and poly(ester imide)s with azobenzene or azo pyridine moieties. The study explores the relationship between various material aspects such as polyimide structure, molar mass, azo dye content, d-spacing value, polymer film thickness, and thermal cis-trans isomerization. The reversibility of the trans-cis-trans reaction was studied using different irradiation wavelengths. This is the first comprehensive article on solid-state cis-trans isomerization for azo polyimides.
Article
Physics, Fluids & Plasmas
Izabela Sliwa, Pavel Maslennikov, Alex Zakharov
Summary: A molecular model is proposed to describe the effective anchoring energy of a liquid crystal system. The model explains the mechanism behind the anchoring transition caused by structural changes in the photosensitive azobenzene layer.
Review
Engineering, Biomedical
Jean -Daniel Malcor, Frederic Mallein-Gerin
Summary: This review article discusses the use of triple-helical peptides as efficient tools to improve cell-biomaterial interactions in tissue engineering. Triple-helical peptides are bioactive molecules that mimic the architectural and biological properties of collagen. They have been successfully used to specifically recognize cell-surface receptors and provide cells seeded on biomaterials with controlled biological cues. Functionalization with triple-helical peptides has enabled researchers to improve cell function for regenerative medicine applications, such as tissue repair. However, this approach still remains under-explored and most functionalization strategies reported in the literature are unable to address collagen-binding receptors.
ACTA BIOMATERIALIA
(2022)
Article
Multidisciplinary Sciences
Connor J. Thompson, Vinh H. Vu, Deborah E. Leckband, Daniel K. Schwartz
Summary: Cadherin transmembrane proteins play important roles in intercellular adhesion and tissue morphogenesis. Experimental evidence shows mutual cooperativity between lateral cis and adhesive trans interactions, leading to the assembly of large intermembrane junctions. This cooperativity is primarily due to allostery and provides insights into how weak cis and trans interactions work together to create strong cell adhesions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemical Research Methods
Xiang Chen, Justin M. Mirazee, Katarzyna A. Skorupka, Hiroshi Matsuo, Philippe Youkharibache, Naomi Taylor, Kylie J. Walters
Summary: T cells engineered to express CARs have transformative therapeutic possibilities. CD8 alpha hinge exhibits structural plasticity and local structural motifs that are important for relaying and amplifying antigen-binding effects.
JOURNAL OF MAGNETIC RESONANCE
(2022)
Article
Chemistry, Multidisciplinary
Patrick M. Killoran, George S. M. Hanson, Sanne J. M. Verhoork, Madeleine Smith, Davide Del Gobbo, Lu-Yun Lian, Christopher R. Coxon
Summary: A method using 4-fluorophenylalanine as a reporter group for F-19 NMR was developed to measure the conformational status of peptidylprolyl bonds in peptide models. This method was applied to study the prolyl bond status in pentapeptide models of the intrinsically disordered region of alpha-synuclein. It was demonstrated that F-19 NMR is a valuable tool for studying proline isomerism under different conditions.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Biswajit Sahariah, Bani Kanta Sarma
Summary: The amino acid Proline has a higher tendency to adopt cis amide geometry, and polyproline tracts can form either PPI or PPII helical conformation. Recent studies have shown a reduced presence of cis amide geometry in the inner Pro residues of a poly-Pro tract. The backbone noncovalent interactions play a crucial role in stabilizing trans Pro-amide geometry and preferring a PPII helical conformation.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Joshua E. Mayfield, Shuang Fan, Shuo Wei, Mengmeng Zhang, Bing Li, Andrew D. Ellington, Felicia A. Etzkorn, Yan Jessie Zhang
ACS CHEMICAL BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Felicia A. Etzkorn, Song Zhao
ACS Chemical Biology
(2015)
Article
Multidisciplinary Sciences
Xingguo R. Chen, Shuang A. Fan, Rachel I. Ware, Felicia A. Etzkorn
Article
Biochemistry & Molecular Biology
Mengmeng Zhang, Xiaodong J. Wang, Xi Chen, Marianne E. Bowman, Yonghua Luo, Joseph P. Noel, Andrew D. Ellington, Felicia A. Etzkorn, Yan Zhang
ACS CHEMICAL BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Ana Y. Mercedes-Camacho, Ashley B. Mullins, Matthew D. Mason, Guoyan G. Xu, Brendan J. Mahoney, Xingsheng Wang, Jeffrey W. Peng, Felicia A. Etzkorn
Article
Biochemistry & Molecular Biology
Joo Min Park, Jia-Hua Hu, Aleksandr Milshteyn, Ping-Wu Zhang, Chester G. Moore, Sungjin Park, Michael C. Datko, Racquel D. Domingo, Cindy M. Reyes, Xiaodong J. Wang, Felicia A. Etzkorn, Bo Xiao, Karen K. Szumlinski, Dorothee Kern, David J. Linden, Paul F. Worley
Article
Environmental Sciences
Vanessa E. Melin, David W. Johnstone, Felicia A. Etzkorn, Terry C. Hrubec
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2014)
Article
Biochemistry & Molecular Biology
Mary Katherine Tarrant, Hee-Sool Rho, Zhi Xie, Yu Lin Jiang, Christopher Gross, Jeffrey C. Culhane, Gai Yan, Jiang Qian, Yoshitaka Ichikawa, Tatsuji Matsuoka, Natasha Zachara, Felicia A. Etzkorn, Gerald W. Hart, Jun Seop Jeong, Seth Blackshaw, Heng Zhu, Philip A. Cole
NATURE CHEMICAL BIOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Ronald J. Nachman, Xiaodong J. Wang, Felicia A. Etzkorn, Krzysztof Kaczmarek, Janusz Zabrocki, Juan Lopez, Geoffrey M. Coast
Article
Multidisciplinary Sciences
Guoyan G. Xu, Carla Slebodnick, Felicia A. Etzkorn
Article
Multidisciplinary Sciences
Andrew T. Namanja, Xiaodong J. Wang, Bailing Xu, Ana Y. Mercedes-Camacho, Kimberly A. Wilson, Felicia A. Etzkorn, Jeffrey W. Peng
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Chemistry, Physical
Felicia A. Etzkorn, Rachel I. Ware, Amanda M. Pester, Diego Troya
JOURNAL OF PHYSICAL CHEMISTRY B
(2019)
Article
Biochemistry & Molecular Biology
Christina S. Kim, Anne M. Brown, Tijana Z. Grove, Felicia A. Etzkorn
Summary: Novel consensus leucine-rich repeat proteins (CLRR4-8) based on the LRR domain of NOD-like receptors show promise in high-affinity binding to bacterial cell wall component MDP. The biphasic binding curves and docking studies suggest multi-MDP binding, indicating potential for future pathogen biosensor design.
Article
Chemistry, Physical
Paul J. Arcoria, Rachel Ware, Sunny Makwana, Diego Troya, Felicia A. Etzkorn
Summary: Fluoro- and chloro-alkene mimics of Gly-Pro and Pro-Pro can participate in n ->pi* donation to stabilize PPII conformations, but are poor n.p* acceptors. Proteo-alkene mimics lack significant n ->pi* interactions, leading to unstable PPII-like geometries.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Felicia A. A. Etzkorn, Jamie L. L. Ferguson
Summary: Full integration of green chemistry into undergraduate curriculum is essential for preparing students for a sustainable future. This article discusses the reasons for curriculum change, institutions leading the way in integration efforts, and available textbooks for both classroom and laboratory. The authors emphasize the need to give college professors more time to revamp the curriculum and to value their efforts. They call on the chemistry education community to participate in these efforts immediately.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
