☆ 4.8 Article

A new method for N-N bond cleavage of N,N-disubstituted hydrazines to secondary amines and direct ortho amination of naphthol and its analogues

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2008)

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

卷 130, 期 18, 页码 5840-+

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AMER CHEMICAL SOC

DOI: 10.1021/ja711153b

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Chemistry, Multidisciplinary

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An unexpected reaction of N,N-disubstituted hydrazine with naphthol and its analogues under simply thermal conditions has been disclosed. 2-Naphthol reacted with various N,N-disubstituted hydrazines under argon to afford 1-amino-2-naphthol and the corresponding secondary amines in excellent yields. Ortho amination of 2-naphthols, hydroxyquinoline, and naphthalenamine occurred when they reacted with N-methyl-N-phenylhydrazine.

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