期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 14, 页码 9353-9359出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00606
关键词
-
资金
- National Science Centre Poland [NCN 2017/26/D/ST5/00112, NCN 2018/31/M/ST5/00450]
This study presents an original method for the preparation of N-alkyl and N-aryl pyrazoles using primary aliphatic or aromatic amines as a limiting reagent. The protocol avoids the use of inorganic reagents, requires short reaction time, mild conditions, and utilizes commercially available starting reagents. Pyrazoles with a variety of N-substituents were successfully obtained using this method for both aliphatic and aromatic amines.
Despite a large number of synthesis procedures for pyrazoles known today, those directly employing primary amines as substrates are rare. Herein, we report an original method for the preparation of N-alkyl and N-aryl pyrazoles from primary aliphatic or aromatic amines as a limiting reagent of the reaction. The protocol utilizes no inorganic reagents and requires a short reaction time, mild conditions, and the use of structurally simple and commercially available starting reagents. During this study, pyrazoles containing a wide variety of N-substituents were obtained using the same procedure for both aliphatic and aromatic amines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据