Article
Medicine, General & Internal
Maria Rosa Burg, Carolin Mitschang, Tobias Goerge, Stefan Werner Schneider
Summary: Livedoid vasculopathy is a rare, chronic-recurrent occlusive disorder in the microcirculation of dermal vessels. Diagnosis is made through a synopsis of history, clinical, and histopathological findings. Early and adequate therapy is crucial for maintaining the quality of life for patients.
FRONTIERS IN MEDICINE
(2022)
Review
Clinical Neurology
N. L. P. Starmans, M. R. van Dijk, L. J. Kappelle, C. J. M. Frijns
Summary: This study retrospectively reviewed patients diagnosed with Sneddon syndrome (SS) between 1996 and 2017, and found that SS predominantly affects young women with a relatively large number of cardiovascular risk factors. The study results showed that there were few statistically significant differences between APL-positive and APL-negative patients in terms of vascular events before diagnosis.
JOURNAL OF NEUROLOGY
(2021)
Review
Medicine, General & Internal
Mireia Segui, Mar Llamas-Velasco
Summary: Livedoid vasculopathy (LV) is a thrombo-occlusive vasculopathy that affects the dermal vessels, presenting as painful purpuric ulcers on the lower extremities. The diagnosis requires a proper clinicopathological correlation, exclusion of differential diagnoses, and consideration of vasculitis as a mimicker or concomitant diagnosis. Treatment options include pain management, wound care, control of cardiovascular risk factors, and the use of antiplatelets and anticoagulants.
FRONTIERS IN MEDICINE
(2022)
Review
Rheumatology
Pierre Loiseau, Thomas Foret, Ersilia M. DeFilippis, Jessie Risse, Anais D. Etienne, Virginie Dufrost, Thomas Moulinet, Doruk Erkan, Herve Devilliers, Denis Wahl, Stephane Zuily
Summary: This meta-analysis demonstrates an increased risk of livedo in aPL-positive SLE patients compared to aPL-negative patients. For daily clinical practice, livedo associated with aPL in patients with SLE may represent a specific group with small vessel disease.
Letter
Ophthalmology
Juan Martin Sanchez, Mauricio Davila, Radgonde Amer
Summary: This article reports a case of a patient with probable catastrophic antiphospholipid syndrome (CAPS) involving the eyes, brain, and skin. The patient was treated with immunomodulatory therapy, Enoxaparin, and retinal laser photocoagulation, leading to significant improvement in symptoms.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2022)
Article
Rheumatology
Ecem Sevim, Salma Siddique, Madhavi Latha S. Chalasani, Susan Chyou, William D. Shipman, Orla O'Shea, Joanna Harp, Oral Alpan, Stephane Zuily, Theresa T. Lu, Doruk Erkan
Summary: This study investigated the activation of the mammalian target of rapamycin (mTOR) in the skin of patients with livedo and antiphospholipid antibodies (aPL). The results showed increased mTOR activity in the skin of aPL-positive patients, which may have implications for further research on the mTOR pathway in these patients.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Dermatology
Chenjing Zhao, Ke Jing, Suying Feng
Summary: This retrospective study analyzed the clinical features of 46 Chinese patients with livedoid vasculopathy (LV), and found that extensive livedo reticularis, pigmented purpuric dermatosis-like lesions, and numbness were common symptoms in these patients.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Alanna Shefler, Scott C. Blaszak, Christopher R. Shea, Angad A. Chadha
Summary: Endovascular procedures using hydrophilic polymer-coated devices can lead to embolization and ischemic complications. It is crucial to identify potential adverse effects early as these coatings are increasingly used worldwide. We present a case of cutaneous complications following hydrophilic polymer embolization in a patient who recently underwent transcatheter aortic valve replacement.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2023)
Review
Immunology
Jason S. Knight, Yogendra Kanthi
Summary: Antiphospholipid syndrome (APS) is an autoimmune thrombophilia characterized by circulating antiphospholipid antibodies. It can lead to vascular thrombosis, obstetrical complications, occlusive vasculopathy, and organ damage. Recent studies have highlighted the role of neutrophil extracellular traps (NETs) and the complement system in APS thrombosis.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Dermatology
Katrin Kofler, Anke Stroelin, Vanessa Geiger, Lukas Kofler
Summary: After IVIG treatment in LV patients, complete remission of symptoms was observed in 68% of patients, with significant improvements in pain and limitations of daily activities, and 92% of patients showed good tolerability to IVIG.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2021)
Article
Hematology
Alisa S. Wolberg, Yaqiu Sang
Summary: This article discusses the pathogenesis of venous thromboembolism and focuses on the role of fibrinogen and factor XIII in thrombus formation and resolution, providing insights for the development of new anticoagulant strategies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Georges Khattar, Fasih Sami Siddiqui, Radu Grovu, Saif Abu Baker, Elie Bou Sanayeh, Chapman Wei, Khalil El Gharib, Saud Bin Abdul Sattar, Dany Elsayegh, Halim El-Hage, Suzanne El Sayegh, Michel Chalhoub, Ahmad Mustafa
Summary: Primary hyperthyroidism (PHPT) is associated with an increased risk of acute venous thromboembolism (VTE). Patients with PHPT are more likely to have acute VTE compared to those without PHPT.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Immunology
Giulia Gasparini, Paola Canepa, Simonetta Verdiani, Luca Carmisciano, Emanuele Cozzani, Denise De Grazia, Orsi Andrea, Giancarlo Icardi, Aurora Parodi
Summary: The study found that aPL antibodies are not significantly associated with thrombotic events in COVID-19 patients and cannot be considered responsible for hypercoagulability. Additionally, cutaneous manifestations such as livedo reticularis and acrocyanosis in COVID-19 patients do not appear to be manifestations of APS.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Dermatology
Michael Occidental, Abdallah Flaifel, Lawrence H. Lin, Melissa Guzzetta, Kristen Thomas, George Jour
Summary: COVID-19, caused by the novel coronavirus, was first identified in Wuhan, China in December 2019, leading to respiratory decline and affecting various organs including the skin. Recent reports have described the clinical spectrum of COVID-19-related lesions, with some cases showing underlying thrombotic microangiopathy and increased complement activation.
JOURNAL OF CUTANEOUS PATHOLOGY
(2021)
Article
Rheumatology
Jozelio Freire Carvalho, Roberto Paulo Correia de Araujo, Thelma Larocca Skare
Summary: This study compared the clinical and laboratory features between pAPS patients with and without Livedo Reticularis (LR). The results showed that pAPS patients with LR had a higher frequency of stroke and Sneddon's syndrome, while patients without LR had a higher frequency of thyroidopathy.
CURRENT RHEUMATOLOGY REVIEWS
(2022)
