Article
Chemistry, Medicinal
Xiaobo Dong, Lei Wang, Guangrong Song, Xu Cai, Wenxin Wang, Jiaqi Chen, Gesheng Wang
Summary: The study demonstrates that physcion protects neuronal cells against I/R injury by inhibiting the TLR4/NF-kB pathway, reducing inflammatory response and oxidative stress, and decreasing apoptosis, suggesting a promising therapeutic candidate for ischemic stroke.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Nutrition & Dietetics
Ying Wei, Mingliang Li, Zhiyuan Feng, Di Zhang, Meiling Sun, Yong Wang, Xiangning Chen
Summary: This study found that corn oligopeptides (CPs) have a regulatory effect on alcohol-induced liver injury and inflammation. CPs can reduce the levels of inflammatory cytokines and liver function indicators, and inhibit the activation of inflammatory signaling pathways and the expression of inflammatory cytokines. These findings suggest that CPs have potential application value in the treatment of acute alcoholic liver disease.
Article
Pharmacology & Pharmacy
Wenjuan Sun, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Summary: The study demonstrates the renoprotective effect of maslinic acid (MA) on acute kidney injury (AKI) induced by renal ischemia-reperfusion injury (IRI) through inhibiting inflammation and apoptosis-related signaling pathways. MA shows promising potential as a therapeutic agent for kidney diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Fengguang Li, Yan Xu, Xing Li, Xinghua Wang, Zhigang Yang, Wanli Li, Wei Cheng, Gangli Yan
Summary: The study demonstrated the therapeutic effect of NC in a rat model of cerebral ischemia/reperfusion injury by reducing NF-kappa B-p65 protein and inflammatory cytokines.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Plant Sciences
Bin Li, Baoke Zhang, Zhenyu Li, Shasha Li, Jun Li, Aiwu Wang, Jinling Hou, Jiping Xu, Rui Zhang
Summary: The study aimed to investigate the potential of ginkgolide C (GC), an active ingredient in Ginkgo biloba leaves, to attenuate cerebral ischemia/reperfusion injury (CI/RI) and its anti-inflammatory effect through suppression of the CD40/NF-kappa B pathway. The results showed that GC reduced neurological scores, cerebral infarct rate, and brain edema, while improving microvessel ultrastructure and blood-brain barrier integrity. GC also inhibited the release of inflammatory mediators and enhanced cell viability. These effects were mediated through the suppression of the CD40/NF-kappa B pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Food Science & Technology
Xiu-Ning Zhang, Ning Zhao, Fang-Fang Guo, Yi-Ran Wang, Shi-Xuan Liu, Tao Zeng
Summary: DADS suppresses LPS-driven inflammatory response in the liver by activating Nrf2, which improves alcoholic liver disease (ALD).
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Nutrition & Dietetics
Pan Liu, Mingrui Zhang, Tianyi Liu, Ruixia Mo, Haotian Wang, Gang Zhang, Yi Wu
Summary: This study aimed to investigate the effects of Avenanthramide (AVA) on colonic damage induced by food allergy and its mechanism. AVA alleviated colonic inflammation and improved intestinal barrier damage by inhibiting NF-KB phosphorylation and enhancing heat shock protein 70 (Hsp70) expression. AVA also modulated microbial composition and increased the production of butyrate. However, the effects of AVA were eliminated by an Hsp70 inhibitor.
Article
Biochemistry & Molecular Biology
Zining Yu, Guangjun Su, Limei Zhang, Gaigai Liu, Yonggang Zhou, Shicai Fang, Qian Zhang, Tianyun Wang, Cheng Huang, Zhihua Huang, Liangdong Li
Summary: The study found that ICT can inhibit microglial activation and M1 polarization, promote M2 polarization, and alleviate inflammatory response and achieve neuroprotection by regulating the GPER-ERK-NF-kappa B signaling pathway.
MOLECULAR MEDICINE
(2022)
Article
Agriculture, Multidisciplinary
Yan Wang, Qianqian Xu, Meijuan Meng, Guangjun Chang, Nana Ma, Xiangzhen Shen
Summary: The present study demonstrates that butyrate can alleviate the inflammatory response and tight junction (TJ) injury in bovine mammary epithelial cells (BMECs) by blocking NF-kappa B activation and decreasing inflammatory cytokine production and myosin light chain kinase (MLCK) expression.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Urology & Nephrology
Seonghun Kim, Sul A. Lee, Heakyung Yoon, Myung Yoon Kim, Jae-Kwang Yoo, So-Hee Ahn, Cheol Hyoung Park, Jimin Park, Bo Young Nam, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Nam Hee Kim, Hyun Sil Kim, Dawool Han, Jong In Yook, Chulhee Choi, Tae-Hyun Yoo
Summary: Ischemia-reperfusion injury is a major cause of acute kidney injury, and immune responses play a significant role in this process. Treatment with Exo-srI kappa B can reduce post-ischemic damage in mice by decreasing NF-kappa B activity and modulating immune cell populations.
KIDNEY INTERNATIONAL
(2021)
Article
Integrative & Complementary Medicine
Jing Li, Xuming Ma, Jun Yang, Luzhen Wang, Yan Huang, Yan Zhu
Summary: This study demonstrates for the first time that lupeol has a cardioprotective effect against I/R-induced myocardial infarction in rats, possibly due to its antioxidant, anti-inflammatory, and anti-apoptotic activities. The results also reveal the mechanisms of the NF-kappa B and Nrf2 signaling pathways.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Cell Biology
Dianbo Long, Yiyang Xu, Guping Mao, Ruobing Xin, Zengfa Deng, Hongyi Liao, Zhiwen Li, Zhi Yang, Baoxi Yu, Zhijian Yang, Aishan He, Ziji Zhang, Yan Kang
Summary: tRNA-derived fragments (tRFs) have been shown to play important roles in cell metabolism by regulating gene expression. This study investigates the role of tRFs in the cellular metabolism of the anterior cruciate ligament (ACL). The findings reveal that TRF365 regulates ACL cell metabolism by targeting IKBKB.
CELL DEATH DISCOVERY
(2022)
Article
Anatomy & Morphology
Yujie Jia, Yu Tong, Lianqiu Min, Yanrong Li, Yan Cheng
Summary: This study revealed that oridonin can alleviate cerebral ischemia/reperfusion injury by relieving neurological deficits, neuronal injury, and microglia activation, as well as inhibiting the activation of the NLRP3 inflammasome through the NF-kappa B signaling pathway. Thus, oridonin shows potential as a candidate for therapy of cerebral ischemia/reperfusion injury in the future.
Article
Neurosciences
Zhijun Pu, Shengnan Xia, Pengfei Shao, Xinyu Bao, Dan Wu, Yun Xu
Summary: This study is the first to demonstrate that dauricine exerts its anti-inflammatory effects and neuroprotection by targeting the STAT5-NF-kappa B pathway, suggesting its potential as a therapeutic target for neuroinflammation and post-ischemia-reperfusion injury.
Article
Immunology
Jingyi Mi, Yang Yang, Hao Yao, Zhirong Huan, Ce Xu, Zhiheng Ren, Wenfu Li, Ying Tang, Rao Fu, Xin Ge
Summary: The study showed that silencing HSPA8 can alleviate spinal cord damage caused by SCII by inhibiting astrocyte activation and NF-κB, NLRP3 inflammasome activation, leading to reduced neuroinflammation and protection of neurons.
JOURNAL OF NEUROINFLAMMATION
(2021)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)