Article
Nutrition & Dietetics
Yusuke Akiyama, Shunsuke Katsuki, Tetsuya Matoba, Yasuhiro Nakano, Susumu Takase, Soichi Nakashiro, Mitsutaka Yamamoto, Yasushi Mukai, Shujiro Inoue, Keiji Oi, Taiki Higo, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Makoto Usui, Kenji Sadamatsu, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Hiroyuki Tsutsui
Summary: Oxysterols are believed to contribute to the development of cardiovascular diseases, and their serum levels are positively associated with cholesterol absorption and synthesis. However, the regulation of different oxysterols in the body is largely unknown. This study aimed to investigate the relationship between clinical factors and cholesterol metabolism markers, as well as identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease.
Article
Nutrition & Dietetics
Shaun Sabico, Kaiser Wani, William B. B. Grant, Nasser M. M. Al-Daghri
Summary: This interventional study aimed to investigate the effects of correcting vitamin D status on the 10-year risk of Atherosclerotic Cardiovascular Disease (ASCVD) in deficient Arab adults. The study found that while only a small proportion of participants achieved optimal vitamin D levels, there was a modest improvement in HDL cholesterol and 10-year ASCVD risk scores for both genders. The improvement was slightly more pronounced in males than females.
Review
Hematology
Natalia Eberhardt, Chiara Giannarelli
Summary: The development of innovative single-cell technologies has allowed for in-depth analysis of the transcriptomic and proteomic profiling of individual blood and tissue cells. Recent single-cell studies have revealed the cellular heterogeneity of atherosclerotic plaque tissue and provided a better understanding of the immune functional states in the context of atherosclerosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Nutrition & Dietetics
Man Hung, Wendy C. Birmingham, Monica Ocampo, Amir Mohajeri
Summary: Cardiovascular diseases (CVD) are the leading cause of death in the United States. This study aimed to determine the association between reported CVD and serum 25-hydroxyvitamin D [25(OH)D]. Using data from the National Health and Nutrition Examination Survey, the study found that deficiency and insufficiency of 25(OH)D were associated with CVD, while adequacy of 25(OH)D was not. Healthcare professionals may consider vitamin D supplementation to improve cardiovascular health in adults for CVD prevention.
Article
Biochemistry & Molecular Biology
Maria Pia Adorni, Bianca Papotti, Maria Orietta Borghi, Elena Raschi, Francesca Zimetti, Franco Bernini, Pier Luigi Meroni, Nicoletta Ronda
Summary: This study investigates the direct effects of tofacitinib on macrophage cholesterol metabolism, finding that it can increase cholesterol efflux, decrease cholesterol uptake and synthesis, and have a favorable impact on macrophage cholesterol metabolism. These findings are important for understanding the impact of tofacitinib on cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agriculture, Multidisciplinary
Fan Zhang, Junhua Li, Cuihua Chang, Luping Gu, Wen Xiong, Yujie Su, Yanjun Yang
Summary: This review discusses the contradictory conclusions about the relationship between egg consumption and cardiovascular disease (CVD) risk, as well as the effects of egg cholesterol intake on cholesterol homeostasis. The study finds that moderate egg consumption has no substantial overall impact on cholesterol homeostasis in healthy individuals. However, excessive cholesterol intake is not recommended for individuals with metabolic disorders. In the future, the impact of egg consumption on CVD risk should be considered from different perspectives.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Suraphan Panyod, Wei-Kai Wu, Sin-Yi Peng, Yea-Jing Tseng, Ya-Chi Hsieh, Rou-An Chen, Huai-Syuan Huang, Yi-Hsun Chen, Hsiao-Li Chuang, Cheng-Chih Hsu, Ting-Chin David Shen, Kai-Chien Yang, Chi-Tang Ho, Ming-Shiang Wu, Lee-Yan Sheen
Summary: Recently, the role of gut microbiota in diseases, including cardiovascular disease, has gained research attention. Ginger essential oil (GEO) and its bioactive compound citral have shown anti-atherosclerotic effects by improving lipid profile, blood sugar, insulin resistance, and reducing TMAO levels and inflammatory cytokines. They also modulate gut microbiota diversity and composition.
NPJ SCIENCE OF FOOD
(2023)
Article
Nutrition & Dietetics
Zhenzhen Wan, Tingting Geng, Rui Li, Xue Chen, Qi Lu, Xiaoyu Lin, Liangkai Chen, Yanjun Guo, Liegang Liu, Zhilei Shan, An Pan, JoAnn E. Manson, Gang Liu
Summary: This study investigated the association between vitamin D concentration and cardiovascular disease risk in type 2 diabetes patients. The results showed that higher serum vitamin D concentrations were significantly associated with lower risks of total CVD and ischemic heart disease (IHD). Maintaining adequate vitamin D status and avoiding deficiency may help prevent CVD complications in patients with type 2 diabetes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Andrei Mihai Surdu, Oana Pinzariu, Dana-Mihaela Ciobanu, Alina-Gabriela Negru, Simona-Sorana Cainap, Cecilia Lazea, Daniela Iacob, George Saraci, Dacian Tirinescu, Ileana Monica Borda, Gabriel Cismaru
Summary: Vitamin D plays a crucial role in cardiovascular health by influencing lipid levels, vascular tone, and atherosclerosis development. Deficiency of this vitamin increases cardiovascular risk, while supplementation has the potential to lower the risk factors.
Article
Endocrinology & Metabolism
Jie Wang, Qi Sun, Yu An, Jia Liu, Song Leng, Guang Wang
Summary: This study found that elevated remnant cholesterol is associated with a higher risk of hypertension in the Chinese population, especially among individuals with diabetes. However, with ideal management of remnant cholesterol, glucose, and other cardiovascular risk factors, the risk of hypertension can be minimized for diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Review
Nutrition & Dietetics
Zeyad Khalil, Benyamin Alam, Amir Reza Akbari, Harbans Sharma
Summary: Vitamin K-2 plays a crucial role in calcium metabolism and shows potential benefits for osteoporosis, cardiovascular disease, parathyroid disorders, cerebral palsy, and sperm motility. Further research is needed to confirm the reproducibility of these positive effects and evaluate the feasibility of using vitamin K-2 as a treatment for these conditions.
Article
Cardiac & Cardiovascular Systems
Simon Hsu, Leila R. Zelnick, Nisha Bansal, Julia Brown, Michelle Denburg, Harold I. Feldman, Charles Ginsberg, Andrew N. Hoofnagle, Tamara Isakova, Mary B. Leonard, Benjamin Lidgard, Cassianne Robinson-Cohen, Myles Wolf, Dawei Xie, Bryan R. Kestenbaum, Ian H. de Boer, CRIC Study Investigators
Summary: The study investigated the associations of the vitamin D metabolite ratio (VDMR), 25-hydroxyvitamin D (25[OH]D), and 1,25-dihydroxyvitamin D (1,25[OH](2)D) with cardiovascular disease (CVD) in chronic kidney disease patients. The results showed that lower VDMR and 1,25(OH)(2)D were associated with incident CVD, while only 25(OH)D was associated with left ventricular mass index. However, none of these metabolites were found to be associated with incident CVD in chronic kidney disease after adjustment for relevant factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Zhuohui Chen, Menghui Liu, Xingfeng Xu, Lixiang He, Peng Wang, Xiaojie Cai, Rihua Huang, Shaozhao Zhang, Xinghao Xu, Yuhui Lai, Yiquan Huang, Miaohong Li, Yifen Lin, Peihan Xie, Xinxue Liao, Xiaodong Zhuang, Yue Guo
Summary: This study investigated the joint association of serum 25-hydroxyvitamin D [25(OH)D] and klotho with mortality risk in American community-dwelling adults. The results showed that vitamin D-associated mortality risk is observed only with concurrently decreasing klotho, indicating that vitamin D metabolism dysfunction increases the risk of mortality.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Margaret Murray, Aimee L. Dordevic, Kate Cox, Andrew Scholey, Lisa Ryan, Maxine P. Bonham
Summary: In this study, a polyphenol-rich seaweed extract showed a slight increase in high-density lipoprotein cholesterol, but did not alter other CVD risk factors. A larger sample size would be needed to confirm the clinical relevance of the changes in HDL cholesterol.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Ginger E. Nicol, Lisa de las Fuentes, Amy E. Riek, Carlos Bernal-Mizrachi, Eric J. Lenze, J. Phillip Miller, Julia A. Schweiger, Michael D. Yingling, Vincent J. Huang, David J. Dixon, Charles H. Hennekens, John W. Newcomer
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2015)
Article
Cell Biology
Jisu Oh, Amy E. Riek, Isra Darwech, Katsuhiko Funai, JianSu Shao, Kathleen Chin, Oscar L. Sierra, Geert Carmeliet, Richard E. Ostlund, Carlos Bernal-Mizrachi
Article
Biochemistry & Molecular Biology
Amy E. Riek, Jisu Oh, Isra Darwech, Veronica Worthy, Xiaobo Lin, Richard E. Ostlund, Rong M. Zhang, Carlos Bernal-Mizrachi
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Jisu Oh, Amy E. Riek, Rong M. Zhang, Samantha A. S. Williams, Isra Darwech, Carlos Bernal-Mizrachi
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Robin R. Bruchas, Lisa de las Fuentes, Robert M. Carney, Joann L. Reagan, Carlos Bernal-Mizrachi, Amy E. Riek, Chi Charles Gu, Andrew Bierhals, Mario Schootman, Theodore K. Malmstrom, Thomas E. Burroughs, Phyllis K. Stein, Douglas K. Miller, Victor G. Davila-Roman
BMC CARDIOVASCULAR DISORDERS
(2013)
Article
Biochemistry & Molecular Biology
Jisu Oh, Amy E. Riek, Sherry Weng, Marvin Petty, David Kim, Marco Colonna, Marina Cella, Carlos Bernal-Mizrachi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Amy E. Riek, Jisu Oh, Jennifer E. Sprague, Alexandra Timpson, Lisa de las Fuentes, Leon Bernal-Mizrachi, Kenneth B. Schechtman, Carlos Bernal-Mizrachi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Amy E. Riek, Jisu Oh, Carlos Bernal-Mizrachi
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2013)
Review
Biochemistry & Molecular Biology
Amy E. Riek, Jisu Oh, Isra Darwech, Clare E. Moynihan, Robin R. Bruchas, Carlos Bernal-Mizrachi
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Sherry Weng, Jennifer E. Sprague, Jisu Oh, Amy E. Riek, Kathleen Chin, Miguel Garcia, Carlos Bernal-Mizrachi
Article
Cardiac & Cardiovascular Systems
Anlong Li, Russell H. Knutsen, Haixia Zhang, Patrick Osei-Owusu, Alex Moreno-Dominguez, Theresa M. Harter, Keita Uchida, Maria S. Remedi, Hans H. Dietrich, Carlos Bernal-Mizrachi, Kendall J. Blumer, Robert P. Mecham, Joseph C. Koster, Colin G. Nichols
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2013)
Article
Health Care Sciences & Services
Ran Xu, Maggie Xing, Kavon Javaherian, Robert Peters, Will Ross, Carlos Bernal-Mizrachi
TELEMEDICINE AND E-HEALTH
(2020)
Review
Physiology
Rong M. Zhang, Kyle P. McNerney, Amy E. Riek, Carlos Bernal-Mizrachi
Summary: Studies have shown that immune cell infiltration and chronic inflammation play a critical role in the development of hypertension and its complications. Depletion of immune cells can improve endothelial function, reduce oxidative stress, lower vascular tone, and prevent kidney damage, indicating potential novel antihypertensive therapies through understanding immune cell functioning.
Editorial Material
Biochemistry & Molecular Biology
James C. Fleet, Carlos Bernal-Mizrachi, Martin Hewison, Rolf Jorde, John White, Margherita Cantorna, Inez Schoenmakers, Reinhold Erben
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
J. Oh, S. J. Matkovich, A. E. Riek, S. M. Bindom, J. S. Shao, R. D. Head, R. A. Barve, M. S. Sands, G. Carmeliet, P. Osei-Owusu, R. H. Knutsen, H. Zhang, K. J. Blumer, C. G. Nichols, R. P. Mecham, A. Baldan, B. A. Benitez, M. L. Sequeira-Lopez, R. A. Gomez, C. Bernal-Mizrachi
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Maruf Hasan, Henry Reyer, Michael Oster, Nares Trakooljul, Siriluck Ponsuksilli, Elizabeth Magowan, Dagmar -Christiane Fischer, Klaus Wimmers
Summary: UVB exposure can increase the supply of vitamin D in pig husbandry and does not affect the growth performance of the pigs. After exposure, there are changes in gene expression in the liver, with the pathways for vitamin D synthesis being preferentially initiated.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Zhen Wang, Shu-ying Yi, Yuan-ying Zhang, Yu-di Wang, Han-lin Chen, Yi-jie Guo, Xin-ming Wei, Du-xiao Yang
Summary: Vitamin D can reverse S1P-induced cell death and alleviate EAE symptoms by regulating S1P levels and related signaling pathways.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)
Correction
Biochemistry & Molecular Biology
Haixiao Chen, Xing Ji, Xinhua Hu, Lihua Chen, Haiyan Lv, Chengyun Xu, Dun Hong, Ximei Wu
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2024)