Article
Neurosciences
Soma S. Singareddy, Helen Roessler, Conor McClenaghan, Jennifer M. Ikle, Robert C. Tryon, Gijs Haaften, Colin G. Nichols
Summary: ATP-sensitive potassium channels play a crucial role in cellular metabolism and excitability in the heart and vasculature. Zebrafish models offer insights into the link between molecular dysfunction and complex pathophysiology.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Genetics & Heredity
Anastasia Zaytseva, Tatyana Tulintseva, Yulya Fomicheva, Valeria Mikhailova, Tatiana Treshkur, Anna Kostareva
Summary: Genetic variants in the ABCC9 gene are associated with various inherited diseases. Gain-of-function mutations lead to Cantu syndrome and other related disorders, while loss-of-function mutations are associated with diseases such as Brugada syndrome. This study reports a patient with a loss-of-function variant in the ABCC9 gene, highlighting the implications for cardiovascular dysfunction.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Koji Ando, Lei Tong, Di Peng, Elisa Vazquez-Liebanas, Hirohisa Chiyoda, Liqun He, Jianping Liu, Koichi Kawakami, Naoki Mochizuki, Shigetomo Fukuhara, Jaime Grutzendler, Christer Betsholtz
Summary: Loss- or gain-of-function mutations in ATP-sensitive potassium channel (K-ATP)-encoding genes, KCNJ8 and ABCC9, can cause central nervous system disorders. This study shows that KCNJ8/ABCC9-containing K-ATP channels play a role in the differentiation of brain vascular smooth muscle cells (VSMCs) and the regulation of cerebral blood flow.
DEVELOPMENTAL CELL
(2022)
Article
Medicine, Research & Experimental
Haixia Zhang, Alex Hanson, Tobias Scherf de Almeida, Christopher Emfinger, Conor McClenaghan, Theresa Harter, Zihan Yan, Paige E. Cooper, G. Schuyler Brown, Eric C. Arakel, Robert P. Mecham, Atilla Kovacs, Carmen M. Halabi, Blanche Schwappach, Maria S. Remedi, Colin G. Nichols
Summary: Cantu syndrome is caused by gain-of-function mutations in potassium channel subunits. An experiment with CRISPR/Cas9 found that R1154Q mutation led to lower K-ATP current density in cardiomyocytes and vascular smooth muscle. Surprisingly, there were distinct SUR2 transcripts, one encoding full-length protein and one with an in-frame deletion, present in R1154Q tissues.
Review
Cell Biology
Jirong Lv, Xue Xiao, Mingxia Bi, Tingting Tang, Deao Kong, Meining Diao, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jiang
Summary: ATP-sensitive potassium channels (KATP channels) play a crucial role in linking the electrical activity of the cell membrane with cell metabolism. They have been found to be expressed in various cells and play important roles in neurodegenerative diseases. The KATP channel openers and inhibitors have protective effects on neurons by regulating neuronal excitability and neurotransmitter release, reducing abnormal protein aggregation and Ca2+ overload, and decreasing reactive oxygen species (ROS) production and microglia activation. However, KATP channels also exhibit dual effects in some cases.
AGEING RESEARCH REVIEWS
(2022)
Article
Multidisciplinary Sciences
Hiromi Nakai-Shimoda, Tatsuhito Himeno, Tetsuji Okawa, Emiri Miura-Yura, Sachiko Sasajima, Makoto Kato, Yuichiro Yamada, Yoshiaki Morishita, Shin Tsunekawa, Yoshiro Kato, Yusuke Seino, Rieko Inoue, Masaki Kondo, Susumu Seino, Keiko Naruse, Koichi Kato, Hiroki Mizukami, Jiro Nakamura, Hideki Kamiya
Summary: Glucose-responsive ATP-sensitive potassium channels (K-ATP) play important roles in the peripheral nervous system, affecting neurite outgrowth and nerve conduction velocity.
Article
Biology
Yajamana Ramu, Jayden Yamakaze, Yufeng Zhou, Toshinori Hoshi, Zhe Lu
Summary: Blocking the Kir6.2 channel in pancreatic beta cells can effectively trigger insulin secretion and lower blood glucose levels, providing a new approach for the treatment of diabetes and other diseases associated with K-ATP hyperactivity.
Article
Multidisciplinary Sciences
Mohammad Amin Manavi, Razieh Mohammad Jafari, Hamed Shafaroodi, Shahram Ejtemaei-Mehr, Mohammad Sharifzadeh, Ahmad Reza Dehpour
Summary: This study demonstrates that Ivermectin has anticonvulsant effects against PTZ- and MES-induced seizures in mice, possibly mediated by its action on GABAA receptors and KATP channels.
Article
Physiology
Simon Schemke, Cor de Wit
Summary: Functional hyperemia in skeletal muscle during exercise involves various mechanisms including adenosine, endothelial autacoids, and K-ATP channels. Muscular contractions and NO release are essential for arteriolar dilation induced by motor nerve stimulation, suggesting redundant mechanisms for coordinated response in the network.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kavitha Ramasamy, Jaikumar Shanmugasundaram, Rajesh Manoharan, Viswanathan Subramanian, Parimala Kathirvelu, Rajagopalan Vijayaraghavan
Summary: The study aimed to investigate the anti-neuropathic effect of 7,3'-dihydroxyflavone against paclitaxel-induced peripheral neuropathy in mice using behavioral tests. It was found that 7,3'-dihydroxyflavone significantly reduced paw withdrawal response score in mechanical and cold allodynia and increased tail flick response time in thermal hyperalgesia. The involvement of GABAA, KATP channels, and adenosine receptors in the anti-neuropathic effect of 7,3'-dihydroxyflavone was also studied.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Cell Biology
Elena De Marchi, Anna Pegoraro, Roberta Turiello, Francesco Di Virgilio, Silvana Morello, Elena Adinolfi
Summary: The study reveals that in the absence of host P2X7R, A2AR promotes tumor growth through immune suppression and neovascularization. This highlights the crucial interaction between P2X7R and A2AR in the tumor microenvironment, providing insights for the development of new combination therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Pavlina Chuntova, Yafei Hou, Ryosuke Naka, Akane Yamamichi, Tiffany Chen, Yitzhar Goretsky, Ryusuke Hatae, Takahide Nejo, Gary Kohanbash, Abigail L. Mende, Megan Montoya, Kira M. Downey, David Diebold, Jayne Skinner, Hong-Erh Liang, Bjoern Schwer, Hideho Okada
Summary: This study developed a new transgenic mouse model, which can be used to address clinically relevant questions and develop future immunotherapeutic strategies.
Article
Biochemistry & Molecular Biology
Michela Pecoraro, Stefania Marzocco, Ada Popolo
Summary: This study demonstrates a cooperative relationship between mCx43 and K-ATP channels in inducing cytoprotection in cardiomyocytes under hypoxic conditions. The presence of mCx43 is essential for the protective effects of diazoxide, an opener of K-ATP channels, against CoCl2-induced mitochondrial damage. These findings highlight the close functional link between mCx43 and K-ATP channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Donatella Malanga, Carmelo Laudanna, Teresa Mirante, Fabiana Colelli, Simona Migliozzi, Pietro Zoppoli, Gianluca Santamaria, Luca Roberto, Carmela De Marco, Marzia Scarfo, Donatella Montanaro, Orlando Paciello, Serenella Papparella, Chiara Mignogna, Alfonso Baldi, Giuseppe Viglietto
Summary: The gain-of-function mutation AKT1E17K is demonstrated to be a bona fide oncogene for mammary epithelium, capable of efficiently initiating breast cancer in mice. The AKT1E17K strain may serve as an appropriate model for human basal-like breast cancer and may aid in the identification of novel therapies specific to this type of tumor.
Review
Cell Biology
Hua-Qian Yang, Fabio A. Echeverry, Assmaa ElSheikh, Ivan Gando, Sophia Anez Arredondo, Natalie Samper, Timothy Cardozo, Mario Delmar, Show-Ling Shyng, William A. Coetzee
Summary: Sarcolemmal/plasmalemmal ATP-sensitive K+ (K-ATP) channels play crucial roles in various cell types and tissues. Recent studies have highlighted that the surface expression of K-ATP channels is tightly regulated and has significant implications in both health and disease.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alejandro Moreno-Dominguez, Patricia Ortega-Saenz, Lin Gao, Olalla Colinas, Paula Garcia-Flores, Victoria Bonilla-Henao, Julian Aragones, Maik Huttemann, Lawrence I. Grossman, Norbert Weissmann, Natascha Sommer, Jose Lopez-Barneo
Review
Physiology
Rong M. Zhang, Kyle P. McNerney, Amy E. Riek, Carlos Bernal-Mizrachi
Summary: Studies have shown that immune cell infiltration and chronic inflammation play a critical role in the development of hypertension and its complications. Depletion of immune cells can improve endothelial function, reduce oxidative stress, lower vascular tone, and prevent kidney damage, indicating potential novel antihypertensive therapies through understanding immune cell functioning.
Editorial Material
Biochemistry & Molecular Biology
James C. Fleet, Carlos Bernal-Mizrachi, Martin Hewison, Rolf Jorde, John White, Margherita Cantorna, Inez Schoenmakers, Reinhold Erben
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Emily A. Scarborough, Keita Uchida, Maria Vogel, Noa Erlitzki, Meghana Iyer, Sai Aung Phyo, Alexey Bogush, Izhak Kehat, Benjamin L. Prosser
Summary: Cardiac remodeling is triggered by hypertension, exercise, and pregnancy, and mainly occurs through hypertrophy of individual cardiomyocytes. Microtubules play a crucial role in cardiac growth by controlling the spatiotemporal translation machinery and distributing mRNA and ribosomes to specific locations within cardiomyocytes during hypertrophic stimulation. Disruption of the microtubule network leads to mislocalized protein synthesis, degradation of new proteins, and inhibition of growth, highlighting the importance of properly localized translation for cardiac hypertrophy.
NATURE COMMUNICATIONS
(2021)
Review
Physiology
Keita Uchida, Emily A. Scarborough, Benjamin L. Prosser
Summary: Microtubules are essential cytoskeletal elements that regulate various cellular functions in eukaryotic cells. In cardiomyocytes, microtubules play canonical roles in trafficking and positioning of molecules and organelles, as well as noncanonical roles in regulating myocyte mechanics and mechanotransduction. Dysregulation of microtubule remodeling is associated with cardiovascular diseases and contributes to contractile dysfunction.
ANNUAL REVIEW OF PHYSIOLOGY
(2022)
Article
Cell Biology
Sai Aung Phyo, Keita Uchida, Christina Yingxian Chen, Matthew A. Caporizzo, Kenneth Bedi, Joanna Griffin, Kenneth Margulies, Benjamin L. Prosser
Summary: This study investigates the transcriptional, autoregulatory, and post-translational mechanisms that contribute to microtubule network remodeling in different stages of heart disease using heart failure patient samples and murine models. The study reveals the operability of autoregulation across tubulin isoforms in the heart and the rapid induction of microtubule detyrosination after hypertrophic stimulus. It provides insights into the rapid rewriting of the tubulin code and the tunable autoregulation of tubulin during pathological progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Vasiliki Courelli, Keita Uchida, Alexia Vite, Benjamin Prosser, Kenneth Margulies, Michael Ibrahim
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Keita Uchida, Emily Scarborough, Jennifer Petrosino, Benjamin Prosser
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Emily Scarborough, Keita Uchida, Izhak Kehat, Benjamin Prosser
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Alice Whitley, Benjamin Prosser, Keita Uchida, Andrew Trafford, Katharine Dibb
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Luciani, Mauro Montalbano, Luca Troncone, Camilla Bacchin, Keita Uchida, Gianlorenzo Daniele, Bethany Jacobs Wolf, Helen M. Butler, Justin Kiel, Stefano Berto, Cortney Gensemer, Kelsey Moore, Jordan Morningstar, Thamonwan Diteepeng, Onder Albayram, Jose F. Abisambra, Russell A. Norris, Thomas G. Di Salvo, Benjamin Prosser, Rakez Kayed, Federica del Monte
Summary: This study found that Tau protein is expressed and aggregates in the heart tissue of patients with heart failure and Alzheimer's disease. Furthermore, monoclonal antibody therapy can improve heart function and clear toxic aggregates, suggesting that Tau may be a potential target for heart failure treatment.
EUROPEAN HEART JOURNAL
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Vasiliki Courelli, Keita Uchida, Alexia Vite, Benjamin Prosser, Kenneth B. Margulies, Michael Ibrahim
Meeting Abstract
Cardiac & Cardiovascular Systems
Jonathan Edwards, Keita Uchida, Nora Yucel, Emily Scarborough, Jeff Brandimarto, Yifan Yang, Li Li, Spencer Williams, Benjamin Prossser, Zolt Arany
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Jonathan J. Edwards, Keita Uchida, Swapnil V. Shewale, Nora Yucel, Emily A. Scarborough, Yifan Yang, Li Li, Benjamin Prosser, Zoltan Arany
CIRCULATION RESEARCH
(2021)
Meeting Abstract
Biophysics
Keita Uchida, Emily Scarborough, Maria Vogel, Benjamin L. Prosser, Izhak Kehat
BIOPHYSICAL JOURNAL
(2021)