Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Environmental Sciences
Arijit Chakraborty, Soma Ghosh, Bratisha Biswas, Sreemanta Pramanik, Jerome Nriagu, Subhamoy Bhowmick
Summary: Arsenic exposure can cause harmful epigenetic alterations, leading to various health complications. This review summarizes the mechanisms underlying arsenic-induced epigenetic changes and proposes therapeutic strategies to alleviate the global burden of arsenic poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Cell Biology
Jack Crouch, Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Vladimir Botchkarev, Daniel Roh
Summary: Senescence is a complex cellular stress response that leads to loss of proliferative capacity and changes in secretory pattern. Transcriptional regulation of multiple genes and epigenetic alterations to DNA and chromatin play crucial roles in the induction and maintenance of senescence. This review highlights the changes in chromatin, DNA methylation, histone alterations, and the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
Review
Genetics & Heredity
Jinkun Xia, Wangsen Cao
Summary: Studies show that epigenetic modifications affect the Klotho gene in renal diseases, impacting disease progression. Lowered Klotho levels worsen the condition, but beneficial changes can be made through epigenetic interventions.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Oncology
Junyuan Xie, Li Gan, Bingjian Xue, Xinxing Wang, Xinhong Pei
Summary: Breast cancer remains the leading cause of cancer-related death in women worldwide. Non-coding RNAs, especially lncRNAs, have been found to play important roles in breast cancer. The study of epigenetic modifications has also contributed to the understanding of the role of ncRNAs in breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Immunology
Liangjie Xu, Cuicui Zhou, Yi Liang, Tinpan Fan, Fen Zhang, Xinxin Chen, Wei Yuan
Summary: This article reviews the interaction between epigenetic modifications and the functions of myeloid-derived suppressor cells (MDSCs), and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modifications impact disease development, providing a promising therapeutic strategy for related disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Qian Xiang, Yongzhao Zhao, Jialiang Lin, Shuai Jiang, Weishi Li
Summary: This study systematically discusses the different epigenetic modifications and their potential functions in the process of spinal ligament aging.
AGEING RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Ashby J. Morrison
Summary: Cellular adaptation to nutrient environment is crucial for survival, failure to adapt can result in cell death and diseases. Metabolism alterations, particularly in cancer cells, play a significant role in the pathogenesis of diseases. Recent studies have shown the interplay between metabolic pathways, epigenetic modifications, and transcriptional regulation in cancer cells.
Review
Pharmacology & Pharmacy
Roberta Giordo, Anna Maria Posadino, Arduino Aleksander Mangoni, Gianfranco Pintus
Summary: An intricate interplay between genetic and environmental factors contributes to the development of type 2 diabetes (T2D) and its complications. Metformin, a derivative of biguanide, exerts pleiotropic effects through multiple epigenetic modifications, which are reported in various organs, tissues, and cellular compartments. This review discusses the emerging evidence regarding metformin-mediated epigenetic modifications, their significance, potential applications, and future research directions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Immunology
Min Mao, Shasha Song, Xin Li, Jiayao Lu, Jie Li, Weifang Zhao, Hanmin Liu, Jingxin Liu, Bin Zeng
Summary: Pulmonary hypertension is a global threat to public health characterized by pulmonary arterial remodeling, increased pulmonary vascular resistance, right ventricular failure, and premature death. Autophagy, a self-digestion process involving autophagy-related proteins, has been found to play important roles in various diseases, including pulmonary hypertension. While the components of autophagy have been well studied, the molecular basis for the epigenetic regulation of autophagy is still not well understood but has gained increasing attention in recent years. This review discusses the current research progress on epigenetic modifications in the autophagic process and their potential as therapeutic targets for pulmonary hypertension.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hui Liu, Huimin Ma, Yang Li, Hua Zhao
Summary: This article reviews the current research status of epigenetic modifications in cervical cancer, including DNA methylation, histone modification, noncoding RNA regulation, and chromatin regulation. The functions and molecular mechanisms of these modifications in the occurrence and progression of cervical cancer are also discussed. This review provides new ideas for early screening, risk assessment, molecular targeted therapy, and prognostic prediction of cervical cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Physics, Multidisciplinary
Raphael Paul, Abdellah Khodja, Andreas Fischer, Robin Masser, Karl Heinz Hoffmann
Summary: This study focuses on optimizing the piston motion of an alpha-Stirling engine to improve its performance in the presence of mechanical friction. By using a low-effort endoreversible Stirling engine model and an indirect iterative gradient method, the research shows the potential improvements in performance.
Editorial Material
Gastroenterology & Hepatology
Andreas Fischer, Burcin Ozdirik, Dominik Geisel, Thomas Malinka, Stefan Pahl
Article
Biochemistry & Molecular Biology
Christoph Koeppl, Nico Lingg, Andreas Fischer, Christina Kroess, Julian Loibl, Wolfgang Buchinger, Rainer Schneider, Alois Jungbauer, Gerald Striedner, Monika Cserjan-Puschmann
Summary: Fusion protein technologies are widely used in biopharmaceutical applications, but they may have negative consequences such as reduced product yield and unwanted changes in expression levels. In this study, we evaluated different N-terminal fusion tag combinations to find an ideal design for a generic fusion tag. The CASPON-tag, a combination of a negatively charged peptide tag, affinity tags, and a caspase-2 cleavage site, showed good performance in enhancing soluble expression and could be efficiently removed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Computer Science, Artificial Intelligence
Christian Abbet, Linda Studer, Andreas Fischer, Heather Dawson, Inti Zlobec, Behzad Bozorgtabar, Jean -Philippe Thiran
Summary: This article introduces a method called Self-Rule to Multi-Adapt (SRMA) that uses self-supervised learning for domain adaptation. The method effectively transfers discriminative knowledge from a few labeled source domain data to a new target domain without requiring fully-labeled source datasets. By capturing visual similarity with intra-domain and cross-domain self-supervision, our method harnesses the structures of both domains. We show that our method outperforms baselines for domain adaptation in single and multi-source settings and validate it on an in-house clinical cohort.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Computer Science, Information Systems
Andreas Fischer, Benny Fuhry, Joern Kussmaul, Jonas Janneck, Florian Kerschbaum, Eric Bodden
Summary: Encrypting data before sending it to the cloud ensures data confidentiality, but vulnerabilities in executed programs give attackers opportunities to leak secrets via SGX side channels. This study introduces the concept of dataflow authentication (DFAuth) to prevent arbitrary modification of program dataflow, providing protection against side-channel attacks. Two flavors of DFAuth were implemented and applied successfully to neural networks and a smart charging scheduler.
ACM TRANSACTIONS ON PRIVACY AND SECURITY
(2022)
Article
Instruments & Instrumentation
Richard Ciesielski, Leonhard M. Lohr, Analia Fernandez Herrero, Andreas Fischer, Alexander Grothe, Heiko Mentzel, Frank Scholze, Victor Soltwisch
Summary: The semiconductor industry requires constant upgrading of metrological methods and equipment to accommodate smaller and more complex nanostructures. Nanometrology plays a crucial role in accurately determining the structural features and elemental composition of nanoscale gratings. Scatterometry and X-ray fluorescence in the soft X-ray and extreme ultraviolet spectral ranges are ideal for this task. This study introduces a new compact measurement chamber that can simultaneously detect the elastically scattered signal and the fluorescence of nanoscale grating samples.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2023)
Article
Biochemistry & Molecular Biology
Philipp Bengel, Manar Elkenani, Bo E. Beuthner, Maik Pietzner, Belal A. Mohamed, Beatrix Pollok-Kopp, Ralph Kraetzner, Karl Toischer, Miriam Puls, Andreas Fischer, Lutz Binder, Gerd Hasenfuss, Moritz Schnelle
Summary: Severe aortic stenosis (AS) is a common pathological condition in an ageing population imposing significant morbidity and mortality. Little is known about the metabolic changes in different hemodynamic conditions of AS, and this study aimed to investigate the metabolomic profiles of different AS subtypes.
Article
Engineering, Multidisciplinary
Karine Arrhenius, Lorena Francini, Andreas Fischer, Oliver Buker, Laurent Garcia Arques
Summary: In this study, the performances of a custom-built optical feedback cavity enhanced absorption spectroscopy (OFCEAS) instrument were evaluated for the determination of energy gases composition. The comparison with gas chromatographic method showed that the OFCEAS measurement technique can measure both main components and trace components with a 2% measurement uncertainty. The OFCEAS method has the advantages of fast response, no daily calibration requirement, and online implementation.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Lena Wiedmann, Francesca De Angelis Rigotti, Nuria Vaquero-Siguero, Elisa Donato, Elisa Espinet, Iris Moll, Elisenda Alsina-Sanchis, Hanibal Bohnenberger, Elena Fernandez-Florido, Ronja Muelfarth, Margherita Vacca, Jennifer Gerwing, Lena-Christin Conradi, Philipp Stroebel, Andreas Trumpp, Carolin Mogler, Andreas Fischer, Juan Rodriguez-Vita
Summary: The presence of peritoneal metastasis in pancreatic cancers is associated with poor prognosis. The authors found that HAPLN1 promotes tumor cell plasticity and pro-tumoral immune microenvironment to facilitate peritoneal dissemination in pancreatic cancers.
NATURE COMMUNICATIONS
(2023)
Article
Mathematics
Andreas Fischer, Igor Litvinchev, Tetyana Romanova, Petro Stetsyuk, Georgiy Yaskov
Summary: This paper explores the optimized packing of different spheres into a given spherical container under non-standard placement conditions. The packing aims to maximize the total number of packed spheres subject to ratio, partial overlapping, and quasi-containment conditions. A nonlinear mixed-integer optimization model is proposed for this problem, and a heuristic algorithm is developed. Computational results for finding global solutions for small instances and good feasible solutions for large instances are provided.
Article
Psychology, Multidisciplinary
Andre Bittermann, Andreas Fischer
ZEITSCHRIFT FUR PSYCHOLOGIE-JOURNAL OF PSYCHOLOGY
(2023)
Article
Materials Science, Ceramics
Uwe Scheithauer, Tetyana Romanova, Oleksandr Pankratov, Eric Schwarzer-Fischer, Martin Schwentenwein, Florian Ertl, Andreas Fischer
Summary: Thanks to additive manufacturing (AM) processes, components with complex geometries can now be flexibly produced. However, AM technologies have only been widely used in limited industrial applications due to high manufacturing costs. This study presents a new approach for optimizing component arrangement in order to reduce manufacturing costs. An example is used to demonstrate a 70% increase in the number of components on a building platform or a 44% reduction in the number of building platforms needed. A three-step method is proposed for automatic optimization of manufacturing preparation for AM components in the future.
CERAMICS-SWITZERLAND
(2023)
Article
Computer Science, Cybernetics
T. E. Romanova, P. I. Stetsyuk, A. Fischer, G. M. Yaskov
Summary: The paper explores the packing problem of circles in a circular container, considering pseudo-inclusion and proportionality conditions. A mathematical model is developed as a mixed integer nonlinear programming problem. A heuristic algorithm is proposed to maximize the total number of circles in the container by optimizing their variable radii. Computational experiments are conducted to validate the approach.
CYBERNETICS AND SYSTEMS ANALYSIS
(2023)
Meeting Abstract
Oncology
Lena Wiedmann, Francesca De Angelis Rigotti, Nuria Vaquero-Siguero, Elisa Donato, Elisa Espinet, Andreas Trumpp, Andreas Fischer, Juan Rodriguez-Vita
Meeting Abstract
Oncology
Ronja Muelfarth, Elisenda Alsina-Sanchis, Iris Moll, Sarah Boehn, Adrian Stoegbauer, Francesca De Angelis Rigotti, Lena Wiedmann, Jacqueline Taylor, Andreas Fischer, Juan Rodriguez Vita
