Current status of viral expression systems in plants and perspectives for oral vaccines development

Immunological aspects of using plant cells as delivery vehicles for oral vaccines

(2014) Sergio Rosales-Mendoza et al.   Expert Review of Vaccines

Challenges in mucosal vaccines for the control of infectious diseases

(2014) T. Azegami et al.   INTERNATIONAL IMMUNOLOGY

A novel mucosal vaccine targeting Peyer’s patch M cells induces protective antigen-specific IgA responses

(2014) Hideaki Shima et al.   INTERNATIONAL IMMUNOLOGY

Design and construction of an in-plant activation cassette for transgene expression and recombinant protein production in plants

(2014) Benjamin Dugdale et al.   Nature Protocols

M cell-targeting strategy facilitates mucosal immune response and enhances protection against CVB3-induced viral myocarditis elicited by chitosan-DNA vaccine

(2014) Ting Ye et al.   VACCINE

Modern Subunit Vaccines: Development, Components, and Research Opportunities

(2013) Peter Michael Moyle et al.   ChemMedChem

Is An Oral Plant-based Vaccine against Hepatitis B Virus Possible?

(2013) Tomasz Pniewski   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Application of an M-cell-targeting ligand for oral vaccination induces efficient systemic and mucosal immune responses against a viral antigen

(2013) Sae-Hae Kim et al.   INTERNATIONAL IMMUNOLOGY

Mutation of a Short Variable Region in HCpro Protein of Potato virus A Affects Interactions with a Microtubule-Associated Protein and Induces Necrotic Responses in Tobacco

(2013) Tuuli Haikonen et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Geminiviruses: masters at redirecting and reprogramming plant processes

(2013) Linda Hanley-Bowdoin et al.   NATURE REVIEWS MICROBIOLOGY

In Plant Activation: An Inducible, Hyperexpression Platform for Recombinant Protein Production in Plants

(2013) B. Dugdale et al.   PLANT CELL

Recombinant Therapeutic Protein Vaccines

(2013) Satoshi Ohtake et al.   PROTEIN AND PEPTIDE LETTERS

Safety and immunogenicity of a plant-produced recombinant monomer hemagglutinin-based influenza vaccine derived from influenza A (H1N1)pdm09 virus: A Phase 1 dose-escalation study in healthy adults

(2013) James F. Cummings et al.   VACCINE

Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells

(2012) Kwang-Chul Kwon et al.   ADVANCED DRUG DELIVERY REVIEWS

Plant-produced recombinant influenza vaccine based on virus-like HBc particles carrying an extracellular domain of M2 protein

(2012) N. V. Ravin et al.   BIOCHEMISTRY-MOSCOW

Transient expression of Human papillomavirus type 16 L2 epitope fused to N- and C-terminus of coat protein of Potato virus X in plants

(2012) Noemi Cerovska et al.   JOURNAL OF BIOSCIENCES

Comparative analysis of recombinant Human Papillomavirus 8 L1 production in plants by a variety of expression systems and purification methods

(2012) Slavica Matić et al.   PLANT BIOTECHNOLOGY JOURNAL

Plant virus expression vectors set the stage as production platforms for biopharmaceutical proteins

(2012) Kathleen Laura Hefferon   VIROLOGY

Co-expression of multiple target proteins in plants from a tobacco mosaic virus vector using a combination of homologous and heterologous subgenomic promoters

(2011) Gourgopal Roy et al.   ARCHIVES OF VIROLOGY

A human papillomavirus 8 E7 protein produced in plants is able to trigger the mouse immune system and delay the development of skin lesions

(2011) Emanuela Noris et al.   ARCHIVES OF VIROLOGY

Efficient production of chimeric Human papillomavirus 16 L1 protein bearing the M2e influenza epitope in Nicotiana benthamiana plants

(2011) Slavica Matić et al.   BMC BIOTECHNOLOGY

Clinical development of plant-produced recombinant pharmaceuticals: Vaccines, antibodies and beyond

(2011) Vidadi Yusibov et al.   Human vaccines & immunotherapeutics

A plant-based system for rapid production of influenza vaccine antigens

(2011) Yoko Shoji et al.   Influenza and Other Respiratory Viruses

Robust production of virus-like particles and monoclonal antibodies with geminiviral replicon vectors in lettuce

(2011) Huafang Lai et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression of a recombinant chimeric protein of hepatitis A virus VP1-Fc using a replicating vector based on Beet curly top virus in tobacco leaves and its immunogenicity in mice

(2011) Ho Yong Chung et al.   PLANT CELL REPORTS

High-level recombinant protein expression in transgenic plants by using a double-inducible viral vector

(2011) S. Werner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical and Clinical Development of Plant-Made Virus-Like Particle Vaccine against Avian H5N1 Influenza

(2010) Nathalie Landry et al.   PLoS One

Non-toxic derivatives of LT as potent adjuvants

(2010) Vanusa P. da Hora et al.   VACCINE

A DNA replicon system for rapid high-level production of virus-like particles in plants

(2009) Zhong Huang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Production and characterization of an orally immunogenicPlasmodiumantigen in plants using a virus-based expression system

(2009) Diane E. Webster et al.   PLANT BIOTECHNOLOGY JOURNAL

High level protein expression in plants through the use of a novel autonomously replicating geminivirus shuttle vector

(2009) Guy L. Regnard et al.   PLANT BIOTECHNOLOGY JOURNAL

Geminivirus strain demarcation and nomenclature

(2008) C. M. Fauquet et al.   ARCHIVES OF VIROLOGY

Expression of HIV-1 antigens in plants as potential subunit vaccines

(2008) Ann Meyers et al.   BMC BIOTECHNOLOGY

A plant-produced influenza subunit vaccine protects ferrets against virus challenge

(2008) Vadim Mett et al.   Influenza and Other Respiratory Viruses

High-yield rapid production of hepatitis B surface antigen in plant leaf by a viral expression system

(2008) Zhong Huang et al.   PLANT BIOTECHNOLOGY JOURNAL

An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles

(2008) Luca Santi et al.   VACCINE

Transient expression of HPV16 E7 peptide (aa 44–60) and HPV16 L2 peptide (aa 108–120) on chimeric potyvirus-like particles using Potato virus X-based vector

(2007) Noemi Čeřovská et al.   PROTEIN EXPRESSION AND PURIFICATION