Article
Agriculture, Dairy & Animal Science
Myles J. Shepherd, Lisa A. Herickhoff
Summary: This study identified important factors that affect post-thaw sperm quality in boar sperm cryopreservation using the efficient Plackett-Burman experimental design method, including glycerol concentration, cooling rate, antioxidant supplementation, and straw size.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Priyashini Dhaver, Brett Pletschke, Bruce Sithole, Roshini Govinden
Summary: Xylanases are hydrolytic enzymes used in various industries. This study optimized the culture conditions and medium components for xylanase production from Trichoderma harzianum using experimental strategies. The optimal condition for xylanase production was found to be a 6-day fermentation at 70 degrees C, pH 5.0, agitation at 160 rpm, with the addition of wheat bran and ammonium sulphate. The xylanase exhibited acid-thermostability and substrate specificity for beechwood xylan.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Ana Virginia Filgueiras, Jesus Gago, Ines Garcia, Victor Manuel Leon, Lucia Vinas
Summary: This study optimized the procedure for extracting microplastics from marine sediments, with the Plackett-Burman design revealing sediment mass and agitation time as the most significant variables.
MARINE POLLUTION BULLETIN
(2021)
Article
Materials Science, Ceramics
Xiurong Guo, Wenjun Jiang, Danfeng Du, Xiujie Shang
Summary: Modified wood ceramic is a carbon-carbon composite material obtained by calcining pine wood in a nitrogen atmosphere using montmorillonite and magnesium chloride as modifiers. The experimental results showed that the filling weight, mass ratios, and heating rate significantly influenced the comprehensive performance of the modified wood ceramics. The structure and properties of the modified wood ceramics were determined using various analytical techniques.
CERAMICS INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Shoriya Aruni Abdul Manaf, Siti Fatimah Zaharah Mohamad Fuzi, Kheng Oon Low, Gurumurthy Hegde, Nor Hasmaliana Abdul Manas, Rosli Md Illias, Kim Seng Chia
Summary: Carbon nanomaterials have the potential to increase xylanase production as cell immobilization supports, and pre-treating them with hydrochloric acid and glutaraldehyde can enhance cell immobilization performance. Factors such as cell loading and agar concentration significantly impact xylanase production with low cell leakage.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thaisa Cardoso de Oliveira, Antonia Carla de Jesus Oliveira, Yuri Basilio Gomes Patriota, Luise Lopes Chaves, Fabio de Oliveira Silva Ribeiro, Regina C. M. de Paula, Edson Cavalcanti Silva-Filho, Durcilene Alves da Silva, Monica Felts de La Roca Soares, Jose Lamartine Soares-Sobrinho
Summary: A new hydrophobic polymer based on angico gum (AG) was developed, and new nanoparticles were produced to expand the applications of natural polysaccharides in nanomedicine. By utilizing Plackett-Burman's experimental design, nanoparticles with different characteristics were successfully produced. NVP-loaded PAG nanoparticles showed significant promotion of drug release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Medicinal
Rania M. Yehia, Dalia A. Attia, Mohamed M. Elmazar, Mohamed A. El-Nabarawi, Mahmoud H. Teaima
Summary: This study investigated the use of microsponges as a carrier system for the drug Adapalene. The Plackett-Burman design was employed to identify key variables affecting the formulation of ADA-MS, with significant effects found for drug percentage, polymer type, and surfactant concentration. Furthermore, ADA-MS exhibited significant cytotoxicity against cell lines and enhanced antimicrobial activity.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Automation & Control Systems
Javad Zolgharnein, Saeideh Dermanaki Farahani
Summary: In this research, a new high yield solvothermal method was used to synthesize a calcium-terephthalate metal-organic framework as an efficient adsorbent for copper(II) removal from aqueous solutions. Experimental designs and optimization approaches were applied to investigate the adsorption process, and the maximum uptake capacity of copper(II) was achieved under the optimum conditions. Additionally, various analyses were conducted to study the chemical and crystal structure of the synthesized compound, as well as the kinetics, isotherms, thermodynamics, and desorption properties.
JOURNAL OF CHEMOMETRICS
(2023)
Article
Polymer Science
Thais Maria Alves Marinho, Vinicius Silva Pontes, Jose Daniel Diniz Melo, Maria Carolina Burgos Costa
Summary: This study prepared poly (urea-formaldehyde) microcapsules by in situ polymerization and evaluated the effects of seven input variables on the properties of the microcapsules. The results showed that stirring speed and emulsifier amount had the most significant effects on the properties of the microcapsules.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Chemistry, Inorganic & Nuclear
Saeideh Dermanaki Farahani, Javad Zolgharnein
Summary: In this study, a new efficient adsorbent, barium-terephthalate metal-organic framework (Ba(BDC)), was synthesized and used to remove sulfate ions from water. The synthesis process involved the use of terephthalate ligand recovered from PET waste. The chemical and crystal structure of Ba(BDC) was analyzed using various techniques. Experimental design optimization approach and regression model were used to find the optimum conditions for maximum removal of sulfate ions. Additionally, kinetics, isotherms, and thermodynamics studies were conducted to provide a comprehensive understanding of the adsorption process.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Chun-ming Ai, Ping-ping Sun, Dan Zhao, Xiao-zhi Mu
Summary: In this study, microbial desulfurization technology was used to reduce the sulfur content in coal and reduce the risk of spontaneous combustion during storage and transportation. By optimizing the conditions and determining the main factors, the desulfurization effect was studied and predicted.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Xiaohan Li, Hui Xu, Fengmao Liu, Qingrong Peng, Fei Chen, Yangyang Guo
Summary: The study evaluated the effect of five factors on the removal of triadimefon and boscalid from rape by ultrasonic washing through Plackett-Burman design. It found that changing pH of water, cleaning time, water volume and temperature during the washing process can improve the removal rate of the two pesticides residue. This research provides a reference for ultrasonic cleaning conditions by a sink dishwasher and positively impacts food safety.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Physical
Franciele Pereira Camargo, Isabel Kimiko Sakamoto, Ariane Bize, Iolanda Cristina Silveira Duarte, Edson Luiz Silva, Maria Bernadete Amancio Varesche
Summary: Different conditions for obtaining H2 from Citrus Peel Waste were evaluated, with pH 8.5, allochthonous inoculum of 3 gTVS.L-1, and substrate concentration of 15 g CPW.L-1 found to be the most significant factors for higher H2 and acetic acid production. Escherichia and Clostridium were the main genera identified under these conditions.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Energy & Fuels
Anthony E. Ciriaco, Sadiq J. Zarrouk, Anthony Downward, Julian McDowell, Warren Mannington
Summary: This study explores an alternative method for probabilistic MWe estimation using experimental design and response surface methodology. The results suggest that the method is feasible, as the simulated MWe potential from the two experimental design models are similar and the polynomial model based on the ED framework accurately predicts the actual production capacity. These findings further indicate that the 353 MWe power generation could be sustainable for the next 40 years at least.
Article
Engineering, Chemical
Xiaoyu Li, Yuefeng Du, Lei Liu, Yanan Zhang, Dafang Guo
Summary: In this study, simulation tests of corncob calibration parameters were conducted based on the discrete element model. The results demonstrated the reliability of parameter calibration and offered a new method for establishing simulation models of corn ear and other materials.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Duyen H. T. Nguyen, Robert H. Utama, Kristel C. Tjandra, Panthipa Suwannakot, Eric Y. Du, Maria Kavallaris, Richard D. Tilley, J. Justin Gooding
Summary: This study develops a synthetic hydrogel with ionic cross-linking to rapidly create hydrogels. The mechanical stiffness of the hydrogel can be tuned by varying the number of charged ionic groups, the length of the polymer arms, and the polymer concentration. It is demonstrated as an extracellular matrix mimic for 3D in vitro cell models.
Article
Chemistry, Physical
Samuel V. Somerville, Peter B. O'Mara, Tania M. Benedetti, Soshan Cheong, Wolfgang Schuhmann, Richard D. Tilley, J. Justin Gooding
Summary: Enzymes with multiple active sites and control over the solution environment enable the formation of complex products from simple reactants. We mimic this concept using nanoparticles to facilitate the electro-chemical carbon dioxide reduction reaction. By altering the rate of CO2 delivery, the activity of the CO producing site, and the applied potential, we show that stable nanoparticles with lower CO formation activity can produce greater amounts of hydrocarbon products. This highlights the importance of the local solution environment and the stability of the catalyst in cascade reactions.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Multidisciplinary Sciences
Lucy Gloag, Agus R. Poerwoprajitno, Soshan Cheong, Zeno R. Ramadhan, Tadafumi Adschiri, J. Justin Gooding, Richard D. Tilley
Summary: In this study, hierarchical nanostructures with nanosized gold cores and nickel branches were successfully synthesized. The dimensions and morphology of these 3D structures were controlled by tuning in each synthetic step. These materials, which have high surface area, high conductivity, and surfaces that can be chemically modified, are ideal electrocatalyst supports. Coating with nickel-iron oxyhydroxide further enhanced their activity and stability for oxygen evolution reaction. This work introduces a synthetic concept to produce a new type of high-performing electrocatalyst support.
Article
Chemistry, Multidisciplinary
Samuel V. V. Somerville, Qinyu Li, Johanna Wordsworth, Sina Jamali, Mohammad Reza Eskandarian, Richard D. D. Tilley, J. Justin Gooding
Summary: Nanozymes mimic the selectivity of enzymes by utilizing features such as control over the arrangement of atoms in the active site and the placement of the active site down a nanoconfined substrate channel. The implementation of enzyme-inspired features has shown improvements in both activity and selectivity of nanoparticles for various catalytic and sensing applications. Controlled active sites on metal nanoparticle surfaces can be achieved through changing the composition of the surface metal or immobilizing single atoms on a metal substrate. Molecular frameworks and unique diffusional environments further enhance selectivity, while nanoconfined substrate channels offer additional control over selectivity through modifying the solution environment and transport of reactants and products.
ADVANCED MATERIALS
(2023)
Editorial Material
Chemistry, Analytical
Eric Bakker, Philippe Buhlmann, J. Justin Gooding, Robert E. Gyurcsanyi, Ernoe Pretsch
Article
Materials Science, Biomaterials
Panthipa Suwannakot, Stephanie Nemec, Newton Gil Peres, Eric Y. Du, Kristopher A. Kilian, Katharina Gaus, Maria Kavallaris, J. Justin Gooding
Summary: Synthetic hydrogels are widely used to mimic the extracellular matrix (ECM) and the physical and biochemical cues observed in natural ECM proteins. Researchers have developed an electrostatically crosslinked PEG-based hydrogel system to create high-throughput 3D in vitro models of the cancer environment. This hydrogel system can be degraded by breaking the interaction between oppositely charged polymer chains.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Analytical
Supatinee Kongkaew, Lingyin Meng, Warakorn Limbut, Guozhen Liu, Proespichaya Kanatharana, Panote Thavarungkul, Wing Cheung Mak
Summary: An innovative modular approach for designing and constructing flexible microfluidic biosensor platforms using a dry manufacturing craft-and-stick approach has been developed. The approach involves the design and fabrication of graphene paper electrode (GPE) units and polyethylene tetraphthalate sheet (PET)/adhesive fluidic units using an economic and generic xurographic craft approach. The assembled microfluidic integrated GPE (MF-iGPE) is flexible, thin (<0.5 mm), and lightweight (0.4 g). This modular craft-and-stick manufacturing approach has the potential to be used in low-resource laboratories or classroom settings.
Review
Chemistry, Multidisciplinary
Haoran Wang, Qiyao Li, Parvej Alam, Haotian Bai, Vandana Bhalla, Martin R. Bryce, Mingyue Cao, Chao Chen, Sijie Chen, Xirui Chen, Yuncong Chen, Zhijun Chen, Dongfeng Dang, Dan Ding, Siyang Ding, Yanhong Duo, Meng Gao, Wei He, Xuewen He, Xuechuan Hong, Yuning Hong, Jing-Jing Hu, Rong Hu, Xiaolin Huang, Tony D. James, Xingyu Jiang, Gen-ichi Konishi, Ryan T. K. Kwok, Jacky W. Y. Lam, Chunbin Li, Haidong Li, Kai Li, Nan Li, Wei-Jian Li, Ying Li, Xing-Jie Liang, Yongye Liang, Bin Liu, Guozhen Liu, Xingang Liu, Xiaoding Lou, Xin-Yue Lou, Liang Luo, Paul R. McGonigal, Zong-Wan Mao, Guangle Niu, Tze Cin Owyong, Andrea Pucci, Jun Qian, Anjun Qin, Zijie Qiu, Andrey L. Rogach, Bo Situ, Kazuo Tanaka, Youhong Tang, Bingnan Wang, Dong Wang, Jianguo Wang, Wei Wang, Wen-Xiong Wang, Wen-Jin Wang, Xinyuan Wang, Yi-Feng Wang, Shuizhu Wu, Yifan Wu, Yonghua Xiong, Ruohan Xu, Chenxu Yan, Saisai Yan, Hai-Bo Yang, Lin-Lin Yang, Mingwang Yang, Ying-Wei Yang, Juyoung Yoon, Shuang-Quan Zang, Jiangjiang Zhang, Pengfei Zhang, Tianfu Zhang, Xin Zhang, Xin Zhang, Na Zhao, Zheng Zhao, Jie Zheng, Lei Zheng, Zheng Zheng, Ming-Qiang Zhu, Wei-Hong Zhu, Hang Zou, Ben Zhong Tang
Summary: This review provides a comprehensive summary of the applications of aggregation-induced emission (AIE) luminogens in biological imaging, dynamic physiological processes, disease diagnosis and treatment, and specific analyte detection and monitoring. The review also discusses critical issues and future directions, aiming to promote the development of AIE in the fields of life and health.
Article
Biophysics
Ying Yang, Sanjun Fan, James A. Webb, Yuanqing Ma, Jesse Goyette, Xueqian Chen, Katharina Gaus, Richard D. Tilley, Justin Gooding
Summary: This study presents an electrochemical approach to reversible fluorescence switching of enhanced green fluorescent proteins (EGFP) on indium tin oxide coated glass. The method allows efficient switching between bright (ON) and dim (OFF) states at the single molecule level. The electrochemical fluorescence switching is fast, reversible, and can be incorporated into advanced fluorescence microscopy.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Daniel E. Hagness, Ying Yang, Richard D. Tilley, J. Justin Gooding
Summary: Affinity biosensors play a crucial role in various areas of human health, such as clinical diagnosis and pharmaceuticals, by utilizing specific binding between target analytes and biological ligands. Electrokinetic phenomena have been investigated as a viable option to improve the performance of affinity biosensors for higher sensitivity and lower detection limit.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Shixian Liu, Yuting Hou, Zirui Li, Chenyu Yang, Guozhen Liu
Summary: A fully integrated device for salivary detection, which operates in a sample-in-answer-out manner, is crucial for noninvasive point-of-care testing and screening of contagious diseases. This study developed a universal platform by integrating a centrifugal microfluidic disc with microfluidic paper-based analytical devices (mu PADs) for salivary diagnostics. The integrated device demonstrated high efficiency in saliva treatment and was able to detect the SARS-CoV-2 N protein with high specificity and comparable performance to commercial paper lateral flow assay test strips.
Editorial Material
Chemistry, Multidisciplinary
J. Justin Gooding, Jean-Francois Masson
Article
Cell Biology
Marina Ulanova, Lucy Gloag, Andre Bongers, Chul-Kyu Kim, Hong Thien Kim Duong, Ha Na Kim, John Justin Gooding, Richard D. Tilley, Joanna Biazik, Wei Wen, Perminder S. Sachdev, Nady Braidy, Alexander E. Kalyuzhny
Summary: Nanoparticle-based magnetic contrast agents have been developed for early non-invasive diagnosis of Alzheimer's disease (AD) using magnetic resonance imaging (MRI). This study developed a biocompatible magnetic nanoparticle targeted to amyloid beta (A beta) plaques to enhance the sensitivity of T2-weighted MRI for imaging of amyloid pathology in AD. The nanoparticles showed no significant cytotoxicity and were able to bind to amyloid species. The study provides promising preliminary results for the development of a targeted non-invasive method for early AD diagnosis using contrast-enhanced MRI.
Review
Chemistry, Analytical
Seyedyousef Arman, Richard D. Tilley, J. Justin Gooding
Summary: This article reviews the development of cellular impedance biosensors, electrochemical impedance spectroscopy, and the general principles and terms associated with the cell-electrode interface. This family of techniques provides real-time quantitative and sensitive information on cell responses to stimuli with high temporal resolution, and their applications in cell biology are illustrated with various examples. The current state of the field, its limitations, possible solutions, and the potential benefits of developing biosensors are discussed.
Correction
Chemistry, Multidisciplinary
Yan Liu, Guo-Zhen Liu, Xiao-Mao Li, Peng Jiang, Yong-Gang Xia, Hai-Xue Kuang, Bing-You Yang
CHINESE JOURNAL OF CHEMISTRY
(2023)