Oral delivery of Acid Alpha Glucosidase epitopes expressed in plant chloroplasts suppresses antibody formation in treatment of Pompe mice

Plant-based oral tolerance to hemophilia therapy employs a complex immune regulatory response including LAP+CD4+ T cells

(2015) X. Wang et al.   BLOOD

Gene therapy for hemophilia

(2015) Roland W. Herzog   Frontiers in Bioscience-Landmark

Exogenous sucrose supply changes sugar metabolism and reduces photosynthesis of sugarcane through the down-regulation of Rubisco abundance and activity

(2015) Ana Karla Moreira Lobo et al.   JOURNAL OF PLANT PHYSIOLOGY

Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cells

(2014) A. Sherman et al.   BLOOD

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

(2014) Y. C. Kim et al.   BLOOD

Peripheral nerve and neuromuscular junction pathology in Pompe disease

(2014) Darin J. Falk et al.   HUMAN MOLECULAR GENETICS

Oral Delivery of Angiotensin-Converting Enzyme 2 and Angiotensin-(1-7) Bioencapsulated in Plant Cells Attenuates Pulmonary Hypertension

(2014) Vinayak Shenoy et al.   HYPERTENSION

Enzyme therapy and immune response in relation to CRIM status: the Dutch experience in classic infantile Pompe disease

(2014) Carin M. van Gelder et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Oral Delivery of ACE2/Ang-(1–7) Bioencapsulated in Plant Cells Protects against Experimental Uveitis and Autoimmune Uveoretinitis

(2014) Pollob K Shil et al.   MOLECULAR THERAPY

Immunology: Oral solutions

(2014) Elie Dolgin   NATURE

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

Immune Responses and Hypercoagulation in ERT for Pompe Disease Are Mutation and rhGAA Dose Dependent

(2014) Sushrusha Nayak et al.   PLoS One

Development of gene transfer for induction of antigen-specific tolerance

(2014) Brandon K Sack et al.   Molecular Therapy-Methods & Clinical Development

Persistent Suppression of Type 1 Diabetes by a Multicomponent Vaccine Containing a Cholera Toxin B Subunit-Autoantigen Fusion Protein and Complete Freund’s Adjuvant

(2013) Béla Dénes et al.   Clinical & Developmental Immunology

B-Cell Depletion and Immunomodulation before Initiation of Enzyme Replacement Therapy Blocks the Immune Response to Acid Alpha-Glucosidase in Infantile-Onset Pompe Disease

(2013) Melissa E. Elder et al.   JOURNAL OF PEDIATRICS

Oral Delivery of Bioencapsulated Proteins Across Blood–Brain and Blood–Retinal Barriers

(2013) Neha Kohli et al.   MOLECULAR THERAPY

Mechanism of oral tolerance induction to therapeutic proteins

(2012) Xiaomei Wang et al.   ADVANCED DRUG DELIVERY REVIEWS

Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells

(2012) Kwang-Chul Kwon et al.   ADVANCED DRUG DELIVERY REVIEWS

Successful immune tolerance induction to enzyme replacement therapy in CRIM-negative infantile Pompe disease

(2012) Yoav H. Messinger et al.   GENETICS IN MEDICINE

Glycosylation-independent Lysosomal Targeting of Acid α-Glucosidase Enhances Muscle Glycogen Clearance in Pompe Mice

(2012) John A. Maga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping the T helper cell response to acid α-glucosidase in Pompe mice

(2012) Sushrusha Nayak et al.   MOLECULAR GENETICS AND METABOLISM

Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells

(2012) Kwang-Chul Kwon et al.   PLANT BIOTECHNOLOGY JOURNAL

Pompe disease gene therapy

(2011) B. J. Byrne et al.   HUMAN MOLECULAR GENETICS

Remodeling the isoprenoid pathway in tobacco by expressing the cytoplasmic mevalonate pathway in chloroplasts

(2011) Shashi Kumar et al.   METABOLIC ENGINEERING

Oral administration of recombinant human acid α-glucosidase reduces specific antibody formation against enzyme in mouse

(2011) T. Ohashi et al.   MOLECULAR GENETICS AND METABOLISM

Low-cost production of proinsulin in tobacco and lettuce chloroplasts for injectable or oral delivery of functional insulin and C-peptide

(2010) Diane Boyhan et al.   PLANT BIOTECHNOLOGY JOURNAL

The Role of Heterologous Chloroplast Sequence Elements in Transgene Integration and Expression

(2010) T. Ruhlman et al.   PLANT PHYSIOLOGY

Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice

(2010) D. Verma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimization of codon composition and regulatory elements for expression of human insulin like growth factor-1 in transgenic chloroplasts and evaluation of structural identity and function

(2009) Henry Daniell et al.   BMC BIOTECHNOLOGY

Cross-reactive immunologic material status affects treatment outcomes in Pompe disease infants

(2009) Priya S. Kishnani et al.   MOLECULAR GENETICS AND METABOLISM

Neural deficits contribute to respiratory insufficiency in Pompe disease

(2009) L. R. DeRuisseau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plant-made vaccine antigens and biopharmaceuticals

(2009) Henry Daniell et al.   TRENDS IN PLANT SCIENCE

A protocol for expression of foreign genes in chloroplasts

(2008) Dheeraj Verma et al.   Nature Protocols