Article
Multidisciplinary Sciences
Kaela M. Varberg, Khursheed Iqbal, Masanaga Muto, Mikaela E. Simon, Regan L. Scott, Keisuke Kozai, Ruhul H. Choudhury, John D. Aplin, Rebecca Biswell, Margaret Gibson, Hiroaki Okae, Takahiro Arima, Jay L. Vivian, Elin Grundberg, Michael J. Soares
Summary: Invasive trophoblast cells play a crucial role in placental development and pregnancy outcomes. ASCL2 is identified as a key regulator of invasive trophoblast cell lineage development in humans and rats. ASCL2 deficiency impairs EVT cell differentiation and impacts placental morphogenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Violeta Stojanovska, Susanne Arnold, Mario Bauer, Hermann Voss, Stefan Fest, Ana Claudia Zenclussen
Summary: This study characterized three different 3D cultures derived from trophoblast cell lines and compared them to primary fetal trophoblasts and placental tissue. The results showed that these 3D cell culture models exhibit similar functionality and gene expression profiles to primary placental tissue, making them ideal models for studying the placenta.
Article
Developmental Biology
Wei Zhou, Ellen Menkhorst, Evdokia Dimitriadis
Summary: This study identified the expression pattern of CLIC4 in the placenta and decidua, and revealed its association with trophoblast cell function and TGF beta signaling. Knockdown of CLIC4 led to increased cell adhesion, migration, and invasion, along with alterations in the expression of downstream targets of the TGF beta signaling pathway. These findings indicate an inhibitory role for CLIC4 in regulating trophoblast migration and invasion.
Article
Biochemistry & Molecular Biology
Xiaole Pan, Saki Noguchi, Misuzu Ando, Tomohiro Nishimura, Masatoshi Tomi
Summary: The study found that overexpression of miR-126 can inhibit the invasive ability of JEG-3 cells by targeting LIN28A, without affecting proliferation and migration. In addition, miR-126-mediated downregulation of LIN28A may contribute to the onset/deterioration of preeclampsia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Developmental Biology
Andreanna Burman, Rolando Garcia-Milian, Madeleine Wood, Natalie A. DeWitt, Vasilis Vasiliou, Seth Guller, Vikki M. Abrahams, Shannon Whirledge
Summary: The use of acetaminophen may interfere with critical trophoblast functions, potentially impacting fetal development.
Review
Endocrinology & Metabolism
Yongdan Ma, Yongyan Hu, Jingmei Ma
Summary: Placenta accreta spectrum disorder (PAS) is a disease characterized by abnormal invasion of the placenta into the myometrium and uterus. The understanding of its mechanisms and signaling pathways is limited due to the lack of suitable animal models. Mouse models, particularly those induced by uterine surgery, have been used to simulate different phenotypes of PAS and investigate its pathogenesis. This review summarizes the approaches of PAS modeling in mice and provides insight into the strengths, limitations, and future perspectives of each strategy.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Meiyuan Jin, Shouying Xu, Jiayong Li, Lu Li, Chao Tang
Summary: The study showed that ARID1A regulates trophoblast cell migration and invasion in human placenta by modulating Snail and MMP-9 proteins, suggesting a critical role in supporting healthy placental function.
REPRODUCTIVE SCIENCES
(2022)
Article
Cell Biology
Qian Yang, Yeling Ma, Yanlei Liu, Xuan Shao, Wentong Jia, Xin Yu, Yu-xia Li, Long Yang, Wenwen Gu, Haibin Wang, Jian Wang, Yan-Ling Wang
Summary: The study demonstrated the crucial role of MNSF beta in regulating trophoblast invasion and fetal development. Lack of MNSF beta led to restricted embryonic growth and fetal loss, primarily due to limited trophoblast invasion. Conjugation with IGF2BP2 stabilized the protein and promoted trophoblast invasion.
CELL PROLIFERATION
(2021)
Article
Immunology
Sainan Zhang, Jinli Ding, Jiayu Wang, Tailang Yin, Yan Zhang, Jing Yang
Summary: This study demonstrated for the first time that decreased expression of CXCL5 in human villous tissue is correlated with RSA. Additionally, it was found that estrogen, progesterone, human chorionic gonadotropin, and decidual stromal cells can regulate the expression of CXCL5 and chemokine receptor 2 (CXCR2) in trophoblast cells in a cell manner.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Piya Prajumwongs, Ratthaphong Phumphu, Orawan Waenphimai, Worachart Lert-itthiporn, Kulthida Vaeteewoottacharn, Sopit Wongkham, Yaovalux Chamgramol, Chawalit Pairojkul, Kanlayanee Sawanyawisuth
Summary: The study found that MPS1 plays a crucial role in the progression of CCA by promoting it through the AKT and STAT3 signaling pathways, making it a potentially attractive target for metastatic CCA treatment.
Article
Cell Biology
Danai Georgiadou, Souad Boussata, Remco Keijser, Dianta A. M. Janssen, Gijs B. Afink, Marie van Dijk
Summary: Mutations in the LINC-HELLP non-coding RNA (HELLPAR) are associated with familial forms of the pregnancy-specific HELLP syndrome, impacting EVT differentiation and the binding of RNA splicing complex proteins PCBP1, PCBP2, and YBX1 to LINC-HELLP. Knockdown of PCBP2, and to a lesser extent YBX1 and PCBP1, leads to failure of EVTs to differentiate towards an invasive phenotype. PCBP2 silencing alters splicing for genes related to cellular assembly, organization, function, maintenance, growth, proliferation, and the cell cycle, indicating its crucial role in EVT differentiation mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Limei Yang, Le Hu, Hongyu Tang, Xuemei Chen, Xueqing Liu, Yue Zhang, Yixian Wen, Yongxiu Yang, Yanqing Geng
Summary: Ti3C2 MXene exposure impairs villus explant extension ability and trophoblast cell functions by inhibiting cell migration and invasion abilities, and enhancing autophagy. Inhibition of autophagy may be a potential therapeutic strategy for alleviating nanoparticle-induced placental toxicity.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Developmental Biology
Juan F. Mejia, Parker Hall, Kelsey M. Hirschi, Paul R. Reynolds, Juan A. Arroyo
Summary: The PKM2 protein is associated with IUGR in placenta, and its activation can protect placental and fetal weights from decreasing. The expression and localization of PKM2 in trophoblast cells change under different oxygen levels.
Article
Immunology
Jinli Ding, Chaogang Yang, Yanxiang Cheng, Jiayu Wang, Sainan Zhang, Sisi Yan, Fan He, Tailang Yin, Jing Yang
Summary: The study demonstrates that trophoblasts induce M2 macrophages polarization via the IL-6/Stat3 signaling pathway, thereby promoting trophoblast invasion and migration. These results reveal the interaction between macrophages and trophoblasts in the maternal-fetal microenvironment during normal pregnancy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pediatrics
Elizabeth M. Kennedy, Karen Hermetz, Amber Burt, Dong Pei, Devin C. Koestler, Ke Hao, Jia Chen, Diane Gilbert-Diamond, Usha Ramakrishnan, Margaret R. Karagas, Carmen J. Marsit
Summary: Placental microRNAs are associated with early childhood growth trajectory and play a role in regulating placental cellular dynamics, impacting infant growth beyond birth.
PEDIATRIC RESEARCH
(2023)
Article
Nutrition & Dietetics
Li Wen, Huisheng Ge, Juan Qiao, Lan Zhang, Xuyang Chen, Mark D. Kilby, Ying Zhou, Jie Gan, Richard Saffery, Jianying Yan, Chao Tong, Hongbo Qi, Philip N. Baker
Article
Biochemistry & Molecular Biology
Yike Yang, Ping Xu, Fangyu Zhu, Jiujiang Liao, Yue Wu, Mingyu Hu, Huijia Fu, Juan Qiao, Li Lin, Biao Huang, Huili Jin, Xiyao Liu, Yangxi Zheng, Li Wen, Richard Saffery, Mark D. Kilby, Jianying Yan, Louise C. Kenny, Hongbo Qi, Chao Tong, Philip N. Bakerl
Summary: This study found that while MitoQ administration in late gestation could protect mice from hypertension and kidney damage induced by RUPP, it exacerbated the PE phenotype when given in early gestation, indicating the necessity of mild oxidative stress for trophoblast proliferation, invasion, and migration.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Obstetrics & Gynecology
Rui-Yuan Zhang, Lan Wang, Wei Zhou, Qi-Mei Zhong, Chao Tong, Ting Zhang, Ting-Li Han, Lian-Rong Wang, Xin Fan, Yan Zhao, Rui-Tu Ran, Yin-Yin Xia, Hong-Bo Qi, Hua Zhang, Tom Norris, Philip N. Baker, Richard Saffery
Summary: This study identified that visceral fat levels, bone minerals, and percent body fat measured before 17 weeks gestation were significantly associated with an increased risk of gestational diabetes mellitus (GDM) in Chinese pregnant women.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Youwen Mei, Jiaxiao Yu, Li Wen, Xin Fan, Yan Zhao, Jie Li, Juan Qiao, Huijia Fu, Pamela Leong, Richard Saffery, Qi Tong, Mark D. Kilby, Hongbo Qi, Chao Tong, Philip N. Baker
Summary: Gestational diabetes mellitus (GDM) has a greater impact on adverse perinatal outcomes and the risk of childhood overweight at 6 months for monochorionic diamniotic (MCDA) twin pregnancies compared to dichorionic diamniotic (DCDA) twin pregnancies. Twin offspring exposed to GDM had a higher risk of being overweight at 6 months of corrected age regardless of chorionicity.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Nutrition & Dietetics
Yue Wu, Jiaxiao Yu, Xiyao Liu, Wenling Wang, Zhi Chen, Juan Qiao, Xiaohui Liu, Huili Jin, Xin Li, Li Wen, Jing Tian, Richard Saffery, Mark D. Kilby, Hongbo Qi, Chao Tong, Philip N. Baker
Summary: The study found that GDM pregnancies are associated with alterations in the metabolome of human breast milk, with only a small subset of compounds being correlated with neonatal body weight.
CLINICAL NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Mingyu Hu, Ji Li, Philip N. Baker, Chao Tong
Summary: Preeclampsia is a major threat to the health of mothers and newborns worldwide, primarily due to placental metabolic abnormalities leading to placental dysfunction.
Review
Obstetrics & Gynecology
Xiyao Liu, Yu Wang, Yue Wu, Jing Zeng, Xi Yuan, Chao Tong, Hongbo Qi
Summary: Placenta accreta spectrum (PAS) is an umbrella term for a range of pregnancy complications caused by abnormal placental implantation, with increasing prevalence and significant clinical importance. Evidence-based data on PAS, including prevalence, risk factors, pathogenesis, clinical presentation, prenatal screening, and management, were reviewed, along with prospects for further research. A visualized workflow for PAS management was also introduced, covering three steps: predelivery, during delivery, and postdelivery.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Genetics & Heredity
Yang Yang, Li Wen, Ting-Li Han, Lan Zhang, Huijia Fu, Jie Gan, Richard Saffery, Chao Tong, Junnan Li, Hongbo Qi, Philip N. Baker, Mark D. Kilby
Summary: This study found significant metabolic differences in maternal plasma between TTTS patients and uncomplicated controls at 11-15 weeks of gestation, suggesting that metabolomics scanning could help identify pregnancies at risk of developing TTTS. Specifically, downregulated fatty acid levels may play a role in the pathogenesis of TTTS.
PRENATAL DIAGNOSIS
(2021)
Article
Obstetrics & Gynecology
Xin Li, Jiaxiao Yu, Li Wen, Qingshu Li, Jianying Yan, Jing Tian, Chao Tong, Qi Tong, Hongbo Qi, Richard Saffery, Mark D. Kilby, Philip N. Baker
Summary: The study indicates that twin neonates are at high risk of vitamin D deficiency, with a positive correlation between maternal and neonatal vitamin D levels. Higher maternal vitamin D levels are associated with smaller discordance of cotwin birthweight.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Cell Biology
Zhi Chen, Liling Xiong, Huili Jin, Jiaxiao Yu, Xin Li, Huijia Fu, Li Wen, Hongbo Qi, Chao Tong, Richard Saffery, Mark D. Kilby, Philip N. Baker
Summary: Reduced expression of alpha-Klotho in the placenta of advanced maternal age pregnancies may lead to premature senescence and loss of invasion, ultimately resulting in placental malformation and adverse perinatal outcomes.
Article
Environmental Sciences
Chunling Huang, Dan Wang, Na Li, Chengshun Yang, Xuemei Chen, Xueqing Liu, Junlin He, Yubin Ding, Chao Tong, Chuan Peng, Fangfang Li, Yingxiong Wang, Rufei Gao
Summary: Exposure to ethephon can potentially decrease sperm numbers and viability, as well as impact female reproduction during early pregnancy by altering endometrial decidualization process and reducing embryo implantation sites. High dose eth exposure in mice leads to decreased hormone levels, weakened decidual response, and altered gene expression related to triglyceride and fatty acid metabolism. The expression of GPR120 and its interaction with eth are critical for the impaired decidualization mediated via eth during early pregnancy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Huili Jin, Tengfei Shan, Sisi Li, Xin Fan, Yan Zhao, Jie Li, Xiqin Tang, Richard Saffery, Chao Tong, Li Wen, Hongbo Qi, Mark D. Kilby, Philip N. Baker
Summary: Feeding patterns have an impact on early growth indices, with breastfeeding associated with higher body fat mass and smaller weight gain.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Toxicology
Dan Wang, Weike Li, Chengshun Yang, Xuemei Chen, Xueqing Liu, Junlin He, Chao Tong, Chuan Peng, Yubin Ding, Yanqing Geng, Xianqing Cao, Fangfang Li, Rufei Gao, Yingxiong Wang
Summary: The study revealed that ethylparaben and propylparaben significantly affect endometrial decidualization in pregnant mice, leading to compromised embryo implantation. Exposure to high doses of ethylparaben and propylparaben resulted in increased levels of progesterone and estrogen, decreased expression of uterine hormone receptors, and ultimately impacted pregnancy outcomes.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Cell Biology
Liling Xiong, Xuan Ye, Zhi Chen, Huijia Fu, Sisi Li, Ping Xu, Jiaxiao Yu, Li Wen, Rufei Gao, Yong Fu, Hongbo Qi, Mark D. Kilby, Richard Saffery, Philip N. Baker, Chao Tong
Summary: SIRT1 is downregulated in AMA placentas, affecting cell function and migration, leading to premature senescence. SIRT1 promotes trophoblast epithelial-mesenchymal transition (EMT) by modulating vimentin acetylation.
Article
Public, Environmental & Occupational Health
Wenwu Gui, Xi Yang, Huimin Jiang, Hongwen Wu, Mao Zeng, Yidi Wen, Tian Qiu, Yong Zhang, Zhi Ma, Chao Tong, Li Luo, Yong Zhao, Lianlian Wang
Summary: With the implementation of China's two-child policy, anxiety among infertile women in China has shown a comparatively high prevalence. Low education levels, middle incomes, oral contraception use, and allergy history may be related risk factors for anxiety.
REPRODUCTIVE HEALTH
(2021)
