Article
Rheumatology
Julio Ramirez, Andrea Cuervo, Raquel Celis, Virginia Ruiz-Esquide, Raul Castellanos-Moreira, Jose Antonio Narvaez, Jose A. Gomez-Puerta, Jose L. Pablos, Raimon Sanmarti, Juan D. Canete
Summary: The study found that 1/3 of RA patients lost clinical remission and changed therapy throughout the 5-year follow-up, which was associated with BMI, lack of biological DMARDs therapy, first-year progression of MRI erosion score, and calprotectin serum levels. Significant radiographic progression was uncommon.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sevtap Tugce Ulas, Katharina Ziegeler, Sophia-Theresa Richter, Sarah Ohrndorf, Robert Biesen, Fabian Proft, Denis Poddubnyy, Torsten Diekhoff
Summary: This study compared the performance of dual-energy CT and CT subtraction in detecting arthritis, with CT-S having the highest diagnostic accuracy. Both iMap and MRI showed good correlation and interreader reliability. Musculoskeletal ultrasound remains the most available modality for arthritis imaging and served as the gold standard in this study.
EUROPEAN RADIOLOGY
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ana Maria Crespo-Rodriguez, Jesus Sanz Sanz, Dalifer Freites, Zulema Rosales, Lydia Abasolo, Juan Arrazola
Summary: Psoriasis is a common skin disease that can develop into psoriatic arthritis (PsA) in up to 30% of patients, leading to impaired function and reduced quality of life. Early diagnosis and effective treatments are crucial for halting PsA progression. Sensitive imaging techniques such as ultrasound and MRI play an important role in the diagnosis, follow-up, and prognosis of PsA.
INSIGHTS INTO IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fausto Salaffi, Marina Carotti, Marco Di Carlo, Luca Ceccarelli, Sonia Farah, Andrea Giovagnoni
Summary: The study focuses on the relationship between joint inflammation and damage of the wrists and hands, functional disability and handgrip strength. The results show that bone edema and synovitis have an influence on the function of the upper extremities. The ultrasound assessment and the magnetic resonance imaging scoring system are useful for semiquantitative assessment of joint inflammation and damage in rheumatoid arthritis (RA).
Review
Medicine, General & Internal
Kate Harnden, Andrea Di Matteo, Kulveer Mankia
Summary: In recent years, rheumatologists have shifted their focus to studying individuals at risk of developing rheumatoid arthritis (RA) rather than just early RA. The use of blood, clinical, and imaging biomarkers can now identify those at risk of progression before the onset of clinical symptoms. Imaging techniques, such as ultrasound and magnetic resonance imaging, have been widely used to understand the pathogenesis of RA and identify individuals at high risk of progression.
FRONTIERS IN MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Chunyu Zhang, Wentao Huang, Chen Huang, Chengqian Zhou, Wei Wei, Yongsheng Li, Yukuan Tang, Yu Luo, Quan Zhou, Wenli Chen
Summary: Magnetic resonance imaging (MRI) is a potential diagnostic modality for early rheumatoid arthritis (RA). A peptide called UVHP was synthesized as a contrast agent, which targets the overexpression of VCAM-1 in RA cells and generates high contrast in MRI, with the characteristics of simplicity, low cost, and low toxicity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Immunology
Lene Terslev, Mikkel Ostergaard
Summary: Subclinical synovitis is linked to structural damage progression and flare risk, indicating clinical composite scores may not fully suppress inflammation; Sustained clinical remission impacts long-term joint damage progression, physical function, and quality of life; Treating subclinical inflammation leads to more frequent strict clinical remission and better physical function, with potential for more adverse events.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Rheumatology
J. Ramirez, A. B. Azuaga-Pinango, B. Frade-Sosa, R. Gumucio-Sanguino, K. Cajiao-Sanchez, A. M. Cuervo, R. Celis, J. A. Narvaez, V Ruiz-Esquide, R. Castellanos-Moreira, A. Ponce, J. A. Gomez-Puerta, J. L. Pablos, R. Sanmarti, J. D. Canete
Summary: In patients with rheumatoid arthritis (RA), ultrasound proliferative synovitis (US PS) is associated with ACPA positivity, erosive disease, and a greater likelihood of needing to change disease-modifying anti-rheumatic drug therapy in the long-term. At the synovial level, this ultrasound pattern is characterized by higher vessel density.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Xanthe Marijn Edmee Matthijssen, Fenne Wouters, Navkiran Sidhu, Ellis Niemantsverdriet, Annette van der Helm-van Mil
Summary: MRI-detected tenosynovitis shows high sensitivity for early ACPA-positive and ACPA-negative RA, indicating that involvement of both juxta-articular (tenosynovitis) and intra-articular synovium is characteristic of RA. Sensitivity for RA is significantly higher than other diseases associated with enthesitis, such as spondyloarthritis and psoriatic arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Paul Studenic, Daniel Aletaha, Maarten de Wit, Tanja A. Stamm, Farideh Alasti, Diane Lacaille, Josef S. Smolen, David T. Felson
Summary: This study aimed to externally validate a revised Boolean remission criteria using a higher patient global assessment (PtGA) threshold and validate the provisionally endorsed index-based criteria. The results showed that using the higher PtGA threshold increased the proportion of patients classified as achieving remission under the "Boolean2.0" criteria, improved agreement with index-based criteria, and did not compromise predictive value for radiographic or functional outcomes. The study findings were endorsed by ACR and EULAR.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Medicine, General & Internal
Jennifer S. S. Weaver, Imran M. M. Omar, Nicholson S. S. Chadwick, Joanna L. L. Shechtel, Jamie M. M. Elifritz, Christopher L. L. Shultz, Mihra S. S. Taljanovic
Summary: Shoulder pain and dysfunction can significantly affect quality of life. Shoulder arthroplasty is a common treatment for advanced shoulder diseases. Different types of arthroplasties are available for various indications, each with specific complications. Imaging plays a crucial role in pre-operative evaluation and post-operative follow-up, helping to assess rotator cuff, glenoid morphology, and complications. This review discusses important considerations and imaging findings for shoulder arthroplasty.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Rheumatology
Sara Kamp Felbo, Charlotte Wiell, Mikkel Ostergaard, Rene Panduro Poggenborg, Pernille Boyesen, Hilde Berner Hammer, Annelies Boonen, Susanne Juhl Pedersen, Inge Juul Sorensen, Ole Rintek Madsen, Ole Slot, Jakob Mollenbach Moller, Marcin Szkudlarek, Lene Terslev
Summary: This study investigated the association between clinical joint tenderness and intra- and periarticular inflammation as assessed by ultrasound and MRI in patients with active PsA. The results showed a weak association between joint tenderness and inflammation, particularly in patients with high levels of pain, disability, and low mental health.
Article
Rheumatology
Soren Andreas Just, Christian Nielsen, Jens Christian Werlinrud, Pia Veldt Larsen, Eva Kildall Hejbol, Helene Broch Tenstad, Henrik Daa Schroder, Torben Barington, Trine Torfing, Frances Humby, Hanne Lindegaard
Summary: In this study, fibrocyte levels in blood and synovial tissue of patients with rheumatoid arthritis were found to correlate with disease activity, imaging, and pulmonary function changes. Despite effective RA treatment, fibrocyte levels did not decrease during the trial. An increase in synovitis in the early RA group was strongly correlated with higher levels of circulating and synovial fibrocytes.
Article
Rheumatology
Ari Polachek, Victoria Furer, Mirna Zureik, Sharon Nevo, Liran Mendel, David Levartovsky, Jonathan Wollman, Valerie Aloush, Reut Tzemah, Ofir Elalouf, Marina Anouk, Mark Berman, Ilana Kaufman, Yael Lahat, Hagit Sarbagil-Maman, Sara Borok, Adi Broyde, Lihi Eder, Daphna Paran, Moshe Iluz, Iris Eshed, Ori Elkayam
Summary: This study compared the discrepancies and agreements between US, MRI, and radiography of the hand in PsA. It found that US and MRI showed good agreement in detecting inflammatory changes, while US, radiography, and MRI had good-to-very good agreement in detecting destructive changes in PsA finger joints.
Article
Rheumatology
Anna E. F. Poulsen, Mette B. Axelsen, Rene P. Poggenborg, Iris Eshed, Simon Krabbe, Daniel Glinatsi, Jakob M. Moller, Mikkel Ostergaard
Summary: WBMRI demonstrates good interscan agreement in patients with inflammatory joint diseases, showing moderate to almost perfect agreement in intra- and interreader assessments. There were more lesions found in patients compared to healthy controls, with varying agreement levels with conventional MRI.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Allen Anandarajah, Caroline Thirukumaran, Katherine McCarthy, Sean McMahon, Changyong Feng, Christopher Ritchlin
Summary: By studying a group of high-need, high-cost patients with lupus, researchers found that these patients accounted for the majority of hospitalizations and medical costs. The clinical and social factors of this group were significantly different from other lupus patients, particularly in terms of blood indicators and social backgrounds.
ARTHRITIS CARE & RESEARCH
(2022)
Review
Immunology
Christopher Ritchlin
Summary: This article discusses the plasticity of the immune response in PsA, focusing on the importance of therapeutic targets including Th17 cells, monocytes, and CD8+ T resident cells. Additionally, it examines the effects of cytokines on tissue populations and new data on the interaction between immune cells and tissue resident cells in PsA.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Review
Dermatology
Di Yan, Johann E. Gudjonsson, Stephanie Le, Emanual Maverakis, Olesya Plazyo, Christopher Ritchlin, Jose U. Scher, Roopesh Singh, Nicole L. Ward, Stacie Bell, Wilson Liao
Summary: Psoriasis is a chronic inflammatory condition characterized by systemic immune dysregulation. Recent advances in genetics, microbiology, immunology, and mouse models have shed light on the complex interplay between heritable and microenvironmental factors in driving psoriatic inflammation. These scientific advancements have paved the way for a more personalized approach to treating psoriatic disease.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Rheumatology
Effie Pournara, Matthias Kormaksson, Peter Nash, Christopher T. Ritchlin, Bruce W. Kirkham, Gregory Ligozio, Luminita Pricop, Alexis Ogdie, Laura C. Coates, Georg Schett, Iain B. McInnes
Summary: Distinct clusters of PsA patients were identified based on their baseline disease manifestations, with varying responses to secukinumab doses observed across different clusters. The study highlights the potential of machine learning in predicting patient outcomes based on PsA clusters.
Article
Rheumatology
Christopher T. Ritchlin, Philip J. Mease, Wolf-Henning Boehncke, John Tesser, Elena Schiopu, Soumya D. Chakravarty, Alexa P. Kollmeier, Xie L. Xu, May Shawi, Yusang Jiang, Shihong Sheng, Yanli Wang, Stephen Xu, Joseph F. Merola, Iain B. McInnes, Atul Deodhar
Summary: The study evaluated the efficacy of guselkumab in PsA patients and found that both Q4W and Q8W treatments resulted in robust and sustained improvements in signs and symptoms across subgroups defined by diverse baseline characteristics.
Article
Rheumatology
Ananta Paine, Paul S. S. Brookes, Soumyaroop Bhattacharya, Dongmei Li, Maria De La Luz Garcia-Hernandez, Francisco Tausk, Christopher Ritchlin
Summary: We found differences in serum metabolites between PsA patients, psoriasis patients, and healthy controls. Differential abundance of bile acids, purines, pyrimidines, glutathione, lipids, and amino acid metabolites were observed in these three groups. Differences were also noted between psoriasis patients who progressed and those who did not progress to PsA. Decreased bile acid and butyrate levels and increased guanine levels in psoriasis patients at risk for PsA were particularly significant and may be reflective of gut microbial dysbiosis and dysregulated hepatic metabolism, leading to altered immune cell proliferation and enhanced cytokine expression.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Roberta G. Marangoni, Poulami Datta, Ananta Paine, Stacey Duemmel, Marc Nuzzo, Laura Sherwood, John Varga, Christopher Ritchlin, Benjamin D. Korman
Summary: Thy-1 expression is significantly increased in the skin of patients with systemic sclerosis and is correlated with the severity of skin involvement. Thy-1 plays a critical regulatory role in the onset and progression of skin fibrosis. Additionally, Thy-1 may serve as a biomarker for evaluating skin fibrosis.
Article
Medicine, Research & Experimental
Christopher T. Ritchlin, Laura C. Coates, Philip J. Mease, Desiree van der Heijde, Jiao Song, Yusang Jiang, May Shawi, Alexa P. Kollmeier, Proton Rahman
Summary: Guselkumab shows efficacy in reducing radiographic progression in patients with active PsA. The APEX trial further evaluates the impact of guselkumab on patients with active PsA and known risk factors for radiographic progression.
Review
Rheumatology
H. Mark Kenney, Yue Peng, Karen L. de Mesy L. Bentley, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz
Summary: Lymphatic muscle cell contractility and coverage are crucial for effective lymphatic drainage and tissue homeostasis. However, the fundamental role of these cells is still poorly understood due to their unique characteristics and difficulties in direct investigation. Further research is needed to uncover the origins, investiture, and maintenance of lymphatic muscle cells, as well as potential therapeutic strategies for controlling lymphatic contractility and drainage.
CURRENT RHEUMATOLOGY REVIEWS
(2023)
Editorial Material
Rheumatology
Ying-Ying Leung, Arthur Kavanaugh, Christopher T. Ritchlin
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Christopher T. Ritchlin, Atul Deodhar, Wolf-Henning Boehncke, Enrique R. Soriano, Alexa P. Kollmeier, Xie L. Xu, Federico Zazzetti, May Shawi, Yusang Jiang, Shihong Sheng, Philip S. Helliwell
Summary: This study evaluated the efficacy and safety of guselkumab, an interleukin-23p19-subunit inhibitor, in patients with active psoriatic arthritis (PsA) who had previously used a tumor necrosis factor inhibitor (TNFi). The results showed that guselkumab provided sustained improvements across multiple domains in both TNFi-naive and TNFi-experienced patients with active PsA, and TNFi-naive patients were more likely to achieve treatment goals related to physical function and pain.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Rheumatology
Christopher T. Ritchlin, Laura C. Coates, Iain B. Mcinnes, Philip J. Mease, Joseph F. Merola, Yoshiya Tanaka, Akihiko Asahina, Laure Gossec, Alice B. Gottlieb, Richard B. Warren, Barbara Ink, Rajan Bajracharya, Vishvesh Shende, Jason Coarse, Robert B. M. Landewe
Summary: The long-term efficacy and safety of Bimekizumab (BKZ) in patients with psoriatic arthritis (PsA) was evaluated. The results showed that the efficacy of BKZ was sustained from Week 16 to Week 52, and patients who switched to BKZ treatment demonstrated similar efficacy to those who received BKZ continuously. BKZ treatment was well tolerated without any new safety signals.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Lihi Eder, Ker-Ai Lee, Vinod Chandran, Jessica Widdifield, Aaron M. Drucker, Christopher Ritchlin, Cheryl F. Rosen, Richard J. Cook, Dafna D. Gladman
Summary: The study aimed to develop a risk prediction model for psoriasis patients to predict their risk of developing psoriatic arthritis (PsA) and evaluate its performance. The results showed that using readily available clinical variables, the development of PsA within clinically meaningful time frames can be predicted with reasonable accuracy for psoriasis patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Stefan Siebert, Kristen M. Sweet, Christopher T. Ritchlin, Elizabeth C. Hsia, Alexa P. Kollmeier, Xie L. Xu, Loqmane Seridi, Qingxuan Song, Sheng Gao, Warner Chen, Michelle Miron
Summary: This study aimed to evaluate gene expression in the blood of patients with psoriatic arthritis (PsA) compared to healthy controls and identify changes associated with the treatment of guselkumab. The results showed dysregulation of immune cell profiles in the blood of PsA patients, which were partially normalized after guselkumab treatment.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Rheumatology
Christopher T. Ritchlin, Philip S. Helliwell, Wolf-Henning Boehncke, Enrique R. Soriano, Elizabeth C. Hsia, Alexa P. Kollmeier, Soumya D. Chakravarty, Federico Zazzetti, Ramanand A. Subramanian, Xie L. Xu, Qing C. Zuraw, Shihong Sheng, Yusang Jiang, Prasheen Agarwal, Bei Zhou, Yanli Zhuang, May Shawi, Chetan S. Karyekar, Atul Deodhar
Summary: The study demonstrated that guselkumab provided sustained improvement in patients with Psoriatic Arthritis, maintaining a favorable benefit-risk profile regardless of prior TNFi exposure.