Article
Anesthesiology
Jonathan Vela, Lene Dreyer, Kristian Kjaer Petersen, Lars Arendt-Nielsen, Kirsten Skjaerbaek Duch, Salome Kristensen
Summary: This study aimed to investigate the use of CBD as an adjuvant analgesic therapy in patients with hand osteoarthritis or psoriatic arthritis. The results showed no significant effects of CBD on pain intensity, sleep quality, depression, anxiety, or pain catastrophizing scores compared to placebo.
Article
Rheumatology
Irina Gessl, Claudia A. Hana, Thomas Deimel, Martina Durechova, Miriam Hucke, Victoria Konzett, Mihaela Popescu, Paul Studenic, Gabriela Supp, Michael Zauner, Josef S. Smolen, Daniel Aletaha, Peter Mandl
Summary: The study aimed to assess the predictive value of tenderness in non-swollen joints for subsequent radiographic progression in rheumatoid arthritis (RA) and psoriatic arthritis (PsA), taking into consideration other potential risk factors. Clinical and sonographic examination of hand joints were performed on patients with RA and PsA. The results showed that tenderness in non-swollen joints was associated with radiographic progression in RA, while the impact was weaker in PsA. Other risk factors such as sonographic signs for synovitis and baseline radiographic damage also had an effect on subsequent structural damage in both diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Celia A. J. Michielsens, Nathan den Broeder, Frank H. J. van den Hoogen, Elien A. M. Mahler, Steven Teerenstra, Desiree van der Heijde, Lise M. Verhoef, Alfons A. den Broeder
Summary: In patients with PsA and axSpA, a T2T TNFi strategy with tapering attempt is non-inferior to a T2T strategy without tapering in terms of the proportion of patients still in low disease activity (LDA) at 12 months, and results in a substantial reduction of TNFi use.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Manouk de Hooge, Alla Ishchenko, Ann-Sophie De Craemer, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Kurt de Vlam, Filip van den Bosch
Summary: This study aimed to examine radiographic axial damage of the sacroiliac joints and spine in patients with psoriatic arthritis (PsA) and spondyloarthritis (SpA) in private and academic Belgian practices. The data comparison between the two patient groups found that patients with SpA tend to have more severe spinal damage compared to those with PsA. In patients with PsA, the cervical spine is more often affected, while in patients with SpA, the location of syndesmophytes is more evenly distributed.
Article
Medicine, Research & Experimental
Arthur Kavanaugh, Xenofon Baraliakos, Sheng Gao, Warner Chen, Kristen Sweet, Soumya D. Chakravarty, Qingxuan Song, May Shawi, Proton Rahman
Summary: This study suggests that psoriatic arthritis with axial involvement (axPsA) and radiographic axial spondyloarthritis (r-axSpA) may be distinct disorders with different clinical manifestations and genetic associations. Additionally, these disorders may respond differently to therapies. The findings contribute to our understanding of the potential genetic and molecular differences between axPsA and r-axSpA.
ADVANCES IN THERAPY
(2023)
Article
Rheumatology
Emilio Filippucci, Gianluca Smerilli, Andrea Di Matteo, Walter Grassi
Summary: Enthesitis plays a crucial role in the diagnosis and management of patients with spondyloarthritis and psoriatic arthritis, but clinical assessment is often inaccurate due to poor specificity. Ultrasound has the potential to improve the evaluation of enthesitis and enhance patient management in this context. Reviewing the OMERACT definitions for ultrasound enthesitis can help identify current limitations and their potential implications for rheumatology research and clinical practice.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Alireza Khabbazi, Masoud Ahangari Maleki, Mohammad Sadegh Soltani-Zangbar, Mehdi Yousefi, Aida Malek Mahdavi
Summary: This study investigated the effects of synbiotic supplementation on regulating Treg cells' response in patients with axial spondyloarthritis. The results showed that synbiotic supplementation significantly increased the proportion of Treg cells, gene expression of related factors, and serum levels of IL-10 and TGF-beta, while reducing the expression of specific miRNA. Significant differences were observed between the synbiotic group and the placebo group in these indicators.
Article
Rheumatology
Tariq Aslam, Farrouq Mahmood, Anetha Sabanathan, Robin Waxman, Philip S. Helliwell
Summary: This study compared the clinical and radiographic phenotypes of PsA patients of South Asian and North European origin, finding that South Asian patients tended to have more severe disease and worse impact on their quality of life compared to North European patients.
Article
Rheumatology
Philip J. Mease, Mei Liu, Sabrina Rebello, Robert R. McLean, Blessing Dube, Meghan Glynn, Peter Hur, Alexis Ogdie
Summary: Patients with PsA who have nail psoriasis demonstrated worse disease activity, quality of life, and work productivity compared to those without nail involvement, highlighting the importance of identifying and managing nail disease in PsA patients.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Rheumatology
Joydeep Samanta, G. S. R. S. N. K. Naidu, Arghya Chattopadhyay, Amal Basnet, Tarun Narang, Varun Dhir, Sunil Dogra, Sanjay Jain, Aman Sharma
Summary: This study compared the efficacy of methotrexate and apremilast in the treatment of psoriatic arthritis and found no significant difference in major clinical outcomes and secondary clinical outcomes between the two drugs. Furthermore, both drugs were found to be safe without any serious adverse events.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Pauline Sanchez, Jean-Guillaume Letarouilly, Yann Nguyen, Johanna Sigaux, Thomas Barnetche, Sebastien Czernichow, Rene-Marc Flipo, Jeremie Sellam, Claire Daien
Summary: This study aimed to systematically review and meta-analyze the effect of probiotics supplementation on symptoms and disease activity in patients with chronic inflammatory rheumatic diseases. The results showed that probiotic supplementation might decrease rheumatoid arthritis activity with a moderate decrease effect on C-reactive protein, but there is a lack of evidence and heterogeneity among studies to recommend them as a treatment option for inflammatory arthritis.
Article
Medicine, General & Internal
Ruben Queiro, Sara Alonso, Isla Morante, Mercedes Alperi
Summary: The psychosocial health of patients with axial spondyloarthritis and psoriatic arthritis has a significant impact on quality of life. Disease activity and severity are associated with alterations in psychosocial health, with a greater impact observed in psoriatic arthritis patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Yu Xue, Jiankang Hu, Dongzhou Liu, Jingyang Li, Huaxiang Wu, Chunyu Tan, Lie Dai, Lingyun Sun, Zhijun Li, Zhengyu Xiao, Cibo Huang, Yan Yan, Fei Ji, Rong Chen, Hejian Zou
Summary: This phase III study evaluated the efficacy and safety of Ixekizumab in Chinese patients with active r-axSpA. The results showed that Ixekizumab was associated with rapid and significant improvements in signs and symptoms of active r-axSpA at week 16, with sustained efficacy at week 52. The safety profile of Ixekizumab was consistent with previous studies, with infections and injection-site reactions being the most commonly reported events of special interest.
Article
Rheumatology
Manouk de Hooge, Alla Ischenko, Serge Steinfeld, Adrien Nzeusseu, Dirk Elewaut, Rik Lories, Filip van den Bosch, Kurt De Vlam
Summary: This study investigates the association between different definitions of axial involvement and syndesmophytes development in patients with Psoriatic Arthritis (PsA). The results show that the probability of developing syndesmophytes is much higher when axial involvement is determined radiographically rather than clinically, particularly in the context of high CRP.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Ashish J. Mathew, Bente Glintborg, Niels Steen Krogh, Merete L. Hetland, Mikkel Ostergaard
Summary: This study explored the registration, pattern, and burden of clinical enthesitis among routine-care patients with psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA) in the Danish nationwide DANBIO registry. The results showed that enthesitis was frequent, particularly in women, and associated with a higher disease burden reported by both physicians and patients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Rheumatology
Allen Anandarajah, Caroline Thirukumaran, Katherine McCarthy, Sean McMahon, Changyong Feng, Christopher Ritchlin
Summary: By studying a group of high-need, high-cost patients with lupus, researchers found that these patients accounted for the majority of hospitalizations and medical costs. The clinical and social factors of this group were significantly different from other lupus patients, particularly in terms of blood indicators and social backgrounds.
ARTHRITIS CARE & RESEARCH
(2022)
Review
Immunology
Christopher Ritchlin
Summary: This article discusses the plasticity of the immune response in PsA, focusing on the importance of therapeutic targets including Th17 cells, monocytes, and CD8+ T resident cells. Additionally, it examines the effects of cytokines on tissue populations and new data on the interaction between immune cells and tissue resident cells in PsA.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Editorial Material
Rheumatology
Jose U. Scher, Alexis Ogdie, Joseph F. Merola, Christopher Ritchlin
ARTHRITIS & RHEUMATOLOGY
(2021)
Review
Dermatology
Di Yan, Johann E. Gudjonsson, Stephanie Le, Emanual Maverakis, Olesya Plazyo, Christopher Ritchlin, Jose U. Scher, Roopesh Singh, Nicole L. Ward, Stacie Bell, Wilson Liao
Summary: Psoriasis is a chronic inflammatory condition characterized by systemic immune dysregulation. Recent advances in genetics, microbiology, immunology, and mouse models have shed light on the complex interplay between heritable and microenvironmental factors in driving psoriatic inflammation. These scientific advancements have paved the way for a more personalized approach to treating psoriatic disease.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Rheumatology
Effie Pournara, Matthias Kormaksson, Peter Nash, Christopher T. Ritchlin, Bruce W. Kirkham, Gregory Ligozio, Luminita Pricop, Alexis Ogdie, Laura C. Coates, Georg Schett, Iain B. McInnes
Summary: Distinct clusters of PsA patients were identified based on their baseline disease manifestations, with varying responses to secukinumab doses observed across different clusters. The study highlights the potential of machine learning in predicting patient outcomes based on PsA clusters.
Article
Rheumatology
Christopher T. Ritchlin, Philip J. Mease, Wolf-Henning Boehncke, John Tesser, Elena Schiopu, Soumya D. Chakravarty, Alexa P. Kollmeier, Xie L. Xu, May Shawi, Yusang Jiang, Shihong Sheng, Yanli Wang, Stephen Xu, Joseph F. Merola, Iain B. McInnes, Atul Deodhar
Summary: The study evaluated the efficacy of guselkumab in PsA patients and found that both Q4W and Q8W treatments resulted in robust and sustained improvements in signs and symptoms across subgroups defined by diverse baseline characteristics.
Article
Rheumatology
Ananta Paine, Paul S. S. Brookes, Soumyaroop Bhattacharya, Dongmei Li, Maria De La Luz Garcia-Hernandez, Francisco Tausk, Christopher Ritchlin
Summary: We found differences in serum metabolites between PsA patients, psoriasis patients, and healthy controls. Differential abundance of bile acids, purines, pyrimidines, glutathione, lipids, and amino acid metabolites were observed in these three groups. Differences were also noted between psoriasis patients who progressed and those who did not progress to PsA. Decreased bile acid and butyrate levels and increased guanine levels in psoriasis patients at risk for PsA were particularly significant and may be reflective of gut microbial dysbiosis and dysregulated hepatic metabolism, leading to altered immune cell proliferation and enhanced cytokine expression.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Roberta G. Marangoni, Poulami Datta, Ananta Paine, Stacey Duemmel, Marc Nuzzo, Laura Sherwood, John Varga, Christopher Ritchlin, Benjamin D. Korman
Summary: Thy-1 expression is significantly increased in the skin of patients with systemic sclerosis and is correlated with the severity of skin involvement. Thy-1 plays a critical regulatory role in the onset and progression of skin fibrosis. Additionally, Thy-1 may serve as a biomarker for evaluating skin fibrosis.
Review
Rheumatology
H. Mark Kenney, Yue Peng, Karen L. de Mesy L. Bentley, Lianping Xing, Christopher T. Ritchlin, Edward M. Schwarz
Summary: Lymphatic muscle cell contractility and coverage are crucial for effective lymphatic drainage and tissue homeostasis. However, the fundamental role of these cells is still poorly understood due to their unique characteristics and difficulties in direct investigation. Further research is needed to uncover the origins, investiture, and maintenance of lymphatic muscle cells, as well as potential therapeutic strategies for controlling lymphatic contractility and drainage.
CURRENT RHEUMATOLOGY REVIEWS
(2023)
Editorial Material
Rheumatology
Ying-Ying Leung, Arthur Kavanaugh, Christopher T. Ritchlin
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Christopher T. Ritchlin, Atul Deodhar, Wolf-Henning Boehncke, Enrique R. Soriano, Alexa P. Kollmeier, Xie L. Xu, Federico Zazzetti, May Shawi, Yusang Jiang, Shihong Sheng, Philip S. Helliwell
Summary: This study evaluated the efficacy and safety of guselkumab, an interleukin-23p19-subunit inhibitor, in patients with active psoriatic arthritis (PsA) who had previously used a tumor necrosis factor inhibitor (TNFi). The results showed that guselkumab provided sustained improvements across multiple domains in both TNFi-naive and TNFi-experienced patients with active PsA, and TNFi-naive patients were more likely to achieve treatment goals related to physical function and pain.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Rheumatology
Christopher T. Ritchlin, Laura C. Coates, Iain B. Mcinnes, Philip J. Mease, Joseph F. Merola, Yoshiya Tanaka, Akihiko Asahina, Laure Gossec, Alice B. Gottlieb, Richard B. Warren, Barbara Ink, Rajan Bajracharya, Vishvesh Shende, Jason Coarse, Robert B. M. Landewe
Summary: The long-term efficacy and safety of Bimekizumab (BKZ) in patients with psoriatic arthritis (PsA) was evaluated. The results showed that the efficacy of BKZ was sustained from Week 16 to Week 52, and patients who switched to BKZ treatment demonstrated similar efficacy to those who received BKZ continuously. BKZ treatment was well tolerated without any new safety signals.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Lihi Eder, Ker-Ai Lee, Vinod Chandran, Jessica Widdifield, Aaron M. Drucker, Christopher Ritchlin, Cheryl F. Rosen, Richard J. Cook, Dafna D. Gladman
Summary: The study aimed to develop a risk prediction model for psoriasis patients to predict their risk of developing psoriatic arthritis (PsA) and evaluate its performance. The results showed that using readily available clinical variables, the development of PsA within clinically meaningful time frames can be predicted with reasonable accuracy for psoriasis patients.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Rheumatology
Stefan Siebert, Kristen M. Sweet, Christopher T. Ritchlin, Elizabeth C. Hsia, Alexa P. Kollmeier, Xie L. Xu, Loqmane Seridi, Qingxuan Song, Sheng Gao, Warner Chen, Michelle Miron
Summary: This study aimed to evaluate gene expression in the blood of patients with psoriatic arthritis (PsA) compared to healthy controls and identify changes associated with the treatment of guselkumab. The results showed dysregulation of immune cell profiles in the blood of PsA patients, which were partially normalized after guselkumab treatment.
ACR OPEN RHEUMATOLOGY
(2023)