Article
Endocrinology & Metabolism
Lydia Baird, Ping Cannon, Manju Kandel, Tuong-Vi Nguyen, Anna Nguyen, Georgia Wong, Ciara Murphy, Fiona C. Brownfoot, Elif Kadife, Natalie J. Hannan, Stephen Tong, Lucy A. Bartho, Tu'uhevaha J. Kaitu'u-Lino
Summary: This study found that the expression of the retrotransposon PEG10 is reduced in the placentas of patients with early-onset preeclampsia. In vitro studies suggest that hypoxia and inflammation may contribute to the downregulation of PEG10. Reduced PEG10 alters the canonical TGF-beta signaling and may be involved in trophoblast dysfunction.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Article
Oncology
Boxing Su, Haibo Han, Yanqing Gong, Xuesong Li, Chaoyue Ji, Jingjing Yao, Jianghui Yang, Weiguo Hu, Wei Zhao, Jianxing Li, Gang Zhang, Liqun Zhou
Summary: Let-7d inhibits intratumoral macrophage M2 polarization and tumor angiogenesis in RCC by targeting IL-10 and IL-13.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Wanfu Lin, Shu Li, Yongbin Meng, Guokai Huang, Shufang Liang, Juan Du, Qun Liu, Binbin Cheng
Summary: This study found that ursodeoxycholic acid (UDCA) can inhibit hypoxic hepatocellular carcinoma (HCC) cell-induced angiogenesis by suppressing HIF-1 alpha/VEGF/IL-8-mediated intercellular signaling.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jinqiu Jiang, Tao Qin, Liang Zhang, Qiao Liu, Jiabin Wu, Rongxin Dai, Lina Zhou, Qin Zhao, Xiaoyan Luo, Hua Wang, Xiaodong Zhao
Summary: Deficiencies in DOCK8 result in quantitative and qualitative defects in IL-10-producing Breg cells, potentially due to abnormal Dock8(-/-) CD4(+) T cells. The study found that recombinant murine IL-21 can restore Bregs function and reduce inflammatory cell infiltration in the lung in a murine asthma model. This provides new insights into potential therapeutic strategies for allergic diseases, such as asthma associated with DOCK8 deficiency.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Po-Kai Yang, Chia-Hung Chou, Chu-Chun Huang, Wen-Fen Wen, Hsin-Fu Chen, Chia-Tung Shun, Hong-Nerng Ho, Mei-Jou Chen
Summary: Obesity may disrupt normal folliculogenesis through increased production of IL-10 in visceral fats, shedding light on the association between obesity and ovulatory dysfunction in patients with polycystic ovary syndrome. However, the short duration of the study limits conclusions on long-term reproductive outcomes.
MOLECULAR METABOLISM
(2021)
Article
Multidisciplinary Sciences
Haifeng Zhang, Busu Li, Qunhua Huang, Francesc Lopez-Giraldez, Yoshiaki Tanaka, Qun Lin, Sameet Mehta, Guilin Wang, Morven Graham, Xinran Liu, In-Hyun Park, Anne Eichmann, Wang Min, Jenny Huanjiao Zhou
Summary: The authors demonstrate that mitochondrial dysfunction caused by mutation of nuclear genes encoding mitochondrial proteins leads to retarded retinal vessel growth and arteriovenous malformations through enhanced TGF beta signaling and altered gene expressions associated with vascular maturation and extracellular matrix. The findings suggest a potential therapeutic target for angiogenesis-associated retinal diseases.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Natalia Gebara, Yolanda Correia, Keqing Wang, Benedetta Bussolati
Summary: Angiogenesis, regulated by extracellular vesicles (EVs) from gestational tissues, plays a crucial role in healthy pregnancy and is dysregulated in pregnancy-related diseases like preeclampsia. The use of EVs from placental stem cells shows promise in clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nanoscience & Nanotechnology
Asmita Banstola, Kishwor Poudel, Shiva Pathak, Prakash Shrestha, Jong Oh Kim, Jee-Heon Jeong, Simmyung Yook
Summary: A dual-targeted nanosystem was constructed for cancer cells and ROS responsiveness, showing enhanced anticancer effects in hypoxic tumor microenvironment; The system's dual targeting promoted drug permeation in cancer cells, and the accelerated drug release through ROS regulation induced cell apoptosis.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Biochemistry & Molecular Biology
Diego Rodriguez, Deepika Watts, Diana Gaete, Sundary Sormendi, Ben Wielockx
Summary: The vascular network is crucial for sensing oxygen levels and hypoxia triggers a cascade of cellular signals, including angiogenesis, regulated by transcription factors such as HIFs and oxygen sensors like PHDs. Understanding how vascular cells respond to hypoxia under varying conditions is important for potential therapeutic targets in vascular dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Allan Kardec Nogueira Alencar, Kenneth F. Swan, Gabriella Pridjian, Sarah H. Lindsey, Carolyn L. Bayer
Summary: During pregnancy, maternal spiral arteries undergo structural changes and placental trophoblasts invade the maternal decidua, which can lead to uteroplacental dysfunction and preeclampsia. Recent studies suggest that membrane-initiated estrogen signaling through GPER may play a role in the regulation of these processes. Understanding the role of GPER in pregnancy complications could lead to new treatment options.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Peripheral Vascular Disease
Xiang-Qun Hu, Chiranjib Dasgupta, Rui Song, Monica Romero, Sean M. Wilson, Lubo Zhang
Summary: Pregnancy-induced hypoxia significantly increases circulating levels of miR-210 in both ewes and their fetuses. The study revealed that miR-210 directly targets and downregulates specific proteins in uterine arteries, leading to significant decreases in Ca2+ sparks and STOCs. This mechanistic link sheds light on pregnancy complications associated with hypoxia and potential therapeutic targets.
Review
Oncology
Samuel S. Widodo, Marija Dinevska, Liam M. Furst, Stanley S. Stylli, Theo Mantamadiotis
Summary: The prognosis for patients with GBM is very poor despite current standard treatments. The immunosuppressive tumour microenvironment hinders the development of effective immunotherapies for GBM, and understanding the role of IL-10 in GBM is crucial for improving immunotherapy.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Yamei Li, Xueya Zhao, Biwei He, Weibin Wu, Huijuan Zhang, Xingyu Yang, Weiwei Cheng
Summary: Autophagy plays a crucial role in maintaining the function of trophoblast cells, with its activation under hypoxia enhancing angiogenesis and protecting against apoptosis, potentially offering a preventive approach for early-onset preeclampsia.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Multidisciplinary Sciences
Jaqueline Poleto Bragato, Gabriela Torres Rebech, Jessica Henrique de Freitas, Marilene Oliveira dos Santos, Sidnei Ferro Costa, Flavia de Rezende Eugenio, Paulo Sergio Patto dos Santos, Valeria Marcal Felix de Lima
Summary: Canine leishmaniasis is a severe public health issue due to infected animals acting as powerful transmitters of the parasite to humans. Studies suggest that the regulation of macrophages and T cells' effector function in CanL depends on miRNAs, with miR-21 playing a crucial role in altering immune response.