Article
Chemistry, Applied
Hadjer Zaak, Hamdi Bendif, Khellaf Rebbas, Lina Aouati, Asma Abdennour, Asma Hamza, Joice Guileine Nkuimi Wandjou, Filippo Maggi
Summary: The phytochemical and biological properties of Ononis alba were investigated for the first time in this study. The main constituents of the essential oil were ketones and carboxylic acids. The n-butanol extract showed the highest phenolic and flavonoid content as well as the best antioxidant capacity. All the extracts exhibited higher efficiency than acarbose in inhibiting alpha-amylase. However, they demonstrated a mild inhibition effect against Staphylococcus aureus and Fusarium oxysporum.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Alice Gadea, Mays Khazem, Thomas Gaslonde
Summary: This review presents the structures of secondary metabolites discovered in Proteaceae, with a focus on bis-5-alkylresorcinols and their cyclized analogues, and summarizes their biological activities. Through data compilation and analysis of over 130 references, a total of about 327 secondary metabolites were identified, with phenol glycosides, derivatives of 5-alkylresorcinols, and tropane alkaloids being the most important classes.
PHYTOCHEMISTRY REVIEWS
(2022)
Article
Endocrinology & Metabolism
Baker F. Al-Mubideen, Ala-Aldeen Ahmad Al-Serhan, Justin Z. Amarin, Arwa Al-Dweikat, Ra'ad Z. Al-Muhaisen, Yusra Abu Shreikh, Haya H. Suradi, Hamzeh J. Al-Ameer, Malek A. Zihlif
Summary: The study demonstrated the hypoglycemic effect of Ononis natrix L. in Wistar rats with streptozotocin-induced diabetes, showing a significant reduction in blood glucose concentration compared to control groups.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Article
Biochemistry & Molecular Biology
Sanae Lahmidi, El Hassane Anouar, Salma Mortada, Mohamed El Hafi, Faouzi My El Abbes, El Mokhtar Essassi, Joel T. Mague
Summary: This work describes the synthesis of three unexpected compounds through a mild condensation reaction and investigates their structures, formation mechanisms, and biological activities. The compounds were characterized using crystallographic studies and spectral data. The study also explores the optimized geometries, electronic distributions, and binding interactions of the compounds. The results show potential antioxidant and antidiabetic activities, as well as promising binding interactions with target enzymes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Edwin R. Sukandar, Sutin Kaennakam, Pia Raab, Xuehong Noest, Kitiya Rassamee, Rudolf Bauer, Pongpun Siripong, Taslim Ersam, Santi Tip-pyang, Warinthorn Chavasiri
Summary: Garcinia picrorhiza, a woody plant native to Indonesia, was found to contain 15 phenolic compounds in its stem bark, including newly discovered bioactive molecules with cytotoxic and anti-inflammatory properties. These findings suggest the potential for furanxanthone derivatives as cytotoxic and anti-inflammatory agents for further pharmacological studies.
Article
Plant Sciences
P. Pablo Ferrer-Gallego
Summary: A nomenclatural revision of Ononis tridentata complex in the Iberian Peninsula is carried out, and the typification of several names is discussed. The lectotypes are designated using specimens at BORD, COI, G, and P herbaria. A second-step epitypification is proposed for O. tridentata. Some names are suggested to be treated as synonyms of O. tridentata subsp. arbuscula, comb. & stat nov. instead of O. tridentata Linnaeus s.str.
Article
Chemistry, Medicinal
Hong -Mei Diao, Yi Hao, Jing Li, Hao-Wei Ling, Kai-Xuan Shi, Wei Zhang, Rong Liu, Xiu-Rong Wu, Chao-Jiang Xiao, Bei Jiang
Summary: Two new flavonoid glycosides (scutelikiosides A and B) and twenty-one known compounds were isolated from the roots of Scutellaria likiangensis Diels. Compound 17 showed significant antimalarial activity close to artemisinin, and compounds 6, 9-12, 14, 18, 19, and 22 exhibited moderate antimalarial activities. The study also provided a summary of the structure-activity relationship of the isolated flavonoids.
Article
Plant Sciences
Patcharawalai Jaisamut, Subhaphorn Wanna, Surasak Limsuwan, Sasitorn Chusri, Kamonthip Wiwattanawongsa, Ruedeekorn Wiwattanapatapee
Summary: The study proposed a drug delivery system to enhance the oral bioavailability of quercetin and resveratrol. The self-microemulsifying formulation significantly improved the oral bioavailability of the combined compounds, without compromising their biological activities, showing promising potential for future research.
Review
Food Science & Technology
Nor Farahin Azizi, Muganti Rajah Kumar, Swee Keong Yeap, Janna Ong Abdullah, Melati Khalid, Abdul Rahman Omar, Mohd Azuraidi Osman, Sharifah Alawieyah Syed Mortadza, Noorjahan Banu Alitheen
Summary: Kefir is a fermented beverage rich in probiotics that offer various nutraceutical benefits, leading to a growing global interest. Due to its potential nutritional advantages, kefir and similar products have a promising future in commercialization.
Article
Biochemistry & Molecular Biology
Yue Jin, Miao Wang, Yan-Fang Yan, Xin-Xin Zhang, Xian-Zhe Li, Hui-Yuan Gao
Summary: In this study, new cassane alkaloids and cassane diterpenoids were isolated and identified from the seeds of Caesalpinia sappan, with their structures elucidated comprehensively. The compounds showed significant cytotoxicity against HepG2 cells, with one of them causing cell cycle arrest and promoting apoptosis.
Editorial Material
Biochemical Research Methods
Chenyang Zhang, Minjie Mou, Ying Zhou, Wei Zhang, Xichen Lian, Shuiyang Shi, Mingkun Lu, Huaicheng Sun, Fengcheng Li, Yunxia Wang, Zhenyu Zeng, Zhaorong Li, Bing Zhang, Yunqing Qiu, Feng Zhu, Jianqing Gao
Summary: This study conducted a comprehensive assessment and analysis on the biological activities of DIGs in drug formulations, providing the first comprehensive activities for both DIGs and DFMs to the pharmaceutical community. The biological targets of each DIG and formulation were fully referenced to available databases, and popular artificial intelligence techniques were used to evaluate the predictive potential of DIGs' activity data. The findings of this work are expected to have significant implications for the future practice of drug discovery and precision medicine.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Kailibinuer Aierken, Jun Li, Nannan Xu, Tao Wu, Deng Zang, Haji Akber Aisa
Summary: Antimicrobial bioactivity-guided isolation of the root extract of Rumex dentatus L. led to the identification of nineteen natural products, including three new compounds (rumexs A-C). The dominant components of R. dentatus were found to be anthraquinone derivatives such as anthraquinone aglycone, oxanthrone C-glycoside, anthraquinone O-glycoside, and anthraquinone dimer. Other derivatives such as naphthol, naphthoquinone, chromone, flavonoid, isocoumarin, and lignanamide were also identified. The crude ethanol extract contained high levels of chrysophanol and emodin. The isolated compounds and fractions showed inhibitory activity against various microbes, and emodin exhibited concentration-dependent inhibitory effects on NO release in LPS-reduced RAW264.7 cells.
Review
Plant Sciences
Antonella Fais, Giovanna Lucia Delogu, Sonia Floris, Benedetta Era, Rosaria Medda, Francesca Pintus
Summary: This review summarizes the compounds identified and characterized from Euphorbia characias, as well as the reported biological activities of this plant, indicating its potential as a source of compounds for biomedical research.
Review
Medicine, Research & Experimental
Shiyang Zhou, Gangliang Huang
Summary: Acetylcholinesterase (AChE) inhibitor is the first choice for treating Alzheimer's disease (AD), but has limitations. Recent studies suggest that butyrylcholinesterase (BuChE) inhibitors or dual-target cholinesterase inhibitors have better therapeutic effects on AD with lower side effects. Dual target cholinesterase inhibitors have become a new hot topic in anti-AD drug research.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Qinghua Han, Yi Qian, Xuda Wang, Qingying Zhang, Jingrong Cui, Pengfei Tu, Hong Liang
Summary: Two new oleanane-type saponins, julibrosides K-L, and three oleanane-type prosapogenins, julibrosides M-O, were isolated from Albizia julibrissin Durazz. Extensive structural analysis was conducted using various NMR techniques and mass spectrometry. Among them, julibroside L exhibited significant cytotoxic activities against multiple cancer cell lines.
Article
Chemistry, Applied
Rahab W. Kamau, Veronica M. Masila, Jacob O. Midiwo, Quintino A. Mgani, Mallika Kumarihamy, Mei Wang, Jianping Zhao, Ilias Muhammad
Summary: A new flavanone-flavonol dimer and 10 known compounds were isolated from the roots of Gnidia apiculata. Four of the known compounds were reported for the first time from the Thymelaeceae plant family. The structures of the isolated compounds were determined using spectroscopic analysis and comparison with literature data. The isolated compounds showed antimicrobial and antiplasmodial activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Balkisu Abdulrahman, Fadime Aydogan, Fazila Zulfiqar, Jianping Zhao, Zulfiqar Ali, Ikhlas A. Khan, Bala Muntari, Bello Oluwasesan
Summary: A targeted investigation of the ethanolic extract of black turtle bean seeds led to the isolation and characterization of five compounds, including a previously undescribed cyclohexane carboxylic acid derivative.
RECORDS OF NATURAL PRODUCTS
(2023)
Article
Mechanics
Jinling Zhao, Hongli Ji, Jinhao Qiu, Jianping Zhao, Xiaojuan Xu
Summary: This article evaluates the elastic properties of composites by inverting guided wave velocities and analyzes the sensitivity of ultrasonic waves to stiffness. By developing novel sensitivity kernels, the authors achieve accurate and efficient sensitivity analysis, and further validate the method by identifying elastic properties.
EUROPEAN JOURNAL OF MECHANICS A-SOLIDS
(2023)
Article
Chemistry, Multidisciplinary
Yiwen Yuan, Jianping Zhao, Jianfeng Li
Summary: Several five-coordinate high-spin p-toluenethiolate Manganese(II) complexes were successfully synthesized using different ligands, and were characterized in detail by various spectroscopic techniques. The crystal structures exhibited flexible ligands and interactions between the ligands and porphyrin planes. The high-spin states of these complexes were confirmed by EPR, and temperature-dependent EPR and measurement comparisons with different ligand equivalents were conducted.
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
(2023)
Article
Medical Laboratory Technology
Yanjiao Lu, Kum Tang, Shanshan Wang, Zhen Tian, Yan Fan, Boyu Li, Meijia Wang, Jianping Zhao, Jungang Xie
Summary: This study demonstrates that low expression of Dachshund homolog 1 (Dach1) in type II alveolar epithelial cells (AECII) contributes to the progression of pulmonary fibrosis (PF). Dach1 deficiency exacerbates PF in mice, while overexpression of Dach1 alleviates lung damage and fibrosis. Mechanistically, Dach1 represses epithelial apoptosis by binding to the promoter of B-cell lymphoma 2 interacting mediators of cell death (Bim), thus preventing PF development.
TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Physical
Haiyan Duan, Xu Chen, Yi-Nan Yang, Jianping Zhao, Xiao-Chun Lin, Wen-Jing Tang, Qiang Gao, Guo-Hong Ning, Dan Li
Summary: Despite many efforts in tuning catalytic performance of metal-organic frameworks (MOFs) through modification of MOF nodes, steric tuning of MOF nodes via ligand modification remains challenging. In this study, two two-dimensional Cu(I) cyclic trinuclear unit (Cu-CTU)-based MOFs with similar structures, named JNM-1 and JNM-5, were successfully synthesized. JNM-5 exhibited higher crystallinity, porosity and chemical stability, but lower catalytic activity for hydroboration reactions compared to JNM-1. However, JNM-5 showed higher substrate selectivity and chemo-selectivity for hydroboration of olefins.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Infectious Diseases
Lulu Zhang, Yan Xiao, Guoliang Zhang, Hongru Li, Jianping Zhao, Mingwei Chen, Fuhui Chen, Ling Liu, Yalun Li, Liping Peng, Feng Zhao, Donghong Yang, Zhongmei Wen, Lei Wu, Shuo Wu, Yajiao Sun, Ying Wang, Lan Chen, Xinming Wang, Lihui Wang, Weimin Li, Haibo Qiu, Yusheng Chen, Zhancheng Gao, Lili Ren, Jianwei Wang
Summary: This study identifies the major respiratory pathogens causing community-acquired pneumonia (CAP) in adults in China, which differ from those in the USA and European countries. These findings are consistent across different geographical regions and study years. Based on the detection rate of pathogens and their association with severe CAP, the ten major pathogens are recommended as priorities for clinical pathogen screening in China.
BMC INFECTIOUS DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Jianping Zhao, Mo Xie, Xu Chen, Ji-Kang Jin, Wei Zhao, Jie Luo, Guo-Hong Ning, Junzhi Liu, Dan Li
Summary: A boron-dipyrromethene (BODIPY) based COF, JNM-12, was synthesized via Schiff-base condensation reaction and exhibited strong visible-light harvesting abilities. JNM-12 showed efficient photocatalytic activity in the oxidative coupling of amines and aerobic oxidation of enamines under visible light irradiation. This work provides a new approach for the synthesis of efficient, economical, and green photocatalysts for organic synthesis.
CHEMISTRY-AN ASIAN JOURNAL
(2023)
Article
Plant Sciences
Zhi-shen Xie, Jian-ping Zhao, Li-min Wu, Shuang Chu, Zheng-hao Cui, Yi-ran Sun, Hui Wang, Hui-fen Ma, Dong-rui Ma, Pan Wang, Xiao-wei Zhang, Zhen-qiang Zhang
Summary: Hederagenin (HD) promotes autophagy and reduces Alzheimer's disease symptoms through the activation of the PPAR alpha/TFEB pathway.
Article
Plant Sciences
Lihui Jiang, Baolin Yao, Xiaoyan Zhang, Lixia Wu, Qijing Fu, Yiting Zhao, Yuxin Cao, Ruomeng Zhu, Xinqi Lu, Wuying Huang, Jianping Zhao, Kuixiu Li, Shuanglu Zhao, Li Han, Xuan Zhou, Chongyu Luo, Haiyan Zhu, Jing Yang, Huichuan Huang, Zhengge Zhu, Xiahong He, Jiri Friml, Zhongkai Zhang, Changning Liu, Yunlong Du
Summary: Salicylic acid inhibits rice root growth by interfering with auxin transport through OsPIN3t-mediated mutation and clathrin-mediated endocytosis, which is different from TyrA23-mediated root growth.
Article
Endocrinology & Metabolism
Jianping Zhao, Jonathan Epstein
Summary: EPE is rarely seen in GG1-3 prostatic adenocarcinoma, and there is no evidence suggesting it as a contraindication for radical prostatectomy. Despite the presence of EPE on biopsy, most patients do not have highly unfavorable pathology at the time of surgery.
Article
Chemistry, Physical
Tsung-Hsuan Yang, Erik S. Cheng, Samuel M. Johnson, Toshihiko Iwao, Jianping Zhao, John G. Ekerdt, Peter L. G. Ventzek, Gyeong S. Hwang
Summary: Plasma-enhanced atomic layer deposition (PEALD) is a promising technique for controlled growth of silicon nitride (SiNx) thin films. The presence of amines, especially primary amines, plays a key role in dichlorosilane (DCS) decomposition, generating H and Cl atoms as by-products. The by-products can strongly bind to the surface, affecting the SiNx ALD process and decreasing the growth rate.
APPLIED SURFACE SCIENCE
(2023)
Article
Construction & Building Technology
Cailong Ma, Sixuan Wang, Jianping Zhao, Xufeng Xiao, Chenxi Xie, Xinlong Feng
Summary: The purpose of this paper is to develop a data and mechanism co-driven model for predicting the shear strength of reinforced concrete (RC) deep beams. A total of 457 RC deep beams with or without web reinforcements are included in the experimental database, and 9 key input features are determined based on the shear mechanism. Six machine-learning models and five mechanism models are compared, and the XGBoost model outperforms others in terms of prediction accuracy and generalization ability. The interpretability of the XGBoost model is enhanced by combining the Shapley additive explanation (SHAP) approach and the proposed interpretable approach based on the shear mechanism. The proposed interpretable approach is validated qualitatively and quantitatively against other mechanism models, demonstrating its recommendation for similar shear issues of RC members.
CONSTRUCTION AND BUILDING MATERIALS
(2023)
Article
Gastroenterology & Hepatology
Yuan-Xiang Lu, Jian-Ping Zhao, Guan-Dou Yuan, Ming-Gen Hu, Chuan-Dong Sun, Kun-Lun Chen, Yao Chen, Yong-Yi Zeng, Zhi-Ying Yang, Wan-Guang Zhang
Summary: This study aimed to investigate the prevalence, patterns, risk factors, and outcomes of peritoneal metastases (PM) in hepatocellular carcinoma (HCC) patients after curative laparoscopic hepatectomy (LH). The results showed that LH was not associated with increased incidence of PM in HCC patients for experienced surgeons, and surgical re-excision of PM was associated with prolonged survival.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Letter
Medicine, General & Internal
Zhenan Deng, Meiling Jin, Changxing Ou, Wei Jiang, Jianping Zhao, Xiaoxia Liu, Shenghua Sun, Huaping Tang, Bei He, Shaoxi Cai, Ping Chen, Penghui Wu, Yujing Liu, Jian Kang, Yunhui Zhang, Mao Huang, Jinfu Xu, Kewu Huang, Qiang Li, Xiangyan Zhang, Xiuhua Fu, Changzheng Wang, Huahao Shen, Lei Zhu, Guochao Shi, Zhongmin Qiu, Zhongguang Wen, Xiaoyang Wei, Wei Gu, Chunhua Wei, Guangfa Wang, Lixin Xie, Jiangtao Lin, Yuling Tang, Zhihai Han, Kian Fan Chung, Qingling Zhang, Nanshan Zhong
CHINESE MEDICAL JOURNAL
(2023)
Article
Plant Sciences
Yi Zhu, Junlin Wang, Lu Tang, Yuxin Shang, Weiyi Zhao, Wei Zhang, Ping Hai, Yongbiao Zheng, Wenbo Li, Yanfang Su
Summary: One new iridoid glucoside and two new lignan glycosides, along with three known compounds, were isolated from the whole plants of Lancea tibetica. The structures were determined by spectroscopic methods and X-ray crystallographic analysis. One of the new iridoid glucosides and the known compounds exhibited moderate antioxidant activity.
PHYTOCHEMISTRY LETTERS
(2024)
Article
Plant Sciences
Yi Deng, Minghua Chen, Junming Yi, Yuguo Zheng
Summary: This study successfully designed and synthesized a series of quinazolinone derivatives containing purine molecules, and found that some compounds exhibited strong antiviral activity against tobacco mosaic virus. The findings have important implications for further development of antiviral drugs.
PHYTOCHEMISTRY LETTERS
(2024)
