Article
Medicine, Research & Experimental
Guangyuan Song, Xingxin Zhu, Zefeng Xuan, Long Zhao, Haijiang Dong, Jian Chen, Zequn Li, Wenfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Shusen Zheng, Penghong Song
Summary: In this study, we identified that GNA14 is downregulated in HCC and negatively correlated with HBV infection, vascular invasion, and prognosis. HBx regulates GNA14 through DNA methylation, affecting the Notch1 and JMJD6 pathways to inhibit tumor proliferation and metastasis. GNA14 shows potential as a biomarker and therapeutic target in HCC.
Article
Biochemistry & Molecular Biology
Hiroaki Kanzaki, Tetsuhiro Chiba, Tatsuya Kaneko, Junjie Ao, Motoyasu Kan, Ryosuke Muroyama, Shingo Nakamoto, Tatsuo Kanda, Hitoshi Maruyama, Jun Kato, Yoh Zen, Ai Kotani, Kazuma Sekiba, Motoyuki Otsuka, Masayuki Ohtsuka, Naoya Kato
Summary: ELAVL1 protein is not only involved in the replication of hepatitis B virus, but also has an impact on the cell growth of hepatocellular carcinoma, making it a potential therapeutic target for HBV-related HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Anja Schollmeier, Mirco Glitscher, Eberhard Hildt
Summary: The hepatitis B virus (HBV) is a major global health problem and a significant causative factor for liver-related diseases. The viral regulatory protein HBx plays a role in the development of hepatocellular carcinomas (HCC) through its pleiotropic functions. However, the flexible and multifunctional nature of HBx hinders the understanding of its mechanisms and the development of associated diseases, leading to controversial results in some studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Virology
Masataka Tsuge
Summary: The text discusses the mechanism of liver carcinogenesis caused by chronic hepatitis B virus infection, as well as the usefulness of human hepatocyte chimeric mouse models in analyzing HBV-associated hepatocarcinogenesis.
Article
Biochemistry & Molecular Biology
Yaojia Ma, Shingo Nakamoto, Junjie Ao, Na Qiang, Tadayoshi Kogure, Keita Ogawa, Miyuki Nakagawa, Kisako Fujiwara, Terunao Iwanaga, Ryuta Kojima, Hiroaki Kanzaki, Keisuke Koroki, Kazufumi Kobayashi, Naoya Kanogawa, Soichiro Kiyono, Masato Nakamura, Takayuki Kondo, Ryo Nakagawa, Sadahisa Ogasawara, Ryosuke Muroyama, Tetsuhiro Chiba, Jun Kato, Naoya Kato
Summary: In this study, antiviral compounds targeting HBx protein were identified by analyzing HBx binding activity. Tranilast, one of the identified compounds, was found to inhibit HBV replication and infection without affecting cell viability. These findings provide new insights into the development of drugs for the treatment of HBV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Yongdong Niu, Liming Chen, Manpeng Wu, Weiyi Huang, Xuejun Wu, Danmei Huang, Yangmin Xie, Ganggang Shi
Summary: The study found that both full-length HBx and HBx C-terminal truncation coexist in HCC, and both can activate FXR signaling. Additionally, HBx-C30 has a weaker coactivating effect on FXR-KNG1 signaling compared to full-length HBx.
Article
Oncology
Cuifang Zhang, Ying Xie, Ruixue Lai, Jianhua Wu, Zhanjun Guo
Summary: Functional analysis reveals that the mutation in the hepatitis B virus X (HBx) gene is associated with hepatocellular carcinoma (HCC) malignancy. The mutation enhances HCC cell proliferation, invasion, and migration, while inhibiting apoptosis. It also promotes tumor growth and alters fibrosis, intracellular reactive oxygen species (ROS), and cytokine levels. The C1653T mutation may serve as a potential biomarker for screening HCC patients and determining the efficacy of apatinib treatment.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Microbiology
Qi Wei, Hongxiao Song, Yanli Gao, Fengchao Xu, Qingfei Xiao, Fei Wang, Bingxin Lei, Junqi Niu, Pujun Gao, Haichun Ma, Guangyun Tan
Summary: There is cross talk between HBV and the host through the CH25H-HBx axis. The expression of CH25H is increased in HBV-infected patients and is associated with low HBV replication. CH25H and its mutants interact with HBx protein and inhibit the nuclear translocation of HBx. 25HC promotes HBV infection but not replication.
Article
Oncology
Ying Li, Chaomin Wang, Ting Zhao, Ranliang Cui, Linfei Hu, Luchen Chang, Xi Wei, Jin Zhang, Yueguo Li
Summary: The study reveals a significant association between CCL15 expression and HBx in HCC, with high CCL15 expression being closely related to poor prognosis in HCC patients. CCL15 may serve as a clinical management indicator for HBV-associated HCC.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Tao Wan, Zhao Lei, Biao Tu, Tianyin Wang, Jiale Wang, Feizhou Huang
Summary: NEDD4 plays a dual role in carcinogenesis, acting as a tumor suppressor in HBV-associated HCC by degrading HBx as an E3 ubiquitin ligase, leading to better overall survival and progression-free survival in patients. High NEDD4 expression is not related to HBV exposure but inhibits proliferation, migration, and invasion in HBV-related HCC cell lines.
FRONTIERS IN ONCOLOGY
(2021)
Article
Food Science & Technology
Bozidar Udovicki, Nikola Tomic, Bojana Spirovic Trifunovic, Sasa Despotovic, Jelena Jovanovic, Liesbeth Jacxsens, Andreja Rajkovic
Summary: The study analyzed the exposure to aflatoxin B1 (AFB1) in commonly consumed foods in Serbia, finding that children had the highest exposure levels, raising concerns for their health. The Margin of Exposure (MOE) calculation and estimation of potential hepatocellular carcinoma (HCC) cases revealed low MOE values and a range of possible HCC cases per year based on population groups.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Fisheries
Sarah L. Carroll, Vernon E. Coyne
Summary: Ocean acidification is becoming more pervasive due to increasing CO2 emissions and global climate change, affecting various trophic levels and posing a threat to community structures and the sustainability of the fishing/aquaculture industry. Understanding the molecular stress response of key organisms can help predict their survival under changing environmental conditions. This study focused on elucidating the molecular stress response of the South African abalone using high throughput iTRAQ-based proteomics methodology.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Inho Kang, Ji Ae Kim, Jinchul Kim, Ju Hyeon Lee, Mi-Jee Kim, Jeong Keun Ahn
Summary: Hepatitis B virus (HBV) infection is a major cause of hepatocellular carcinoma (HCC). In this study, the researchers discovered a new mechanism of HBV-associated HCC metastasis. HBV X protein (HBx) interacts with the suppressor of cytokine signaling 1 (SOCS1), resulting in the activation of NF-kappa B and the transcription of factors associated with epithelial-mesenchymal transition (EMT), which promotes the invasiveness and migration of cancer cells.
Article
Oncology
Chunyan Zhang, Huan Yang, Liwei Pan, Guangfu Zhao, Ruofei Zhang, Tianci Zhang, Zhixiong Xiao, Ying Tong, Yi Zhang, Richard Hu, Stephen J. Pandol, Yuan-Ping Han
Summary: This study highlights the potential mechanism of HBV-mediated malignancy through the downregulation of TFEB by HBx, leading to the accumulation of ITGB1 in HCC cells and promoting cell migration.
Review
Gastroenterology & Hepatology
Masataka Tsuge
Summary: Chronic hepatitis B virus (HBV) infection is a global health issue that can lead to severe liver dysfunction and hepatocellular carcinoma. Current antiviral therapies are effective in suppressing viral replication, but difficulty in complete virus elimination, along with alterations in intracellular metabolism and signaling pathways, contribute to the development of hepatocarcinogenesis in chronic HBV infection.
LIVER INTERNATIONAL
(2021)
Article
Food Science & Technology
Jaslyn Jie Lin Lee, Xi Cui, Kong Fei Chai, Guili Zhao, Wei Ning Chen
FOOD AND BIOPROCESS TECHNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Mingming Wang, Fayin Ye, He Wang, Ruijin Yang, Xiao Hua
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2020)
Article
Biotechnology & Applied Microbiology
Yun Nian Tan, Pei Pei Lee, Wei Ning Chen
Article
Food Science & Technology
Junjun Liu, Wenbin Zhang, Pengfei Li, Zhumao Jiang, Ruijin Yang
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yong Xing Tan, Wai Kit Mok, Wei Ning Chen
Summary: In this study, fermented BSG using Bacillus subtilis WX-17 was found to have higher nutritional components such as amino acids, fatty acids, and Vitamin K(2)MK7. Additionally, higher amounts of short-chain fatty acids were produced after fermentation. The fermentation also had different effects on gut microbiota composition, demonstrating the potential of utilizing BSG as functional food ingredients through microbial fermentation.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Lu Wang, Jiali Gu, Yinghui Feng, Mingming Wang, Yanjun Tong, Yingjie Liu, Xiaomei Lyu, Ruijin Yang
Summary: This study aimed to optimize the catalytic performances of CEs by flexible loop exchange, resulting in mutants with improved isomerization activity and thermostability. Molecular dynamics simulations showed that loop exchange enlarged the entrance of the active site for substrate binding and benefited proton transfer. This work demonstrated the importance of the flexible loop surrounding the active site in determining the isomerization activity and thermostability of CEs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Xuan Zhang, Yanjun Tong, Jing Wang, Xiaomei Lyu, Ruijin Yang
Summary: The study demonstrated that milk fermented by Bacillus subtilis JNFE0126 has potential as a novel functional food in preventing thrombosis-related cardiovascular diseases, showing promising thrombolytic and milk-clotting activities with good sensory acceptance.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Food Science & Technology
Xiangling Shu, Yanjun Tong, Ruijin Yang
Summary: This study investigated the modulatory effects of XOS on emotions and behaviors in a mouse model of chronic stress-induced depression. The results showed that XOS could improve depressive-like behavior by modulating neurotransmitters and gut microbiota. These findings suggest that XOS has the potential to be used as a prebiotic for mood disorders.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Cheng Zhang, Xiaomei Lyu, Wei Zhao, Ruijin Yang
Summary: This study used RF technology to prepare low-fat French fries and found that moderate RF treatment can reduce the oil content of fries without altering their texture, providing new possibilities for the development of low-fat fried foods.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Agriculture, Multidisciplinary
Mingming Wang, Qiqi Chen, Xiao Hua, Ruijin Yang
Summary: In this study, an innovative and sustainable strategy using highly-porous polymeric adsorbents was developed for the efficient purification of tea saponin (TS). The proposed method enabled the direct isolation of high-purity TS from industrial camellia oil production, with a high recovery ratio. This methodology shows promising potential for industrial-scale purification.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Agriculture, Multidisciplinary
Jianfen Ye, Xiao Hua, Xingfeng Shao, Ruijin Yang
Summary: The acidification of peanut polysaccharide at pH 3.0 led to the formation of a stable gel structure for preparing oil-in-water emulsions, which exhibited resistance to digestion and maintained a strong structure. This emulsion showed promising potential as a cholesterol-free and low-fat salad dressing substitute.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Xuan Zhang, Xiaomei Lyu, Yanjun Tong, Jing Wang, Jianfen Ye, Ruijin Yang
Article
Multidisciplinary Sciences
Yong Xing Tan, Wai Kit Mok, Wei Ning Chen
Article
Biotechnology & Applied Microbiology
Yun Nian Tan, Pei Pei Lee, Wei Ning Chen
FERMENTATION-BASEL
(2020)
Article
Chemistry, Multidisciplinary
Jaslyn Jie Lin Lee, Bamabas Chan, Cui Chun, Kalpana Bhaskaran, Wei Ning Chen
Article
Biochemical Research Methods
Tanushree Halder, Elke Stroeher, Hui Liu, Yinglong Chen, Guijun Yan, Kadambot H. M. Siddique
Summary: Improving the root system of wheat is crucial for enhancing grain yield and climate resilience. This study identified proteins associated with root length and root mass in wheat using label-free quantitative proteomics. The findings revealed potential biomarkers that could be used for improving the root system of wheat.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Yinhua Pan, Quanqing Zou, Wu Yin, Zhen Huang, Yingzhu Zhao, Zongming Mo, Lihui Li, Jianrong Yang
Summary: A prognostic model of BC based on LNM-related genes was established in this study, providing guidance for prognosis evaluation and precise treatment of BC. The genes related to lymph node metastasis in BC are largely unknown and need further exploration. Searching for potential lymph node metastasis-related genes of BC will provide meaningful biomarkers for BC treatment. Our model, based on TCGA-BRCA data, effectively predicted patient outcomes and classified BC patients. The identified feature genes might have a predictive function in immunotherapy. The results of this study provide a new reference for the prognosis and treatment of BC patients with lymph node metastasis.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Qiushi Liang, Joon M. Pijnenburg, Erikjan Rijkers, Arnold G. Vulto, Ans T. van der Ploeg, Niek P. van Til, Eva C. Vlaar, Jeroen A. A. Demmers, W. W. M. Pim Pijnappel
Summary: Pompe disease is a lysosomal storage disorder characterized by glycogen accumulation in skeletal muscle, leading to profound pathology. This study showed that lentiviral gene therapy with LV-IGF2.GAAco can nearly completely correct disease-associated proteomic changes, supporting its future clinical development as a new treatment option for Pompe disease.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Chuang Liu, Wenjing Zhang, Qianli Dong, Haipeng Liu
Summary: This study fills the knowledge gap about the matrix proteins involved in the formation of mineralized exoskeletons in decapod crustaceans. By comparing with well-studied molluscan biomineralization proteins, it is proposed that decapod crustaceans evolved novel proteins while sharing some proteins with molluscs. This study provides insights into the evolution and adaptation of crustaceans and molluscs in forming their exoskeletons.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Rania D. Baka, Josipa Kules, Angelo Beletic, Vladimir Farkas, Dina Resetar Maslov, Blanka Beer Ljubic, Ivana Rubic, Vladimir Mrljak, Mark McLaughlin, David Eckersall, Zoe Polizopoulou
Summary: This study analyzed serum samples from dogs with epilepsy and identified potential markers of epilepsy, proteins involved in nerve tissue regeneration, and proteins altered by antiepileptic medication. The findings provide insight into the pathogenesis of epilepsy and the effects of medication on extracellular matrix proteins.
JOURNAL OF PROTEOMICS
(2024)
Article
Biochemical Research Methods
Viviane M. Codognoto, Fabiana F. de Souza, Thais R. Cataldi, Carlos A. Labate, Laiza S. de Camargo, Pedro H. Esteves Trindade, Roberto R. da Rosa Filho, Diego J. B. de Oliveira, Eunice Oba
Summary: This study aimed to compare urine proteomics from non- and pregnant buffaloes to identify potential biomarkers of early pregnancy. A total of 798 proteins were reported in the urine considering all groups, and the differential proteins play essential roles during pregnancy.
JOURNAL OF PROTEOMICS
(2024)
