☆ 4.7 Article

Mining the Gastric Cancer Secretome: Identification of GRN as a Potential Diagnostic Marker for Early Gastric Cancer

JOURNAL OF PROTEOME RESEARCH (2012)

期刊

JOURNAL OF PROTEOME RESEARCH

卷 11, 期 3, 页码 1759-1772

出版社

AMER CHEMICAL SOC

DOI: 10.1021/pr201014h

关键词

proteomics; gastric cancer; secretome; iTRAQ; GRN; granulin; biomarker

类别

Biochemical Research Methods

资金

National Medical Research Council
National Research Foundation of Singapore

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摘要

Gastric cancer is the second leading cause of cancer deaths worldwide, and currently, there are no clinically relevant biomarkers for gastric cancer diagnosis or prognosis. In this study, we applied a 2D-LC-MS/MS based approach, in combination with iTRAQ labeling, to study the secretomes of the gastric cancer cell lines AGS and MKN7. By performing a comparative analysis between the conditioned media and the whole cell lysates, our workflow allowed us to differentiate the bona fide secreted proteins from the intracellular contaminants within the conditioned media. Ninety proteins were found to have higher abundance in the conditioned media as compared to the whole cell lysates of AGS and MKN7 cells. Using a signal peptide and nonclassical secretion prediction tool and an online exosome database, we demonstrated that up to 92.2% of these 90 proteins can be exported out of the cells by classical or nonclassical secretory pathways. We then performed quantitative comparisons of the secretomes between AGS and MKN7, identifying 43 differentially expressed secreted proteins. Among them, GRN was found to be frequently expressed in gastric tumor tissues, but not in normal gastric epithelia by immunohistochemistry. Sandwich ELISA assay also showed elevation of serum GRN levels in gastric cancer patients, particularly those with early gastric cancer. Receiver operating characteristic (ROC) curves analysis confirmed that serum GRN can provide diagnostic discriminations for gastric cancer patients

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LANCET GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Surgery

Admission discipline and timing of admission may influence outcomes for gastrointestinal bleeding patients

Koy Min Chue, Jonathan Yongwei Boey, Bridget Si Min Ng, Jun Liang Teh, Guowei Kim, Asim Shabbir, Yiong Huak Chan, Mikael Hartman, Jimmy Bok Yan So

Summary: This study aimed to investigate the impact of admitting discipline and timing of admission on patient outcomes in Background Bleeding of the gastrointestinal tract (BGIT). Results showed that admission to a surgical discipline appeared to have at least equivalent patient outcomes compared to a medical discipline. Patients presenting with BGIT after office-hours were more likely to experience a delay to endoscopy, although it did not affect patient mortality.

ANZ JOURNAL OF SURGERY (2021)

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Article Gastroenterology & Hepatology

Severity of gastric intestinal metaplasia predicts the risk of gastric cancer: a prospective multicentre cohort study (GCEP)

Jonathan W. J. Lee, Feng Zhu, Supriya Srivastava, Stephen Kk Tsao, Christopher Khor, Khek Yu Ho, Kwong Ming Fock, Wee Chian Lim, Tiing Leong Ang, Wan Cheng Chow, Jimmy Bok Yan So, Calvin J. Koh, Shijia Joy Chua, Andrew S. Y. Wong, Jaideepraj Rao, Lee Guan Lim, Khoon Lin Ling, Chung-King Chia, Choon Jin Ooi, Andrea Rajnakova, Wai Ming Yap, Manuel Salto-Tellez, Bow Ho, Richie Soong, Kee Seng Chia, Yik Ying Teo, Ming Teh, Khay-Guan Yeoh

Summary: This study found that gastric intestinal metaplasia (IM) is a significant risk factor for early gastric neoplasia (EGN) in regions with low-intermediate incidence of gastric cancer. Based on the results, it is recommended that high-risk patients (OLGIM III-IV) undergo endoscopic surveillance every 2 years, and intermediate-risk patients (OLGIM II) every 5 years.

GUT (2022)

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Article Infectious Diseases

Positive impact of oral hydroxychloroquine and povidone-iodine throat spray for COVID-19 prophylaxis: An open-label randomized trial

Raymond Chee Seong Seet, Amy May Lin Quek, Delicia Shu Qin Ooi, Sharmila Sengupta, Satish Ramapatna Lakshminarasappa, Chieh Yang Koo, Jimmy Bok Yan So, Boon Cher Goh, Kwok Seng Loh, Dale Fisher, Hock Luen Teoh, Jie Sun, Alex R. Cook, Paul Anantharajah Tambyah, Mikael Hartman

Summary: The study found that chemoprophylaxis with either oral hydroxychloroquine or povidone-iodine throat spray was superior to oral vitamin C in reducing SARS-CoV-2 infection in young and healthy men. Participants receiving zinc/vitamin C combination had the highest rate of interruptions due to side effects.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Association of metabolic-bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants

Nicholas L. Syn, David E. Cummings, Louis Z. Wang, Daryl J. Lin, Joseph J. Zhao, Marie Loh, Zong Jie Koh, Claire Alexandra Chew, Ying Ern Loo, Bee Choo Tai, Guowei Kim, Jimmy Bok-Yan So, Lee M. Kaplan, John B. Dixon, Asim Shabbir

Summary: Metabolic-bariatric surgery significantly reduces all-cause mortality and extends life expectancy in obese adults, with a more pronounced effect seen in patients with pre-existing diabetes.

LANCET (2021)

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Editorial Material Gastroenterology & Hepatology

Gastrointestinal: Black esophagus

H. S. S. Bong, Y. S. A. Soh, A. Shabbir, JB-Y So

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022)

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Article Surgery

Gastro-esophageal reflux disease (GERD) after peroral endoscopic myotomy (POEM)

Jun Liang Teh, Hui Yu Tham, Alex Yu Sen Soh, Corrisa Chee, Guowei Kim, Asim Shabbir, Reuben Kong Min Wong, Jimmy Bok Yan So

Summary: This study focused on reflux after POEM, finding that 43.1% of patients had symptomatic reflux, 60% had endoscopic evidence of esophagitis, and 56% had increased acid exposure on pH-impedance test.

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2022)

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Article Biochemistry & Molecular Biology

Global analysis of RNA-binding proteins identifies a positive feedback loop between LARP1 and MYC that promotes tumorigenesis

Ng Desi, Qing Yun Tong, Velda Teh, Jia Jia Chan, Bin Zhang, Hossein Tabatabaeian, Hui Qing Tan, Katannya Kapeli, Wenhao Jin, Chun You Lim, Zhi Hao Kwok, Hwee Tong Tan, Shi Wang, Bei-En Siew, Kuok-Chung Lee, Choon-Seng Chong, Ker-Kan Tan, Henry Yang, Dennis Kappei, Gene W. Yeo, Maxey Ching Ming Chung, Yvonne Tay

Summary: In addition to genomic alterations, aberrant changes in post-transcriptional regulation can modify gene function and drive cancer development. This study identified LARP1 as an upregulated post-transcriptional regulator in colorectal cancer (CRC) that targets the 3' UTR of the oncogene MYC, promoting CRC tumorigenesis.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

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Editorial Material Oncology

ASO Author Reflections: Combination Intra-Peritoneal and Systemic Chemotherapy for Gastric Cancer with Peritoneal Metastases

Daryl K. A. Chia, Jia Jun Ang, Raghav Sundar, Guowei Kim, Asim Shabbir, Jimmy B. Y. So, Wei Peng Yong

ANNALS OF SURGICAL ONCOLOGY (2022)

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Article Medical Laboratory Technology

Evaluation of low-density lipoprotein cholesterol equations by cross-platform assessment of accuracy-based EQA data against SI-traceable reference value

Hwee Tong Tan, Sharon Yong, Hong Liu, Qinde Liu, Tang Lin Teo, Sunil Kumar Sethi

Summary: This study evaluated the accuracy of the Friedewald equation and two alternative equations (Martin/Hopkins and Sampson) for calculating LDLC. The results showed that the Martin/Hopkins equation had the best agreement with LDLC reference values and enabled a more accurate classification of LDLC levels.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

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Article Oncology

The ISSPP PIPAC database: design, process, access, and first interim analysis

Michael Bau Mortensen, Olivier Glehen, Philipp Horvath, Martin Huebner, Kim Hyung-Ho, Alfred Koenigsrainer, Marc Pocard, Marc Andre Reymond, Jimmy So, Claus Wilki Fristrup

Summary: This article discusses the establishment of an international PIPAC database under the International Society for the Study of Pleura and Peritoneum, providing an overview of the design process and preliminary results. The database, launched in June 2020, received data from ten institutions, demonstrating its feasibility and comparability to existing literature.

PLEURA AND PERITONEUM (2021)

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