The Physiology of Proinsulin C-Peptide: Unanswered Questions and a Proposed Model

Mechanisms of C-peptide-mediated rescue of low O2-induced ATP release from erythrocytes of humans with Type 2 diabetes

(2015) Jennifer P. Richards et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

C-peptide: New findings and therapeutic possibilities

(2015) John Wahren et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Proinsulin C-Peptide Prevents Impaired Wound Healing by Activating Angiogenesis in Diabetes

(2015) Young-Cheol Lim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Physiological effects and therapeutic potential of proinsulin C-peptide

(2014) Gina L. C. Yosten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Low O2-induced ATP release from erythrocytes of humans with type 2 diabetes is restored by physiological ratios of C-peptide and insulin

(2014) Jennifer P. Richards et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Insulin Receptor Signaling in Normal and Insulin-Resistant States

(2014) J. Boucher et al.   Cold Spring Harbor Perspectives in Biology

Synergistic effects of C-peptide and insulin on low O2-induced ATP release from human erythrocytes

(2013) Jennifer P. Richards et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Prevention of VEGF-mediated microvascular permeability by C-peptide in diabetic mice

(2013) Y.-C. Lim et al.   CARDIOVASCULAR RESEARCH

C-Peptide Activates AMPK  and Prevents ROS-Mediated Mitochondrial Fission and Endothelial Apoptosis in Diabetes

(2013) M. P. Bhatt et al.   DIABETES

Impact of C-Peptide Preservation on Metabolic and Clinical Outcomes in the Diabetes Control and Complications Trial

(2013) J. M. Lachin et al.   DIABETES

Evidence for an interaction between proinsulin C-peptide and GPR146

(2013) Gina L C Yosten et al.   JOURNAL OF ENDOCRINOLOGY

Dynamic localization and functional implications of C-peptide might for suppression of iNOS in high glucose-stimulated rat mesangial cells

(2013) Yanning Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Persistent C-peptide

(2013) Massimo Pietropaolo   Current Opinion in Endocrinology Diabetes and Obesity

Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107

(2012) Gina L. C. Yosten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The Clinical Potential of C-Peptide Replacement in Type 1 Diabetes

(2012) J. Wahren et al.   DIABETES

C-Peptide Prevents Hyperglycemia-Induced Endothelial Apoptosis Through Inhibition of Reactive Oxygen Species–Mediated Transglutaminase 2 Activation

(2012) Mahendra Prasad Bhatt et al.   DIABETES

C-peptide-stimulated nitric oxide production in a cultured pulmonary artery endothelium is erythrocyte mediated and requires Zn2+

(2012) Adam W. Giebink et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Proinsulin C-peptide activates α-enolase: implications for C-peptide–cell membrane interaction

(2012) Tatsuya Ishii et al.   JOURNAL OF BIOCHEMISTRY

Regulation of blood flow distribution in skeletal muscle: role of erythrocyte-released ATP

(2012) Mary L. Ellsworth et al.   JOURNAL OF PHYSIOLOGY-LONDON

C-peptide reduces high-glucose-induced apoptosis of endothelial cells and decreases NAD(P)H-oxidase reactive oxygen species generation in human aortic endothelial cells

(2011) V. Cifarelli et al.   DIABETOLOGIA

C-peptide reduces pro-inflammatory cytokine secretion in LPS-stimulated U937 monocytes in condition of hyperglycemia

(2011) Jaime Haidet et al.   INFLAMMATION RESEARCH

C-Peptide as a Therapeutic Tool in Diabetic Nephropathy

(2010) Claire E. Hills et al.   AMERICAN JOURNAL OF NEPHROLOGY

C-peptide and long-term complications of diabetes

(2010) Patrizia Luppi et al.   PEDIATRIC DIABETES

Proinsulin C-peptide interaction with protein tyrosine phosphatase 1B demonstrated with a labeling reaction

(2009) Theres Jägerbrink et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: Evidence for PKC activation and oxidative stress-activated signaling pathways

(2009) Rafik Ragheb et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cellular and physiological effects of C-peptide

(2009) Claire E. Hills et al.   CLINICAL SCIENCE

C-peptide is internalised in human endothelial and vascular smooth muscle cells via early endosomes

(2009) P. Luppi et al.   DIABETOLOGIA

Human C-peptide antagonises high glucose-induced endothelial dysfunction through the nuclear factor-κB pathway

(2008) P. Luppi et al.   DIABETOLOGIA

Protein Kinase C-ζ Phosphorylates Insulin Receptor Substrate-1, -3, and -4 But Not -2: Isoform Specific Determinants of Specificity in Insulin Signaling

(2008) Sihoon Lee et al.   ENDOCRINOLOGY

Intracellular Signalling by C-Peptide

(2008) Claire E. Hills et al.   Experimental Diabetes Research