期刊
DIABETES RESEARCH AND CLINICAL PRACTICE
卷 107, 期 3, 页码 309-319出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.diabres.2015.01.016
关键词
Neuropathy; Nephropathy; Retinopathy; Na+, K+-ATPase; eNOS; Reactive oxygen species
Much new information on C-peptide physiology has appeared during the past 20 years. It has been shown that C-peptide binds specifically to cell membranes, elicits intracellular signaling via G-protein and Ca2+-dependent pathways, resulting in activation and increased expression of endothelial nitric oxide synthase, Na+, K+-ATPase and several transcription factors of importance for anti-inflammatory, anti-oxidant and cell protective mechanisms. Studies in animal models of diabetes and early clinical trials in patients with type 1 diabetes demonstrate that C-peptide in replacement doses elicits beneficial effects on early stages of diabetes-induced functional and structural abnormalities of the peripheral nerves, the kidneys and the retina. Much remains to be learned about C-peptide's mechanism of action and long-term clinical trials in type 1 diabetes subjects will be required to determine C-peptide's clinical utility. Nevertheless, even a cautious evaluation of the available evidence presents the picture of a bioactive endogenous peptide with therapeutic potential (C) 2015 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据