Article
Biochemistry & Molecular Biology
Junchul Shin, Soon-Gook Hong, Soo Young Choi, Meghan E. Rath, Jason Saredy, Daniel G. Jovin, Jacqueline Sayoc, Hye-Sang Park, Satoru Eguchi, Victor Rizzo, Rosario Scalia, Hong Wang, Steven R. Houser, Joon-Young Park
Summary: Tumor suppressor p53 plays a pivotal role in regulating mitochondrial remodeling in endothelial cells. It controls the content, fusion/fission processes, and intracellular signaling molecules associated with mitophagy and apoptosis pathways. In addition, p53 is involved in the mechanism of flow-induced mitochondrial remodeling by binding to mitochondrial transcription factor A (TFAM) and improving mtDNA integrity.
Article
Cell Biology
Qian Hao, Jiaxiang Chen, Junming Liao, Yingdan Huang, Yu Gan, Sarit Larisch, Shelya X. Zeng, Hua Lu, Xiang Zhou
Summary: ARTS and p53 collaborate closely in mitochondria-engaged apoptosis, with ARTS inducing apoptosis by antagonizing anti-apoptotic proteins and p53 activating the expression of ARTS.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Meng Zhao, Yizhuo Wang, Ling Li, Shuyun Liu, Chengshi Wang, Yujia Yuan, Guang Yang, Younan Chen, Jingqiu Cheng, Yanrong Lu, Jingping Liu
Summary: Reducing mtROS levels attenuated renal dysfunction, mitochondrial damage, and inflammation in IRI-AKI mice. The loss of TFAM can impact mtDNA maintenance, mitochondrial energy metabolism, and cytokine release. Insights into the role of mtROS and TFAM in IRI-AKI provide potential therapeutic targets for renal repair.
Article
Chemistry, Multidisciplinary
Meng Zhao, Shuyun Liu, Chengshi Wang, Yizhuo Wang, Meihua Wan, Fang Liu, Meng Gong, Yujia Yuan, Younan Chen, Jingqiu Cheng, Yanrong Lu, Jingping Liu
Summary: The study demonstrates that MSC-EVs can alleviate mtDNA damage and inflammation after acute kidney injury, with their effects partially dependent on the TFAM signaling pathway. This suggests that MSC-EVs are promising nanotherapeutics for diseases characterized by mitochondrial damage, highlighting the essential role of TFAM in maintaining their regenerative capacity.
Article
Cell Biology
Nasab Ghazal, Jessica N. Peoples, Tahmina A. Mohiuddin, Jennifer Q. Kwong
Summary: Contrary to previous beliefs, the adult heart shows remarkable resilience to acute insults to mtDNA regulation, maintaining mitochondrial function and cardiac function even with decreased TFAM protein levels. This resilience is only compromised with long-term TFAM inactivation, leading to mitochondrial dysfunction and cardiomyopathy.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Zhijie Zhu, Xuankang Wang, Zhiwen Song, Xiaoshuang Zuo, Yangguang Ma, Zhihao Zhang, Cheng Ju, Zhuowen Liang, Kun Li, Xueyu Hu, Zhe Wang
Summary: This study found that PBM could promote the recovery of mitochondrial respiratory chain complex activity, increase ATP production, alleviate neuronal apoptosis, and reverse motor dysfunction after SCI in rats. The neuroprotective effects of PBM were mediated by activation of the AMPK/PGC-1 alpha/TFAM pathway to restore mitochondrial bioenergetics.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Urology & Nephrology
Ken Ishii, Hanako Kobayashi, Kensei Taguchi, Nan Guan, Andraia Li, Carmen Tong, Olena Davidoff, Pamela Tran, Madhulika Sharma, Navdeep S. Chandel, Meghan E. Kapp, Agnes B. Fogo, Craig R. Brooks, Volker H. Haase
Summary: TFAM deficiency disrupts mitochondrial function in kidney cells, leading to impaired nephron maturation and severe cystic disease development; reduced TFAM expression and mitochondrial depletion are molecular features of kidney cystic disease, suggesting their contribution to pathogenesis.
KIDNEY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Majda Mehmedovic, Martial Martucci, Henrik Spahr, Layal Ishak, Anup Mishra, Maria Eugenia Sanchez-Sandoval, Carlos Pardo-Hernandez, Bradley Peter, Maria Sanchez-Sandoval, Siet M. van den Wildenberg, Maria Falkenberg, Geraldine Farge
Summary: This study provides a biochemical characterization of the pathogenic TFAM variant P178L and suggests that the mutation severely impairs mtDNA transcription initiation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Ana Sierra-Magro, Fernando Bartolome, David Lozano-Munoz, Jesus Alarcon-Gil, Elena Gine, Marina Sanz-SanCristobal, Sandra Alonso-Gil, Marta Cortes-Canteli, Eva Carro, Ana Perez-Castillo, Jose A. Morales-Garcia
Summary: Parkinson's disease (PD) is a neurodegenerative disorder caused by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The transcription factor CCAAT/Enhancer Binding Protein beta (C/EBP beta) may be a good therapeutic target for PD treatment due to its altered levels in neurodegenerative diseases. A list of PD-related genes regulated by C/EBP beta was generated, including mitochondrial transcription factor A (TFAM). The absence of C/EBP beta may lead to the accumulation of non-functional mitochondria due to impaired autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Shruti Patrick, Pruthvi Gowda, Kirti Lathoria, Vaishali Suri, Ellora Sen
Summary: The mutation of the IDH1 gene results in decreased nuclear levels of YAP1 and TFAM, leading to mitochondrial fragmentation and ROS generation, as well as altered localization of TERT in mitochondria, which ultimately affects cell apoptosis. Treatment with the Src kinase inhibitor bosutinib further enhances ROS production and induces apoptosis, indicating a crucial role of YAP1 in regulating redox homeostasis through mitochondrial dysfunction and TERT shuttling.
JOURNAL OF CELL SCIENCE
(2021)
Article
Oncology
Hao Ni, Min Guo, Xuepei Zhang, Lei Jiang, Shuai Tan, Juan Yuan, Huanhuan L. Cui, Yanan Min, Junhao Zhang, Susanne Schlisio, Chunhong Ma, Wangjun Liao, Monica Nister, Chunlin Chen, Shuijie Li, Nailin Li
Summary: In this study, it was found that inhibition of VEGF by Ki8751 suppressed cancer cell proliferation by increasing mitochondrial biogenesis and ROS production. Ki8751 also modulated mitochondrial biogenesis and cancer cell apoptosis by inhibiting the Akt-PGC1 alpha-TFAM signaling pathway.
CANCER BIOLOGY & MEDICINE
(2021)
Review
Cell Biology
Han Dong, Shih-Yin Tsai
Summary: Mitochondria are crucial for energy production and play a vital role in various biological processes in eukaryotic cells. Skeletal muscle heavily relies on mitochondria for energy supplementation and also relies on them for maintaining calcium and reactive oxygen species levels. This review summarizes recent studies on mitochondria function and quality control in skeletal muscle, focusing on in vivo studies of rodents and human subjects. The interplay between mitochondrial functions and muscle fiber type-specific phenotypes, as well as the impact of aging and exercise on skeletal muscle and mitochondria properties, is also discussed.
Article
Biochemistry & Molecular Biology
Qinghuan Kong, Xiaoyu Yan, Meiyu Cheng, Xin Jiang, Long Xu, Luyan Shen, Huimei Yu, Liankun Sun
Summary: In ovarian cancer cells, p62 coordinates the mitochondrial localization of p53, promoting cell apoptosis by inhibiting mtDNA transcription and mitochondrial function, leading to enhanced sensitivity to cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Changfeng Li, Ying Zhang, Jiao Liu, Rui Kang, Daniel J. Klionsky, Daolin Tang
Summary: The study reveals that zalcitabine, an antiviral drug, can suppress pancreatic cancer cell growth through inducing ferroptosis, a type of cell death. This effect is mediated by zalcitabine-induced mitochondrial DNA stress and the activation of a DNA sensing pathway, leading to cell death via lipid peroxidation. Genetically or pharmacologically inhibiting this pathway reduces the anticancer effects of zalcitabine.
Article
Immunology
Diogo Dominguini, Monique Michels, Leticia B. Wessler, Emilio L. Streck, Tatiana Barichello, Felipe Dal-Pizzol
Summary: The administration of mefenamic acid (MFA) in animals with polymicrobial sepsis reduces inflammatory parameters and mitochondrial damage, improving mitochondrial function, reducing oxidative damage, and protecting the central nervous system.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Cell Biology
Ayesha Saleem, Sobia Iqbal, Yuan Zhang, David A. Hood
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Melania Collu-Marchese, Michael Shuen, Marion Pauly, Ayesha Saleem, David A. Hood
BIOSCIENCE REPORTS
(2015)
Article
Cell Biology
Ayesha Saleem, Adeel Safdar, Yu Kitaoka, Xiaoxing Ma, Olivia S. Marquez, Mahmood Akhtar, Aisha Nazli, Rahul Suri, John Turnbull, Mark A. Tarnopolsky
Article
Geriatrics & Gerontology
Joanne Clark-Matott, Ayesha Saleem, Ying Dai, Yevgeniya Shurubor, Xiaoxing Ma, Adeel Safdar, Myron Flint Beal, Mark Tarnopolsky, David K. Simon
NEUROBIOLOGY OF AGING
(2015)
Article
Cell Biology
Adeel Safdar, Konstantin Khrapko, James M. Flynn, Ayesha Saleem, Michael De Lisio, Adam P. W. Johnston, Yevgenya Kratysberg, Imtiaz A. Samjoo, Yu Kitaoka, Daniel I. Ogborn, Jonathan P. Little, Sandeep Raha, Gianni Parise, Mahmood Akhtar, Bart P. Hettinga, Glenn C. Rowe, Zoltan Arany, Tomas A. Prolla, Mark A. Tarnopolsky
Article
Cell Biology
Adeel Safdar, Sofia Annis, Yevgenya Kraytsberg, Chloe Laverack, Ayesha Saleem, Konstantin Popadin, Dori C. Woods, Jonathan L. Tilly, Konstantin Khrapko
CURRENT OPINION IN GENETICS & DEVELOPMENT
(2016)
Review
Endocrinology & Metabolism
Adeel Safdar, Ayesha Saleem, Mark A. Tarnopolsky
NATURE REVIEWS ENDOCRINOLOGY
(2016)
Meeting Abstract
Clinical Neurology
A. Saleem, A. Safdar, M. Khan, P. Azzopardi, D. Rusiecki, A. Saleem, M. Tarnopolsky
NEUROMUSCULAR DISORDERS
(2016)
Article
Biochemistry & Molecular Biology
Aisha Nazli, Adeel Safdar, Ayesha Saleem, Mahmood Akhtar, Lauren I. Brady, Jeremy Schwartzentruber, Mark A. Tarnopolsky
EUROPEAN JOURNAL OF HUMAN GENETICS
(2017)
Review
Biochemistry & Molecular Biology
Karim Sidhom, Patience O. Obi, Ayesha Saleem
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Letter
Nutrition & Dietetics
Sarah M. Reyes, Kozeta Miliku, Deborah Chan, Meredith Brockway, Sarah Turner, Katherine A. Kearns, Christina Raimondi, Ayesha Saleem, Lauren E. Kelly, Nathan C. Nickel, Meghan B. Azad
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Benjamin Bydak, Taiana M. Pierdona, Samira Seif, Karim Sidhom, Patience O. Obi, Hagar Labouta, Joseph W. Gordon, Ayesha Saleem
Summary: Extracellular vesicles (EVs) play a crucial role in cellular communication and can be influenced by exercise. This study investigated the characteristics of skeletal muscle-derived EVs and the effect of acute contractile activity. The results showed that EVs from myotubes were smaller and had higher protein yield compared to EVs from myoblasts. Acute stimulation did not affect the biophysical profile or protein markers in EVs. Further research is needed to explore the effects of chronic contractile activity on the biophysical characteristics and cargo of skeletal muscle-specific EVs.
Meeting Abstract
Biochemistry & Molecular Biology
Ayesha Saleem, Adeel Safdar, Maria Haikalis, Mahmood Akhtar, Hassan Haziri, Mark Tarnopolsky
Meeting Abstract
Biochemistry & Molecular Biology
Ayesha Saleem, Adeel Safdar, Maria Haikalis, Mahmood Akhtar, Rahul Suri, Mark Tarnopolsky
Meeting Abstract
Biochemistry & Molecular Biology
Ayesha Saleem, Adeel Safdar, Yu Kitaoka, Mahmood Akhtar, Olivia Marquez, Mark Tarnopolsky