Article
Plant Sciences
Zhengrui Wang, Hui-Fen Kuo, Tzyy-Jen Chiou
Summary: Recent research has shown that inositol pyrophosphates act as phosphate signaling molecules, perceived by the SPX domains in eukaryotic cells to regulate Pi transport and signaling. The PP-InsP-SPX signaling module is evolutionarily conserved and extensively utilized in plant systems for Pi transport and signaling.
Article
Biochemistry & Molecular Biology
Han Wu, Fenglin Wang, Jian-Hui Jiang
Summary: The CRISPR-Cas9 and dCas9 systems have revolutionized genome engineering and regulation, enabling conditional control of genetic manipulation through the CRISPR-dCas9 transcriptional systems. Current strategies mainly focus on the conditional control of gRNA function and dCas9 protein using external and internal triggers.
Article
Chemistry, Medicinal
Dehui Zhang, David A. Perrey, Ann M. Decker, Tiffany L. Langston, Vijayakumar Mavanji, Danni L. Harris, Catherine M. Kotz, Yanan Zhang
Summary: The study identified a promising dual small molecule agonist that can increase wakefulness and alleviate narcolepsy symptoms, with positive effects demonstrated in experiments on elderly mice, supporting the development of orexin agonists as potential treatments for orexin-deficient disorders in the future.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Qingdong Chai, Lei Xie, Meng Gao, Yingnan Liu, Xiangyu Xu, Xiaohong Huang, Pu Chen, Tong Wu, Qi Wan, Biao Kong
Summary: A super-assembled nanosystem was developed to eliminate multiple cell injury factors and provide protection to cells after ischemia reperfusion, while selectively and quantitatively detecting zinc ions.
Article
Chemistry, Analytical
Jorge Espina-Casado, Tania Fontanil, Alfonso Fernandez-Gonzalez, Santiago Cal, Alvaro J. Obaya, Marta Elena Diaz-Garcia, Rosana Badia-Laino
Summary: Carbon dots were synthesized from glutathione and surface-modified with beta-Cyclodextrin and FP, showing potential applications as drug carriers. The fluorescence changes allowed distinction of cancer cells with no alterations in cell morphology, enabling bioimaging and cancer diagnosis.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Spectroscopy
Yu Zhu Yang, Min Qing, Xiao Ye Luo, Juan Xie, Li Na Zhang
Summary: A dual-response fluorescent probe EDBI with high selectivity, rapid response, and low detection limit for discriminative determination of HSO3- and N2H4 was developed in this study. The probe utilizes ratiometric fluorescence and fluorescence on-off mode to distinctly sense HSO3- and N2H4 based on different reaction sites.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Chemistry, Medicinal
Caterine Henriquez Ruiz, Estefanie Osorio-Llanes, Mayra Hernandez Trespalacios, Evelyn Mendoza-Torres, Wendy Rosales, Carlos Mario Melendez Gomez
Summary: Quorum Sensing (QS) is a cell-to-cell communication mechanism used by some bacterial species. The study of the molecular mechanisms linking signal molecules with bacterial pathogenesis is of growing interest, as it can be used as a therapeutic alternative and to study bacterial resistance phenomena. This study can be approached from different perspectives, such as molecular signals, modulation strategies, regulation strategies of bacterial QS circuits, and the structural evolution of autoinducers. This mini-review highlights the importance of molecular diversity in designing new antimicrobial agents.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Mark C. Renton, Sean L. McGee, Kirsten F. Howlett
Summary: Research reveals that PKD signaling is involved in tissue-specific responses to obesity, including reduced insulin signaling and dysfunction in adipose tissue, liver, and heart.
Article
Engineering, Biomedical
Lianyu Yu, Sha Yang, Zeyu Liu, Xiaopei Qiu, Xiaoqi Tang, Shuang Zhao, Hanqing Xu, Mingxuan Gao, Jing Bao, Ligai Zhang, Dan Luo, Kai Chang, Ming Chen
Summary: In this study, an integrative DNA tetrahedral nanomachine was self-assembled for the sensitive detection and negative feedback regulation of intracellular miRNAs. The nanomachine exhibited excellent sensitivity and specificity, and demonstrated the ability to synchronously regulate target cells. It has promising applications in the early diagnosis and tailored management of cancers.
MATERIALS TODAY BIO
(2022)
Review
Neurosciences
Rong Guo, Dylan Thomas Vaughan, Ana Lourdes Almeida Rojo, Yanhua H. Huang
Summary: This review critically summarizes the mechanisms by which sleep influences reward function and suggests that improving sleep quality may serve as complementary therapy for treating substance use disorders. It also highlights the potential of formulating sleep metrics for predicting individual susceptibility to substance use disorders and other reward-associated psychiatric diseases.
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jin Wang, Tian Tian, Xin Li, Yan Zhang
Summary: With the growing knowledge of noncoding RNAs related to various diseases, they are emerging as novel drugs and drug targets. Nucleic acid drugs based on different types of noncoding RNAs have been designed and tested, along with the development of chemical biological methods to regulate disease-associated noncoding RNAs. New strategies and approaches are promising for gene expression regulation and next-generation drug development.
Review
Neurosciences
Man Wang, Lei Xu, Yuechen Han, Xue Wang, Fang Chen, Junze Lu, Haibo Wang, Wenwen Liu
Summary: Regenerating spiral ganglion neurons (SGNs) is of great clinical significance for recovering sensorineural hearing loss, but challenges remain in terms of the effectiveness of regeneration, maturation and function of newly generated neurons, and auditory function recovery.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Chemistry, Analytical
Peipei Li, Luo Luo, Dan Cheng, Yan Sun, Youyu Zhang, Meiling Liu, Shouzhuo Yao
Summary: This study developed porphyrin-based metal-organic frameworks (MOFs) with different properties as sensitive electrochemiluminescence (ECL) sensors. By controlling the reaction time, the MOFs exhibited excellent ECL performance and were used for the highly sensitive and selective detection of thrombin. This research provides a new approach for effective ECL immunoassays in the diagnosis of diseases.
ANALYTICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Maggie C. Evans, Rebecca E. Campbell, Greg M. Anderson
Summary: This review discusses the different mechanisms by which leptin, as a crucial factor, integrates and relays information about metabolic, psychological, environmental, and immune conditions to the central neuronal network that governs reproductive function.
CURRENT OPINION IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Masami Lintuluoto, Yota Horioka, Saki Hongo, Juha Mikael Lintuluoto, Yoshifumi Fukunishi
Summary: CD44 protein plays a role in cell adhesion and interaction with hyaluronan (HA) molecule. Classic molecular dynamics simulations show that different conformations of CD44 affect its affinity with HA, with external force influencing the conformational change and binding affinity.
Article
Clinical Neurology
Anne Venner, Rebecca Y. Broadhurst, Lauren T. Sohn, William D. Todd, Patrick M. Fuller
Review
Neurosciences
Mahesh M. Karnani, Cornelia Schone, Edward F. Bracey, J. Antonio Gonzalez, Paulius Viskaitis, Han-Tao Li, Antoine Adamantidis, Denis Burdakov
PROGRESS IN NEUROBIOLOGY
(2020)
Article
Multidisciplinary Sciences
Satvinder Kaur, Roberto De Luca, Mudasir A. Khanday, Sathyajit S. Bandaru, Renner C. Thomas, Rebecca Y. Broadhurst, Anne Venner, William D. Todd, Patrick M. Fuller, Elda Arrigoni, Clifford B. Saper
NATURE COMMUNICATIONS
(2020)
Article
Neurosciences
Marie Barbier, J. Antonio Gonzalez, Christophe Houdayer, Denis Burdakov, Pierre-Yves Risold, Sophie Croizier
Summary: This study utilized tracing and immunohistochemical methods to investigate the neural projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST) and various hypothalamic structures, revealing the neuroanatomical basis for the interplay between stress and feeding behaviors.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Denis Burdakov, Mahesh M. Karnani
Article
Multidisciplinary Sciences
William D. Todd, Anne Venner, Christelle Anaclet, Rebecca Y. Broadhurst, Roberto De Luca, Sathyajit S. Bandaru, Lindsay Issokson, Lauren M. Hablitz, Olga Cravetchi, Elda Arrigoni, John N. Campbell, Charles N. Allen, David P. Olson, Patrick M. Fuller
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Paulius Viskaitis, Myrtha Arnold, Celia Garau, Lise T. Jensen, Lars Fugger, Daria Peleg-Raibstein, Denis Burdakov
Summary: Ingested non-essential amino acids activate hypothalamic orexin/hypocretin neurons and shift behavior from eating to exploration. This effect is independent of the gut/brain communication pathway. The study also suggests that the reduction in food intake caused by non-essential amino acids is related to the modulation of food palatability.
Article
Multidisciplinary Sciences
Han-Tao Li, Dane C. Donegan, Daria Peleg-Raibstein, Denis Burdakov
Summary: This study explores a deep brain stimulation (DBS) strategy for modulating anxiety symptoms by targeting the lateral hypothalamus (LH). The researchers identify a DBS waveform that inhibits anxiety-related neural activity and suppresses anxiety behaviors in mouse models without any noticeable side effects. These findings suggest that acute hypothalamic DBS could be a potential strategy for managing treatment-resistant anxiety disorders.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Nikola Grujic, Jeroen Brus, Denis Burdakov, Rafael Polania
Summary: This study reveals that mice exhibit rational behavior by adaptively allocating their sensory resources to maximize reward consumption in previously unexperienced environments. Despite imprecise perception of commonly occurring stimuli, this suggests awareness and efficient adaptation to neurocognitive limitations.
Article
Multidisciplinary Sciences
Roberto De Luca, Stefano Nardone, Kevin P. Grace, Anne Venner, Michela Cristofolini, Sathyajit S. Bandaru, Lauren T. Sohn, Dong Kong, Takatoshi Mochizuki, Bianca Viberti, Lin Zhu, Antonino Zito, Thomas E. Scammell, Clifford B. Saper, Bradford B. Lowell, Patrick M. Fuller, Elda Arrigoni
Summary: This study investigates the mechanisms by which orexin neurons contribute to arousal maintenance and state stability through silencing sleep-promoting neurons. The findings provide alternate insights into the role of orexin neurons in maintaining wakefulness.
NATURE COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Daria Peleg-Raibstein, Paulius Viskaitis, Denis Burdakov
Summary: Seeking and ingesting nutrients is crucial for survival, but the classical behavioural sequence of seeking, ingesting, and resting may not be advantageous for all nutrients. Some nutrients are more essential for survival, and a key choice needs to be made after ingestion: to eat more and rest, or to terminate eating and search for better food. Recent research suggests that specific ingested macronutrients can rapidly and differentially modulate a group of neurons called hypothalamic hypocretin/orexin neurons (HONs), which promote explorative behaviors. This nutrient-specific modulation engages different reflex arcs: seek -> ingest -> seek and seek -> ingest -> rest.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Neurosciences
Nikola Grujic, Alexander Tesmer, Ed Bracey, Daria Peleg-Raibstein, Denis Burdakov
Summary: This study reveals the involvement of orexin neurons in rapid arousal dynamics and reward perception. Pupil dilation, a quantitive arousal marker, is strongly correlated with orexin cell activity and is under their control. Orexin cells specialize in rapid and multiplexed communication of momentary arousal and reward states. The findings provide insights into the biological significance of eye pupil size.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Keshav S. Subramanian, Logan Tierno Lauer, Anna M. R. Hayes, Lea Decarie-Spain, Kara McBurnett, Anna C. Nourbash, Kristen N. Donohue, Alicia E. Kao, Alexander G. Bashaw, Denis Burdakov, Emily E. Noble, Lindsey A. Schier, Scott E. Kanoski
Summary: Food intake is regulated by both learned appetitive responses and physiological appetition signals. This study shows that melanin-concentrating hormone (MCH)-producing neurons in the lateral hypothalamic area (LHA) integrate these processes to promote caloric intake. The activity of MCH neurons is responsive to food-related cues and increases during eating, suggesting their involvement in the appetitive and consummatory processes.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Dane Donegan, Daria Peleg-Raibstein, Olivier Lambercy, Denis Burdakov
Summary: By studying the neural activation in the hypothalamus during premovement and its role in controlling adaptive movements, important insights into the behavioral and cognitive impact of neural signals are gained.