期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 529, 期 5, 页码 929-956出版社
WILEY
DOI: 10.1002/cne.24988
关键词
AgRP; NPY; anterograde and retrograde tract tracing; dorsomedial division of the bed nucleus of the stria terminalis; hypothalamic nuclei; MCH; ORX; POMC
资金
- Conseil regional de Bourgogne-Franche-Comte
- Francis Crick Institute
- Novartis Foundation [19B145]
- Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung [PZ00P3_167934/1]
- Swiss National Science Foundation (SNF) [PZ00P3_167934] Funding Source: Swiss National Science Foundation (SNF)
This study utilized tracing and immunohistochemical methods to investigate the neural projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST) and various hypothalamic structures, revealing the neuroanatomical basis for the interplay between stress and feeding behaviors.
As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti-related peptide (AgRP), melanin-concentrating-hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST. Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress-related feeding behaviors.
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