Article
Biochemistry & Molecular Biology
Satish Bodakuntla, Xidi Yuan, Mariya Genova, Sudarshan Gadadhar, Sophie Leboucher, Marie-Christine Birling, Dennis Klein, Rudolf Martini, Carsten Janke, Maria M. Magiera
Summary: The research reveals that the glutamylases TTLL1 and TTLL7 generate unique and distinct glutamylation patterns on neuronal microtubules, affecting microtubule function and neuronal degeneration in different ways. This demonstrates the importance of specific patterns of tubulin glutamylation in maintaining physiological homeostasis.
Article
Pharmacology & Pharmacy
Jafar Rezaie, Tahereh Etemadi, Maryam Feghhi
Summary: This article presents the current understanding of how exosomes regulate innate immune responses and discusses their potential applications in cancer therapy and immunotherapy.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Cell Biology
Kunzhao Du, Zhen Zhang, Zhiwei Zeng, Jinling Tang, Trevor Lee, Tao Sun
Summary: Knockout of Mettl3 significantly affects gene transcription and translation regulation, especially leading to altered translation of crucial genes and elevated translation of a significant number of mRNAs. This highlights the distinct functions of Mettl3 and Fto in brain development, with Mettl3 playing a profound role in regulating translation of major mRNAs controlling proper cortical development.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Huiming Zhang, Zhaolian Lu, Yu Zhan, Judith Rodriguez, Chen Lu, Yong Xue, Zhenguo Lin
Summary: Regulation of gene expression starts from transcription initiation, which is critical for generating correct transcripts with proper abundance. This study investigated the roles of histone H3 methylations and chromatin remodelling genes on the regulation of transcription initiation in yeast at a genome-scale, highlighting the impact of MINC depletion on stimulating new transcription initiation sites and the contribution of histone methylation to repressing transcription initiation in coding regions.
Article
Dermatology
Kenji Yamaguchi, Emi Kanno, Hiromasa Tanno, Ayako Sasaki, Yuki Kitai, Takayuki Miura, Naoyuki Takagi, Miki Shoji, Jun Kasamatsu, Ko Sato, Yuka Sato, Momoko Niiyama, Yuka Goto, Keiko Ishii, Yoshimichi Imai, Shinobu Saijo, Yoichiro Iwakura, Masahiro Tachi, Kazuyoshi Kawakami
Summary: Dectin-1 accelerates wound healing by inducing early-phase neutrophil accumulation, while Dectin-2 is involved in prolonged neutrophilic responses and neutrophil extracellular trap formation, leading to delayed wound healing.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emilia Dimitrova, Angelika Feldmann, Robin H. van der Weide, Koen D. Flach, Anna Lastuvkova, Elzo de Wit, Robert J. Klose
Summary: Precise control of gene expression during development is crucial, and CKM-Mediator plays a critical role in this process. It establishes physical links between gene regulatory elements and enables gene expression and priming for induction in embryonic stem cells. CKM-Mediator is specifically involved in controlling interactions between inactive gene regulatory elements bound by PRCs, and it facilitates the binding of PRC1 to its target sites. Interestingly, CKM-Mediator and PRC1 collaboration in creating long-range interactions does not contribute to gene priming during differentiation, but rather gene activation relies on an interaction-independent mechanism where CKM supports core Mediator engagement with gene promoters.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Rajani Raman, Anna Bognar, Ghazaleh Ghamkhari Nejad, Nick Taubert, Martin Giese, Rufin Vogels
Summary: This study examines and compares the contributions of dynamic and static features to the single-unit responses in the temporal cortex. The results show that dynamic body stimuli evoke stronger responses in the dorsal patch compared to the ventral patch. The dynamic body selectivity of neurons in the ventral patch is influenced by both static features and motion, while the dynamic body selectivity in the dorsal patch is primarily driven by motion.
Review
Virology
Md Golzar Hossain, Yan-dong Tang, Sharmin Akter, Chunfu Zheng
Summary: This article specifically discusses the effects of the furin cleavage site on the spike protein of SARS-CoV-2, highlighting its impact on viral replication, pathogenesis, host immune responses, and vaccination. It offers novel insights into the current COVID-19 pandemic.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Microbiology
Yo-Han Ko, Kum-Kang So, Jeesun Chun, Dae-Hyuk Kim
Summary: This study demonstrates the significant roles of two DNA methyltransferases from Cryphonectria parasitica in fungal development and virulence. Mutations in CpDmt1 and CpDmt2 affect fungal biology in different ways, influencing conidium production, response to heat stress, and virulence. Both genes play essential roles in antiviral responses, including viral clearance, highlighting the importance of fungal DNMTases in regulating biological functions and responses to hypoviral infection.
Article
Environmental Sciences
Linyi Wei, Yong Wang, Shu Liu, Guang J. Zhang, Bin Wang
Summary: The study reveals that the surface temperature responses to aerosols and clouds exhibit complex spatial variations globally, amplified by local surface climate sensitivities, resulting in significant surface temperature responses to aerosol radiative cooling during the daytime and cloud radiative warming during the nighttime.
ENVIRONMENTAL RESEARCH LETTERS
(2021)
Article
Psychology, Multidisciplinary
Marion Robin, Jean Belbeze, Alexandra Pham-Scottez, Mario Speranza, Gerard Shadili, Jerome Silva, Maurice Corcos
Summary: This study aims to explore the relationship between facial emotion recognition and adverse experiences in patients with borderline personality disorder. The results suggest that different types of adverse experiences are associated with the emotion regulation of these patients.
Article
Psychology, Developmental
Marlon Goering, Sylvie Mrug
Summary: Pubertal timing is a significant predictor of externalizing and internalizing problems in adolescence, and both early and off-time pubertal timing may be associated with negative developmental outcomes. The effects of pubertal timing can persist into young adulthood, but they are not mediated by peer deviance or school connectedness.
JOURNAL OF YOUTH AND ADOLESCENCE
(2022)
Article
Plant Sciences
Chae Woo Lim, Haeji Koh, Sung Chul Lee
Summary: This study reveals that CaMFT02 in pepper negatively regulates drought stress tolerance through modulating ABA signaling, and CaMFT03 plays a similar negative regulatory role in salt stress tolerance.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Ecology
Jonathan W. F. Ribeiro, Natashi A. L. Pilon, Davi R. Rossatto, Giselda Durigan, Rosana M. Kolb
Summary: This study found that savanna tree species are constrained by waterlogging, while gallery forest and generalist species are able to colonize and survive in wet grasslands despite low seedling emergence and sapling growth constrained by gas exchange rates.
Article
Immunology
James A. Harker, Trever T. Greene, Burton E. Barnett, Phuc Bao, Aleksandr Dolgoter, Elina I. Zuniga
Summary: The IL-6 cytokine family signals through gp130 combined with a cytokine-specific receptor. Gp130 signaling on CD4 T cells is vital in controlling chronic infection of mice with LCMV Cl13. IL-6 and IL-27 signaling have distinct and overlapping roles, with IL-6 regulating Tfh differentiation, IL-27 regulating CD4 T cell survival, and both promoting IL-21.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Geriatrics & Gerontology
Sophie Hu, Scott Patten, Anna Charlton, Karyn Fischer, Gordon Fick, Eric E. Smith, Zahinoor Ismail
Summary: This study compared the utility of MBI-C and NPI-Q in capturing non-cognitive symptoms in patients with subjective cognitive decline, mild cognitive impairment, and dementia. The results showed that both MBI-C and NPI-Q were effective in characterizing these symptoms, and MBI-C was able to capture non-cognitive symptoms across different cognitive stages.
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
(2023)
Article
Psychiatry
Asmita Bhattarai, Nathan King, Kamala Adhikari, Gina Dimitropoulos, Dan Devoe, Jin Byun, Melanie Li, Daniel Rivera, Simone Cunningham, Andrew G. M. Bulloch, Scott B. Patten, Anne Duffy
Summary: Childhood adversities and parental divorce are associated with mental health concerns among university students. Childhood adversities may impact later mental health through an association with stress sensitivity, self-esteem, and sleep problems.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychology, Developmental
Ellie Vyver, Angela X. Han, Gina Dimitropoulos, Scott B. Patten, Daniel J. Devoe, Gisele Marcoux-Louie, Debra K. Katzman
Summary: This study examined health administrative data from two pediatric tertiary care ED programs and found an increase in pediatric hospitalizations for anorexia nervosa (AN) during the first year of the COVID-19 pandemic in Canada. The study also observed a decrease in non-ED hospitalizations during the same period. This is the first Canadian study to confirm the impact of the pandemic on children and adolescents with AN.
JOURNAL OF ADOLESCENT HEALTH
(2023)
Letter
Clinical Neurology
Ruth Ann Marrie, John D. Fisk, Randy Walld, James M. Bolton, Jitender Sareen, Scott B. Patten, Alexander Singer, Lisa M. Lix, Carol A. Hitchon, Renee El-Gabalawy, Alan Katz, James J. Marriott, Charles N. Bernstein
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Psychology, Clinical
Maya N. Sohn, Gina Dimitropoulos, Ana Ramirez, Claire McPherson, Alida Anderson, Amlish Munir, Scott B. Patten, Alexander McGirr, Daniel J. Devoe
Summary: Objective: This study aimed to compare the prevalence of non-suicidal self-injury (NSSI), suicidal ideation (SI), suicide attempts (SA), and deaths by suicide among controls and individuals with eating disorders (EDs). Results showed that individuals with EDs had significantly higher prevalence of NSSI, SI, and SA compared to controls.
INTERNATIONAL JOURNAL OF EATING DISORDERS
(2023)
Article
Psychiatry
Eliana Brehaut, Dipika Neupane, Brooke Levis, Yin Wu, Ying Sun, John P. A. Ioannidis, Sarah Markham, Pim Cuijpers, Scott B. Patten, Andrea Benedetti, Brett D. Thombs
Summary: This study evaluated how optimal cutoff thresholds are selected in depression screening tool studies. The results showed that most studies attempted to identify an optimal cutoff, but the methods used were heterogeneous and lacked a rationale. Additionally, a majority of the studies selected non-standard cutoffs and had limited recommendations and reporting guidelines.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2023)
Letter
Psychiatry
Scott B. B. Patten, Gina Dimitropoulos, Jeanne V. A. Williams, Sandy Rao, Mina Fahim, Vandad Sharifi, Pardis Pedram, Andrew G. M. Bulloch
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychiatry
Samreen Shafiq, Paul Everett Ronksley, Tayler Dawn Scory, Meghan Jessica Elliott, Andrew Gabriel McKay Bulloch, Scott Burton Patten
Summary: Despite the clinical efficacy of lithium, its use is believed to be declining. This study used administrative health data to examine new and prevalent lithium users and rates of discontinuation over a 10-year period. The results suggest a decrease in total lithium users, with potential stabilization or reversal in recent years. Discontinuation rates were highest among 18-24 year olds.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Multidisciplinary Sciences
Asmita Bhattarai, Gina Dimitropoulos, Andrew G. M. Bulloch, Suzanne C. Tough, Scott B. Patten
Summary: This study examined the association between specific childhood adversities and rate of all-cause hospitalization in adulthood, and found that childhood adversities significantly increased hospitalization rate in young and middle adulthood. It also identified adulthood socioeconomic and health-related factors as potential mediators of this association.
Article
Multidisciplinary Sciences
Elizabeth A. Spry, Craig A. Olsson, Stephanie R. Aarsman, Hanafi Mohamad Husin, Jacqui A. Macdonald, S. Ghazaleh Dashti, Margarita Moreno-Betancur, Primrose Letcher, Ebony J. Biden, Kimberly C. Thomson, Helena McAnally, Christopher J. Greenwood, Melissa Middleton, Delyse M. Hutchinson, John B. Carlin, George C. Patton
Summary: Personality traits of parents in young adulthood, well before the conception of their offspring, are associated with various parental resources and attributes during pregnancy and postpartum, as well as with infant biobehavioural characteristics. The effect sizes range from small to moderate when considering parents' personality traits as continuous exposures, and from small to large when considering them as binary exposures. These findings highlight the importance of parental personality in early life development and its potential long-term impact on a child's health and development.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Xia Qiu, Yin Wu, Ying Sun, Brooke Levis, Jizhou Tian, Jill T. Boruff, Pim Cuijpers, John P. A. Ioannidis, Sarah Markham, Roy C. Ziegelstein, Simone N. Vigod, Andrea Benedetti, Brett Thombs, Chen He, Ankur Krishnan, Parash Mani Bhandari, Dipika Neupane, Zelalem Negeri, Mahrukh Imran, Danielle B. Rice, Marleine Azar, Matthew J. Chiovitti, Simon A. Gilbody, Lorie B. Kloda, Scott D. Patten, Nicholas Mitchell, Ruben Alvarado, Jacqueline Barnes, Cheryl Tatano Beck, Carola Bindt, Humberto Correa, Tiago Castro e Couto, Genesis Chorwe-Sungani, Valsamma Eapen, Nicolas Favez, Ethel Felice, Gracia Fellmeth, Michelle Fernandes, Sally Field, Barbara Figueiredo, Jane R. W. Fisher, Eric P. Green, Simone Honikman, Louise M. Howard, Pirjo A. Kettunen, Jane Kohlhoff, Zoltan Kozinszky, Angeliki A. Leonardou, Michael Maes, Pablo Martinez, Sandra Nakic Rados, Daisuke Nishi, Susan J. Pawlby, Tamsen J. Rochat, Heather J. Rowe, Deborah J. Sharp, Alkistis Skalkidou, Johanne Smith-Nielsen, Alan Stein, Kuan-Pin Su, Inger Sundstroem-Poromaa, Meri Tadinac, S. Darius Tandon, Iva Tendais, Annamaria D. Toereki, Thach Tran, Kylee Trevillion, Katherine S. Turner, Mette Vaever, Thandi M. van Heyningen, Johann Vega-Dienstmaier, Karen A. Wynter, Kimberly Yonkers
Summary: Item 10 of the EPDS assesses self-harm thoughts but may also elicit concerns about accidental self-harm. The EPDS-9, which omits item 10, is sometimes used in research due to concerns about its implications. A meta-analysis of individual participant data showed that EPDS-9 performs similarly to the full EPDS in detecting major depression among pregnant and postpartum women.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, General & Internal
Jessica Heerde, Rohan Borschmann, Jesse Young, Stuart A. Kinner, Susan M. Sawyer, George C. Patton
Summary: This systematic review aims to synthesize international literature on mortality rates and risk and protective factors among people who have experienced homelessness. The study will search for cohort studies examining mortality in this population and assess the quality of included studies. The findings will be disseminated through academic channels.
Article
Medicine, General & Internal
Shaza Almweisheer, Charles N. Bernstein, Lesley A. Graff, Scott B. Patten, James Bolton, John D. Fisk, Carol A. Hitchon, James J. Marriott, Ruth Ann Marrie
Summary: This study aimed to assess the mental health of individuals with immune-mediated inflammatory diseases (IMID) and compare the differences across different types of diseases. The study found that over half of the participants with multiple sclerosis (MS), inflammatory bowel disease (IBD), and rheumatoid arthritis (RA) reported flourishing mental health, with similar levels across the disease groups.
Article
Psychiatry
Jordan Edwards, Paul Kurdyak, Charlotte Waddell, Scott B. Patten, Graham J. Reid, Leslie Anne Campbell, Katholiki Georgiade
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Health Care Sciences & Services
Brooke Allemang, Susan Samuel, Katelyn Greer, Keighley Schofield, Karina Pintson, Megan Patton, Marcela Farias, Kathleen C. C. Sitter, Scott B. B. Patten, Andrew S. S. Mackie, Gina Dimitropoulos
Summary: This study examines the transition readiness of youth with co-occurring chronic health and mental health conditions using a combination of quantitative and qualitative data. The findings demonstrate that widely used tools for measuring transition readiness do not address the complex needs of this group.
HEALTH EXPECTATIONS
(2023)