Article
Biochemistry & Molecular Biology
Elena Petukhova, Daria Ponomareva, Karin Rustler, Burkhard Koenig, Piotr Bregestovski
Summary: In this study, it was found that Glyght can modulate GABAergic synaptic transmission by acting on extrasynaptic glycine receptors, without affecting postsynaptic GABA receptors and neurotransmitter release mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hiroki Toyoda, Ayano Katagiri, Takafumi Kato, Hajime Sato
Summary: Intranasal administration of rotenone impairs conditioned taste aversion memory in mice by decreasing GABAergic synaptic transmission and causing LTD impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Logan J. Voss
Summary: The study aims to answer the question regarding the different network dynamical states of a cortical slice as a function of excitatory drive, using extracellularly recorded population field potentials. It demonstrates that different levels of excitatory drive lead to different functional states, reflecting different modes of neocortical activation.
Article
Neurosciences
Rachael F. Ryner, Isabel D. Derera, Moritz Armbruster, Anar Kansara, Mary E. Sommer, Antonella Pirone, Farzad Noubary, Michele Jacob, Chris G. Dulla
Summary: Infantile and epileptic spasms syndrome (IESS) is characterized by spasms, abnormal EEG, and epilepsy. The molecular and circuit-level causes of IESS are not well understood. This study found that inhibitory circuit dysfunction occurs in mice with deletions in adenomatous polyposis coli (APC), which may contribute to IESS-related phenotypes.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Hirohito M. Kondo, Hiroki Terashima, Ken Kihara, Takanori Kochiyama, Yasuhiro Shimada, Jun Kawahara
Summary: Attention levels fluctuate during daily activities, and the factors influencing sustained attention are still unknown. This study used psychological, neuroimaging, and neurochemical approaches to investigate mechanisms of sustained attention. Participants performed gradual-onset continuous performance tasks while being scanned with fMRI. The results showed that the dorsal attention network was activated during intermittent responses, and there was a correlation between reaction-time variability and signal changes in the left fronto-parietal regions. MRS measurements also revealed associations between neurometabolite levels and performance under different task demands.
Article
Neurosciences
Logan J. Voss
Summary: Propofol disrupts memory consolidation and actively facilitates memory decay in the cerebral cortex.
Article
Biochemistry & Molecular Biology
Dipak Roy, Madhuri Puvvada, Sampath K. T. Kapanaiah, Anant Bahadur Patel
Summary: This study used NMR spectroscopy to investigate the metabolic activity of neurons and astrocytes in ALS mice, and found differential changes in metabolic activity, suggesting the involvement of astrocytes in the pathogenesis of ALS.
NEUROCHEMICAL RESEARCH
(2022)
Article
Neurosciences
Henk Karst, Wouter J. Droogers, Nelleke van der Weerd, Ruth Damsteegt, Nicky van Kronenburg, R. Angela Sarabdjitsingh, Marian Joels
Summary: Early life stress (ELS) alters the excitation-inhibition-balance (EI-balance) in the mouse brain by influencing the GABA-switch, which is accelerated in ELS mice compared to controls. This accelerated switch is associated with increased expression of the inward chloride transporter NKCC1. Both pre- and postsynaptic chloride homeostasis are affected by this switch, leading to altered glutamatergic transmission.
Article
Neurosciences
Benjamin Rein, Megan Conrow-Graham, Allea Frazier, Qing Cao, Zhen Yan
Summary: The study found that treatment with the HDAC5 inhibitor LMK235 can normalize histone acetylation levels to restore GABAergic signaling in the prefrontal cortex (PFC) and significantly improve social preference in 16p11.2duplication mice.
Article
Neurosciences
Yeri J. Song, Bo Xing, Aaron J. Barbour, Chengwen Zhou, Frances E. Jensen
Summary: This study found alterations in GABA(A) receptor-mediated inhibitory synaptic transmission in Fragile X syndrome models, affecting the maturation of E-I circuitry and synaptic plasticity, leading to impaired critical period and auditory deficits in the auditory cortex.
Article
Multidisciplinary Sciences
Yoshihiko Oke, Fumikazu Miwakeichi, Yoshitaka Oku, Johannes Hirrlinger, Swen Huelsmann
Summary: By using calcium imaging in double-transgenic mice expressing fluorescent marker proteins, we found that the inspiratory neuronal network in the preBotC develops during the early postnatal period. Excitatory and glycinergic neurons formed the majority of inspiratory neurons, and their composition rates inverted at p5-6. The activity patterns of these two types of inspiratory neurons became synchronized with the inspiratory rhythmic bursting pattern in the preBotC within the first postnatal week. GABAergic and GABA-glycine cotransmitting inspiratory neurons were present in a small population just after birth, but almost disappeared until p10.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Meng Li, Lena Vera Danyeli, Lejla Colic, Gerd Wagner, Stefan Smesny, Tara Chand, Xin Di, Bharat B. Biswal, Jorn Kaufmann, Juergen R. Reichenbach, Oliver Speck, Martin Walter, Zuemruet Duygu Sen
Summary: Reproducible resting-state functional connectivity patterns and their alterations have significant implications in neuropsychiatric research. This study utilizes multimodal imaging and magnetic resonance spectroscopy to investigate the correlation between regional neurotransmitter levels and rsFC strength, providing insights into the modulation of interaction between brain regions at a macroscopic level.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Taisuke Yoneda, Kenji Hayashi, Yumiko Yoshimura
Summary: This study aims to characterize the functional properties and experience-dependent plasticity of surviving subplate neurons in the late stage of cortical development. The results show that subplate neurons exhibit broad tuning in sensory responses and can undergo visual plasticity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Xiaona Fu, Mengting Qin, Xiaoming Liu, Lan Cheng, Lan Zhang, Xinli Zhang, Yu Lei, Qidong Zhou, Peng Sun, Liangjie Lin, Ying Su, Jing Wang
Summary: This study investigated the relationship between GABA levels, cortical thickness, and executive function in MCI patients. The results showed that MCI patients had lower GABA+/Cr levels in the ACC and PCC, while there were no differences in cortical thickness between the two groups. Therefore, GABA in the ACC and PCC could be a potential diagnostic marker for the decline in executive function in MCI.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Ziheng Zhou, Yueyang Pan, Si Zhou, Shuguang Wang, Dengwei Zhang, Ye Cao, Xiaosen Jiang, Jie Li, Linnan Zhu, Lijian Zhao, Shen Gu, Ge Lin, Zirui Dong, Hai-Xi Sun
Summary: This study investigates the mechanisms of corticogenesis by analyzing single-cell RNA sequencing data from mouse and human fetal cortexes. The study identifies a specific population of cells, called D-T-U, which undergoes direct neuronal transition from deep-layer neurons to upper-layer neurons during fetal cortical development in mice. These findings may shed light on the differences in cortical development between humans and mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Neurosciences
Anton Dvorzhak, Igor Melnick, Rosemarie Grantyn
BRAIN RESEARCH BULLETIN
(2018)
Article
Neurosciences
Vahid Rahmati, Knut Kirmse, Knut Holthoff, Stefan J. Kiebel
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Neurosciences
Holger Haselmann, Francesco Mannara, Christian Werner, Jesus Planaguma, Federico Miguez-Cabello, Lars Schmidl, Benedikt Gruenewald, Mar Petit-Pedrol, Knut Kirmse, Joseph Classen, Fatih Demir, Nikolaj Kloecker, David Soto, Soeren Doose, Josep Dalmau, Stefan Hallermann, Christian Geis
Article
Neurosciences
Anton Dvorzhak, Nordine Helassa, Katalin Torok, Dietmar Schmitz, Rosemarie Grantyn
JOURNAL OF NEUROSCIENCE
(2019)
Article
Cell Biology
Tom Flossmann, Thomas Kaas, Vahid Rahmati, Stefan J. Kiebel, Otto W. Witte, Knut Holthoff, Knut Kirmse
Editorial Material
Neurosciences
Knut Kirmse
Article
Biology
Chuanqiang Zhang, Shang Yang, Tom Flossmann, Shiqiang Gao, Otto W. Witte, Georg Nagel, Knut Holthoff, Knut Kirmse
Article
Neurosciences
Alexey V. Rossokhin, Irina N. Sharonova, Anton Dvorzhak, Julia V. Bukanova, Vladimir G. Skrebitsky
Article
Multidisciplinary Sciences
Anton Dvorzhak, Rosemarie Grantyn
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Multidisciplinary Sciences
Juergen Graf, Chuanqiang Zhang, Stephan Lawrence Marguet, Tanja Herrmann, Tom Flossmann, Robin Hinsch, Vahid Rahmati, Madlen Guenther, Christiane Frahm, Anja Urbach, Ricardo Melo Neves, Otto W. Witte, Stefan J. Kiebel, Dirk Isbrandt, Christian A. Huebner, Knut Holthoff, Knut Kirmse
Summary: NKCC1 is the primary transporter for chloride uptake in immature principal neurons, and its function in vivo network dynamics and cognitive abilities remains unclear. The study found that deletion of NKCC1 from telencephalic glutamatergic neurons impacts neuronal synchrony in neonatal hippocampal brain slices, but has minor effects on network activity and behavioral performance in the long term.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Marta Orlando, Anton Dvorzhak, Felicitas Bruentgens, Marta Maglione, Benjamin R. Rost, Stephan J. Sigrist, Joerg Breustedt, Dietmar Schmitz
Summary: This study investigated the functional and structural changes associated with presynaptic potentiation induced by the adenylyl cyclase activator forskolin. Multi-modal imaging techniques revealed an increase in the surface area used for glutamate release, no change in the coupling distance between calcium channels and release sites, and rapid remodeling of synaptic ultrastructure at potentiated boutons. These findings suggest that early structural rearrangements enable long-term increase in synaptic strength.
Editorial Material
Physiology
Knut Kirmse
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Neurosciences
Stefan Hirschberg, Anton Dvorzhak, Seyed M. A. Rasooli-Nejad, Svilen Angelov, Marieluise Kirchner, Philipp Mertins, Gilla Laettig-Tuennemann, Christoph Harms, Dietmar Schmitz, Rosemarie Grantyn
Summary: The study demonstrated that C-terminal modified EAAT2 enhanced glutamate uptake, facilitated the clearance of glutamate at synapses, and alleviated mHTT-induced movement deficits.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Knut Kirmse, Chuanqiang Zhang
Summary: GABAergic signaling plays a crucial role in the inhibitory stabilization and coordination of excitatory neurons in mature cortical circuits. This review examines how GABA-releasing interneurons acquire their network functions during development, focusing on the visual neocortex and hippocampus in mice and rats. The authors propose that inhibitory stabilization is not functional at the onset of patterned activity, and that glutamatergic neurons are stable by themselves. The strengthening of inhibitory synaptic transmission toward eye opening shapes cortical network dynamics and allows the developing cortex to disengage from extra-cortical synaptic drive. The framework presented in this review has implications for our understanding of human cortical development and the treatment of neonatal seizures.
Article
Biology
Juergen Graf, Vahid Rahmati, Myrtill Majoros, Otto W. Witte, Christian Geis, Stefan J. Kiebel, Knut Holthoff, Knut Kirmse
Summary: Spontaneous correlated activity is a common characteristic of immature neural circuits. However, little is known about the cellular dynamics and intrinsic mechanisms underlying network burstiness. By mapping the developmental trajectories of spontaneous network activity in the hippocampal area CA1 of mice, it was found that network burstiness peaks in the second postnatal week, reflecting an increased functional coupling of individual neurons to local population activity. However, pairwise neuronal correlations are low, and network bursts recruit CA1 pyramidal cells in a virtually random manner.