Review
Biochemistry & Molecular Biology
P. A. Haseena, Latha Diwakar, Vijayalakshmi Ravindranath
Summary: Oxidative stress plays a significant role in the development and progression of neurodegenerative disorders. The glutathione and glutaredoxin system in the brain is important for defense against reactive oxygen species. Enhancing this system could help protect the brain during aging.
Article
Biochemistry & Molecular Biology
Antonio Currais, Devin Kepchia, Zhibin Liang, Pamela Maher
Summary: This article provides an overview of the research progress on the oxytosis/ferroptosis regulated cell death pathway, with a focus on the role of the AMPK pathway. However, further research is needed to understand the conditions under which AMPK signaling has a protective effect in oxytosis/ferroptosis, as well as its role in the brain, especially the aging brain.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Neurosciences
Guimei Zhang, Yaru Zhang, Yanxin Shen, Yongchun Wang, Meng Zhao, Li Sun
Summary: Alzheimer's disease is the most common cause of dementia, but the exact mechanism is still unclear. Recent research has shown that iron metabolism, lipid peroxidation, and oxidative stress play vital roles in the pathogenesis of AD, and the iron-dependent cell death known as ferroptosis may be involved in neurological disorders, including AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Spectroscopy
Ting Zhou, Zhu Su, Xinyi Wang, Minchuan Luo, Yifeng Tu, Jilin Yan
Summary: Detection of hydrogen peroxide and glucose was enhanced by utilizing the oxidative property of hydrogen peroxide. Fluorescence from photoluminescent silver nanoclusters could be quenched by reduced glutathione, offering a sensitive detection method. The study demonstrated successful application of this method for glucose measurement in human serum samples.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Biochemistry & Molecular Biology
Zhibin Liang, Pamela Maher
Summary: Alzheimer's disease is a common age-associated disease with no effective treatments. Using phenotypic screening assays, Sterubin from Yerba Santa was identified as a potential drug candidate for AD treatment. Sterubin exhibits neuroprotective and anti-inflammatory effects, and can prevent memory decline.
Article
Biochemistry & Molecular Biology
Marketa Luklova, Jan Novak, Romana Kopecka, Michaela Kameniarova, Vladena Gibasova, Bretislav Brzobohaty, Martin Cerny
Summary: Plants, as sessile organisms, have to adapt to the environmental variations recurring in a day-night cycle. Extensive research has uncovered the transcriptional control of plants' inner clock and revealed the regulatory mechanisms governing plant diel responses. This study analyzed the proteome of Arabidopsis thaliana mutant genotypes collected during the day and night, identifying significant changes in protein abundance. The results highlighted the role of ROS metabolism and phytohormone cytokinin in the observed regulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Dehao Yu, Luo Wang, Jingao Li, Xuanwei Zeng, Yuanyuan Jia, Junyu Tian, Anahit Campbell, Huabing Sun, Heli Fan
Summary: In this study, a dual-responsive fluorescent probe was used to confirm the elevated levels of GSH and H2O2 in cancer cells. Based on these findings, a redox-inducible DNA interstrand crosslink precursor was developed.
CHEMICAL COMMUNICATIONS
(2023)
Review
Food Science & Technology
Oluwaseun Hannah Ademuyiwa, Beatrice Mofoluwaso Fasogbon, Oluwafemi Ayodeji Adebo
Summary: Brain aging is an inevitable aspect of old age, leading to changes in the brain such as shrinking of certain parts and decreased communication between neurons. Previous drug treatments for related ailments have had undesirable side effects, but recent research suggests the potential use of natural compounds. This review explores the potential of black pepper as a substance for managing brain aging.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Talia Ho, Soha Ahmadi, Kagan Kerman
Summary: Alzheimer's disease, a progressive neurodegenerative disorder, affects approximately 40 million people worldwide. Despite extensive research on its pathogenesis and risk factors, treatment options remain limited. The role of copper and glutathione in Alzheimer's disease, as well as their interactions, have been relatively understudied. This review aims to provide a more accessible understanding of their individual roles and interactions in Alzheimer's disease by collecting and assessing relevant research.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Plant Sciences
Ameena Fatima Alvi, Noushina Iqbal, Mohammed Albaqami, Nafees A. Khan
Summary: In plants, sulfur is crucial for the formation of biomolecules and thiol groups composed of sulfur play essential roles in various metabolic processes. Reactive sulfur species (RSS), including hydrogen sulfide, persulfides, and polysulfides, are synthesized from cysteine and are considered important signaling molecules involved in the regulation of cellular function. Research on RSS biosynthesis, signaling, and their relationship to abiotic stresses is still in its early stages, but understanding their roles is crucial for plant survival under stress conditions.
PHYSIOLOGIA PLANTARUM
(2023)
Article
Biochemistry & Molecular Biology
S. Charisis, E. Ntanasi, M. Yannakoulia, C. A. Anastasiou, M. H. Kosmidis, E. Dardiotis, G. Hadjigeorgiou, P. Sakka, A. S. Veskoukis, D. Kouretas, N. Scarmeas
Summary: The study found that higher baseline plasma GSH levels were associated with a decreased risk of developing AD and with a better preservation of executive functioning longitudinally in non-demented older adults living in the community.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Michael S. Rafii, Reisa A. Sperling, Michael C. Donohue, Jin Zhou, Claire Roberts, Michael C. Irizarry, Shobha Dhadda, Gopalan Sethuraman, Lynn D. Kramer, Chad J. Swanson, David Li, Stephen Krause, Robert A. Rissman, Sarah Walter, Rema Raman, Keith A. Johnson, Paul S. Aisen
Summary: The AHEAD 3-45 Study aims to investigate the feasibility of intervention therapy before the clinical symptoms of Alzheimer's disease appear, and utilizes innovative approaches to accelerate the screening process for selecting suitable participants.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biochemistry & Molecular Biology
Paloma Bermejo-Bescos, Karim L. Jimenez-Aliaga, Juana Benedi, Sagrario Martin-Aragon
Summary: This study aimed to explore the effects of quercetin and rutin on the intracellular redox homeostasis, BACE1 activity, and APP expression in AD mice. The results showed that both quercetin and rutin could improve the antioxidant capacity, reduce lipid peroxidation, and downregulate the expression of APP and BACE1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Leszek Szablewski
Summary: Alzheimer's disease is the most common cause of dementia in elderly people, with aging being a main risk factor. Impairment of brain energy and glucose hypometabolism are hallmarks of the disease. There are several hypotheses on the role of glucose hypometabolism in AD, but further investigations are needed on this subject.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yeong-Chin Jou, Shou-Chieh Wang, Yuan-Chang Dia, Shou-Tsung Wang, Min-Hua Yu, Hsin-Yi Yang, Lei-Chin Chen, Cheng-Huang Shen, Yi-Wen Liu
Summary: The study demonstrated that GSTM5 acts as a tumor suppressor in bladder cancer cells without significantly affecting chemoresistance to cisplatin and mitomycin C, and the cellular levels of GSH are key mechanisms underlying the anticancer effect of GSTM5. Low gene expression and high DNA methylation levels of GSTM5 may serve as tumor markers for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Miklos Nagy, Bela Fiser, Milan Szori, Laszlo Vanyorek, Bela Viskolcz
Summary: Isocyanoaminoarenes are a versatile group of fluorophores with potential applications in various fields. This paper presents the preparation and optical study of a novel isocyano derivative and its variations. The conversion of one amino group into an isocyano group greatly enhanced the polar character of the dyes, resulting in improved solvatochromism and reduced fluorescence in polar solvents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Emoke Sikora, Gabor Muranszky, Ferenc Kristaly, Bela Fiser, Laszlo Farkas, Bela Viskolcz, Laszlo Vanyorek
Summary: Granulated carbon nanotube-supported palladium and platinum-containing catalysts were developed for efficient chlorate ion hydrogenation. The catalysts achieved >99 n/n% chlorate conversion in aqueous phase and maintained their catalytic activity after repeated use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Viktoria Hajdu, Emoke Sikora, Ferenc Kristaly, Gabor Muranszky, Bela Fiser, Bela Viskolcz, Miklos Nagy, Laszlo Vanyorek
Summary: In this study, magnetizable amine functionalized ferrite supported palladium catalysts were developed for the synthesis of 2,4-diaminotoluene. By decorating the supports with palladium, high selectivity and yield were achieved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Zsofia Borbala Rozsa, Ravikumar Thangaraj, Bela Viskolcz, Milan Szori
Summary: The use of carbon dioxide as a reagent in organic synthesis can help reduce atmospheric CO2 levels. This study investigates the effects and membrane permeability of compounds produced from the reaction of CO2 and 1,3-butadiene using molecular dynamics simulations and ab initio calculations. The findings show that these compounds can penetrate the membrane and disrupt its structure.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Organic
Balazs Olasz, Bela Fiser, Milan Szori, Bela Viskolcz, Michael C. Owen
Summary: This study investigates the reactivity of 4-hydroxy-2-nonenal (HNE) towards cysteine and cysteinate in different solvent environments. The results show that water enhances the reactivity of HNE towards cysteine, and the reactivity is further increased when cysteine is ionized to cysteinate.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Polymer Science
Dalal K. Thbayh, Edina Reizer, Mousumi U. Kahaly, Bela Viskolcz, Bela Fiser
Summary: This study used computational tools to investigate the potential and applicability of synthetic and natural antioxidants, and compared their antioxidant potential. The results showed that the natural antioxidant had higher antioxidant capacity, but the synthetic antioxidant also had potential applications.
Article
Polymer Science
Ravikumar Thangaraj, Bela Fiser, Xuanbing Qiu, Chuanliang Li, Bela Viskolcz, Milan Szori
Summary: 2,4- and 2,6-isomers of toluene diisocyanates are important raw materials in the polyurethane industry. These compounds undergo dimerization reactions, which affect their properties. By calculating the formation enthalpy, it was found that only the formation of the 11-dimer resulted in exothermic behavior, while the 1-2-dimer was endothermic. The mechanism of the dimerization reactions for these isomers were further investigated, and specific pathways with lower activation energies were identified.
Article
Biochemistry & Molecular Biology
Timea B. Gerzsenyi, Agnes M. Ilosvai, Gergely Szilagyi, Milan Szori, Csaba Varadi, Bela Viskolcz, Laszlo Vanyorek, Emma Szori-Doroghazi
Summary: A simplified, fast, and effective method was developed to synthesize manganese ferrite magnetic nanoparticles (MnFe2O4 MNPs), which were successfully applied in DNA isolation for the first time. The particle properties were optimized through synthesis at different furnace temperatures using an ultrasonic-cavitation-assisted combustion method. The results showed that MnFe2O4 nanoparticles synthesized at 573 K exhibited desirable characteristics for DNA binding and isolation, leading to comparable DNA yield to commercial extraction products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Erika Kopcsik, Zoltan Mucsi, Bence Kontra, Laszlo Vanyorek, Csaba Varadi, Bela Viskolcz, Miklos Nagy
Summary: Aromatic isocyanides have recently gained attention as potential antifungal and anticancer drugs, as well as high-performance fluorescent probes for detecting toxic metals in vivo. The understanding of structure-behavior relationships and the development of novel derivatives are crucial due to the unique photophysical properties of aromatic isocyanides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Alexandra Jakab-Nacsa, Viktoria Hajdu, Laszlo Vanyorek, Laszlo Farkas, Bela Viskolcz
Summary: The aim of this work is to characterize, rank, and compare the catalysts of 2,4-dinitrotoluene catalytic hydrogenation to 2,4-toluenediamine by applying the Miskolc Ranking 21 (MIRA21) model. This systematic overview provides a comprehensive picture of the reaction, technological process, and the previous and new research results. Eight catalysts achieved the highest ranking (D1), whereas the transition metal oxide-supported platinum or palladium catalysts led the MIRA21 catalyst ranking list.
Article
Biochemistry & Molecular Biology
Adam Prekob, Viktoria Hajdu, Zsolt Fejes, Ferenc Kristaly, Bela Viskolcz, Laszlo Vanyorek
Summary: The catalytic activity of a palladium catalyst with a porous carbon support was investigated for benzophenone hydrogenation. The choice of solvent was found to influence the selectivity and yields of the two possible reaction products, benzhydrol and diphenylmethane. In isopropanol, the catalyst exhibited high selectivity towards diphenylmethane with a conversion rate of 99% after 240 minutes at 323 K, which may be attributed to the presence of structural nitrogens in the support.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alexandra Jakab-Nacsa, Attila Garami, Bela Fiser, Laszlo Farkas, Bela Viskolcz
Summary: The MIRA21 model aims to characterize heterogeneous catalysts using unbiased quantifiable data from 15 different variables, standardize catalyst characterization, and provide an easy tool for comparing, ranking, and classifying catalysts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Viktoria Hajdu, Adam Prekob, Gabor Muranszky, Ferenc Kristaly, Lajos Daroczi, Lajos Harasztosi, Zoltan Kaleta, Bela Viskolcz, Miklos Nagy, Laszlo Vanyorek
Summary: To address the challenges in the development of industrial catalysts, researchers have prepared intelligent, magnetizable NiFe2O4- and CoFe2O4-supported palladium catalysts that can be easily recovered by magnetic separation. The easy and fast preparation method involved solvothermal synthesis and sonochemical decomposition. Amino functionalization of the supports enhanced the metal-support interaction. The amine-functionalized catalysts showed better stability and retained high activity due to reduced palladium leaching.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Agnes M. Ilosvai, Timea B. Gerzsenyi, Emoke Sikora, Lajos Harasztosi, Ferenc Kristaly, Bela Viskolcz, Csaba Varadi, Emma Szori-Doroghazi, Laszlo Vanyorek
Summary: By using modified microwave-assisted synthesis, the reaction time for nucleic acid extraction can be significantly reduced, and the amine-functionalized magnesium ferrite nanoparticles show equal effectiveness in DNA extraction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Hadeer Q. Waleed, Marcell Csecsi, Vivien Konyhas, Zsanett R. Boros, Bela Viskolcz, Zsolt Fejes, Bela Fiser
Summary: This study investigated the alcoholysis reaction of phenyl isocyanate with butan-1-ol in the presence of tertiary amine catalysts. Both experimental and theoretical results demonstrated the significant effect of tertiary amine catalysts on the formation of urethane. These findings have implications for the design and development of polyurethane catalysts.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)