Review
Pharmacology & Pharmacy
Wenhui Liu, Zhiying Luo, Yiping Liu, Bao Sun
Summary: Immune checkpoint inhibitors (ICIs) have made unprecedented advances in cancer treatment, but the increasing incidence of immune-related adverse events (irAEs) is impairing their overall benefits. Despite proposed factors and mechanisms, there is still an incomprehensive understanding of irAEs. Hence, it is urgent to identify risk factors and biomarkers that predict irAE development, and understand the underlying mechanisms of these adverse events.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Oncology
Chrysoula Mytareli, Dimitrios C. C. Ziogas, Athina Karampela, Petros Papalexis, Vasiliki Siampanopoulou, Alexandros Lafioniatis, Olga Benopoulou, Helen Gogas, Anna Angelousi
Summary: Immune checkpoint inhibitors (ICIs) are the standard treatment for various types of cancer, but they can also cause immune-related adverse events (irAEs), including endocrine irAEs. This systematic review examines rare and very rare endocrine irAEs associated with ICIs, focusing on their diagnosis, treatment, and underlying pathogenesis. The aim is to increase clinical awareness and promote early detection and proper management of these potentially fatal endocrine irAEs.
Article
Chemistry, Applied
Ian W. Ashworth, Debasis Dey, Olivier Dirat, Paul McDaid, Daniel Lee, Justin Moser, Kausik K. Nanda
Summary: The presence of low levels of N-nitrosamines in active pharmaceutical intermediates and active ingredients is a topic of concern for industry and regulatory authorities. Experimental data suggests that the current kinetic model of dialkylamine nitrosation may overpredict the formation of N-nitrosamines. Furthermore, research shows that trialkylamines undergo nitrosative dealkylation to form N-nitrosamines, but at a significantly lower rate compared to dialkylamines.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Chemistry, Applied
Ian W. Ashworth, Alexander Blanazs, Jonathan J. Byrne, Olivier Dirat, Jared W. Fennell, Nadine Kuhl, Stuart L. Wells, Matthew P. Whiting
Summary: The risk assessment of N-nitrosamines in pharmaceuticals has shifted from focusing on known small-molecule N-nitrosamines to the potential generation of complex nitrosamine drug substance-related impurities. This article proposes a standard set of three orthogonal nitrosation forced degradation types to investigate the potential formation of novel N-nitrosamines from complex amines. The findings from these conditions can be used for risk assessment and further development of synthesis processes for testing purposes.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Cell Biology
Jichang Liu, Yadong Wang, Xiaogang Zhao, Kai Wang, Chao Wang, Jiajun Du
Summary: This study reveals the significant association between splicing factors and tumor microenvironment remodeling. Evaluating different splicing factor patterns enhances our understanding of the tumor microenvironment and improves effective immunotherapy strategies.
Article
Cell Biology
Jichang Liu, Yadong Wang, Xiaogang Zhao, Kai Wang, Chao Wang, Jiajun Du
Summary: This study identifies the potential roles of splicing factors in the tumor microenvironment and immune regulation. Different splicing factor patterns were associated with specific immune landscapes and were used to classify patients into immune subtypes with different pharmacogenomic landscapes and cell features. The findings enhance our understanding of the tumor microenvironment and can potentially improve immunotherapy strategies.
Article
Gastroenterology & Hepatology
Xinyang Liu, Lu Yao, Jing Cheng, Meidong Xu, Shiyao Chen, Yunshi Zhong, Mengjiang He, Weifeng Chen, Yiqun Zhang, Wenzheng Qin, Jianwei Hu, Mingyan Cai, Liqing Yao, Pinghong Zhou, Quanlin Li
Summary: This study systematically described the landscape of peroral endoscopic myotomy (POEM) related adverse events (AEs) and developed a predictive model and risk-scoring system to predict major AEs. Results showed that POEM is a safe procedure with low rates of severe AEs, and the prediction model demonstrated good performance in predicting major AEs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Geography
Giorgia Bressan, Michel Deshaies
Summary: In Australia, the development of coal seam gas industry has significantly changed the landscape of the agricultural production area in Western Downs, Queensland, due to extensive development of unconventional gas resources. The extraction of large water volumes associated with coal seam gas production is considered an asset and encouraged for beneficial use. However, the sustainability of these new mining and non-mining activities still needs proper attention.
JOURNAL OF RURAL STUDIES
(2023)
Review
Biochemistry & Molecular Biology
Colin P. S. Kruse, Sarah E. Wyatt
Summary: This article reviews the response of plants to gravity, focusing on the differential protein and gene regulation induced by the absence of gravity stimulus aboard the International Space Station. It proposes an integrated theoretical schematic of gravity response, with nitric oxide and cysteine S-nitrosation playing a central role. The proposed model is supported by the evolutionary conservation of regulatory amino acids within protein components and may have implications for studying various environmental and stress responses.
Article
Oncology
Zhuangyao Liao, Ming Li, Guoming Wen, Kun Wang, Dengbo Yao, Enming Chen, Yuwei Liang, Tong Xing, Kaihui Su, Changchun Liang, Zhen Che, Qing Ning, Jun Tang, Wenbin Yan, Yuxi Li, Lin Huang
Summary: In this study, the angiogenesis pattern in osteosarcoma was explored, and a prognostic model called ANGscore was constructed to clarify the underlying mechanism in the immune microenvironment. It was found that patients with a high ANGscore had a worse prognosis and exhibited an immune desert phenotype. The ANGscore was also associated with immune cell infiltration and the response rate to immunotherapy. Therefore, the ANGscore can accurately differentiate the prognosis and immune characteristics of osteosarcoma populations and guide individualized treatment strategies during immunotherapy.
NPJ PRECISION ONCOLOGY
(2023)
Article
Engineering, Chemical
Jean Constantino Gomes da Silva, Jose Luiz Francisco Alves, Guilherme Davi Mumbach, Michele Di Domenico
Summary: This study aimed to understand the photocatalytic process and optimize reactor design for efficient ethylene regulation to improve the shelf-life of fruits and vegetables. Two different reactor geometries were modeled using 2D computational fluid dynamics, and it was found that an annular cylinder coated with a catalyst can significantly enhance ethylene conversion rates. However, this comes at the cost of operational complexities and increased pressure drop.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Martin Baunach, Somak Chowdhury, Pierre Stallforth, Elke Dittmann
Summary: The study demonstrates that recombination plays a key role in the evolution of bacterial NRP synthetase genes, guiding the structural diversification of NRP families through mixing and matching of biosynthesis genes.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Article
Chemistry, Physical
Christian T. Haakansson, Timothy R. Corkish, Peter D. Watson, Damien B. 't Hart, Allan J. McKinley, Duncan A. Wild
Summary: A combined experimental and theoretical approach was used to study the properties of bromide-ethylene and iodide ethylene gas-phase complexes. The experimental results showed that the electron stabilisation of the complexes were 0.19 eV for bromide complex and 0.14 eV for iodide complex. Computational calculations predicted two minimum energy structures for each halide, either linearly appending to a hydrogen atom of the ethylene molecule or orthogonally appending to the carbon-carbon double bond. The energy difference between these two structural motifs was found to be approximately 1.3 kJ mol(-1) for both halides.
CHEMICAL PHYSICS LETTERS
(2022)
Article
Multidisciplinary Sciences
Pei-An Fu, Chin-Yao Shen, Shuen-Ru Yang, Chun-Hui Lee, Hui-Wen Chen, Edward Chia-Cheng Lai, Wei-Pang Chung
Summary: Denosumab reduces skeletal-related events (SREs) in breast cancer patients with bone metastases, but its long-term efficacy and safety are limited by lack of real-world data. This retrospective study on 132 denosumab-treated patients found that 11.1% experienced SREs in the first year, with the rate increasing over time. Additionally, 7.6% developed osteonecrosis of the jaw (ONJ), but most of those who resumed denosumab did not experience recurrence of ONJ.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Ji Wen, Michael Rusch, Samuel W. Brady, Ying Shao, Michael N. Edmonson, Timothy Shaw, Brent B. Powers, Liqing Tian, John Easton, Charles G. Mullighan, Tanja Gruber, David Ellison, Jinghui Zhang
Summary: This study identified 722 unique RNA editing sites in coding regions across pediatric cancers, with 70% being nonsynonymous recoding variants. The majority of editing sites were canonical A-to-I or C-to-U sites. RNA editing was enriched in brain tumors compared to other cancers, with a focus on glutamate receptors and ion channels involved in neurotransmitter signaling.
Article
Chemistry, Applied
Nguyen Quang Hung, Nguyen Thi Hong Anh, Nguyen Sinh Khang, Nguyen Thi Thanh Huong, Nguyen Thi Luyenb, Dang Viet Hau, Nguyen Tien Dat
Summary: The chemical composition and anti-inflammatory activity of the endemic Lysimachia baviensis were studied for the first time in this research. A new stilbene and two new chalcone glycosides were isolated from the methanol extract of L. baviensis. These compounds showed strong inhibition of nitric oxide production in LPS-induced cells.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Nguyen Hoang Anh, Duong Thi Hai Yen, Nguyen The Cuong, Bui Huu Tai, Pham Hai Yen, Pham The Chinh, Pham Van Cuong, Nguyen Hoai Nam, Phan Van Kiem, Su-Hyeon Cho, SeonJu Park, Nguyen Xuan Nhiem
Summary: Four new compounds were isolated from the leaves of Mallotus apelta and their structures were determined. However, none of these compounds showed cytotoxic activity against human prostate cancer and breast cancer cells.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Plant Sciences
Bui Thi Mai Anh, Do Thi Trang, Hoang Thi Tuyet Lan, Phan Van Kiem, Bui Huu Tai, Nguyen Viet Dung, Ninh Khach Thanh Nam, Nguyen The Cuong, Nguyen Xuan Nhiem, Nguyen Thi Mai
Summary: One new phenylpropanoid glycoside and 13 known compounds were isolated from Tinospora sinensis (Lour.) Merr. The phenylpropanoid glycoside showed significant inhibitory activity against NO production in macrophages. Several other compounds also exhibited moderate NO inhibitory activity.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Engineering, Chemical
Anh-Duc Pham, Quang Bang Tao, Pham Cam Nam
Summary: Maintaining the efficiency of solar cell panels by keeping their surface clean is a tedious task. This study proposes a simple and cost-effective method of fabricating a flexible and transparent superhydrophobic film. The film's superhydrophobicity is achieved through a combination of surface roughness and low surface energy. The film demonstrates high mechanical durability and flexibility, making it a potential protective cover for solar cells.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Clinical Neurology
Bach Xuan Tran, Tham Thi Nguyen, Hao Si Anh Nguyen, Laurent Boyer, Pascal Auquier, Guillaume Fond, Ha Thi Nhi Tran, Hung Manh Nguyen, Jongkwan Choi, Carl A. Latkin, Cyrus S. H. Ho, Syeda F. Husain, Roger S. McIntyre, Melvyn W. B. Zhang, Roger C. M. Ho
Summary: This study evaluated the potential of portable fNIRS as an adjunct diagnostic tool for bipolar and unipolar disorders during cognitive tasks. The study found differences in hemodynamics measured by fNIRS between bipolar and unipolar disorder patients during cognitive tasks. Therefore, assessing hemodynamics using portable fNIRS during cognitive tasks may serve as an adjunct diagnostic tool for mood disorders in low-resource environments.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Bach Xuan Tran, Tham Thi Nguyen, Laurent Boyer, Guillaume Fond, Pascal Auquier, Hao Si Anh Nguyen, Ha Thi Nhi Tran, Hung Manh Nguyen, Jongkwan Choi, Huong Thi Le, Carl A. Latkin, Kalpana Isabel Nathan, Syeda F. Husain, Roger S. McIntyre, Cyrus S. H. Ho, Melvyn W. B. Zhang, Roger C. M. Ho
Summary: This study aimed to evaluate the use of a portable fNIRS device as a diagnostic tool for assessing hemodynamics in people with schizophrenia in Vietnam. The results showed that individuals with schizophrenia did not exhibit significant activation in the frontal lobe during cognitive tasks. However, during the Verbal Fluency Test, certain areas of the prefrontal cortex showed promising diagnostic potential for schizophrenia.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Vu Anh Trong Dam, Ha Ngoc Do, Thao Bich Thi Vu, Khanh Long Vu, Hoang Minh Do, Nga Thu Thi Nguyen, Tham Thi Nguyen, Thuc Minh Thi Vu, Thao Phuong Thi Nguyen, Pascal Auquier, Laurent Boyer, Guillaume Fond, Carl A. Latkin, Cyrus S. H. Ho, Roger C. M. Ho
Summary: This study aims to explore the associations of the parent-child relationship, self-esteem, and resilience on the mental wellbeing and satisfaction with life of Vietnamese adolescents. The results showed that factors such as family support and sharing, higher academic performance, self-esteem, and resilience had a positive effect on life satisfaction and mental wellbeing. Female participants had higher satisfaction with life but lower mental wellbeing scores compared to male participants.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Plant Sciences
Nguyen Minh Thuy, La Bao Phung, Ngo Van Tai, Vo Quang Minh
Summary: In recent years, there has been increasing interest in the color and function of the Butterfly pea flower. However, preserving its extract has proven difficult, leading to the application of foam drying technology. This study investigated the effect of foaming conditions on the characteristics of the foam, and determined the most suitable conditions for the process. The research findings demonstrated that albumin ratio, carboxymethyl cellulose (CMC) ratio, and whipping time strongly influenced the foaming process, with the optimal conditions being 9.3% albumin, 0.79% CMC, and a stirring time of 19 minutes. The resulting foam-mat dried powder showed high quality and is suitable for various processing processes.
PLANT SCIENCE TODAY
(2023)
Article
Chemistry, Multidisciplinary
Dang Xuan Du, Nguyen Huu Duy Khang, Nguyen Huu Tri, Pham Cam Nam, Nguyen Minh Thong
Summary: In this study, the multitarget activity of Wedelolactone against Alzheimer's disease was investigated using density functional theory and molecular docking techniques. The scavenging efficiency of Wedelolactone for the HOO· radical in an aqueous environment was found to be higher than Trolox. The chelation capacity of metals and the inhibitory effect of Wedelolactone on AChE and BChE enzymes were also examined.
Article
Food Science & Technology
Nguyen Minh Thuy, Nguyen Thi Tieu Phung, Tran Ngoc Giau, Vo Quoc Tien, Ngo Van Tai, Vo Quang Minh
Summary: This study investigates the effects of adding Gac aril and xanthan gum on the quality characteristics of macaroni. The results show that adding 7% Gac aril and 1.5% xanthan gum can enhance the color, structure, and bioactive compounds (beta-carotene and lycopene) of macaroni.
ACTA SCIENTIARUM POLONORUM-TECHNOLOGIA ALIMENTARIA
(2023)
Article
Chemistry, Multidisciplinary
Nguyen Minh Thong, Mai Van Bay, Quan V. V. Vo, Tran Duc Manh, Pham Cam Nam
Summary: This study used computational methods to investigate the multitarget mechanisms of 5-hydroxy ferulic acid in preventing cancer. The results showed that 5-hydroxy ferulic acid has strong antiradical activity and can form stable complexes with Cu(II) ions. It also exhibited effective inhibition of the thymidylate synthase enzyme. Based on these findings, 5-hydroxy ferulic acid may be a promising cancer treatment.
Article
Chemistry, Multidisciplinary
Mai Van Bay, Pham Cam Nam, Nguyen Thi Hoa, Adam Mechler, Quan V. Vo
Summary: This study investigated the antiradical properties of Sumatranus lignans (SL) against hydroperoxyl radicals in different media using density functional theory (DFT) calculations. The results showed that compounds 6 and 7 exhibited higher antiradical activity than resveratrol, ascorbic acid, and Trolox in both lipidic and aqueous environments.
Article
Chemistry, Multidisciplinary
Khuong Quoc Vo, Man Van Tran, Thu Anh Nguyen, Anh-Thi Tran Cao, Sy Van Vu, Kha Ni Tran, Nguyen Thanh Si, Vu-Nhat Pham
Summary: In this study, a nanosubstrate for trace determination of sulfathiazole (STZ) was prepared using surface-enhanced Raman scattering (SERS) technique. The nanosubstrate, composed of spinous gold nanoparticles (SGNPs) with long tips, showed high sensitivity and good reproducibility. It could detect STZ at low concentrations and had an excellent linear correlation between concentration and intensity. The nanosubstrate has potential applications in measuring various antibiotics.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Physical
Pham Vu Nhat, Nguyen Thanh Si, Andre Fielicke, Vitaly G. Kiselev, Minh Tho Nguyen
Summary: The geometry of the neutral Au-18 gold cluster was investigated using quantum chemical calculations and far-infrared multiple photon dissociation spectroscopy. Two potential isomers, derived from a star-like Au-17 structure, were identified to contribute to the experimental IR spectrum. The detection of a stable core-shell isomer in the Au-18 cluster is intriguing and has not been found before for small neutral gold clusters. The calculated IR spectra of both isomers agree well with the experimental FIR-MPD spectra.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Thi H. Ho, Viet Q. Bui, Quynh Anh T. Nguyen, Yoshiyuki Kawazoe, Seong-Gon Kim, Pham Cam Nam
Summary: Density functional theory calculations were used to study the electrocatalytic potential of single boron atom doping in defective ReS2 monolayers. The results showed that B-doped defective ReS2 exhibited remarkable conductivity and acted as an active catalyst for nitrogen reduction reactions, with promising applications.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
