Article
Clinical Neurology
Benjamin Ongnok, Thawatchai Khuanjing, Titikorn Chunchai, Patcharapong Pantiya, Sasiwan Kerdphoo, Busarin Arunsak, Wichwara Nawara, Thidarat Jaiwongkam, Nattayaporn Apaijai, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: The study explored the neuroprotective effects of donepezil on a doxorubicin-induced chemobrain model, showing that donepezil can alleviate neurological deficits and pathologies induced by chemotherapy without affecting doxorubicin's anticancer efficacy.
Article
Dermatology
Rafael A. C. Souza, Carla Patricia Martinelli-Klay, Armando J. d'Acampora, Geraldo J. S. Bernardes, Sandro M. Sgrott, Laila A. C. Souza, Tommaso Lombardi, Thais R. Sudbrack
Summary: Orally administered sildenafil and tadalafil can improve skin flap healing and viability by increasing vascularization and showed positive results in the experiment.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ryota Murata, Hiroshi Watanabe, Hiroto Nosaki, Kento Nishida, Hitoshi Maeda, Motohiro Nishida, Toru Maruyama
Summary: In this study, a long-acting Thioredoxin (Trx) was prepared by fusing human Trx with human serum albumin (HSA) and its efficacy in treating drug-induced heart failure was evaluated. The results showed that HSA-Trx administration suppressed the adverse effects of drug-induced cardiomyopathy, including heart weight decrease, myocardial fibrosis increase, and markers for myocardial damage. HSA-Trx also inhibited oxidative stress and inflammation, as well as the expression of myocardial atrophy factors. The findings suggest that HSA-Trx can improve the pathological condition associated with doxorubicin-induced cardiomyopathy.
Review
Pharmacology & Pharmacy
Kurt Miller, Uwe May, Wolf-Dietrich Beecken, Georgios Hatzichristodoulou, Michael Boehm, Stefan Fink
Summary: This study evaluated the benefits and risks of reclassifying tadalafil, a phosphodiesterase type 5 inhibitor, as an over-the-counter medication. The expert panel concluded that the benefits outweighed the risks and considered the risk mitigation strategies of packaging label and patient information leaflet to be sufficient.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bassant Elbardisy, Nabila Boraie, Sally Galal
Summary: In this study, oral tadalafil (TD) was successfully transformed into dilutable TD-NEs for pulmonary delivery through nebulization. The optimal formulation, P2(TD), showed good drug loading and particle size, stability, and safety, making it a promising treatment for pediatric pulmonary arterial hypertension (PAH).
Article
Chemistry, Medicinal
Puwei Zhang, Jianing Zhang, Lin Zhao, Shizheng Li, Kun Li
Summary: The study found that quercetin can alleviate AC-induced cardiotoxicity and enhance the antitumor activity of AC in TNBC cells, making it a potential novel agent for treating TNBC.
PHYTOTHERAPY RESEARCH
(2022)
Article
Urology & Nephrology
Moritz von Bueren, Severin Rodler, Isabell Wiesenhuetter, Florian Schroeder, Alexander Buchner, Christian Stief, Christian Gratzke, Christian Wuelfing, Johannes von Bueren
Summary: The study indicates a preference for tadalafil in patients who have tried both PDE5 inhibitors, especially in younger age, lower BMI, and those with sustained morning erections.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Cardiac & Cardiovascular Systems
Yu Qi, Jianzhou Chen, Junfeng Duan, Lina Kang, Kun Wang, Ziwei Chen, Biao Xu, Rong Gu
Summary: The study found that MVP expression was upregulated in DOX-treated murine hearts. Cardiac-specific MVP overexpression can alleviate DOX-induced cardiac dysfunction, oxidative stress, and fibrosis. Mechanistically, MVP overexpression reduces cardiomyocyte apoptosis in DiCM by activating the AKT signaling pathway.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Zhe Yang, Tengling Li, Jianzhong Xian, Jia Chen, Yin Huang, Qin Zhang, Xiufang Lin, Hongyun Lu, Yubi Lin
Summary: This study found that SGLT2i attenuated cardiac dysfunction and adverse remodeling in ACM by suppressing cardiac fibrosis and inflammation via reverting the HIF-2 alpha signaling pathway. This suggests that SGLT2i is a novel and available therapy for ACM.
Article
Andrology
Bahadir Ermec, Mehmet Gokhan Culha, Gulay Kocak, Lutfi Canat, Alper Otunctemur, Fatih Altunrende
Summary: This study evaluated the effect of vitamin D replacement in patients with LUTS/ED who did not respond to tadalafil treatment. The results showed that after vitamin D replacement, the erectile function and prostate symptom scores of the patients significantly improved.
Article
Urology & Nephrology
Anil Eker, Serdar Celik, Elif Ebru Ozer, Ismail Basmaci, Ertugrul Sefik, Ibrahim Halil Bozkurt, Bulent Gunlusoy, Tansu Degirmenci
Summary: This study compared the effects of hyperbaric oxygen (HBO) treatment with PDE5I treatment on erectile dysfunction and determined patient-dependent factors affecting the efficacy and duration of HBO treatment. The study found that HBO can improve erectile function and can be a reasonable alternative for patients who cannot use PDE5Is.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Obstetrics & Gynecology
Fumi Furuhashi, Hiroaki Tanaka, Shintaro Maki, Makoto Tsuji, Shoichi Magawa, Michiko K. Kaneda, Masafumi Nii, Kayo Tanaka, Toru Ogura, Yuki Nishimura, Masayuki Endoh, Tadashi Kimura, Tomomi Kotani, Akihiko Sekizawa, Tomoaki Ikeda
Summary: The study shows that tadalafil treatment is safe for pregnant women with hypertensive disorder of pregnancy (HDP) and does not prolong the gestational period. The incidence of headaches in the tadalafil treatment group is significantly lower compared to the conventional treatment group.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Zubeyir Huyut, Hamit Hakan Alp, Nuri Bakan, Serkan Yildirim, Mehmet Ramazan Sekeroglu
Summary: This study found that vardenafil, tadalafil, and udenafil can increase VEGF, BMP2, and VitaminD(3) levels, and promote angiogenesis.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Naja Nyffenegger, Anna Flace, Cedric Doucerain, Franz Duerrenberger, Vania Manolova
Summary: The study found that the oral ferroportin inhibitor VIT-2763 alone or in combination with the iron chelator DFX can improve anemia and erythropoiesis in the Hbb(th3/+) mouse model of beta-thalassemia, with no interference between the two drugs. VIT-2763 decreases serum iron and TSAT, while DFX mainly reduces liver iron concentration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Andreas Boening, Edgar Welk, Martina Heep, Carina Hemmerich, Bernd Niemann, Klaus-Dieter Schluter, Zulfugar T. Taghiyev
Summary: The study demonstrates that oral administration of levosimendan before ischemia/reperfusion improves functional recovery in the heart, but this effect is only moderate when cardioplegia is included. Differences between hearts exposed to cardioplegia or to global ischemia may explain why the beneficial effects of levosimendan do not directly translate into better clinical outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Owais M. Bhat, Xinxu Yuan, Rakesh C. Kukreja, Pin-Lan Li
Summary: The lysosomal CER-mTOR signaling pathway plays a crucial role in arterial medial calcification (AMC) by affecting lysosome-multivesicular body interaction, exosome secretion, and arterial stiffening. Torin-1, an mTOR inhibitor, shows potential as a therapeutic agent for preventing calcification and arterial stiffening in AMC.
Review
Pharmacology & Pharmacy
Arun Samidurai, Lei Xi, Anindita Das, Audra N. Iness, Navin G. Vigneshwar, Pin-Lan Li, Dinender K. Singla, Sakthivel Muniyan, Surinder K. Batra, Rakesh C. Kukreja
Summary: Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of enzymes that regulate the spatial and temporal relationship of second messenger signaling in the cellular system. The PDE1 sub-family consists of three subtypes with different affinities for cAMP and cGMP, and their catalytic activity is stimulated by binding to Ca2+/calmodulin, playing a critical role in various diseases.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Zhuo Li, Fangnan Wu, Lei Xi, Zhenjun Tian
Summary: Exercise training post-myocardial infarction activates the CHI3L1/PAR2 signaling pathway, improving myocardial function and enhancing cardiac angiogenesis in the infarcted heart.
Article
Biology
Zoya O. Serebrovska, Lei Xi, Lesya Tumanovska, Angela M. Shysh, Sergii Goncharov, Michael Khetsuriani, Taisia O. Kozak, Denis A. Pashevin, Victor E. Dosenko, Sergii V. Virko, Viktor A. Kholin, Oksana N. Grib, Natalie A. Utko, Egor Egorov, Anna O. Polischuk, Tetiana Serebrovska
Summary: The study investigated the effects of intermittent hypoxia-hyperoxia training (IHHT) on pro-inflammatory factors in healthy elderly individuals and patients with early signs of Alzheimer's disease (AD). IHHT was found to improve cognitive function, potentially through upregulating circulating levels of inflammatory markers and triggering cellular adaptive reprogramming.
Article
Health Care Sciences & Services
Dumitru Andrei Iacobas, Lei Xi
Summary: The genomic fabric paradigm (GFP) characterizes the topology of the transcriptome by analyzing the abundance and variability of transcripts, as well as the inter-coordination of gene expressions. It has been applied to study heart failures induced by different conditions and revealed important findings about gene expression regulation and gene networks.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Arun Samidurai, Lei Xi, Anindita Das, Rakesh C. Kukreja
Summary: Cyclic guanosine monophosphate (cGMP) is an important second messenger in cells, and phosphodiesterase 5 (PDE5) is a member of the cyclic nucleotide phosphodiesterase (PDE) family that targets cGMP. PDE5 inhibitors, such as sildenafil and tadalafil, are used for various medical conditions beyond erectile dysfunction. Preclinical studies have shown their potential therapeutic benefits in cardiovascular, cancer, neurological, and aging-related disorders.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY
(2023)
Article
Cell Biology
Rakesh C. Kukreja, Rui Wang, Saisudha Koka, Anindita Das, Arun Samidurai, Lei Xi
Summary: This article discusses the potential use of combination therapy with PDE5 inhibitor and HCQ in the treatment of type 2 diabetes (T2D). Previous studies have shown that this combination treatment can reduce blood glucose and lipid levels, improve insulin sensitivity, and reduce myocardial infarction.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Oncology
Chunmeng Zhang, Pranita Atri, Palanisamy Nallasamy, Seema Parte, Sanchita Rauth, Rama Krishna Nimmakayala, Saravanakumar Marimuthu, Ramakanth Chirravuri-Venkata, Rakesh Bhatia, Sushanta Halder, Ashu Shah, Jesse L. Cox, Lynette Smith, Sushil Kumar, Jason M. Foster, Rakesh C. Kukreja, Parthasarathy Seshacharyulu, Moorthy P. Ponnusamy, Surinder K. Batra
Summary: In this study, Bosutinib was identified as a candidate drug to target MUC4 oncogenic mucin using an in silico screening method. Bosutinib treatment alone or in combination with other drugs reduced viability, migration, and colony formation in PDAC cell lines, as well as proliferation and growth in human PDAC organoids and xenografts. Bosutinib downregulated MUC4 mucin at both transcription and translation levels and disrupted the Src-ERK/AKT-FosL1 pathway, leading to decreased expression of MUC4 and MUC5AC mucins. Overall, Bosutinib is a promising mucin-targeting drug that can be used in the treatment of mucinous tumors.
Article
Physiology
Lei Xi, Donatas Kraskauskas, Sakthivel Muniyan, Surinder K. Batra, Rakesh C. Kukreja
Summary: Androgen-deprivation therapy (ADT) is the primary systemic therapy for advanced or metastatic prostate cancer (PCa), but it may cause metabolic and cardiovascular adverse events. In this study, a murine model of ADT was established using a gonadotropin-releasing hormone (GnRH) agonist leuprolide, and the effects on metabolism and cardiac function were investigated. The results showed that long-term ADT with leuprolide increased abdominal adiposity and cardiac injury biomarker levels, and sildenafil did not prevent these adverse changes.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sumit Saha, Xianjun Fang, Christopher D. Green, Anindita Das
Summary: This review discusses the role of mTORC1 as a unified target for treating cardiac dysfunction in type 2 diabetes (T2D) and examines whether SGLT2 inhibitors can target mTORC1 signaling to benefit patients with diabetic cardiomyopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Arun Samidurai, Manu Saravanan, Ramzi Ockaili, Donatas Kraskauskas, Suet Ying Valerie Lau, Varun Kodali, Shakthi Ramasamy, Karthikeya Bhoopathi, Megha Nair, Sean K. K. Roh, Rakesh C. C. Kukreja, Anindita Das
Summary: Rapamycin treatment can effectively alleviate cardiac remodeling and inflammation in diabetic patients by inhibiting robust activation of mTOR signaling. This treatment can preserve left ventricular ejection fraction and reduce fibrosis, as well as inhibit the formation of NLRP3 inflammasomes and reduce apoptosis in cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Arun Samidurai, Ramzi Ockaili, Chad Cain, Sean K. Roh, Scott M. Filippone, Donatas Kraskauskas, Rakesh C. Kukreja, Anindita Das
Summary: The study developed a preclinical model of myocardial I/R injury in conscious diabetic rabbits and demonstrated the efficacy of rapamycin at the onset of reperfusion to limit the adverse effects of AMI.