Article
Pharmacology & Pharmacy
Antonella Obinu, Giovanni Pietro Burrai, Roberta Cavalli, Grazia Galleri, Rossana Migheli, Elisabetta Antuofermo, Giovanna Rassu, Elisabetta Gavini, Paolo Giunchedi
Summary: In this study, solid lipid nanoparticles (SLN) loaded with GEN were developed to improve its oral bioavailability by avoiding first-pass metabolism through intestinal lymphatic absorption. The SLN obtained by hot homogenization showed high stability and drug loading capacity.
Article
Pharmacology & Pharmacy
Chenhui Wang, Xiaowei Liu, Ruihan Zhao, Meiqing Yang, Wenqian Liu, Qiuyang Dai, Xiaofeng Bao, Yong Chen, Jun Ma
Summary: This study aimed to improve the dissolution and oral bioavailability of chrysin by developing a stable solid dispersion formulation. The optimized solid dispersion showed enhanced dissolution rates and had acceptable stability. In rat models, the solid dispersion of chrysin exhibited stronger antihyperlipidemic effects compared to chrysin raw material.
Article
Biochemistry & Molecular Biology
Dan Li, Xiaolin Yao, Qingxia Gou, Guifang Cao, Kai Xu, Yongli Yang
Summary: This study aimed to investigate the promotion of lipid oxidation in oil-in-water emulsions and digestive properties of the bionic dynamic gastrointestinal system. The whey protein isolate (WPI) and gum arabic (GA) complexes loaded with iron ions, known as WPI/GA(Fe3+) nanoparticles (WGS) and WPI/GA(Fe3+) fibers (WGF), showed improved oxidative stability of lipids and controlled iron-ion release, making them potential novel stable iron fortifiers in food emulsions.
Article
Pharmacology & Pharmacy
Wei Xu, Zhaoyou Deng, Yifei Xiang, Dujuan Zhu, Dandan Yi, Yihao Mo, Yu Liu, Lanqian Qin, Ling Huang, Bingjie Wan, Liqin Wu, Xin Feng, Jiakang He
Summary: In this study, a tolfenamic acid solid lipid nanoparticle (TA-SLN) suspension was prepared to improve the sustained release and bioavailability of nonsteroidal anti-inflammatory drugs. The TA-SLN suspension showed improved sustained drug release in vitro and increased pharmacokinetic parameters in pigs compared with TA injection, indicating its potential as a promising new formulation.
Review
Chemistry, Multidisciplinary
Chuan-He Tang, Huan-Le Chen, Jin-Ru Dong
Summary: Although SLNs and NLCs have been used as drug delivery systems, they have been less investigated as food-grade nanovehicles for nutraceuticals. This review comprehensively explores the development and utilization of food-grade SLNs and NLCs as nanosized delivery systems. It discusses issues such as incorporation and release of bioactives, oxidative stability, lipid digestion and absorption, intestinal transport, and encapsulation and delivery of nutraceuticals. The review also highlights the performance of these nanoparticles in improving stability, bioavailability, and bioactivities of curcuminoids.
APPLIED SCIENCES-BASEL
(2023)
Article
Plant Sciences
Khanit Sa-ngiamsuntorn, Ampa Suksatu, Yongyut Pewkliang, Piyanoot Thongsri, Phongthon Kanjanasirirat, Suwimon Manopwisedjaroen, Sitthivut Charoensutthivarakul, Patompon Wongtrakoongate, Supaporn Pitiporn, Jarinya Chaopreecha, Supasek Kongsomros, Kedchin Jearawuttanakul, Warawuth Wannalo, Phisit Khemawoot, Somchai Chutipongtanate, Suparerk Borwornpinyo, Arunee Thitithanyanont, Suradej Hongeng
Summary: This study investigated the anti-SARS-CoV-2 activity of Andrographis paniculata extract and andrographolide in human lung epithelial cells, showing that they significantly inhibited the production of infectious virions with low cytotoxicity. These findings suggest that A. paniculata and andrographolide have potential as monotherapy or in combination with other drugs against SARS-CoV-2 infection.
JOURNAL OF NATURAL PRODUCTS
(2021)
Review
Chemistry, Medicinal
Viliana Gugleva, Velichka Andonova
Summary: The challenge faced by researchers in achieving sufficient ocular bioavailability is due to the complex structure of the eye and its protective physiological mechanisms. Low viscosity eye drops and short ocular residence time contribute to low drug concentration at the target site. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are being developed as drug delivery platforms to overcome these challenges and enhance ocular bioavailability. They are biocompatible, biodegradable, and can be sterilized and scaled-up. Surface modifications can prolong ocular residence time, enhance penetration, and improve performance.
Review
Food Science & Technology
Zixin Guo, Yixiang Liu, Yangchao Luo
Summary: This paper explores the role of dietary lipids in the absorption and utilization of carotenoids, discussing the mechanisms of intestinal absorption, regulation of lipid transporters and intracellular metabolizing enzymes, and the efflux process of chyle particles. It emphasizes the importance of selecting appropriate dietary lipids for the absorption and utilization of different carotenoids.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Applied
Qihong Zhang, Hui Wang, Zongmiao Feng, Zhaohui Lu, Chen Su, Yunchun Zhao, Jingbo Yu, Alexandr Dushkin, Weike Su
Summary: This study successfully prepared a SD-CUR carrier with enhanced solubility and permeability, demonstrating superior pharmacological activity in hyperlipidemia rats, providing new approaches and directions for the prevention and treatment of hyperlipidemia.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Medicinal
Yaxin Chen, Niaoniao He, Ting Yang, Shuyun Cai, Yi Zhang, Jinjing Lin, Mingqing Huang, Weizhu Chen, Yiping Zhang, Zhuan Hong
Summary: In this study, a solid lipid nanoparticle-microcapsule delivery system was creatively constructed to encapsulate fucoxanthin (FX), aiming to improve its stability and bioavailability. The encapsulated FX showed higher storage stability, sustained release, and significantly improved bioavailability compared to free FX. The research results provide a theoretical basis for the development and application of FX in pharmaceuticals or functional foods.
Article
Instruments & Instrumentation
Saurabh Shrivastava, Chanchal Deep Kaur
Summary: This study developed a delivery system based on andrographolide-loaded solid lipid nanoparticles, which achieved high entrapment efficiency, bioavailability, and lymphatic targeting through formulation optimization. In vivo studies demonstrated enhanced bioavailability and specificity of the formulation, without causing histopathological damage to the liver, spleen, and thymus.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Morten J. Dille, Tuna Baydin, Kare A. Kristiansen, Kurt I. Draget
Summary: Emulsions with smaller droplet sizes have a higher rate of lipolysis and uptake in vivo, while medium droplets show the highest lipolysis rate. This suggests that droplet size plays a crucial role in the digestion and absorption of oils and lipophilic compounds.
Article
Biochemistry & Molecular Biology
Yi-Ting Ruan, Wen-jun Wang, Guo-Dong Zheng, Zhong-Ping Yin, Ji-Guang Chen, Jing-En Li, Ling-Li Chen, Qing-Feng Zhang
Summary: This study encapsulated astilbin with different shell materials and found that chitosan and sodium caseinate significantly delayed and decreased astilbin feces excretion in rats, while lecithin had a weaker effect. This may be attributed to the difference in mucoadhesive properties between the shell materials. Additionally, all three shell materials improved the stability of the nanoparticles both in vitro and in vivo.
Article
Food Science & Technology
Yasi Yu, Dechu Chen, Yee Ying Lee, Nannan Chen, Yong Wang, Chaoying Qiu
Summary: Curcumin-loaded solid lipid nanoparticles (Cur-SLN) were prepared using different lipid matrix (MLCD or TP) and three surfactants (T20, SQ, and Rha). The MLCD-based SLNs had smaller size and lower surface charge, while the Rha-based SLNs showed small size but low stability. The emulsifiers had an impact on crystal polymorphism and bioavailability, with T20-SLNs exhibiting higher digestibility and bioavailability. Mathematical modeling analysis showed that Cur was mainly released from the intestinal phase, and T20-SLNs had a faster release rate.
Article
Pharmacology & Pharmacy
Basalat Imran, Fakhar Ud Din, Zakir Ali, Anam Fatima, Muhammad Waseem Khan, Dong Wuk Kim, Maimoona Malik, Saba Sohail, Sibgha Batool, Muhammad Jawad, Kanwal Shabbir, Alam Zeb, Barkat Ali Khan
Summary: In this study, dexibuprofen solid lipid nanoparticles (DBPN-SLNs) were successfully prepared and optimized. The optimized formulation exhibited desirable morphological characteristics and stability, and significantly delayed the drug release, resulting in enhanced oral bioavailability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Xiu-Qin Zheng, Lei-Xin Song, Zhu-Zhen Han, Ying-Bo Yang, Yi Zhang, Li-Hua Gu, Li Yang, Gui-Xin Chou, Zheng-Tao Wang
Summary: In this study, five new triterpenoids were isolated from the fruit spikes of Prunella vulgaris L., along with 15 known triterpenoids. Their structures were elucidated, and their anti-thyroid cancer activities were evaluated. Three of the compounds showed apparent inhibitory activity against thyroid cancer.
NATURAL PRODUCT RESEARCH
(2023)
Article
Engineering, Biomedical
Haibao Peng, Xingcai Zhang, Peng Yang, Jiaxu Zhao, Wei Zhang, Nianping Feng, Wuli Yang, Jing Tang
Summary: In this study, a metal-organic framework (MOF)-red blood cell (RBC) membrane-camouflaged multi-drug-delivery nanoplatform was designed and fabricated for combined ferroptosis-apoptosis treatment of multidrug-resistant cancer. The nanoplatform, created through a solvothermal synthesis process, demonstrated the ability to deplete glutathione, increase reactive oxidative species oxidative stress, and exhibit remarkable anticancer properties. This research provides a new strategy for overcoming multidrug resistance.
BIOACTIVE MATERIALS
(2023)
Article
Plant Sciences
Hao Qiu, Lei-Xin Song, Ying-Bo Yang, Si-Yu Zhang, Zhu-Zhen Han, Zheng-Tao Wang, Li Yang
Summary: Two undescribed stilbenoid diglycosides, dendrosonside A and dendrosonside B, were isolated from the stems of Dendrobium 'Sonia'. Their structures were elucidated and they showed inhibition of nitric oxide production.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Chemistry, Applied
Jia-Ying Zhao, Qi Liao, Jian-Wei Zhang, Guo-Qiang Lin, Zhengtao Wang, Dingding Gao, Qing-Hua Li, Ping Tian
Summary: In this study, a metal-free cascade dihalogenation-cyclization reaction was reported for the convenient preparation of dibrominated cis-tetrahydrobenzofuran-5(4H)-ones and cis-dihydrobenzopyran-6(5H)-ones. These products bear 1,4-dibromobut-1-enyl subunit in trans-trans and trans-cis form. The anticancer activity against MDA-MB-468 cells was also observed for the corresponding products.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Review
Chemistry, Analytical
Longchan Liu, Ziying Wang, Qian Zhang, Yuqi Mei, Linnan Li, Huwei Liu, Zhengtao Wang, Li Yang
ANALYTICAL CHEMISTRY
(2023)
Article
Plant Sciences
Yin Cao, Mingrui Li, Lihua Gu, Xin Zhao, An Zhou, Yuping Miao, Yi Wu, Zunji Ke, Rongfeng Hu, Zhengtao Wang, Xiaojun Wu
Summary: The study investigated the effects of Kaixin San (KXS) on hippocampal neurons and cardiac ferroptosis in mice with rapid-eye-movement (REM) sleep deprivation. The results showed that KXS improved learning and memory, prevented mitochondrial damage, alleviated myocardial injury, and reversed the expression of proteins involved in ferroptosis in the hippocampus and heart tissues.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Physical
Rui Tian, Yufan Guo, Fazhen Luo, Tianshu Yang, Zhenhua Zhou, Zhengtao Wang, Yan Xie
Summary: This paper reports the synthesis of multifunctional carbon dots (CFCDs) using herbal medicine as a precursor, and investigates their fluorescent properties and biological activities. The obtained CFCDs have a graphitic structure, abundant functional groups, high aqueous solubility, and excellent stability. CFCDs exhibit pH-dependent fluorescence properties and low cytotoxicity, making them suitable for cell imaging. Moreover, CFCDs have good hemostatic effects and can promote platelet aggregation. CFCDs have potential for wide application in the medical domain.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Food Science & Technology
Lihua Gu, Yue Jiang, Yuanyuan Han, Li Yang, Zhengtao Wang
Summary: A practical TLC-direct bioassay method was established for screening and evaluating antioxidant activity. The method involved a series of reactions, including the production of lipid peroxides by UV irradiation of linoleic acid and the conversion of peroxides into malondialdehyde. A dot blot test using TLC separation showed that substances with anti-lipid peroxidation activity appeared as white spots/zones on a red background. The method was validated for selectivity, sensitivity, linearity, precision, and recovery, and was successfully used to identify active antioxidant constituents from Perilla fruits.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Deqing Ruan, Jingyi Yang, Qianfei Luo, Yanhong Shi, Lili Ding, Zhengtao Wang, Rui Wang, Li Yang
Summary: In this study, we found that goitrin, an alkaloid from Radix Isatidis, showed protective effects in LPS-induced septic shock by inhibiting caspase-11 non-canonical inflammasome pathway. This finding provides a new therapeutic strategy for the clinical treatment of septic shock.
Article
Plant Sciences
Ruiyang Gao, Zhilun Yu, Cheng Lv, Xiaolong Geng, Yijing Ren, Junyu Ren, Hao Wang, Fangbin Ai, Beibei Zhang, Bei Yue, Zhengtao Wang, Wei Dou
Summary: This study found that a plant called Allium macrostemon Bunge (AMB) promotes hair regrowth in AGA mice and identifies the underlying molecular mechanisms. AMB stimulates proliferation and migration of human hair dermal papilla cells (HDPC) and enhances growth factors expression through the activation of the Wnt/β-catenin signaling pathway. Treatment with AMB extract promotes hair regeneration in AGA mice. These findings contribute to the potential use of AMB in alopecia treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zhonglian Yu, Mengqin Xia, Jiping Lan, Li Yang, Zhengtao Wang, Rui Wang, Hongxun Tao, Yanhong Shi
Summary: The Lycium genus, including Lycium barbarum L., Lycium chinense Mill., and Lycium ruthenicum Murr., has been used as a source of medicines and nutrient supplements in China for thousands of years. These fruits have been extensively studied and commercialized for their health-related properties, including antioxidant, immunomodulatory, anti-tumor, hepatoprotective, and neuroprotective effects. However, there is limited systematic and comprehensive information available on the Lycium genus.
Article
Pharmacology & Pharmacy
Hongyu Zhang, Jingwen Guo, Zhi Wang, Na Wang, Nianping Feng, Yongtai Zhang
Summary: This study aimed to compare the performance differences of trans-ferulic acid-encapsulated nanostructured lipid carriers (NLCs) and solid lipid nanoparticles (SLNs) in transport by Caco-2 cells. The NLC particles (diameter: 102.6 nm) composed of Compritol((R)) 888 ATO, ethyl oleate, Cremophor((R)) EL, and Transcutol(R) P were larger than the SLNs (diameter: 86.0 nm) formed without liquid lipid (ethyl oleate), and the former had a higher encapsulation efficiency for trans-ferulic acid (p < 0.05). In vitro cultured Caco-2 cell transport was used to simulate intestinal absorption, and the cellular uptake of NLCs was higher than that of SLNs (p < 0.05). Compared to SLNs, NLCs greatly enhanced trans-ferulic acid permeation through the Millicell (TM) membrane (p < 0.05). This work confirms that NLCs have better properties than SLNs in terms of increasing drug transport by Caco-2 cells.
ACTA PHARMACEUTICA
(2023)
Article
Biophysics
Huining Ding, Qing Xia, Jiaqi Shen, Chunyun Zhu, Yongtai Zhang, Nianping Feng
Summary: The clinical translational success of nanomedicine and immunotherapy has demonstrated the immense potential of nanotechnology and immunization. Combining immunotherapy with nanomedicine effectively overcomes the limitations of single therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Materials Science, Biomaterials
Jing Zang, Jinniu Zhang, Yijun Mei, Yaoxuan Xiong, Tianyuan Ci, Nianping Feng
Summary: Immunogenic dead cells, engineered through the sequential treatment of live tumor cells with UV irradiation and cryo-shocking, can serve as a lung-targeting vehicle and tumor vaccine for chemoimmunotherapy. The drug-loaded dead cells can be trapped in the pulmonary capillaries and enhance drug accumulation in local tissues, while also eliciting antitumor immune responses. In a lung tumor-bearing mice model, this system achieved synergistic antitumor efficacy and prolonged survival.
BIOMATERIALS SCIENCE
(2023)
Article
Plant Sciences
Qi Xie, Xianrun Hu, Xiang Zhao, Zedong Xiang, Qianping Chen, Zhejun Xie, Hanxue Wang, Yonglin Zhao, Xuemei Cheng, Changhong Wang
Summary: This study confirmed the positive effects of the macromolecular portion (POL) and small molecule portion (EPP) from Codonopsis Radix (CR) on improving scopolamine-induced memory impairment. The mechanisms involved the regulation of cholinergic function, enhanced antioxidant defense, and suppression of inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
