Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives

A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features

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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

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A Novel Coronavirus from Patients with Pneumonia in China, 2019

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The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

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Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs

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Chronological Changes of Viral Shedding in Adult Inpatients with COVID-19 in Wuhan, China

(2020) Jing-Tao Huang et al.   CLINICAL INFECTIOUS DISEASES

Andrographolide as a potential inhibitor of SARS-CoV-2 main protease: an in silico approach

(2020) Sukanth Kumar Enmozhi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

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Ethnomedicines of Indian origin for combating COVID-19 infection by hampering the viral replication: using structure-based drug discovery approach

(2020) Selvaraj Alagu Lakshmi et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Computational investigation on Andrographis paniculata phytochemicals to evaluate their potency against SARS-CoV-2 in comparison to known antiviral compounds in drug trials

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Drug discovery strategies for SARS-CoV-2

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Estimates of the severity of coronavirus disease 2019: a model-based analysis

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Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19

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Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2

(2020) Markus Hoffmann et al.   NATURE

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

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Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage

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Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19

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Covid-19: Remdesivir has little or no impact on survival, WHO trial shows

(2020) Owen Dyer   BMJ-British Medical Journal

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

(2020) Arif Jamal Siddiqui et al.   Plants-Basel

Current approaches for target-specific drug discovery using natural compounds against SARS-CoV-2 infection

(2020) Prashant Khare et al.   VIRUS RESEARCH

High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents

(2020) Phongthon Kanjanasirirat et al.   Scientific Reports

Stable, Monodisperse, and Highly Cell-Permeating Nanocochleates from Natural Soy Lecithin Liposomes

(2019) Martina Asprea et al.   Pharmaceutics

An Immortalized Hepatocyte-like Cell Line (imHC) Accommodated Complete Viral Lifecycle, Viral Persistence Form, cccDNA and Eventual Spreading of a Clinically-Isolated HBV

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Andrographolide, A Natural Antioxidant: An Update

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Nanoemulsion as a strategy for improving the oral bioavailability and anti-inflammatory activity of andrographolide

(2018) Ching-Chi Yen et al.   International Journal of Nanomedicine

A novel immortalized hepatocyte-like cell line (imHC) supports in vitro liver stage development of the human malarial parasite Plasmodium vivax

(2018) Yongyut Pewkliang et al.   MALARIA JOURNAL

Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide

(2018) Yan Dai et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

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Broad-spectrum antiviral properties of andrographolide

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A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

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Natural Products as Sources of New Drugs from 1981 to 2014

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Middle East Respiratory Syndrome Coronavirus: Another Zoonotic Betacoronavirus Causing SARS-Like Disease

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Activity of Andrographolide and Its Derivatives on HPV16 Pseudovirus Infection and Viral Oncogene Expression in Cervical Carcinoma Cells

(2015) Tipaya Ekalaksananan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Activity of andrographolide against chikungunya virus infection

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Synthesis, structure–activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents

(2014) Hao Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats

(2014) Haw-Wen Chen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Andrographolide exerts anti-hepatitis C virus activity by up-regulating haeme oxygenase-1 via the p38 MAPK/Nrf2 pathway in human hepatoma cells

(2013) Jin-Ching Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Changes in the contents of four active diterpenoids at different growth stages in Andrographis paniculata (Burm.f.) Nees (Chuanxinlian)

(2013) Nanthanit Pholphana et al.   Chinese Medicine

Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers

(2011) Khanit Sa-ngiamsuntorn et al.   BMC BIOTECHNOLOGY

A Potential Andrographolide Analogue against the Replication of Herpes Simplex Virus Type 1 in Vero Cells

(2011) Supawadee Seubsasana et al.   Medicinal Chemistry

Evaluation of molecular pharmaceutical and in-vivo properties of spray-dried isolated andrographolide-PVP

(2010) C. Bothiraja et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Activity of Andrographolide and Its Derivatives against Influenza Virus in Vivo and in Vitro

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Inhibition of the Epstein–Barr Virus Lytic Cycle by Andrographolide

(2008) Tsuey-Pin Lin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME–Tox)

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Pharmacological Aspects of Andrographis paniculata on Health and Its Major Diterpenoid Constituent Andrographolide

(2008) Kanokwan Jarukamjorn et al.   JOURNAL OF HEALTH SCIENCE