Article
Electrochemistry
Shukai Sun, Xuanming Xu, Airong Niu, Zhixiang Sun, Yue Zhai, Shun Li, Chao Xuan, Yusun Zhou, Xiaomin Yang, Tingting Zhou, Qingwu Tian
Summary: A new glassy carbon electrode (GCE) with acetylene black (AB) as a sensitizer was developed for the determination of Doxorubicin (DOX) in human serum. The developed method showed satisfactory selectivity, repeatability, and stability, with a linear detection range of 0.01-2.5 μM and a detection limit of 3.006 nM. The prepared AB/GCE sensor could be applied for the quantitative analysis of DOX in real human serum samples.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Xuanming Xu, Shun Li, Xingwei Luan, Chao Xuan, Peng Zhao, Tingting Zhou, Qingwu Tian, Deng Pan
Summary: A highly sensitive and selective electrochemical sensor based on acetylene black and copper (II) metal organic framework modified glassy carbon electrode was developed for the detection of Imatinib (IMB) concentration. The sensor exhibited excellent electrocatalytic response and was successfully applied for IMB determination in human serum samples.
FRONTIERS IN CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Cheng-Hui Shen, Yu-Na Chang, You-Liang Chen, Chung-Wei Kung
Summary: A highly porous and chemically stable metal-organic framework (MOF) with enriched sulfonate groups, SO3-MOF-808, is synthesized and proposed as a porous alternative to Nafion for modulating the selectivity of electrochemical reactions. The use of SO3-MOF-808 thin film as an electrode coating significantly improves the current signal for dopamine oxidation and the selectivity against interfering compounds.
ACS MATERIALS LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Rafael da Silva, Priscila Cervini, M. Rafael Buoro, T. G. Eder Cavalheiro
Summary: A composite material based on acetylene black and a vegetable oil/MDI polyurethane was prepared and evaluated as a voltammetric electrode. The 60% AB composition showed the best performance with good conductivity and voltammetric response.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Rasha Rahman Poolakkandy, Annamalai Ramalakshmi Neelakandan, Muhammed Fasil Puthiyaparambath, Rajanikant Golgodu Krishnamurthy, Raghu Chatanathodi, Mini Mol Menamparambath
Summary: The development of an all-integrated flexible sensor for the cost-effective detection of dopamine is presented in this study. A nickel cobaltite/multi-walled carbon nanotube composite with excellent sensitivity was synthesized and demonstrated to detect dopamine in real-life samples. The interaction mechanism between dopamine, nickel cobaltite, and multi-walled carbon nanotubes was revealed using Density Functional Theory (DFT) calculations.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Article
Geriatrics & Gerontology
Annelies Heylen, Yannick Vermeiren, Sophia E. De Rooij, Rikie M. Scholtens, Barbara C. Van Munster, Debby Van Dam, Peter P. De Deyn
Summary: The study found that there is a disturbance in serotonin levels in postoperative patients with cognitive impairment regardless of whether they have delirium or not. This serotonergic disturbance is more pronounced in patients with both delirium and cognitive impairment.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Chemistry, Analytical
Peihong Deng, Jingyun Xiao, Jinxia Feng, Yaling Tian, Yiyong Wu, Junhua Li, Quanguo He
Summary: A sub-millimeter paste electrode with an inner diameter of 0.8 mm was prepared by combining rGO and AB, showing better performance in electrochemical behavior compared to a conventional size electrode with a diameter of 3 mm. The electrode exhibited higher sensitivity, a wider linear range, and a lower detection limit for Tyr, making it suitable for analysis in food and biological samples.
MICROCHEMICAL JOURNAL
(2021)
Review
Chemistry, Analytical
Qing Li, Jing-Tao Wu, Ying Liu, Xiao-Man Qi, Hong-Guang Jin, Chun Yang, Jun Liu, Guang-Li Li, Quan-Guo He
Summary: Black phosphorus has attracted significant attention due to its anisotropic electro-conductivity and tunable direct bandgap, making it suitable for various electrochemical sensing applications. Research efforts have explored synthesis methods, protection strategies, and sensing applications of BP and its derivatives, along with functionalization mechanisms, sensing strategies, and properties.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Lucia Abad-Gil, Sergio Lucas-Sanchez, M. Jesus Gismera, M. Teresa Sevilla, Jesus R. Procopio
Summary: This paper presents an HPLC method with electrochemical detection using a gold electrode for the determination of the most commonly used antimicrobial agents in cosmetic products. The method has low limits of detection and can successfully analyze cosmetic products with different compositions.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Hilal Torul, Mehmet Gumustas, Berat Urguplu, Aytekin Uzunoglu, Ismail Hakki Boyaci, Huseyin Celikkan, Ugur Tamer
Summary: A disposable and low-cost paper-based electrode (PBE) assembly utilizing a nitrocellulose membrane was developed for use in HPLC-EC, with a custom-built flow cell device designed via stereolithography 3D printing. Modification of the working electrode with gold nanoparticles and carboxylated-multi-walled carbon nanotubes allowed for enhanced electrochemical signal detection, achieving amperometric detection of catecholamines at a specific potential.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Energy & Fuels
Kanmani Moorthi, Johnbosco Yesuraj, Kibum Kim, Sakar Mohan
Summary: Mixed transition-metal oxides (MTMOs) have been widely studied as battery-type electrodes for their high electrical conductivity and structural stability. However, capacity degradation has limited their practical use. In this study, nitrogen-doped carbon dots (NCDs) integrated bismuth molybdenum oxide (Bi2MoO6; BMO) composites were successfully synthesized using a hydrothermal method. The composites showed rod-like morphology and exhibited enhanced specific capacity and cyclic stability. The results demonstrate that the NCD/BMO composite is a promising electrode material for supercapacitor applications.
Article
Chemistry, Physical
Xiangjun Wang, Zhichang Xiao, Xinghao Zhang, Debin Kong, Bin Wang, Peng Wu, Yan Song, Linjie Zhi
Summary: A three-step approach has been developed to create a multi-layered porous PBC/graphene sandwich with enhanced chemical bonding interactions. The chemically induced compatible interface significantly improves mass transfer efficiency when used as electrode material in supercapacitors and lithium-sulfur batteries.
Article
Electrochemistry
Runqiang Liu, Xuli Hu, Yuanhang Cao, Haotian Pang, Wenlei Hou, Yansheng Shi, Haoming Li, Xinming Yin, Hongyuan Zhao
Summary: In this study, an electrochemical sensor based on AB nanoparticles was developed for sensitive detection of ISO, and the excellent performance and stability of the sensor were demonstrated.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2022)
Article
Chemistry, Analytical
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezgintuerk
Summary: The ultrasensitive immunosensor based on AB/EpxSPPyr composite coated ITO electrode was designed for IL-6 detection with excellent sensitivity. The EpxSPPyr polymer synthesis and application enhanced the signal response and detection sensitivity of the biosensor.
Article
Chemistry, Analytical
Suchanat Boonkaew, Anna Dettlaff, Michal Sobaszek, Robert Bogdanowicz, Martin Jonsson-Niedziolka
Summary: This study reports the integration of boron/nitrogen co-doped diamond graphene nanowalls (DGNW) with screen-printed graphene electrode (SPGE) for the detection of serotonin. The DGNW-modified electrode exhibits high surface area, high electrocatalytic activity, wide potential window, and low background current. It shows good anti-fouling ability and significant current response enhancement, making it suitable for neurotransmitter detection.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Bingbing Liu, Jie Cao, Lu Liu, Min Zeng, Hongli Yu, Hao Wu
Summary: This study investigated the effect of processing with Chebulae Fructus on the chemical composition of Euphorbia pekinensis (EP) and found that it could alter the composition and reduce toxicity, providing a scientific basis for optimizing processing technology and handling other ethnomedicines with toxic properties.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Renuka P. Rathnasekara, Abu M. Rustum
Summary: A simple and robust HPLC method was developed for simultaneous determination of four active pharmaceutical ingredients and their degradation products. The method successfully separated the peaks of interest and demonstrated stability-indicating capability by separating the degradation products in stressed samples.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Bryan Lee, Gita Kharal, Benjamin Sreenan, Claire Lin, Ruosheng Zeng, Colin A. Fox, Patricia Ellison, Robert O. Ryan, Paul J. Brett, David Aucoin, Xiaoshan Zhu
Summary: In this study, a new type of Mn-doped nanocrystals was developed for detecting a biomarker of a fatal disease. The sensitivity of the detection was enhanced by surface treatment and time-resolved reading, achieving a detection limit comparable to enzyme-based immunoassay.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xiaoling Liu, Ting Yang, Lu Chen, Lili Lan, Guoxiang Sun, Ping Guo
Summary: In this study, the quality of Yiqing tablet was comprehensively evaluated using multi-component quantification, multi-dimensional fingerprint construction, and antioxidant activity analysis. The results showed that the sample had 25 components with antioxidant activity according to the HPLC fingerprint and most bands of FTIR also showed antioxidant activity. Based on the evaluation results of HPLC and FTIR fingerprint, all samples were classified as first level, demonstrating the consistency of sample quality. This study provides a new idea for achieving comprehensive quality evaluation of traditional Chinese medicines.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Siqi Li, Hao Guo, Yan Gao, Wen Tian, Shan Wang, Chen Shen, Lili Xu, Hailong Liu, Jinliang Zhang, Yingwu Wang
Summary: Using competitive ELISA to detect free cytokines is limited in accurately determining their real state and quantity. In this study, a novel cytokine immunoassay was developed using Rosetta molecular docking prediction technique to establish a method that can detect the true concentration of free cytokines without disrupting the dynamic equilibrium.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Changqing Yu, Tiantian Xie, Haiyan Liu, Ligai Bai
Summary: A phenyl-hybrid monolithic adsorbent with porous structure and multiple functional groups was prepared. It was used for the online extraction and quantification of coumarins in mouse plasma, showing good removal ability and selectivity.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Joao B. Pereira Jr, Vanessa S. Carvalho, William Q. Ferreira, Rennan G. O. Araujo, Sergio L. C. Ferreira
Summary: This work presents a simple, cost-effective, and environmentally friendly method for determining the content of multiple elements in medicinal herbs using ICP OES. The optimized experimental parameters result in low dissolved organic carbon content and residual acidity concentration. The accuracy of the method is confirmed through the analysis of certified reference materials, and its environmental friendliness is validated using the AGREE metric. Principal component analysis is used to classify the medicinal herbs based on their inorganic constituent concentrations.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Orwa Siddig, Chenxi Liu, Mohamed Abdulbagi, Min Song, Yu-ting Lu, Tai-jun Hang
Summary: In this study, a reliable LC-QTOF-MS method was developed to separate and characterize process-related substances and degradation products of Lurasidone hydrochloride. The results showed that Lurasidone hydrochloride exhibited instability under certain stress conditions, and several previously unidentified compounds were discovered. The study emphasizes the importance of monitoring and controlling related substances in the manufacturing processes to optimize the process and ensure quality control.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Jiaxi Fang, Luping Wang, Di Zhang, Yan Liang, Shouxin Li, Jingkui Tian, Qiang He, Juan Jin, Wei Zhu
Summary: This study reports that a novel compound called CPS-A exhibits therapeutic effects on cisplatin-induced acute kidney injury (AKI) and explores its potential mechanisms through transcriptomics and metabolomics. CPS-A improves cell viability, reduces inflammatory markers, and attenuates cisplatin-induced kidney injury. The study also identifies potential targets related to amino acid metabolism.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ricardo Conde, Nadia Oliveira, Elisabete Morais, Ana Paula Amaral, Adriana Sousa, Goncalo Graca, Ignacio Verde
Summary: Decreased levels of tyrosine, glutamate, valine, leucine, and isoleucine are associated with worsening pathological cognitive decline. Decreased levels of isobutyrate, histidine, acetone, and unknown-1 metabolite are potential biomarkers with neuroprotective and antioxidant actions for cognitive decline.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
A. L. Santunione, F. Palazzoli, P. Verri, D. Vandelli, V. Castagnetti, C. Profeta, E. Silingardi
Summary: This study describes two fatal suicide cases involving four cardiovascular drugs, and presents the concentrations and distribution of these drugs in different post-mortem specimens. The study developed a fast, sensitive, and simple method for drug detection suitable for forensic purposes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Meiyun Shi, Xinyue Zheng, Yuncheng Ge, Ning Zhang, Luyao Yu, Xujian Duan, Yajun Liu, Hongyu Xue, Jiansong You, Lei Yin
Summary: This study investigated the cellular uptake of low, medium and high molecular weight polyethylene glycol (PEG) in MCF-7 cells using UPLC-MS/MS and CID techniques. The results showed that PEG600, PEG2K, PEG4K and PEG10K exhibited low toxicity and had limited cellular entry at concentrations of 5-1200 μg/mL. Additionally, the environmental friendliness of the developed analytical methods was evaluated.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Ruijin Geng, Mengjie Yu, Jinbiao Xu, Yuanwang Wei, Qiong Wang, Junguo Chen, Fei Sun, Kun Xu, Han Xu, Xiaohui Liu, Juhua Xiao, Xianchao Zhang, Baogang Xie
Summary: This study validated serum methionine as a potential biomarker for Kawasaki disease (KD), and found that its alteration is associated with the activation of DNMT1 in KD patients.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Eman Shawky, Rasha A. Nassra, Aliaa M. T. El-Alkamy, Shaimaa M. Sallam, Samah M. El Sohafy
Summary: This study employed network pharmacology-based analysis and reverse molecular docking to investigate the molecular targets and pathways associated with gynecological disorders and the potential therapeutic effects of fenugreek constituents. The results highlighted the potential of steroidal saponins, isoflavones, and flavones as active constituents of fenugreek with implications for lactation, reproductive processes, and estrogenic activity. Animal model study further supported the presence of these bioactive compounds and their effects on body weight, serum prolactin levels, serum estradiol levels, and ovarian histological structure.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)
Article
Chemistry, Analytical
Xuelong Zhao, Ruixue Dai, Jing Wang, Liangliang Cao, Peidong Chen, Weifeng Yao, Fangfang Cheng, Beihua Bao, Li Zhang
Summary: This study identified the skin-permeable and skin-retainable components of Cayratia japonica ointment and found that flavonoids are the main active components that play a crucial role in the inflammatory and proliferative phases of wound healing.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2024)