Article
Biochemistry & Molecular Biology
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
Summary: A new strategy for fabricating a sensitive immunosensor for the determination of CC Chemokine receptor 4 (CCR4) in complex serum samples was developed through polymer modification on a disposable indium tin oxide electrode. The immunosensor exhibited promising performance for quantifying CCR4 antigen and showed successful analytical performance in terms of sensitivity, selectivity, repeatability, reproducibility, and long-term stability. It also displayed only 27.54% loss in initial signal after nine weeks of storage at 4 degrees C, indicating its potential for clinical diagnosis.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Analytical
Karen Y. P. S. Avelino, Leony S. Oliveira, Norma Lucena-Silva, Cesar A. S. Andrade, Maria D. L. Oliveira
Summary: A biosensor composed of PPy films and AuNPs was developed for specific detection of HPV genotypes, with modified oligonucleotides designed for strict recognition. The biosensor exhibited high sensitivity and specificity for HPV detection, as well as monitoring of the p53 gene biomarker. The flexible system showed a linear range for HPV detection with high sensitivity and accuracy.
Article
Chemistry, Analytical
Guanghui Tian, Feng Guo, Chuanbin Fan, Ziao Zong, Junli Wang, Jiakun Xu
Summary: Two hypercrosslinked microporous carbazole-based polymers (C-POP-1 and C-POP-2) were synthesized using an efficient Friedel-Crafts coupling approach. The porous structures of the polymers were controlled by regulating the length of two-node linear organic blocks. The aptasensor based on C-POP-2 demonstrated excellent electrochemical detection behavior for penicillin, allowing for quantitative detection of trace penicillin in real samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Biophysics
Felix Hempel, Jessica Ka Yan Law, Thanh Chien Nguyen, Ruben Lanche, Anna Susloparova, Xuan Thang Vu, Sven Ingebrandt
Summary: The study investigated single-cell adhesion on organic electrochemical transistors using an impedimetric readout method, demonstrating single-cell resolution and potential future applications.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Electrochemistry
Nicolas Gauthier, Anshuman Agrawal, Olivier Dubrunfaut, Sylvain Franger, Bernard Lestriez, Jean-Claude Badot, Loic Assaud
Summary: This study aims to understand the interactions between liquid electrolyte and solid composite electrode in a Li-ion battery. By replacing the common active material with an insulating gamma-Al2O3 compound, the interaction between carbon black electronic additive and liquid electrolyte was detected. Broadband dielectric spectroscopy (BDS) and electrochemical impedance spectroscopy (EIS) were used to characterize charge transport at different scales. The influence of ion adsorption on carbon black surface on electron transport was emphasized and explained.
ELECTROCHIMICA ACTA
(2023)
Article
Electrochemistry
Hebing Pei, Fang Chen, Wei Guo, Qianqian Jia, Ruibin Guo, Nijuan Liu, Zunli Mo
Summary: Chirality is a basic attribute of objects in three-dimensional space and is widely present in nature. A new type of chiral NGQDs was obtained by covalently grafting L/D-cysteine to NGQDs. The chiral NGQDs were found to specifically identify L/D-tartaric acid isomers and the mechanism of chiral recognition was discussed through molecular simulation and docking calculations. This study expands the application range of graphene quantum dots and provides new ideas for the preparation of chiral inorganic nanomaterials.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Materials Science, Multidisciplinary
Lakshmi Variar, M. N. Muralidharan, Sunil K. Narayanankutty, Seema Ansari
Summary: In this study, a low-cost three-phase epoxy resin composite using calcium copper titanate (CCTO) and carbon black (CB) as fillers was developed for meeting the growing demand for miniaturization and increased functionality of electronic devices. The dielectric, mechanical, and dynamic mechanical properties of the composites were investigated by preparing them using solution casting method and characterizing them using scanning electron microscopy and X-ray diffraction analysis.
MATERIALS RESEARCH BULLETIN
(2022)
Article
Nanoscience & Nanotechnology
James Alfred Isaac, Lea Rose Mangani, Didier Devaux, Renaud Bouchet
Summary: Solid-state batteries are revolutionary technologies with increased safety and energy density compared to liquid-electrolyte-based batteries. Composite polymer/ceramic electrolytes are promising candidates for reliable solid-state batteries due to the potential synergy between organic and inorganic materials. This study thoroughly investigates multilayer systems using electrochemical impedance spectroscopy (EIS) and proposes models to analyze the transport properties of the polymer and ceramic electrolytes. Interesting findings include the decoupling of polarization resistance components and the independence of the polymer/ceramic interfacial capacitance on electrolyte salt concentration.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Monica Penas-Caballero, Jesus Martin-Cordon, Violeta Barranco, Juan Carlos Galvan, Marianella Hernandez Santana, Miguel A. Lopez-Manchado, Raquel Verdejo
Summary: An autonomous self-healing polymer coating based on epoxy resin and superabsorbent polymer blend has been developed as an anticorrosion coating. It shows excellent performance in preventing coating delamination, protecting metal from corrosion, and enabling local repair of cracks.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Chemistry, Physical
Rongrong Yuan, Hongming He
Summary: A carbazole-bearing porous organic polymer (POP) was successfully prepared through an efficient reaction and can be used to fabricate an electrochemical aptasensor for rapid and precise detection of trace PCL with excellent monitoring performance.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Physical
George Zardalidis, Dimitrios Chatzogiannakis, Emmanouil Glynos, Filippos Farmakis
Summary: The contact between solid polymer electrolytes and electrodes in lithium-ion batteries is crucial for cell capacitance and life. In this study, low-molecular polyethylene glycol electrolytes with different chain termination groups showed varying electrochemical stability when in contact with metallic lithium. The electrolyte with hydroxy chain ends exhibited poor behavior and high decomposition, while the one with methoxy chain ends formed a stable electrolytic system.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Chemistry, Analytical
Sida Ren, Xi Zhang, Zhijie Li, Xiaoxia Jian, Junjian Zhao, Yan-Yan Song
Summary: An electrochemical biosensor for Gram-negative bacteria, based on a conductive polymer with artificial muscle properties, was established with specific and sensitive recognition. The sensor achieved effective recognition through specific carbohydrate-carbohydrate interaction, enhanced by impulse voltage application. With a low cost, high efficiency, and rapid detection time, the biosensor shows promising potential for application in portable devices and paving the way for the construction of electrochemical biosensors.
Article
Chemistry, Analytical
Ibrar Alam, Benchaporn Lertanantawong, Thana Sutthibutpong, Primana Punnakitikashem, Piyapong Asanithi
Summary: A tryptophan (Trp) sensor based on molecularly imprinted polymer was developed for sensitive and selective determination of Trp using electrochemical impedance spectroscopy. The sensor exhibited a wide linear range and low detection limit, and was successfully applied for Trp determination in complex samples such as milk and cancer cell media.
Article
Biophysics
Shichao Ding, Zhaoyuan Lyu, Suiqiong Li, Xiaofan Ruan, Mingen Fei, Yang Zhou, Xiangheng Niu, Wenlei Zhu, Dan Du, Yuehe Lin
Summary: An electrochemical sensor based on molecularly imprinted polypyrrole nanotubes has been developed for the detection of glyphosate with high sensitivity and specificity. The sensor demonstrates a wide detection range, low limit of detection, excellent stability, reproducibility, and selectivity against interferents. The sensor's practicality has been verified by detecting glyphosate in orange juice and rice beverages, making it suitable for monitoring pesticides in actual food and environmental samples.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Rongrong Yuan, Zhuojun Yan, Alateng Shaga, Hongming He
Summary: A novel porous organic polymer (POP) with high surface area and stability was successfully prepared and used to fabricate an ultrasensitive electrochemical aptasensor for detecting trace ampicillin. The biosensor exhibited a low detection limit and accurate monitoring ability for detecting amp in multiple real samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Chemistry, Analytical
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
CURRENT ANALYTICAL CHEMISTRY
(2019)
Article
Chemistry, Analytical
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Analytical
Elif Burcu Aydin
Article
Chemistry, Analytical
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Chemistry, Analytical
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Analytical
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
Summary: This study developed an impedimetric immunosensor for the determination of CCR4 with linear response, low detection limit, and excellent reproducibility. The sensor also showed good recovery in serum samples. The research established a new approach that could be beneficial for future cancer biomarker detection.
Article
Materials Science, Biomaterials
Elif Burcu Aydin, Muhammet Aydin, Abdulcelil Yuzer, Mine Ince, Kasim Ocakoglu, Mustafa Kemal Sezginturk
Summary: A novel impedimetric biosensing system based on anti-KLK 4 antibodies and Zn-PcTCa matrix was developed, showing good sensitivity, excellent specificity, and high stability for detecting KLK 4 antigen.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Chemistry, Analytical
Elif Burcu Aydin, Mustafa Kemal Sezginturk
Summary: A highly sensitive impedimetric immunosensor for IL 8 cancer biomarker was successfully fabricated using a simple process, with a wide linear detection range, low limit of detection, and high sensitivity. The biosensor demonstrated high reproducibility, repeatability, and selectivity against interference biomarkers.
Article
Biochemistry & Molecular Biology
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
Summary: A new and ultrasensitive impedimetric biosensor modified by P(Thi-diSuc) polymer is developed for the detection of PSMA. This biosensor offers a fast fabrication process, high sensitivity, and a wide detection range for PSMA quantification.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Materials Science, Biomaterials
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
Summary: A conducting nanocomposite layer was fabricated to develop an impedance biosensor for rapid and effective detection of the COVID-19 specific spike receptor binding domain (RBD) protein. The biosensor showed a wide linear dynamic range, ultra-low detection limit, great selectivity, suitable repeatability, multiple reusability, and excellent reproducibility.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Chemistry, Analytical
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
Summary: A label-free electrochemical biosensing system was developed for the diagnosis of coronavirus with a novel production procedure for the fabrication of gold nanoparticles-capped bioelectrode. The bioelectrode showed promising application potential for RBD biosensing by forming covalent ester linking between hydroxylated ITO electrode and GNPs-capped MUA.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
Summary: A novel selective and ultrasensitive sandwich biosensor was developed for the detection of nucleocapsid biomarkers of SARS-CoV-2. The biosensor exhibited good selectivity, high storage stability, acceptable repeatability, and a low detection limit. This strategy provides a new perspective for the early screening of SARS-CoV-2 infection.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Elif Burcu Aydin, Muhammet Aydin, Mustafa Kemal Sezginturk
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).