Article
Materials Science, Multidisciplinary
Lilan Gao, Xinwei Tian, Yansong Tan, He Tian, Qijun Gao, Zheng Liu, Dezhao Kong, Chunqiu Zhang
Summary: Studying the anisotropic mechanical properties of cartilage induced by inhomogeneous structure is significant for preventing cartilage damage and developing biomaterials. The depth-dependent fracture behavior of knee articular cartilage was investigated, revealing its excellent load bearing capacity and ductility. Different layers of cartilage play distinct roles in the fracture process.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Orthopedics
Wassif Kabir, Claudia Di Bella, Peter F. M. Choong, Cathal D. O'Connell
Summary: The study characterized the elastic and viscoelastic properties of human knee articular cartilage, providing valuable insights for evaluating tissue-engineered materials and reporting a range of biomechanical properties for human distal femoral articular cartilage for the first time.
Article
Materials Science, Multidisciplinary
Jize Liu, Shuting Xu, Zhichao Ma, Yue Jiang, Hongwei Zhao, Luquan Ren
Summary: Water loss and surface defects pose a significant risk to osteoarticular diseases. This study investigates the effects of water content and surface defects on the mechanical properties of cartilage. The results demonstrate that tissue structure and permeability are the main factors influencing the strength and ductility of cartilage. Raman spectroscopy analysis reveals the transition of water bonds in the cartilage layer, leading to decreased permeability and increased resistance to deformation. The organic matrix content determined by Raman spectroscopy is negatively correlated with permeability and positively correlated with cartilage strength.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2022)
Article
Engineering, Biomedical
Jay M. Patel, Claudia Loebel, Kamiel S. Saleh, Brian C. Wise, Edward D. Bonnevie, Liane M. Miller, James L. Carey, Jason A. Burdick, Robert L. Mauck
Summary: This study demonstrates that a hyaluronic acid hydrogel system can interdigitate with and promote sealing of degenerated cartilage, restoring fluid pressurization within the tissue and preventing further fluid flow and matrix loss from the defect surface. Additionally, the hydrogel therapy can guide localized extracellular matrix deposition through presenting chemo mechanical cues, showing therapeutic potential for damaged cartilage treatment across different length scales.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Civil
Yuan Tian, Yifan Fei, Yuli Huang, Xinzheng Lu
Summary: This study proposes a universal rate-dependent damping model and implements it in the open-source finite-element analysis software OpenSees. A comparison with traditional damping models shows that the proposed model has higher accuracy and flexibility in simulating the distribution of damping energy dissipation in various frequency domains.
ENGINEERING STRUCTURES
(2022)
Article
Engineering, Biomedical
Jin Wook Hwang, Dipul Chawla, Guebum Han, Melih Eriten, Corinne R. Henak
Summary: This study investigated the mechanical behaviors of cartilage equilibrated in media of varying osmolarity and viscosity. Results showed that increasing solution osmolarity and viscosity both led to larger energy dissipation and decreased dynamic modulus of cartilage.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Chaosheng Lin, Zhenhan Deng, Jianyi Xiong, Wei Lu, Kang Chen, Yizi Zheng, Weimin Zhu
Summary: Articular cartilage lesion is a common disease that can lead to osteoarthritis if not properly managed. Both mechanical debridement and laser have been used clinically, but radiofrequency has gained attention due to its advantages. However, the safety and efficacy of radiofrequency have been questioned. This article reviews the development history and mechanism of radiofrequency, and summarizes the methods to ensure its safety and effectiveness through power and temperature control.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Yihao Zhou, Xun Zhao, Jing Xu, Yunsheng Fang, Guorui Chen, Yang Song, Song Li, Jun Chen
Summary: The study found that dispersing micromagnets in a silicone matrix can achieve a highly efficient soft magnetoelastic generator, with a higher magnetomechanical coupling factor than rigid materials. This new type of flexible magnetic material can be used for stretchable, water-resistant magnetoelastic generators that can conform to human skin, opening up a new avenue for human-body-centered applications.
Article
Biology
Anand O. Masson, Bryce Besler, W. Brent Edwards, Roman J. Krawetz
Summary: Characterizing the biomechanical properties of mouse cartilage is crucial for understanding tissue homeostasis and degeneration. This study presents a 3D automated surface mapping system and methodology that allows for mechanical characterization with high spatial resolution. The technique comprehensively characterizes cartilage function in mouse models and has the potential to improve our understanding of tissue structure-function interplay.
Article
Chemistry, Multidisciplinary
Nan Jiang, Zhan Su, Yixin Sun, Rong Ren, Jiahao Zhou, Ruiye Bi, Songsong Zhu
Summary: This study identifies three distinct zones in the condylar fibrocartilage and analyzes their components and structure from macro- to nanoscale. Each zone expresses specific proteins related to its mechanics, and the heterogeneity of the fibrocartilage allows for efficient energy dissipation through different scales. The findings provide insights into cartilage biomechanics research and the design of energy-dissipative materials.
Review
Engineering, Biomedical
Noemie Petitjean, Patrick Canadas, Pascale Royer, Daniele Noel, Simon Le Floc'h
Summary: Articular cartilage is a thin tissue that covers the ends of long bones in the joints, allowing frictionless movements. Repairing articular cartilage is a challenge that has been addressed with various approaches, but there are still gaps in understanding its mechanical properties, especially at different scales.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Review
Polymer Science
Mohammad Mostakhdemin, Ashveen Nand, Maziar Ramezani
Summary: This review discusses the elemental keys for designing and testing artificial cartilage, addressing advanced methods and underexplored aspects in the field. It covers topics such as the structure of articular cartilage, properties of hydrogels, mechanical testing approaches, and wear mechanisms. The presentation of bilayer hydrogels as a niche in tissue artificialization and the assessment of recent gaps are also highlighted.
Review
Materials Science, Multidisciplinary
Nian Liu, Huabo Zhang, Xingyu Ni, Tiancheng Liu, Nan Jiang
Summary: This review compares the similarities and differences between condylar cartilage and tibial plateau cartilage in terms of composition, structure, biomechanics, and tissue-engineering strategies. The researches included in this review concluded the focus and deficiency of the studies. The two cartilages are roughly divided into four layers in structure, but there are differences in cell shape and size as well as the way collagen exists. The tibial cartilage has stronger compression resistance compared to the condylar cartilage, which is related to their roles in normal life.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Engineering, Biomedical
Angela Semitela, Andre F. Girao, Carla Fernandes, Goncalo Ramalho, Susana C. Pinto, Antonio Completo, Paula A. A. P. Marques
Summary: This study utilized different depth-dependent alignments of polycaprolactone-gelatin electrospun fibers to assemble three-dimensional scaffold architectures for evaluating chondrocyte responses under various culture conditions. The results showed that the depth-dependent fiber alignments in the 3D scaffolds enhanced chondrocyte proliferation and migration towards the fibrous systems, while mechanical stimulation protocols significantly increased cell metabolic activity and extracellular matrix deposition.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yun Dong, Weibin Hui, Zhiyuan Rui, Yusong Ding, Fangming Lian, Yi Tao
Summary: This study reveals the phonon mechanism of angle-dependent superlubricity between black phosphorus layers based on molecular dynamics simulations and quantum theories. Friction exhibits 180° periodicity with the highest friction at 0° and 180° and lowest at 90°. Thermal excitation reduces friction at 0° due to thermal lubrication, while high temperature increases friction at 90° due to thermal collision. Phonon spectra show that energy dissipation channels can be formed at the interface with 0°, enhancing dissipation efficiency, whereas these channels are destroyed at 90°, hindering frictional dissipation.
Article
Mechanics
Sylvia C. L. Durian, Sam Dillavou, Kwame Markin, Adrian Portales, Bryan O. Torres Maldonado, William T. M. Irvine, Paulo E. Arratia, Douglas J. Durian
Summary: We present a solvable model to study the time-dependent spreading of partially wetting droplets on a substrate. The model considers both small droplets driven by capillarity and large droplets driven by gravity. We measure the equilibrium radius vs droplet volume for various household fluids and compare the results with predictions based on energy minimization, finding good agreement. We then develop equations of motion for the spreading dynamics, taking into account the forces balance inside the droplet and at the moving contact line. Our approach successfully describes prior data for capillary-driven droplets and fits well to new data for gravity-driven droplets.
Article
Orthopedics
Marianne Lintz, Remy E. Walk, Simon Y. Tang, Lawrence J. Bonassar
Summary: Diabetes has been found to impact the biochemical composition, collagen fiber architecture, and mechanical behavior of intervertebral discs. Diabetic discs showed increased glycosaminoglycan and collagen content, as well as disorganized and unaligned collagen fibers at the boundary between the nucleus pulposus and annulus fibrosus. These changes made the diabetic discs stiffer and more resistant to deformation compared to wild-type discs. The findings suggest that diabetes may predispose individuals to degenerative disc disease later in life.
Article
Surgery
Nicholas A. Vernice, Sarah Caughey, Nabih Berri, Jason Harris, Alicia Matavosian, Xue Dong, Ryan J. Bender, Lawrence Bonassar, Jason A. Spector
Summary: This study explores the use of 3D-printed polylactic acid scaffolds and decellularized xenografts to bioengineer nipples in situ. The results demonstrate the maintenance of scaffold shape, diameter, and projection, as well as an increase in tissue volume. Histologic analyses reveal the preservation of native cartilage architecture and the invasion of fibrovascular tissue after 6 months. These findings support the potential use of decellularized allografts to enhance tissue ingrowth within a PLA scaffold for nipple reconstruction.
ANNALS OF PLASTIC SURGERY
(2022)
Article
Materials Science, Multidisciplinary
B. Kim, J. M. Middendorf, N. Diamantides, C. Dugopolski, S. Kennedy, E. Blahut, I Cohen, N. Bouklas, L. J. Bonassar
Summary: This study investigates the relationship between scaffold architecture and mechanical response in collagen scaffolds used for tissue-engineered cartilage. It demonstrates that the differences in mechanical response between scaffold architectures are primarily detected at the micro-scale due to the disparity in pore architecture. Confocal strain mapping combined with digital image correlation is critical for designing and optimizing architectures for porous materials.
EXPERIMENTAL MECHANICS
(2022)
Article
Chemistry, Physical
J. F. Wycoff, S. Dillavou, M. Stern, A. J. Liu, D. J. Durian
Summary: This study investigates the feasibility and effect of desynchronous learning in a decentralized, physics-driven learning network. The results show that desynchronization can improve performance and enable better exploration of the solution space.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Orthopedics
Karan Vishwanath, Scott R. McClure, Lawrence J. Bonassar
Summary: This study characterized the lubricating ability of pAAm hydrogel and revealed its effectiveness in lubricating both native and degraded cartilage explants, suggesting an affinity for the articulating surface of the cartilage.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Engineering, Biomedical
Nicole Diamantides, Leigh Slyker, Sara Martin, Marcos R. Rodriguez, Lawrence J. Bonassar
Summary: This study aimed to investigate the effects of high sugar concentrations and extended glycation times on high concentration collagen pre-glycation. It was found that successful collagen gelation and rheological properties were strongly dependent on the ratio of added sugars to added AGEs.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Physics, Applied
Sam Dillavou, Menachem Stern, Andrea J. Liu, Douglas J. Durian
Summary: Contrastive learning algorithms have been proposed to train physical systems to perform machine-learning tasks based on local evolution rules. In this study, a physics-driven contrastive learning scheme is introduced and implemented for a network of variable resistors. The system effectively trains itself and optimizes its resistance values without the need for a central processor or external information storage. Once trained, the system can rapidly and automatically perform specific tasks.
PHYSICAL REVIEW APPLIED
(2022)
Article
Engineering, Biomedical
Jongkil Kim, Lawrence J. Bonassar
Summary: This study demonstrates the profound effects of gelation pH on cellular activity, collagen fibril structure, and mechanical properties of collagen gels. Acidic and basic gelation pH resulted in cell death, while neutral pH showed a relatively high cell viability. Physiologic gelation pH displayed the greatest collagen deposition, and collagen fibril structure was affected by gelation pH. The gelation pH also influenced the equilibrium modulus of the gels.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Chemistry, Physical
Nuno A. M. Araujo, Liesbeth M. C. Janssen, Thomas Barois, Guido Boffetta, Itai Cohen, Alessandro Corbetta, Olivier Dauchot, Marjolein Dijkstra, William M. Durham, Audrey Dussutour, Simon Garnier, Hanneke Gelderblom, Ramin Golestanian, Lucio Isa, Gijsje H. Koenderink, Hartmut Loewen, Ralf Metzler, Marco Polin, C. Patrick Royall, Andela Saric, Anupam Sengupta, Cecile Sykes, Vito Trianni, Idan Tuval, Nicolas Vogel, Julia M. Yeomans, Iker Zuriguel, Alvaro Marin, Giorgio Volpe
Summary: Self-organisation is the spontaneous emergence of spatio-temporal structures and patterns from the interaction of smaller individual units. Confinement can mediate and control self-organisation by limiting the translational and rotational degrees of freedom, acting as a catalyst or inhibitor. By constraining the self-organisation process in soft-matter systems, confinement can actively steer the emergence or suppression of collective phenomena in space and time.
Article
Multidisciplinary Sciences
Nanqi Bao, Qingkun Liu, Michael F. Reynolds, Marc Figueras, Evangelos Smith, Wei Wang, Michael C. Cao, David A. Muller, Manos Mavrikakis, Itai Cohen, Paul L. McEuen, Nicholas L. Abbott
Summary: Biological systems convert chemical energy into mechanical work using protein catalysts. Synthetic chemomechanical systems have been slow and require high temperatures, but this study introduces a bioinspired chemical strategy that generates surface stresses to drive microactuation at ambient conditions. This strategy can integrate photochemically controlled reactions and reconfigure microstructures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Materials Science, Biomaterials
Serafina G. Lopez, Jongkil Kim, Lara A. Estroff, Lawrence J. Bonassar
Summary: In this study, the researchers removed proteoglycans (GAGs) from collagen gel-based tissue engineered constructs using chondroitinase ABC (cABC) and found that it improved collagen fiber alignment and mechanical properties without compromising compressive strength. The increased fiber organization also appeared to prevent the propagation of large defects under loading. This study provides a new method of modulating the extracellular matrix for improved collagen fiber formation and mechanical properties in tissue engineered constructs.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Mechanics
Meera Ramaswamy, Itay Griniasty, Danilo B. Liarte, Abhishek Shetty, Eleni Katifori, Emanuela Del Gado, James P. Sethna, Bulbul Chakraborty, Itai Cohen
Summary: Nearly all dense suspensions undergo dramatic and abrupt thickening transitions in their flow behavior when sheared at high stresses. In this study, we propose a complete theory of viscosity and find that the viscosity of two different systems can be collapsed onto a single universal curve. By incorporating microscale particle interactions into a scaling variable, we gain insights into the fundamental physical aspects of shear thickening transition. This research is of great importance for understanding the rheological behavior of fluids.
JOURNAL OF RHEOLOGY
(2023)
Article
Multidisciplinary Sciences
Teaya Yang, David Hathcock, Yuchao Chen, Paul L. McEuen, James P. Sethna, Itai Cohen, Itay Griniasty
Summary: We propose a design paradigm for multistate machines that utilizes bifurcations of energy landscapes to organize state transitions, allowing for quick and significant changes in system states through small control parameter variations. This approach is attractive due to its robustness and insensitivity to fabrication errors and noise, and we develop an efficient algorithm to search for component interactions that result in these bifurcation structures. Proof of concept is demonstrated through the design of magnetoelastic machines guided by magnetic energy landscapes, showing the ability to achieve multiple transition pathways between states near bifurcations. This approach has significant implications, particularly in the fields of soft robotics and microscale design where traditional macroscale designs are challenging to implement.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Physics, Fluids & Plasmas
Sam Dillavou, Yohai Bar -Sinai, Michael P. Brenner, Shmuel M. Rubinstein
Summary: Traditionally, contact area is considered a proxy for friction, but bond density and spatial distribution of contact also play important roles. By measuring and imaging, we found that spatial distribution significantly affects static frictional strength.
