☆ 4.7 Article

Hydrophosphinylation of Unactivated Terminal Alkenes Catalyzed by Nickel Chloride

JOURNAL OF ORGANIC CHEMISTRY (2013)

期刊

JOURNAL OF ORGANIC CHEMISTRY

卷 78, 期 13, 页码 6599-6608

出版社

AMER CHEMICAL SOC

DOI: 10.1021/jo4008749

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类别

Chemistry, Organic

资金

National Science Foundation [0953368]
Robert A. Welch Foundation [P-1666]
Texas Christian University Invest in Scholarship (TCU-IS) Program
Division Of Chemistry
Direct For Mathematical & Physical Scien [0953368] Funding Source: National Science Foundation

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Protocol

Reagent

摘要

The room-temperature hydrophosphinylation of unactivated monosubstituted alkenes using phosphinates (ROP(O)H-2) and catalytic NiCl2 in the presence of dppe is described. The method is competitive with prior palladium-catalyzed reactions and uses a much cheaper catalyst and simple conditions. The scope of the reaction is quite broad in terms of unactivated terminal olefins, proceeds at room temperature, often avoids chromatographic purification, and allows one-pot conversion to various organophosphorus compounds.

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